References
- Yun JW. Possible anti-obesity therapeutics from nature – a review. Phytochemistry 2010;71:1625–41
- Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685–93
- Gillis CN. Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 1997;54:1–8
- Wenbin S, Ying Y, Boren J, et al. Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARγ2 and C/EBPα gene expression. Life Sci 2007;80:618–25
- Gu W, Kim KA, Kim DH. Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. Biol Pharm Bull 2013;36:102–7
- Hwang JT, Lee MS, Sung MJ, et al. Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways. Phytother Res 2009;23:262–6
- Kim MS, Lee MS, Kim SH, et al. Anti-obesity Effects of Ginsenoside Rd via AMPK and PPAR Gamma. Korean J Biotech Bioeng 2007;22:341–4
- Hwang JT, Kim SH, Lee MS, et al. Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. Biochem Biophys Res Commun 2007;364:1002–8
- Ko SR, Suzuki Y, Suzuki K, et al. Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method. Chem Pharm Bull 2007;55:1522–7
- Shin JY, Lee JM, Shin HS, et al. Anti-cancer effect of ginsenoside F2 against glioblastoma multiforme in xenograft model in SD rats. J Ginseng Res 2012;36:86–92
- Mai TT, Moona JY, Song YW, et al. Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells. Cancer Lett 2012;321:144–53
- Ma DL, Chana DSH, Leung CH. Molecular docking for virtual screening of natural product databases. Chem Sci 2011;2:1656--65
- Sohn YS, Lee Y, Park C, et al. Pharmacophore identification for peroxisome proliferator-activated receptor gamma agonists. Bull Korean Chem Soc 2011;32:201--7
- Berman HM, Westbrook J, Feng Z, et al. The protein data bank. Nucleic Acids Res 2000;28:235–42
- Goodsell DS, Morris GM, Olson AJ. Automated docking of flexible ligands: applications of AutoDock. J Mol Recognit 1996;9:1–5
- Jones G, Willett P, Glen RC, et al. Development and validation of a genetic algorithm for flexible docking. J Mol Biol 1997;267:727–48
- Rarey M, Kramer B, Lengauer T, Klebe G. A fast flexible docking method using an incremental construction algorithm. J Mol Biol 1996;261:470–89
- Morris GM, Goodsell DS, Halliday RS. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 1998;19:1639–62
- Park H, Lee J, Lee, S. Critical assessment of the automated AutoDock as a new docking tool for virtual screening. Prot Struct Funct Bioinform 2006;65:549–54
- Bursulaya BD, Totrov M, Abagyan R, Brooks CL III. Comparative study of several algorithms for flexible ligand docking. J Computer-Aided Mol Des 2003;17:755–63
- Sathishkumar N, Sathiyamoorthy S, Ramya M, et al. Molecular docking studies of anti-apoptotic BCL-2, BCL-XL, and MCL-1 proteins with ginsenosides from Panax ginseng. J Enzyme Inhibit Med Chem 2012;27:685–92
- Lagunin A, Stepanchikova A, Filimonov D, Poroikov V. PASS: prediction of activity spectra for biological active substances. Bioinform Appl Notes 2000;16:747–8
- Lagunin A, Filimonov D, Poroikov V. Multi-targeted natural products evaluation based on biological activity prediction with PASS. Curr Pharm Des 2010;16:1703–17
- Farmer SR. Regulation of PPARγ activity during adipogenesis. Int J Obes 2005;29:S13–16
- Park D, Yoon M. Compound K, a novel ginsenoside metabolite, inhibits adipocyte differentiation in 3T3-L1 cells: involvement of angiogenesis and MMPs. Biochem Biophys Res Commun 2012;422:263–7
- Lee OH, Lee HH, Kim JH, Lee BY. Effect of ginsenosides Rg3 and Re on glucose transport in mature 3T3-L1 adipocytes. Phytother Res 2011;25:768–73
- Kovsan J, Ben-Romano R, Souza SC, et al. Regulation of adipocyte lipolysis by degradation of the perilipin protein. J Biol Chem 2007;282:21704–11
- Blanchette-Mackie EJ, Dwyer NK, Barber LT, et al. Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J Lipid Res 1995;36:1211–26
- Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 2000;16:145–71