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Commentary

Toxicogenomic evaluation of chemically induced chromosomal imbalance using DNA image analysis

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Pages 303-307 | Received 23 Oct 2012, Accepted 03 Dec 2012, Published online: 17 Jan 2013

References

  • Alavantic D, Sunjevaric I, Pecevski J, et al. (1988). In vivo genotoxicity of nitrates and nitrites in germ cells of male mice. I: evidence for gonadal exposure and lack of heritable effects. Mutat Res 204:689–95
  • Andreassi MG, Picano E, Del Ry S, et al. (2001). Chronic long-term nitrate therapy: possible cytogenetic effect in humans? Mutagenesis 16:517–21
  • Bouzika E. (1997). Study on DNA ploidy and nuclear area of intensive tumor cells using image analysis system. School of Medicine, Department of Medical Physics, University of Patras, Patra, Greece
  • Buhmeida A, Hilska M, Elzagheid A, et al. (2009). DNA image cytometry predicts disease outcome in stage II colorectal carcinoma. Anticancer Res 29:99–106
  • Carvalho CR, Clarindo WR, Abreu IS. (2011). Image cytometry: nuclear and chromosomal DNA quantification. Methods Mol Biol 689:51–68
  • Cohen C. (1996). Image cytometric analysis in pathology. Hum Pathol 27:482–93
  • Combelles CM, Carabatsos MJ, London SN, et al. (2000). Centrosome-specific perturbations during in vitro maturation of mouse oocytes exposed to cocaine. Exp Cell Res 260:116–26
  • Duesberg P. (1999). Are centrosomes or aneuploidy the key to cancer? Science 284:2091–2
  • Duesberg P. (2005). Does aneuploidy or mutation start cancer? Science 307:41
  • Duesberg P, Iacobuzio-Donahue C, Brosnan JA, et al. (2012). Origin of metastases: subspecies of cancers generated by intrinsic karyotypic variations. Cell Cycle 11:1151–66
  • Duesberg P, Li R, Fabarius A, Hehlmann R. (2005). The chromosomal basis of cancer. Cell Oncol 27: 293–318
  • Duesberg P, Li R, Rasnick D, et al. (2000). Aneuploidy precedes and segregates with chemical carcinogenesis. Cancer Genet Cytogenet 119:83–93
  • Duesberg P, Rasnick D. (2000). Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil Cytoskeleton 47:81–107
  • Duesberg P, Rasnick D, Li R, et al. (1999). How aneuploidy may cause cancer and genetic instability. Anticancer Res 19:4887–906
  • Ermiah E, Abdalla F, Buhmeida A, et al. (2012). Prognostic significance of DNA image cytometry in Libyan breast cancer. Oncology 83:165–76
  • Faranda A, Costa A, Canova S, et al. (1997). Image and flow cytometric analyses of DNA content in human solid tumors. A comparative study. Anal Quant Cytol Histol 19:338–44
  • Fattore L, Piras G, Corda MG, Giorgi O. (2009). The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration. Neuropsychopharmacology 34:1091–101
  • Ferrucci LM, Sinha R, Ward MH, et al. (2010). Meat and components of meat and the risk of bladder cancer in the NIH-AARP Diet and Health Study. Cancer 116:4345–53
  • Friedrich RE, Hieke N, Stern C, et al. (2004). DNA-flow cytometry, DNA-image cytometry and proliferation index (MIB-5) in irradiated rat salivary glands and salivary gland tumors. In Vivo 18:213–22
  • Gallo V, Khan A, Gonzales C, et al. (2008). Validation of biomarkers for the study of environmental carcinogens: a review. Biomarkers 13: 505–34
  • Giaretti W, Pentenero M, Gandolfo S, Castagnola P. (2012). Chromosomal instability, aneuploidy and routine high-resolution DNA content analysis in oral cancer risk evaluation. Future Oncol 8:1257–71
  • Gregory TR. (2001). The bigger the C-value, the larger the cell: genome size and red blood cell size in vertebrates. Blood Cells Mol Dis 27:830–43
  • Grufferman S, Schwartz AG, Ruymann FB, Maurer HM. (1993). Parents’ use of cocaine and marijuana and increased risk of rhabdomyosarcoma in their children. Cancer Causes Control 4:217–24
  • Hatzi VI, Terzoudi GI, Loutsidou AC, et al. (2011). Proliferative and aneugenic effects of butylated hydroxytoluene (BHT) and sodium nitrate in Tetrahymena pyriformis macronuclei using DNA image analysis. Curr Top Toxicol 7:99–103
  • Hellman K, Johansson H, Andersson S, et al. (2012). Prognostic significance of cell cycle- and invasion-related molecular markers and genomic instability in primary carcinoma of the vagina. Int J Gynecol Cancer 23:41–51
  • Huff J. (1995). Mechanisms, chemical carcinogenesis, and risk assessment: cell proliferation and cancer. Am J Ind Med 27:293–300
  • Ito N, Fukushima S, Tsuda H. (1985). Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants. Crit Rev Toxicol 15:109–50
