1,145
Views
37
CrossRef citations to date
0
Altmetric
Review Article

Epigenetic priming of the metabolic syndrome

&
Pages 353-361 | Published online: 16 Apr 2011

References

  • Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, Lane RH. 2008. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 41:91–102.
  • Barnes SK, Ozanne SE. 2010. Pathways linking the early environment to long-term health and lifespan. Prog Biophys Mol Biol Epub ahead of print.
  • Bogdarina I, Haase A, Langley-Evans S, Clark AJ. 2010. Glucocorticoid effects on the programming of AT1b angiotensin receptor gene methylation and expression in the rat. PLoS ONE 5:e9237.
  • Bonasio R, Tu S, Reinberg D. 2010. Molecular signals of epigenetic states. Science 330:612–616.
  • Bruce KD, Byrne CD. 2009. The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J 85:614–621.
  • Bruce KD, Cagampang FR, Argenton M, Zhang J, Ethirajan PL, Burdge GC, Bateman AC, Clough GF, Poston L, Hanson MA, McConnell JM, Byrne CD. 2009. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology 50:1796–1808.
  • Bruce KD, Hanson MA. 2010. The developmental origins, mechanisms, and implications of metabolic syndrome. J Nutr 140:648–652.
  • Burdge GC, Lillycrop KA, Phillips ES, Slater-Jefferies JL, Jackson AA, Hanson MA. 2009. Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition. J Nutr 139:1054–1060.
  • Burdge GC, Slater-Jefferies J, Torrens C, Phillips ES, Hanson MA, Lillycrop KA. 2007. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr 97:435–439.
  • Cagampang FR, Poore KR, Hanson MA. 2011. Developmental origins of the metabolic syndrome: body clocks and stress responses. Brain Behav Immun 25:214–220.
  • Campión J, Milagro FI, Martínez JA. 2009. Individuality and epigenetics in obesity. Obes Rev 10:383–392.
  • Catalano PM. 2010. Obesity, insulin resistance, and pregnancy outcome. Reproduction 140:365–371.
  • Clausen TD, Mathiesen ER, Hansen T, Pedersen O, Jensen DM, Lauenborg J, Schmidt L, Damm P. 2009. Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes. J Clin Endocrinol Metab 94:2464–2470.
  • Dunn GA, Bale TL. 2009. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology 150:4999–5009.
  • Durán P, Cintra L, Galler JR, Tonkiss J. 2005. Prenatal protein malnutrition induces a phase shift advance of the spontaneous locomotor rhythm and alters the rest/activity ratio in adult rats. Nutr Neurosci 8:167–172.
  • Elahi MM, Cagampang FR, Mukhtar D, Anthony FW, Ohri SK, Hanson MA. 2009. Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br J Nutr 102:514–519.
  • Etchegaray JP, Lee C, Wade PA, Reppert SM. 2003. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421:177–182.
  • Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. 2005. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102:10604–10609.
  • Froy O. 2011. The circadian clock and metabolism. Clin Sci 120:65–72.
  • Gluckman PD, Hanson MA. 2007. Developmental plasticity and human disease: research directions. J Intern Med 261:461–471.
  • Gluckman PD, Hanson MA, Beedle AS. 2007. Non-genomic transgenerational inheritance of disease risk. Bioessays 29:145–154.
  • Godfrey KM. 1998. Maternal regulation of fetal development and health in adult life. Eur J Obstet Gynecol Reprod Biol 78:141–150.
  • Green CB, Takahashi JS, Bass J. 2008. The meter of metabolism. Cell 134:728–742.
  • Grundy SM. 2005. Metabolic syndrome: therapeutic considerations. Handb Exp Pharmacol 107–133.
  • Hales CN, Barker DJ. 1992. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595–601.
  • Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, Winter PD. 1991. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 303:1019–1022.
  • Kasturi SS, Tannir J, Brannigan RE. 2008. The metabolic syndrome and male infertility. J Androl 29:251–259.
  • King JC. 2006. Maternal obesity, metabolism, and pregnancy outcomes. Annu Rev Nutr 26:271–291.
  • Ko CH, Takahashi JS. 2006. Molecular components of the mammalian circadian clock. Hum Mol Genet 15 Spec No 2:R271–R277.
  • Koza RA, Rogers P, Kozak LP. 2009. Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation. Epigenetics 4:512–518.
  • la Fleur SE, Kalsbeek A, Wortel J, Fekkes ML, Buijs RM. 2001. A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus. Diabetes 50:1237–1243.
