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Research Article

Synthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents

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Pages 733-743 | Received 24 Jul 2013, Accepted 15 Sep 2013, Published online: 24 Oct 2013

References

  • Doshi A, Miller GE. Medical Expenditure Panel Survey 2006. Available from: http://hyper.ahajournals.org/content/42/6/1206 [last accessed Feb 2013]
  • Moutinho-Ribeiro P, Figueira P, Lopes SS, et al. Metolazone-associated acute liver failure and pancreatitis: first case report. Am J Gastroenterol 2001;96:S258
  • Sturgess NC, Kozlowski RZ, Carrington CA, et al. Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. Br J Pharmacol 1988;95:83–94
  • Gavero I, Roach AG. A new antihypertensive agent with a peripheral site of action: in vivo pharmacological studies. Life Sci 1980;27:1525–40
  • Shetty BV, Campenella LA, Thomas TL, et al. Synthesis and activity of some 3-Aryl-3-Aralkyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamides. J Med Chem 1970;13:886–95
  • Carta F, Supuran CT. Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005–2013). Expert Opin Ther Pat 2013;23:681–91
  • Ekinci D, Kurbanoglu NI, Salamci E, et al. Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds. J Enzyme Inhib Chem 2012;27:845–8
  • El-Sabbagh OI, Shabaan MA, Kadry HH, Al-Din ES. New octahydroquinazoline derivatives: synthesis and hypotensive activity. Eur J Med Chem 2010;45:5390–6
  • Alagarsamy V, Venkatesaperumal R, Vijayakumar S, et al. Synthesis and pharmacological investigation of some novel 2-phenyl-3-(substituted methyl amino) quinazolin-4(3H)-ones as H1-receptor blockers. Pharmazie 2002;57:306–7
  • Alagarsamy V. Synthesis and pharmacological investigation of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones as histamine H1-receptor blockers. Pharmazie 2004;59:753–5
  • Alagarsamy V, Solomon VR, Vanikavitha G, et al. Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones. Bio Pharm Bull 2002;25:1432–5
  • Alagarsamy V, Shankar D, Solomon VR, et al. Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents. Acta Pharm 2009;59:75–88
  • Hour MJ, Huang LJ, Kuo SC, et al. 6-Alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 2000;43:4479–87
  • Alagarsamy V, Giridhar R, Yadav MR, et al. AntiHIV, antibacterial and antifungal activities of some novel 1,4-disubstituted-1,2,4-triazolo[4,3-a] quinazolin-5(4 h)-ones. Ind J Pharm Sci 2006;68:532–5
  • Cragoe EJ. (Ed.). Chemistry and pharmacology of drugs, Vol. 2: diuretics: chemistry, pharmacology and medicine. New York: Wiley; 1983
  • Krungkrai J, Scozzafava A, Reungprapavut S, et al. Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action. Bioorg Med Chem 2005;13:483–9
  • Siddiqui N, Ahsan W, Alam MS, et al. Design, synthesis and evaluation of anticonvulsant activity of pyridinyl-pyrrolidones: a pharmacophore hybrid approach. Archiv Pharmazie 2012;345:185–94
  • Siddiqui AA, Mishra R, Shaharyar M. Synthesis, characterization and antihypertensive activity of pyridazinone derivatives. Eur J Med Chem 2010;45:2283–90
  • Shahar yar M, Ansari ZH. Synthesis and in vivo diuretic activity of biphenyl benzothiazole-2-carboxamide derivatives. Acta Polo Pharm – Drug Res 2009;66:387–92
  • Krakoff LR, Selvadurai R, Sytter E. Effect of methylprednisolone upon arterial pressure and the renin angiotensin system in the rat. Am J Physiol 1975;228:613–17
  • Sezik E, Aslan M, Yesilada E, Ito S. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci 2005;76:1223–38
  • Mosaad SM, Mohammed KI, Ahmed MA, Abdel-Hamide SG. Synthesis of certain new 6-iodoquinazolines as potential antitubercular agents. J Appl Sci 2004;4:302–7
  • El-Azab AS, Al-Omar MA, Abdel-Aziz AA, et al. Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study. Eur J Med Chem 2010;45:4188–98
  • Aslan HG, Karacan N. Aromatic sulfonyl hydrazides and sulfonyl hydrazones: antimicrobial activity and physical properties. Med Chem Res 2013;22:1330–8
  • Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G. Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms. Chem Rev 2012;112:4421–68
  • Supuran CT. Structure-based drug discovery of carbonic anhydrase inhibitors. J Enzyme Inhib Chem 2012;27:759–72
  • Lipschitz WL, Haddian Z, Kerpscar A. Bioassay of diuretics. J Pharmacol Exp Ther 1943;79:97–110
  • El-Sabbagh OI, Shabaan MA, Kadry HH, Al-Din ES. New octahydroquinazoline derivatives: synthesis and hypotensive activity. Eur J Med Chem 2010;45:5390–6
  • Pohl JEF, Thurston H. Use of diazoxide in hypertension with renal failure. Bri Med J 1971;4:142–5

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