Interpreting cobalt blood concentrations in hip implant patients

References

• Coleman RF, Herrington J, Scales JT. Concentration of wear products in hair, blood, and urine after total hip replacement. Br Med J 1973; 1:527–529.
   PubMed Web of Science ®Google Scholar
• Bartolozzi A, Black J. Chromium concentrations in serum, blood clot and urine from patients following total hip arthroplasty. Biomaterials 1985; 6:2–8.
   PubMed Web of Science ®Google Scholar
• Michel R, Nolte M, Reich M, Loer F. Systemic effects of implanted prostheses made of cobalt-chromium alloys. Arch Orthop Trauma Surg 1991; 110:61–74.
   PubMed Web of Science ®Google Scholar
• Jacobs JJ, Urban RM, Gilbert JL, Skipor AK, Black J, Jasty M, Galante JO. Local and distant products from modularity. Clin Orthop 1995; 319:94–105.
   PubMed Web of Science ®Google Scholar
• Levine H, Ballard WT, Shanbhag A, Jacobs JJ. Particle debris. In: Callaghan JJ, Rosenberg AG, Rubash HE, eds. The Adult Hip Volume 1. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2007:276–285.
   Google Scholar
• Smith-Petersen MN. Evolution of mould arthroplasty of the hip joint. J Bone Joint Surg Br 1948; 30:59–75.
   Web of Science ®Google Scholar
• McKee GK, Watson-Farrar J. Replacement of arthritic hips by the McKee-Farrar prosthesis. J Bone Joint Surg Br 1966; 48:245–259.
   PubMedGoogle Scholar
• McKee GK, Chen SC. The statistics of the McKee-Farrar method of total hip replacement. Clin Orthop 1973; 95:26–33.
   PubMed Web of Science ®Google Scholar
• August AC, Aldam CH, Pynsent PB. The McKee-Farrar hip arthroplasty. A long-term study. J Bone Joint Surg Br 1986; 68: 520–527.
   PubMed Web of Science ®Google Scholar
• Dobbs HS. Survivorship of total hip replacements. J Bone Joint Surg 1980; 62B:168–173.
   Web of Science ®Google Scholar
• Charnley J, Cupic Z. The nine and ten year results of the low-friction arthroplasty of the hip. Clin Orthop 1973; 95:9–25.
   PubMed Web of Science ®Google Scholar
• Willert HG, Semlitsch M. Reactions of the articular capsule to wear products of artificial joint prostheses. J Biomed Mater Res 1977; 11:157–164.
   PubMed Web of Science ®Google Scholar
• Weber BG. Experience with the Metasul total hip bearing system. Clin Orthop 1996; 329S:S69–S77.
   Web of Science ®Google Scholar
• Jacobs JJ, Urban RM, Hallab NJ, Skipor AK, Fischer A, Wimmer MA. Metal-on-metal bearing surfaces. J Am Acad Orthop Surg 2009; 17:69–76.
   PubMed Web of Science ®Google Scholar
• Amstutz HC, Grigoris P. Metal on metal bearings in hip arthroplasty. Clin Orthop 1996; 329:S11–S34.
   PubMed Web of Science ®Google Scholar
• Heaton KT, Dorr LD. Total hip arthroplasty with metasul articulation. Oper Tech Orthop 2001; 11:244–252.
   Google Scholar
• USFDA (United States Food and Drug Administration). Recalls Specific to Metal-on-Metal Hip Implants. Retrieved on September 6, 2013, from: http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/ImplantsandProsthetics/MetalonMetalHipImplants/ucm241770.htm#2. Silver Spring, MD: U.S. Food and Drug Administration; 2013.
   Google Scholar
• Antoniou J, Zukor DJ, Mwale F, Minarik W, Petit A, Huk OL. Metal ion levels in the blood of patients after hip resurfacing: A comparison between twenty-eight and thirty-six-millimeter-head metal-on-metal prostheses. J Bone Joint Surg Am 2008; 90:142–148.
   PubMed Web of Science ®Google Scholar
• Clarke MT, Lee PT, Arora A, Villar RN. Levels of metal ions after small- and large-diameter metal-on-metal hip arthroplasty. J Bone Joint Surg Br 2003; 85:913–917.
   PubMed Web of Science ®Google Scholar
• Back DL, Young DA, Shimmin AJ. How do serum cobalt and chromium levels change after metal-on-metal hip resurfacing?Clin Orthop 2005; 438:177–181.
