Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice

References

• Abrams J. 1995. The role of nitrates in coronary heart disease. Arch Intern Med 155:357–364.
   PubMedGoogle Scholar
• Agarwal DP, Goedde HW. 1992. Pharmacogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 2:48–62.
   PubMedGoogle Scholar
• Boffetta P, Hashibe M, La Vecchia C, Zatonski W, Rehm J. 2006. The burden of cancer attributable to alcohol drinking. Int J Cancer 119:884–887.
   PubMed Web of Science ®Google Scholar
• Chen C, Mann J, Yoshida A. 1995. Transgenesis of the aldehyde dehydrogenase-2 (ALDH2) locus in a mouse model and in cultured human cells. Adv Exp Med Biol 372:131–136.
   Google Scholar
• Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. 2008. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321:1493–1495.
   PubMed Web of Science ®Google Scholar
• Chen Z, Foster MW, Zhang J, Mao L, Rockman HA, Kawamoto T, Kitagawa K, Nakayama KI, Hess DT, Stamler JS. 2005. An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. PNAS 102:12159–12164.
   PubMed Web of Science ®Google Scholar
• Daiber A, Wenzel P, Oelze M, Munzel T. 2008. New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance. Clin Res Cardiol 97:12–20.
   PubMed Web of Science ®Google Scholar
• Daiber A, Wenzel P, Oelze M, Schuhmacher S, Jansen T, Munzel T. 2009. Mitochondrial aldehyde dehydrogenase (ALDH-2)—marker of and marker for nitrate tolerance in response to nitroglycerin treatment. Chem-Biol Interact 178:40–47.
   PubMed Web of Science ®Google Scholar
• Davis VE, Walsh MJ. 1970. Alcohols, amines and alkaloids: a possible biochemical basis for alcohol addiction. Science 167:1005–1007.
   PubMed Web of Science ®Google Scholar
• Druesne-Pecollo N, Tehard B, Mallet Y, Gerber M, Norat T, Hercberg S, Latino-Martel P. 2009. Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer. Lancet Oncol 10:173–180.
   PubMed Web of Science ®Google Scholar
• Eriksson CJ. 1977. Acetaldehyde metabolism in vivo during ethanol oxidation. Adv Exp Med Biol 85A:319–341.
   Google Scholar
• Fang JL, Vaca CE. 1995. Development of a 32P-postlabelling method for the analysis of adducts arising through the reaction of acetaldehyde with 2’-deoxyguanosine-3’-monophosphate and DNA. Carcinogenesis 16:2177–2185.
   PubMedGoogle Scholar
• Gehring PJ, Watanabe PG, Blau GE. 1976. Pharmacokinetic studies in evaluation of the toxicological and environmental hazard of chemicals. In: Mehlman MA, Shaprio RE, Blumenthal H, editors. Advances in modern toxicology. Vol. 1, Part 1. Washington: Hemisphere Publishing Corporation. pp. 195–270.
   Google Scholar
• International Agency for Research on Cancer. 1988. IARC monographs on the evaluation of the carcinogenic risks to humans. Allyl compounds, aldehydes, epoxides and peroxides. Lyon: IARC. pp. 101–132.
   Google Scholar
• IPCS (The International Programme on Chemical Safety). 1995. Environmental health Criteria No. 167 Acetaldehyde. Geneva: World Health Organization. pp. 1–129.
   Google Scholar
• Isse T, Matsuno K, Oyama T, Kitagawa K, Kawamoto T. 2005a. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain and liver after ethanol gavages. Alcohol Clin Exp Res 29:1959–1964.
   Google Scholar
• Isse T, Oyama T, Matsuno K, Ogawa M, Narai-Suzuki R, Yamaguchi T, Murakami T, Kinaga T, Uchiyama I, Kawamoto T. 2005b. Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice. J Toxicol Sci 30:329–337.
   PubMedGoogle Scholar
• Isse T, Oyama T, Matsuno K, Uchiyama I, Kawamoto T. 2005c. Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality. J Toxicol Sci 30:315–328.
   PubMedGoogle Scholar
• Kawamoto T, Isse T, Kunugita N, Yang M, Kitagawa K, Suenaga R, Matsumoto A, Oyama T. 2003a. Effects of genetic polymorphism of drug metabolizing enzymes on smoking and drinking. J UOEH Supplement 1: 97–106.
   Google Scholar
• Kawamoto T, Kitagawa K, Isse T, Matsumoto A, Yamaguchi T, Suzuki R, Ogawa M, Kinaga T, Katsuno K, Kunugita N, Oyama T. 2003b. Application of Aldh2 knockout mice to biochemical research of alcohol. Jpn J Psychiatr Res Alcohol 10:3–10. (In Japanese)
   Google Scholar
• Kenney WC. 1982. Acetaldehyde adducts of phospholipids. Alcohol Clin Exp Res 6:412–416.