  • Lanham SA, Roberts C, Hollingworth T, Sreekumar R, Elahi MM, Cagampang FR, Hanson MA, Oreffo RO. 2010. Maternal high-fat diet: effects on offspring bone structure. Osteoporos Int 21:1703–1714.
  • Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. 2005. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135:1382–1386.
  • Lillycrop KA, Slater-Jefferies JL, Hanson MA, Godfrey KM, Jackson AA, Burdge GC. 2007. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 97:1064–1073.
  • Mehedint MG, Craciunescu CN, Zeisel SH. 2010. Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci USA 107:12834–12839.
  • Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P. 2008. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134:329–340.
  • Napoli C, Glass CK, Witztum JL, Deutsch R, D’Armiento FP, Palinski W. 1999. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet 354:1234–1241.
  • Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. 2010. Chronic high-fat diet in fathers programs ß-cell dysfunction in female rat offspring. Nature 467:963–966.
  • Park JH, Stoffers DA, Nicholls RD, Simmons RA. 2008. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest 118:2316–2324.
  • Reppert SM, Weaver DR. 2002. Coordination of circadian timing in mammals. Nature 418:935–941.
  • Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA. 2004. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol 2:e377.
  • Rutter J, Reick M, McKnight SL. 2002. Metabolism and the control of circadian rhythms. Annu Rev Biochem 71:307–331.
  • Samuelsson AM, Matthews PA, Argenton M, Christie MR, McConnell JM, Jansen EH, Piersma AH, Ozanne SE, Twinn DF, Remacle C, Rowlerson A, Poston L, Taylor PD. 2008. Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension 51:383–392.
  • Schibler U, Sassone-Corsi P. 2002. A web of circadian pacemakers. Cell 111:919–922.
  • Simmons RK, Alberti KG, Gale EA, Colagiuri S, Tuomilehto J, Qiao Q, Ramachandran A, Tajima N, Brajkovich Mirchov I, Ben-Nakhi A, Reaven G, Hama Sambo B, Mendis S, Roglic G. 2010. The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation. Diabetologia 53:600–605.
  • Srinivasan M, Katewa SD, Palaniyappan A, Pandya JD, Patel MS. 2006. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am J Physiol Endocrinol Metab 291:E792–E799.
  • Stamatakis E, Zaninotto P, Falaschetti E, Mindell J, Head J. 2010. Time trends in childhood and adolescent obesity in England from 1995 to 2007 and projections of prevalence to 2015. J Epidemiol Community Health 64:167–174.
  • Stoffers DA, Desai BM, DeLeon DD, Simmons RA. 2003. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes 52:734–740.
  • Suter M, Bocock P, Showalter L, Hu M, Shope C, McKnight R, Grove K, Lane R, Aagaard-Tillery K. 2011. Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates. FASEB J 25:714–726.
  • Torrens C, Priya E, Bruce KD, Cagampamg FR, Siow RCM, Hanson MA, Byrne CD, Mann GE, Clough GF. 2011. Impact of maternal high fat feeding on priming of vascular dysfucntion in offspring: Impaired redox status and scavenging of free radicals (In submission - Hypertension).
  • Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J. 2005. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308:1043–1045.
  • van Straten EM, Bloks VW, Huijkman NC, Baller JF, van Meer H, Lütjohann D, Kuipers F, Plösch T. 2010. The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction. Am J Physiol Regul Integr Comp Physiol 298:R275–R282.
  • Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM. 2010. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology 151:4756–4764.
  • Waterland RA, Travisano M, Tahiliani KG, Rached MT, Mirza S. 2008. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond) 32:1373–1379.
  • World Health Organisation. 2008. 2008–2013 Action plan for the Global strategy for the prevention and control of non-communicable diseases. WHO, Geneva, 2008.
  • Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM. 2006. Nuclear receptor expression links the circadian clock to metabolism. Cell 126:801–810.
  • Zhang J, Zhang F, Didelot X, Bruce KD, Cagampang FR, Vatish M, Hanson M, Lehnert H, Ceriello A, Byrne CD. 2009. Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genomics 10:478.
  • Zheng S, Pan YX. 2010. Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats. J Nutr Biochem Oct 7 [Epub ahead of print].

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.