   PubMedGoogle Scholar
• De Smet K, Calistri A, De Haan R, Campbell PA, Ebramzadeh E, Pattyn C, Gill HS. Metal ion measurement as a diagnostic tool to identify problems with metal-on-metal hip resurfacing. J Bone Joint Surg Am 2008; 90:202–208.
   PubMed Web of Science ®Google Scholar
• Engh CA Jr, MacDonald S, Sritulanondha S, Thompson A, Naudie D, Engh C. Metal ion levels after metal-on-metal total hip arthroplasty: a randomized trial. Clin Orthop 2009; 467:101–111.
   PubMed Web of Science ®Google Scholar
• Jacobs JJ, Skipor AK, Doorn PF, Campbell P, Schmalzried TP, Black J, Amstutz HC. Cobalt and chromium concentrations in patients with metal on metal total hip replacements. Clin Orthop 1996; 329:S256–S263.
   PubMed Web of Science ®Google Scholar
• Langton DJ, Jameson SS, Joyce TJ, Hallab NJ, Natu S, Nargol AV. Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: a consequence of excess wear. J Bone Joint Surg Br 2010; 92:38–46.
   PubMed Web of Science ®Google Scholar
• MacDonald SJ. Can a safe level for metal ions in patients with metal-on-metal total hip arthroplasties be determined?J Arthroplasty 2004; 19:71–77.
   PubMed Web of Science ®Google Scholar
• Vendittoli PA, Mottard S, Roy AG, Dupont C, Lavigne M. Chromium and cobalt ion release following the Durom high carbon content, forged metal-on-metal surface replacement of the hip. J Bone Joint Surg Br 2007; 89:441–448.
   PubMed Web of Science ®Google Scholar
• Walter LR, Marel E, Harbury R, Wearne J. Distribution of chromium and cobalt ions in various blood fractions after resurfacing hip arthroplasty. J Arthroplasty 2008; 23:814–821.
   PubMed Web of Science ®Google Scholar
• Finley BL, Monnot AD, Gaffney SH, Paustenbach DJ. Dose-response relationships for blood cobalt concentrations and health effects: A review of the literature and application of a biokinetic model. J Tox Environ Health Part B 2012; 15:493–523.
   PubMed Web of Science ®Google Scholar
• Finley BL, Monnot AD, Paustenbach DJ, Gaffney SH. Derivation of a chronic oral reference dose for cobalt. Regul Toxicol Pharmacol 2012; 64:491–503.
   PubMed Web of Science ®Google Scholar
• Mayo Clinic. Test Catalog. Test ID: COS (80084) Cobalt, Serum. Retrieved on August 1, 2013, from: http://www.mayomedicallaboratories.com/test-catalog/print/80084. 2013.
   Google Scholar
• Paustenbach DJ, Tvermoes BE, Unice KM, Finley BL, Kerger BD. A review of the health hazards posed by cobalt. Crit Rev Toxicol 2013; 43:316–362.
   PubMed Web of Science ®Google Scholar
• Mayo Clinic. Evaluation of metal-on-metal wear of orthopedic implants. The role of serum chromium and cobalt analysis. Communique 2012; 37:1–6.
   Google Scholar
• MHRA (Medicines and Healthcare Products Regulatory Agency). All Metal-On-Metal (MOM) Hip Replacements. London: MHRA; 2012.
   Google Scholar
• Sampson B, Hart A. Clinical usefulness of blood metal measurements to assess the failure of metal-on-metal hip implants. Ann Clin Biochem 2012; 49:118–131.
   PubMed Web of Science ®Google Scholar
• Hart AJ, Hester T, Sinclair K, Powell JJ, Goodship AE, Pele L, et al. The association between metal ions from hip resurfacing and reduced T-cell counts. J Bone Joint Surg Br 2006; 88:449–454.
   PubMedGoogle Scholar
• Hart AJ, Skinner JA, Winship P, Faria N, Kulinskaya E, Webster D, et al. Circulating levels of cobalt and chromium from metal-on-metal hip replacement are associated with CD8 + T-cell lymphopenia. J Bone Joint Surg Br 2009; 91:835–842.
   PubMed Web of Science ®Google Scholar
• USFDA (United States Food and Drug Administration). Information for Orthopaedic Surgeons about Metal-on-Metal Hip Implant Surgery. Retrieved on September 3, 2013, from: http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/ImplantsandProsthetics/MetalonMetalHipImplants/ucm241667.htm. Silver Spring, MD: U.S. Food and Drug Administration; 2013.