   Google Scholar
• Kitagawa K, Kawamoto T, Kunugita N, Tsukiyama T, Okamoto K, Yoshida A, Nakayama K, Nakayama KI. 2000. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 476:306–311.
   PubMed Web of Science ®Google Scholar
• Lutz WK. 1979. In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat Res 65:289–356.
   PubMed Web of Science ®Google Scholar
• Matsuo K, Hamajima N, Shinoda M, Hatooka S, Inoue M, Takezaki T, Tajima K. 2001. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. Carcinogenesis 22:913–916.
   PubMed Web of Science ®Google Scholar
• Munzel T, Daiber A, Mulsch A. 2005. Explaining the phenomenon of nitrate tolerance. Circ Res 97:618–628.
   PubMed Web of Science ®Google Scholar
• Muramatsu T, Higuchi S, Shigemori K, Saito M, Sasao M, Harada S. 1989. Ethanol patch test—a simple and sensitive method for identifying ALDH phenotype. Alcohol Clin Exp Res 13:229–231.
   PubMed Web of Science ®Google Scholar
• Noori P, Hou SM. 2001. Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers. Carcinogenesis 22:1825–1830.
   PubMedGoogle Scholar
• Ogawa M, Oyama T, Isse T, Saito K, Tomigahara Y, Endo Y, Kawamoto T. 2007. A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype. Toxicol Lett 168:148–154.
   PubMed Web of Science ®Google Scholar
• Oyama T, Isse T, Kagawa N, Kinaga T, Kim YD, Morita M, Sugio K, Weiner H, Yasumoto K, Kawamoto T. 2005. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. Front Biosci 10:951–960.
   PubMedGoogle Scholar
• Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T. 2007a. Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice. Front Biosci 12:1927–1934.
   PubMedGoogle Scholar
• Oyama T, Kim YD, Isse T, Pham TTP, Ogawa M, Yamaguchi T, Kinaga T, Yashima Y, Kim H, Kawamoto T. 2007b. A pilot study on subacute ethanol treatment of ALDH2 KO mice. J Toxicol Sci 32:421–428.
   PubMedGoogle Scholar
• Schuhmacher S, Schulz E, Oelze M, Konig A, Roegler C, Lange K, Sydow L, Kawamoto T, Wenzel P, Munzel T, Lehmann J, Daiber A. 2009. A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena. Br J Pharmacol 158:510–520.
   Google Scholar
• Seitz HK, Oneta CH. 1998. Gastrointestinal alcohol dehydrogenase. Nutr Rev 56:52–60.
   PubMed Web of Science ®Google Scholar
• Sjoquist B, Liljequist S, Engel J. 1982. Increased salsolinol levels in rat striatum and limbic forebrain following chronic ethanol treatment. J Neurochem 39:259–262.
   PubMedGoogle Scholar
• Tuma DJ, Hoffman T, Sorrell MF. 1991. The chemistry of acetaldehyde-protein adducts. Alcohol (suppl) 1:271–276.
   Google Scholar
• Vasiliou V, Bairoch A, Tipton KF, Nebert DW. 1999. Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. Pharmacogenet Genom 9:421–434.
   Google Scholar
• Weiner H, Wei B, Zhou J. 2001. Subunit communication in tetrameric class 2 human liver aldehyde dehydrogenase as the basis for half-of-the-site reactivity and the dominance of the oriental subunit in a heterotetramer. Chem Biol Interact 130–132:47–56.
   Google Scholar
• Wenzel P, Hink U, Oelze M, Seeling A, Isse T, Bruns K, Steinhoff L, Brandt M, Kleschyov AL, Schulz E, Lange K, Weiner H, Lehmann J, Lackner KJ, Kawamoto T, Munzel T, Daiber A. 2007. Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2− /−mice. Br J Pharmacol 150:526–533.
   Google Scholar
• Wenzel P, Muller J, Zurmeyer S, Schuhmacher S, Schulz E, Oelze M, Pautz A, Kawamoto T, Wojnowski L, Kleinert H, Munzel T, Daiber A. 2008b. ALDH-2 deficiency increases cardiovascular oxidative stress—evidence for indirect antioxidative properties. Biochem Biophys Res Comm 367:137–143.
   PubMed Web of Science ®Google Scholar
• Wenzel P, Schuhmacher S, Kienhofer J, Muller J, Hortmann M, Oelze M, Schulz E, Treiber N, Kawamoto T, Scharffetter-Kochanek K, Munzel T, Burkle A, Bachschmid MM, Daiber A. 2008a. Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc Res 80:280–289.
   PubMed Web of Science ®Google Scholar
• Wolff PH. 1972. Ethnic differences in alcohol sensitivity. Science 175:449–450.
   PubMed Web of Science ®Google Scholar
• Yin SJ. 1994. Alcohol dehydrogenase: enzymology and metabolism. Alcohol Supplement 2:113–119.
   Google Scholar
• Yoskida A, Huang IY, Ikawa M. 1984. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci USA 81:258–261.
   Google Scholar