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Research Article

Melanotan II injection resulting in systemic toxicity and rhabdomyolysis

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Pages 1169-1173 | Received 06 Aug 2012, Accepted 12 Oct 2012, Published online: 05 Nov 2012

References

  • Shapiro ML, Baldea A, Luchette FA. Rhabdomyolysis in the intensive care unit. J Intensive Care Med 2011.
  • Langan EA, Nie Z, Rhodes LE.Melanotropic peptides: more than just ‘Barbie drugs’ and ‘sun-tan jabs’? Br J Dermatol 2010; 163:451–455.
  • Ugwu SO, Blanchard J, Dorr RT, Levine N, Brooks C, Hadley ME, . Skin pigmentation and pharmacokinetics of melanotan-I in humans. Biopharm Drug Dispos 1997; 18:259–269.
  • SCENESSE® (afamelanotide). http://www.clinuvel.com/en/scenesse/scenesse®-afamelanotide.
  • Fitzgerald LM, Fryer JL, Dwyer T, Humphrey SM. Effect of MELANOTAN, (Nle4-D-Phe7)-α-MSH, on melanin synthesis in humans with MC1R variant alleles. Peptides 2006; 27:388–394.
  • Dorr RT, Dvorakova K, Brooks C, Lines R, Levine N, Schram K, . Increased eumelanin expression and tanning is induced by superpotent melanotropin [Nle4-D-Phe7]-α-MSH in humans. Photochem Photobiol 2000; 72:526–532.
  • Dorr RT, Ertl G, Levine N, Brooks C, Bangert JL, Powell MB, . Effects of a superpotent melanotropic peptide in combination with solar uv radiation on tanning of the skin in human volunteers. Arch Dermatol 2004; 140:827–835.
  • Barnetson RS, Ooi TKT, Zhuang L, Halliday GM, Reid CM, Walker PC, . [Nle4-D-Phe7]-α-melanocyte stimulating hormone significantly increased pigmentation and decreased uv damage in fair-skinned caucasian volunteers. J Invest Dermatol 2006; 126:1869–1878.
  • Langan EA, Ramlogan D, Jamieson LA, Rhodes LE. Changes in moles linked to use of unlicensed ‘sun tan jab’. BMJ 2009; 338:b277.
  • Cardones AR, Grichnik JM. Alpha-Melanocyte-stimulating hormone-induced eruptive naevi. Arch Dermatol 2009; 145:441–444.
  • Paurobally D, Jason F, Dezfoulian B, Nikkels AF. Melanotan-associated melanoma. BJD 2011; 164:1403–1405.
  • Ferrandiz-Pulido C, Fernandez-Figueras MT, Quer A, Ferrandiz C. An eruptive pigmented lesion after melanotan injection. Clin Exp Dermatol 2011; 36:801–802.
  • Hadley ME, Dorr RT. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides 2006; 27:921–930.
  • Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-i clinical study. Life Sci 1996; 58:1777–1784.
  • Palatin Technologies Incorporated. Bremalontide fact sheet. http://www.palatin.com/pdfs/bremelanotide.pdf
  • Giuliano F, Clement P, Droupy S, Alexandre L, Bernabé J. Melanotan II: investigation of the inducer and facilitator effects on penile erection in anaesthetized rats. Neuroscience 2006; 138:293–301.
  • Song CK, Jackson RM, Harris RBS, Richard D, Bartness TJ. Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue. Am J Physiol Regul Integr Comp Physiol 2005; 289:R1467–R1476.
  • Strader AD, Shi H, Ogawa R, Seeley RJ, Reizes O. The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents. J Pharmacol Exp Ther 2007; 322: 1153–1161.
  • Banno R, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, . The melanocortin agonist melanotan II increases insulin sensitivity in OTELF rats. Peptides 2004; 25:1279–1286.
  • Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD. Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 1997; 91:789–798.
  • Chai M, Varga EV, Stankova M, Mayorov A, Perry JW, Yamamura HI, . Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists. Chem Biol Drug Des 2006; 68:183–193.
  • Evans-Brown M, Dawson RT, Chandler M, McVeigh J. Use of melanotan I and II in the general population is unlicensed, unregulated, and potentially harmful. BMJ 2009; 338:b566.
  • United States Food and Drug Administration. “FDA issues warning letter to Melanocorp, Inc For Illegal Sale of Melanotan II.” 9/6/2007. www.fda.gov.
  • Danish Medicines Agency. “Warnings against the product Melanotan.” 8/11/2008. www.dkma.dk.
  • Irish Medicines Board. “Melanotan Powder for Injection.” Notice Information – Warning. 2/272009. www.imb.ie.
  • Norwegian Medicines Agency. “Melanotan – dangerous and illegal tan.” 11/3/2009. www.slk.no.
  • Swedish Medical Products Agency. “MPA warns against using Melanotan II.” 7/26/2010. www.lakemedelsverket.se.
  • Medicines and Healthcare products Regulatory Agency. “‘Tan jab’ is an unlicensed medicine and may not be safe – warns medicines regulator.” 11/17/2008. www.mhra.gov.uk.
  • Tan Injections. www.melanotan.info
  • Kohler M, Thomas A, Geyer H, Petrou M, Schänzer W, Thevis M. Confiscated black market products and nutritional supplements with non-approved ingredients analyzed in the cologne doping control laboratory 2009. Drug Test Anal 2010; 2:533–537.
  • Graham MR, Ryan P, Baker JS, Davies B, Thomas NE, Cooper SM, . Counterfeiting in performance- and image-enhancing drugs. Drug Test Anal 2009; 1:135–142.
  • Cordaro FG, Lombardo S, Cosentino M. Selling androgenic anabolic steroids by the pound: identification and analysis of popular websites on the Internet. Scand J Med Sci Sports 2011; 21:e247–e259.

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