   Google Scholar
• Pritchett JW. Adverse reaction to metal debris: Metallosis of the resurfaced hip. Cur Orthop Pract 2012; 23:50–58.
   Google Scholar
• Langton DJ, Joyce TJ, Jameson SS, Lord J, Van Orsouw M, Holland JP, et al. Adverse reaction to metal debris following hip resurfacing: the influence of component type, orientation and volumetric wear. J Bone Joint Surg Br 2011;93:164–171.
   PubMed Web of Science ®Google Scholar
• Milosev I, Trebse R, Kovac S, Cor A, Campbell P. Dissociation of the metal inlay from the polyethylene liner in an uncemented threaded cup. Arch Orthop Trauma Surg 2005; 125:134–141.
   PubMed Web of Science ®Google Scholar
• Matsuda Y, Yamamuro T, Kasai R, Matsusue Y, Okumura H. Severe metallosis due to abnormal abrasion of the femoral head in a dual bearing hip prosthesis. A case report. J Arthroplasty 1992; 7:439–445.
   PubMedGoogle Scholar
• Mohammed R, Cnudde P. Severe metallosis owing to intraprosthetic dislocation in a failed dual-mobility cup primary total hip arthroplasty. J Arthoplasty 2012; 27:493.e1–493.e3.
   PubMedGoogle Scholar
• Winter GD. Tissue reactions to metallic wear and corrosion products in human patients. J Biomed Mater Res 1974; 8:11–26.
   PubMed Web of Science ®Google Scholar
• Liao Y, Hoffman E, Wimmer M, Fischer A, Jacobs J, Marks L. CoCrMo metal-on-metal hip replacements. Phys Chem Chem Phys 2013; 15:746–756.
   PubMed Web of Science ®Google Scholar
• Catelas I, Medley JB, Campbell PA, Huk OL, Bobyn JD. Comparison of in vitro with in vivo characteristics of wear particles from metal-metal hip implants. J Biomed Mater Res B Appl Biomater 2004; 70:167–178.
   PubMed Web of Science ®Google Scholar
• Billi F, Benya P, Kavanaugh A, Adams J, McKellop H, Ebramzadeh E. The John Charnley Award: An accurate and extremely sensitive method to separate, display, and characterize wear debris: Part 2: Metal and ceramic particles. Clin Orthop 2012; 470:339–350.
   PubMed Web of Science ®Google Scholar
• Catelas I, Bobyn JD, Medley JB, Krygier JJ, Zukor DJ, Huk OL. Size, shape, and composition of wear particles from metal-metal hip simulator testing: Effects of alloy and number of loading cycles. J Biomed Mater Res Part A 2003; 67:312–327.
   PubMed Web of Science ®Google Scholar
• Groth HE, Shilling JM. Tissue response to carbon-reinforced polyethylene. J Orthop Res 1983; 1:129–135.
   PubMedGoogle Scholar
• Debnath UK, Fairclough JA, Williams RL. Long-term local effects of carbon fibre in the knee. Knee 2004; 11:259–264.
   PubMed Web of Science ®Google Scholar
• Brent J, Devlin JJ. Commentary. Dilemmas about the toxicological consequences of metal-on-metal hip prostheses – What we do and do not know, and what we should do?Clin Toxicol 2013; 51:195–198.
   Web of Science ®Google Scholar
• USFDA (United States Food and Drug Administration). FDA Executive Summary Memorandum. Metal-on-Metal Hip Implant Systems. Prepared for the June 27–28, 2012 Meeting of the Orthopaedic and Rehabilitation Devices Advisory Panel Gaithersburg Hilton - Gaithersburg, Maryland 2012.
   Google Scholar
• USFDA (United States Food and Drug Administration). Information about Soft Tissue Imaging and Metal Ion Testing. Retrieved on April 25, 2013, from: http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/ImplantsandProsthetics/MetalonMetalHipImplants/ucm331971.htm. Silver Spring, MD: U.S. Food and Drug Administration; 2013.
   Google Scholar
• Griffin WL, Fehring TK, Kudrna JC, Schmidt RH, Christie MJ, Odum SM, Dennos AC. Are metal ion levels a useful trigger for surgical intervention?J Arthroplasty 2012; 27:32–36.
   PubMed Web of Science ®Google Scholar
• Newton AW, Ranganath L, Armstrong C, Peter V, Roberts NB. Differential distribution of cobalt, chromium, and nickel between whole blood, plasma and urine in patients after metal-on-metal (mom) hip arthroplasty. J Orthop Res 2012; 30:1640–1646.
