1,489
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Cytotoxic activities of some benzothiazole-piperazine derivatives

, , &
Pages 649-654 | Received 21 Aug 2014, Accepted 21 Aug 2014, Published online: 21 Oct 2014

References

  • Lion CJ, Matthews CS, Wells G, et al. Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones (‘quinols’). Bioorg Med Chem Lett 2006;16:5005–8
  • Kashiyama E, Hutchinson I, Chua M, et al. Synthesis, metabolic formation and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles. J Med Chem 1999;42:4172–84
  • Kumbhare RM, Dadmal T, Kosurkar U, et al. Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: a novel class of cytotoxic agents. Bioorg Med Chem Lett 2012;22:453–5
  • Solomon VR, Hu C, Lee H. Hybrid pharmacophore design and synthesis of isatin–benzothiazole analogs for their anti-breast cancer activity. Bioorg Med Chem Lett 2009;17:7585–92
  • Saeed S, Rashid N, Jones PG, et al. Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents. Eur J Med Chem 2010;45:1323–31
  • Leong CO, Gaskell M, Martin EA, et al. Antitumour 2-(4-aminophenyl) benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Brit J Cancer 2003;88:470–7
  • Boumendjel A, Nicolle E, Moraux T, et al. Piperazino-benzopyranones and phenalkylaminobenzopyranones: potent inhibitors of breast cancer resistance protein (ABCG2). J Med Chem 2005;48:7275–81
  • Tuncbilek M, Guven EB, Onder T, Cetin Atalay R. Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-d-ribofuranosyl) purine derivatives, which lead to senescence-induced cell death in liver cancer cells. J Med Chem 2012;55:3058–65
  • Yarim M, Koksal M, Durmaz I, Atalay R. Cancer cell cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives. Int J Mol Sci 2012;13:8071–85
  • Gurdal EE, Yarim M, Durmaz I, Cetin-Atalay R. Cytotoxic activities of some novel benzhydrylpiperazine derivatives. Drug Res 2013;63:121–8
  • Gurdal EE, Durmaz I, Cetin-Atalay R, Yarim M. Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives. J Enzyme Inhib Med Chem 2014;29:205–14
  • Al-Soud YA, Al-Sa’doni HH, Saeed B, et al. Synthesis and in vitro antiproliferative activity of new benzothiazole derivatives. Arkivoc 2008;15:225–38
  • Al-Soud YA, Al-Sa’doni HH, Amajaour HA, et al. Synthesis, characterization and anti-HIV and antitumor activities of new coumarin derivatives. Z Naturforsch 2008;63b:83–9
  • Kaplancikli ZA, Altintop MD, Turan-Zitouni G, et al. Synthesis, antimicrobial activity and cytotoxicity of novel oxadiazole derivatives. J Enzyme Inhib Med Chem 2012;27:51–7
  • Abou El Ella DA, Müller FKU. A new scaffold for D3 dopaminergic affinity containing arylpiperazine fragment: molecular modeling, synthesis, in vitro and in vivo pharmacological evaluation. Bull Pharm Sci 2007;30:259–73

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.