Genotoxicity and cytotoxicity of ZnO and Al₂O₃ nanoparticles

References

• Akhtar MJ, Ahamed M, Kumar S, et al. (2012). Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species. Int J Nanomedicine 7:845–57
   PubMed Web of Science ®Google Scholar
• Balasubramanyam WX, Sailaja N, Mahboob M, et al. (2009). In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test. Mutagenesis 24:245–51
   PubMed Web of Science ®Google Scholar
• Bo Y, Jin C, Liu Y, et al. (2014). Metabolomic analysis on the toxicological effects of TiO2 nanoparticles in mouse fibroblast cells: from the perspective of perturbations in amino acid metabolism. Toxicol Mech Methods 24:461–9
   PubMed Web of Science ®Google Scholar
• Brown DM, Donaldson K, Borm PJ, et al. (2004). Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol 286:344–53
   PubMed Web of Science ®Google Scholar
• Chiang HM, Xia Q, Zou X, et al. (2012). Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells. J Nanosci Nanotechnol 12:2126–35
   PubMed Web of Science ®Google Scholar
• De Berardis B, Civitelli G, Condello M, et al. (2010). Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol Appl Pharmacol 246:116–27
   PubMed Web of Science ®Google Scholar
• Demir E, Burgucu D, Turna F, et al. (2013). Determination of TiO2, ZrO2, and Al2O3 nanoparticles on genotoxic responses in human peripheral blood lymphocytes and cultured embyronic kidney cells. J Toxicol Environ Health A 76:990–1002
   PubMed Web of Science ®Google Scholar
• Dufour EK, Kumaravel T, Nohynek GJ, et al. (2006). Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. Mutat Res 607:215–24
   PubMed Web of Science ®Google Scholar
• Gopalan RC, Osman IF, Amani A, et al. (2009). The effect of zinc oxide and titanium dioxide nanoparticles in the comet assay with UVA photoactivation of human sperm and lymphocytes. Nanotoxicology 3:33–9
   Web of Science ®Google Scholar
• Hackenberg S, Scherzed A, Technau A, et al. (2013). Functional responses of human adipose tissue-derived mesenchymal stem cells to metal oxide nanoparticles in vitro. J Biomed Nanotechnol 9:86–95
   PubMed Web of Science ®Google Scholar
• Karlsson HL. (2010). The comet assay in nanotoxicology research. Anal Bioanal Chem 399:651–66
   PubMedGoogle Scholar
• Klaude M, Eriksson S, Nygren J, Ahnström G. (1996). The comet assay: mechanisms and technical considerations. Mutat Res 12:89–96
   Google Scholar
• Moschini E, Gualtieri M, Colombo M, et al. (2013). The modality of cell–particle interactions drives the toxicity of nanosized CuO and TiO2 in human alveolar epithelial cells. Toxicol Lett 222:102–16
   PubMed Web of Science ®Google Scholar
• Nel NH, Xia T, Madler L, Li N. (2006). Toxic potential of materials at the nanolevel. Science 311:622–7
   PubMed Web of Science ®Google Scholar
• Osman IF, Baumgartner A, Cemeli E, et al. (2010). Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells. Nanomedicine (Lond) 5:1193–203
   PubMed Web of Science ®Google Scholar
• Radziun E, Dudkiewicz Wilczyńska J, Książek I, et al. (2011). Assessment of the cytotoxicity of aluminium oxide nanoparticles on selected mammalian cells. Toxicol In Vitro 25:1694–700
   PubMed Web of Science ®Google Scholar
• Reddy KM, Feris K, Bell J, et al. (2007). Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems. Appl Phys Lett 90:2139021–23
   PubMed Web of Science ®Google Scholar
• Roy R, Singh SK, Chauhan LK, et al. (2014). Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition. Toxicol Lett 227:29–40
   PubMed Web of Science ®Google Scholar
• Sharma V, Anderson D, Dhawan A. (2012a). Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2). Apoptosis 17:852–70
   PubMed Web of Science ®Google Scholar
• Sharma V, Shukla RK, Saxena N, et al. (2009). DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett 185:211–18
   PubMed Web of Science ®Google Scholar
• Sharma V, Singh P, Pandey AK, Dhawan A. (2012b). Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res 745:84–91
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175:184–91
   PubMed Web of Science ®Google Scholar
• Syama S, Reshma SC, Sreekanth PJ, et al. (2013). Effect of zinc oxide nanoparticles on cellular oxidative stress and antioxidant defense mechanisms in mouse liver. Toxicol Environ Chem 95:495–503
   Web of Science ®Google Scholar
• Tice RR, Agurell E, Anderson D, et al. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206–21
   PubMed Web of Science ®Google Scholar
• Tice RR, Agurell E, Anderson D, et al. (2012). Distinctive toxicity of TiO2 rutile/anatase mixed phases nanoparticles on Caco-2 cells. Chem Res Toxicol 25:646–55
   PubMed Web of Science ®Google Scholar
• Tripathi G, Gough JE, Dinda A, Basu B. (2013). In vitro cytotoxicity and in vivo osseointergration properties of compression-molded HDPE-HA-Al2O32 hybrid biocomposites. J Biomed Mater Res A 101:1539–49
   PubMed Web of Science ®Google Scholar
• Wahab R, Kaushik NK, Verma AK, et al. (2011). Fabrication and growth mechanism of ZnO nanostructures and their cytotoxic effect on human brain tumor U87, cervical cancer HeLa, and normal HEK cells. J Biol Inorg Chem 16:431–42
   PubMed Web of Science ®Google Scholar
• Wang J, Zhou G, Chen C, et al. (2007). Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176–85
   PubMed Web of Science ®Google Scholar
• Wang Y, Aker WG, Hwang HM, et al. (2011). A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ 409:4753–62
   PubMed Web of Science ®Google Scholar
• Xiong D, Fang T, Yu L, et al. (2011). Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage. Sci Total Environ 409:1444–52
   PubMed Web of Science ®Google Scholar
• Yang H, Liu C, Yang D, et al. (2009). Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol 29:69–78
   PubMed Web of Science ®Google Scholar
• Zhang L, Gu FX, Chan JM, et al. (2008). Nanoparticles in medicine: therapeutic. Clin Pharmacol Ther (St. Louis) 83:761–9
   PubMed Web of Science ®Google Scholar