   PubMed Web of Science ®Google Scholar
• Finley BL, Unice KM, Kerger BD, Otani JM, Paustenbach DJ, Galbraith DA, et al. 31-day study of cobalt (II) chloride ingestion in humans: Pharmacokinetics and clinical effects. J Tox Enviro Health Part A 2013; 76:1–14.
   PubMedGoogle Scholar
• Daniel J, Ziaee H, Pynsent PB, McMinn DJW. The validity of serum levels as a surrogate measure of systemic exposure to metal ions in hip replacement. J Bone Joint Surg Br 2007; 89:736–741.
   PubMedGoogle Scholar
• Gardner FH. The use of cobaltous chloride in the anemia associated with chronic renal disease. J Lab Clin Med 1953; 41:56–64.
   PubMed Web of Science ®Google Scholar
• Rohn RJ, Bond WH. Observations on some hematological effects of cobalt-iron mixtures. Lancet 1953; 73:317–324.
   Google Scholar
• Rohn RJ, Bond WH, Klotz LJ. The effect of cobalt-iron therapy in iron deficiency anemia in infants. J Indiana State Med Assoc 1953; 46:1253–1260.
   PubMedGoogle Scholar
• Taylor A, Marks V, Shabaan AA, Mahmood HA, Duckham JM, Lee HA. Cobalt-induced lipaemia and erythropoiesis. Clinical Chemistry and Chemical Toxicology of Metals: Proc First Int Symp 1977:105–108.
   Google Scholar
• Wolf J, Levy IJ. Treatment of sickle cell anemia with cobalt chloride. Arch Intern Med 1954; 93:387–396.
   Web of Science ®Google Scholar
• Wright JV. Bio-identical steroid hormone replacement: selected observations from 23 years of clinical and laboratory practice. Ann NY Acad Sci 2005; 1057:506–524.
   PubMed Web of Science ®Google Scholar
• Kesteloot H, Roelandt J, Willems J, Claes JH, Joossens JV. An enquiry into the role of cobalt in the heart disease of chronic beer drinkers. Circulation 1968; 37:854–864.
   PubMed Web of Science ®Google Scholar
• Paustenbach DJ, Tvermoes BE, Otani JM, Unice KM, Finley BL, Galbraith DA. Abstract Number 2556/Poster Board-144. Cobalt blood concentrations and health effects in adult volunteers during a 90-day cobalt supplement ingestion study. In: Society of Toxicology, ed. Society of Toxicology’s (SOT) 52nd Annual Meeting, March 10–14, 2013, 2013 Annual Meeting Abstract Supplement: Late-Breaking Abstract Submissions. Reston, VA: Society of Toxicology. 2013:24–25.
   Google Scholar
• Bowie EA, Hurley PJ. Cobalt chloride in the treatment of refractory anaemia in patients undergoing long-term haemodialysis. Aust NZ J Med 1975; 5:306–314.
   PubMedGoogle Scholar
• Licht A, Oliver M, Rachmilewitz EA. Optic atrophy following treatment with cobalt chloride in a patient with pancytopenia and hypercellular marrow. Isr J Med Sci 1972; 8:61–66.
   PubMedGoogle Scholar
• Duckham JM, Lee HA. The treatment of refractory anaemia of chronic renal failure with cobalt chloride. Quart J Med 1976; 45:277–294.
   PubMedGoogle Scholar
• Meecham HM, Humphrey P. Industrial exposure to cobalt causing optic atrophy and nerve deafness: A case report. J Neurol Neurosurg Psychiat 1991; 54:374–375.
   PubMed Web of Science ®Google Scholar
• Schirrmacher UO. Case of cobalt poisoning. Br Med J 1967; 1: 544–545.
   PubMed Web of Science ®Google Scholar
• Schleisner P. Cobalt in anaemia. Acta Med Scand 1956; 154:177–185.
   PubMed Web of Science ®Google Scholar
• Kriss JP, Carnes WH, Gross RT. Hypothyroidism and thyroid hyperplasia in patients treated with cobalt. JAMA 1955; 157:117–121.
   PubMed Web of Science ®Google Scholar
• Davis JE, Fields JP. Experimental production of polycythemia in humans by administration of cobalt chloride. Proc Soc Exp Biol Med 1958; 99:493–495.
   PubMed Web of Science ®Google Scholar
• Sidell CM, Erickson JG, McCleary JE. Cobalt folliculitis. Calif Med 1958; 88:20–21.
