Low levels of circulating alpha-1 antitrypsin are associated with spontaneous abortions

References

• Rai R, Regan L. Recurrent miscarriage. Lancet 2006;368:601–11
   PubMed Web of Science ®Google Scholar
• Branch DW, Gibson M, Silver RM. Clinical practice. Recurrent miscarriage. N Engl J Med 2010;363:1740–7
   PubMed Web of Science ®Google Scholar
• ACOG practice bulletin. Management of recurrent pregnancy loss. Number 24, February 2001 (Replaces Technical Bulletin Number 212, September 1995). American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002;78:179–90
   PubMed Web of Science ®Google Scholar
• Weintraub AY, Sheiner E, Levy A, et al. Pregnancy complications in women with inherited thrombophilia. Arch Gynecol Obstet 2006;274:125–9
   PubMedGoogle Scholar
• Lisowska-Myjak B, Sygitowicz G, Wolf B, Pachecka J. Serum alpha-1-antitrypsin concentration during normal and diabetic pregnancy. Eur J Obstet Gynecol Reprod Biol 2001;99:53–6
   PubMedGoogle Scholar
• Christiansen OB, Nielsen HS, Kolte AM. Inflammation and miscarriage. Semin Fetal Neonatal Med 2006;11:302–8. [Epub 6 May 2006]
   PubMed Web of Science ®Google Scholar
• Blank CA, Brantly M. Clinical features and molecular characteristics of alpha 1-antitrypsin deficiency. Ann Allergy 1994;72:105–20; quiz 120–2
   PubMedGoogle Scholar
• Yaghmaei M, Hashemi M, Shikhzadeh A, et al. Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus. Diabetes Res Clin Pract 2009;84:201–4. [Epub 2 Apr 2009]
   PubMedGoogle Scholar
• Bristow CL, Di Meo F, Arnold RR. Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus. Clin Immunol Immunopathol 1998;89:247–59
   PubMedGoogle Scholar
• Baron J, Sheiner E, Abecassis A, et al. Alpha-1-antitrypsin insufficiency is a possible contributor to preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2012;25:934--7
   PubMed Web of Science ®Google Scholar
• Legge M, Duff GB, Potter HC, Hoetjes MM. Maternal serum alpha 1-antitrypsin concentrations in normotensive and hypertensive pregnancies. J Clin Pathol 1984;37:867–9
   PubMed Web of Science ®Google Scholar
• Weintraub AY, Sheiner E. Anticoagulant therapy and thromboprophylaxis in patients with thrombophilia. Arch Gynecol Obstet 2007;276:567–71. [Epub 9 Sep 2007]
   PubMedGoogle Scholar
• Espana F, Gilabert J, Aznar J, et al. Complexes of activated protein C with alpha 1-antitrypsin in normal pregnancy and in severe preeclampsia. American journal of obstetrics and gynecology 1991;164:1310–6
   PubMed Web of Science ®Google Scholar
• Knofler M. Critical growth factors and signalling pathways controlling human trophoblast invasion. Int J Dev Biol 2010;54:269–80
   PubMed Web of Science ®Google Scholar
• Plaisier M, Kapiteijn K, Koolwijk P, et al. Involvement of membrane-type matrix metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial cells: role of MT3-MMP. J Clin Endocrinol Metab 2004;89:5828–36
   PubMedGoogle Scholar
• Plaisier M, Koolwijk P, Hanemaaijer R, et al. Membrane-type matrix metalloproteinases and vascularization in human endometrium during the menstrual cycle. Mol Hum Reprod 2006;12:11–8. [Epub 16 Jan 2006]
   PubMed Web of Science ®Google Scholar
• Plaisier M, Dennert I, Rost E, et al. Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. Hum Reprod 2009;24:185–97. [Epub 14 Oct 2008]
   PubMed Web of Science ®Google Scholar
• Pham CT. Neutrophil serine proteases fine-tune the inflammatory response. Int J Biochem Cell Biol 2008;40:1317–33. [Epub 29 Nov 2007]
   PubMed Web of Science ®Google Scholar
• Quenby S, Bates M, Doig T, et al. Pre-implantation endometrial leukocytes in women with recurrent miscarriage. Hum Reprod 1999;14:2386–91
   PubMed Web of Science ®Google Scholar
• Tuder RM, Zhen L, Cho CY, et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol 2003;29:88–97
   PubMed Web of Science ®Google Scholar
• Ikari Y, Fujikawa K, Yee KO, Schwartz SM. Alpha(1)-proteinase inhibitor, alpha(1)-antichymotrypsin, or alpha(2)-macroglobulin is required for vascular smooth muscle cell spreading in three-dimensional fibrin gel. J Biol Chem 2000;275:12799–805
   PubMedGoogle Scholar
• Lee S, Lee Y, Hong K, et al. Effect of recombinant alpha-1 antitrypsin Fc-fused (AAT-Fc) protein on the inhibition of inflammatory cytokine production and streptozotocin (STZ)-induced diabetes. Mol Med 2013. [Epub 27 March 2013]
   Google Scholar
• Hill JA, Polgar K, Anderson DJ. T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. J Am Med Assoc 1995;273:1933–6
   PubMed Web of Science ®Google Scholar
• Polgar K, Hill JA. Identification of the white blood cell populations responsible for Th1 immunity to trophoblast and the timing of the response in women with recurrent pregnancy loss. Gynecol Obstet Invest 2002;53:59–64
   PubMed Web of Science ®Google Scholar
• Raghupathy R, Makhseed M, Azizieh F, et al. Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol 1999;196:122–30
   PubMed Web of Science ®Google Scholar
• Shaarawy M, Nagui AR. Enhanced expression of cytokines may play a fundamental role in the mechanisms of immunologically mediated recurrent spontaneous abortion. Acta Obstet Gynecol Scand 1997;76:205–11
   PubMed Web of Science ®Google Scholar
• Yui J, Garcia-Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts. Placenta 1994;15:819–35
   PubMed Web of Science ®Google Scholar
• Paradisi R, Porcu E, Venturoli S, et al. Maternal serum levels of pro-inflammatory cytokines in missed and threatened abortion. Am J Reprod Immunol 2003;50:302–8
   PubMed Web of Science ®Google Scholar
• Wilson R, McInnes I, Leung B, et al. Altered interleukin 12 and nitric oxide levels in recurrent miscarriage. Eur J Obstet Gynecol Reprod Biol 1997;75:211–4
   PubMed Web of Science ®Google Scholar