  • Konishi H, Mohseni M, Tamaki A, et al. (2012). Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells. Proc Natl Acad Sci USA 108:17773–8
  • Lanigan RS, Yamarik TA. (2002). Final report on the safety assessment of BHT(1). Int J Toxicol 21 Suppl 2:19–94
  • Loutsidou AC, Hatzi VI, Chasapis CT, et al. (2011). DNA content alterations in Tetrahymena pyriformis macronucleus after exposure to food preservatives sodium nitrate and sodium benzoate. Acta Biol Hung 63:483–9
  • Mello ML, Russo J. (1990). Image analysis of Feulgen-stained c-H-ras-transformed NIH/3T3 cells. Biochem Cell Biol 68:1026–31
  • Monteiro LS, Palmeira C, Bento MJ, Lopes C. (2009). DNA content in malignant salivary gland tumours. Oral Dis 15:295–301
  • Negrini S, Gorgoulis VG, Halazonetis TD. (2010). Genomic instability—an evolving hallmark of cancer. Nat Rev Mol Cell Biol 11:220–8
  • Pliss GB, Frolov AG. (1991). Sodium nitrate as a possible promotor of bladder carcinogenesis in rats. Vopr Onkol 37:203–6
  • Renaud FL, Colon I, Lebron J, et al. (1995). A novel opioid mechanism seems to modulate phagocytosis in Tetrahymena. J Eukaryot Microbiol 42:205–7
  • Roels S, Ducatelle R, Cornelissen H. (1996). Quantitative image analysis as an alternative to chemical analysis for follow-up of liver biopsies from a toucan with hemochromatosis. A technique with potential value for the follow-up of hemochromatosis in humans. Anal Quant Cytol Histol 18:221–4
  • Roels SL, Van Daele AJ, Van Marck EA, Ducatelle RV. (2000). DNA ploidy and nuclear morphometric variables for the evaluation of melanocytic tumors in dogs and cats. Am J Vet Res 61:1074–9
  • Ross JS, Linette GP, Stec J, et al. (2003). DNA ploidy and cell cycle analysis in breast cancer. Am J Clin Pathol 120 Suppl:S72–84
  • Sauvant MP, Pepin D, Piccinni E. (1999). Tetrahymena pyriformis: a tool for toxicological studies. A review. Chemosphere 38:1631–69
  • Stefanidou M, Alevisopoulos G, Chatziioannou A, Koutselinis A. (2003). Assessing food additive toxicity using a cell model. Vet Hum Toxicol 45:103–5
  • Stefanidou M, Alevisopoulos G, Maravelias C, et al. (1999). Phagocytosis of the protozoon Tetrahymena pyriformis as an endpoint in the estimation of cocaine salt and cocaine freebase toxicity. Addict Biol 4:449–52
  • Stefanidou M, Alevizopoulos G, Spiliopoulou C. (2008). DNA content of Tetrahymena pyriformis as a biomarker for different toxic agents. Chemosphere 74:178–80
  • Stefanidou M, Chatziioannou A, Livaditou A, et al. (2002). DNA toxicity of cocaine hydrochloride and cocaine freebase by means of DNA image analysis on Tetrahymena pyriformis. Biol Pharm Bull 25:332–4
  • Stefanidou ME, Hatzi VI, Terzoudi GI, et al. (2010). Effect of cocaine and crack on the ploidy status of Tetrahymena pyriformis: a study using DNA image analysis. Cytotechnology 63:35–40
  • Stefanidou ME, Hatzi VI, Terzoudi GI, et al. (2011). Tartrazine mediated DNA-content alterations on Tetrahymena pyriformis macronuclei by means of the DNA image analysis. Curr Top Toxicol 7:105–8
  • Syrios J, Sougioultzis S, Xynos ID, et al. (2012). Survival in patients with stage IV noncardia gastric cancer–the influence of DNA ploidy and Helicobacter pylori infection. BMC Cancer 12:264
  • Terranova R. (2008). The many faces of constitutive heterochromatin. Med Sci (Paris) 24:720–4
  • Torres-Rendon A, Stewart R, Craig GT, et al. (2009). DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression. Oral Oncol 45:468–73
  • Treat EG, Heaphy CM, Massie LW, et al. (2010). Telomere DNA content in prostate biopsies predicts early rise in prostate-specific antigen after radical prostatectomy for prostate cancer. Urology 75:724–9
  • Umemura T, Kodama Y, Hioki K, et al. (2001). Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis. J Cancer Res Clin Oncol 127:583–90
  • Werness BA, Afify AM, Bielat KL, et al. (1999). Altered surface and cyst epithelium of ovaries removed prophylactically from women with a family history of ovarian cancer. Hum Pathol 30:151–7
  • Yildirim-Assaf S, Coumbos A, Hopfenmuller W, et al. (2007). The prognostic significance of determining DNA content in breast cancer by DNA image cytometry: the role of high grade aneuploidy in node negative breast cancer. J Clin Pathol 60:649–55
  • Zatonski T, Krecicki T, Dus D, et al. (2004). DNA ploidy and DNA index in aneuploid laryngeal cancer. Pol Merkur Lekarski 16:232–5

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