   PubMedGoogle Scholar
• Veien NK, Kaaber K. Nickel, cobalt and chromium sensitivity in patients with pompholyx (dyshidrotic eczema). Contact Dermatitis 1979; 5:371–374.
   PubMed Web of Science ®Google Scholar
• Holly RG. Anemia in pregnancy. Obstet Gynecol 1955; 5:562–568.
   PubMed Web of Science ®Google Scholar
• Frigerio E, Pigatto PD, Guzzi G, Altomare G. Metal sensitivity in patients with orthopaedic implants: a prospective study. Contact Dermatitis 2011; 64:273–279.
   PubMed Web of Science ®Google Scholar
• Waterman AH, Schrik JJ. Allergy in hip arthroplasty. Contact Dermatitis 1985; 13:294–301.
   PubMed Web of Science ®Google Scholar
• Deutman R, Mulder TJ, Brian R, Nater JP. Metal sensitivity before and after total hip arthroplasty. J Bone Joint Surg Am 1977; 59:862–865.
   PubMed Web of Science ®Google Scholar
• Kwon YM, Thomas P, Summer B, Pandit H, Taylor A, Beard D, et al. Lymphocyte proliferation responses in patients with pseudotumors following metal-on-metal hip resurfacing arthroplasty. J Orthop Res 2010; 28:444–450.
   PubMed Web of Science ®Google Scholar
• Park YS, Moon YW, Lim SJ, Yang JM, Ahn G, Choi YL. Early osteolysis following second-generation metal-on-metal hip replacement. J Bone Joint Surg Am 2005; 87:1515–1521.
   PubMed Web of Science ®Google Scholar
• Thomas P, Braathen LR, Dorig M, Aubock J, Nestle F, Werfel T, Willert HG. Increased metal allergy in patients with failed metal-on-metal hip arthroplasty and peri-implant T-lymphocytic inflammation. Allergy 2009; 64:1157–1165.
   PubMed Web of Science ®Google Scholar
• Korovessis P, Petsinis G, Repanti M, Repantis T. Metallosis after contemporary metal-on-metal total hip arthroplasty. Five to nine-year follow-up. J Bone Joint Surg Am 2006; 88:1183–1191.
   PubMed Web of Science ®Google Scholar
• Shahrdar C, Campbell P, Mirra J, Dorr LD. Painful metal-on-metal total hip arthroplasty. J Arthroplasty 2006; 21:289–293.
   PubMed Web of Science ®Google Scholar
• Polyzois I, Nikolopoulos D, Michos I, Patsouris E, Theocharis S. Local and systemic toxicity of nanoscale debris particles in total hip arthroplasty. J Appl Toxicol 2012; 32:255–269.
   PubMed Web of Science ®Google Scholar
• Gill HS, Grammatopoulos G, Adshead S, Tsialogiannis E, Tsiridis E. Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty. Trends Mol Med 2012; 18:145–155.
   PubMed Web of Science ®Google Scholar
• Billi F, Campbell P. Nanotoxicology of metal wear particles in total joint arthroplasty: A review of current concepts. J Appl Biomater Biomech 2010; 8:1–6.
   PubMed Web of Science ®Google Scholar
• Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, et al. The effect of nano- and micron-sized particles of cobalt–chromium alloy on human fibroblasts in vitro. Biomaterials 2007; 28:2946–2958.
   PubMed Web of Science ®Google Scholar
• Brown C, Fisher J, Ingham E. Biological effects of clinically relevant wear particles from metal-on-metal hip prostheses. Proc Inst Mech l Eng Part H J Eng Med 2006; 220:355–369.
   PubMed Web of Science ®Google Scholar
• Brown C, Lacharme-Lora L, Mukonoweshuro B, Sood A, Newson RB, Fisher J, et al. Consequences of exposure to peri-articular injections of micro- and nano-particulate cobalt-chromium alloy. Biomaterials 2013; 34:8564–8580.
   PubMed Web of Science ®Google Scholar
• Behl B, Papageorgiou I, Brown C, Hall R, Tipper JL, Fisher J, Ingham E. Biological effects of cobalt-chromium nanoparticles and ions on dural fibroblasts and dural epithelial cells. Biomaterials 2013;34:3547–3558.
   PubMed Web of Science ®Google Scholar
• Raghunathan VK, Devey M, Hawkins S, Hails L, Davis SA, Mann S, et al. Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity. Biomaterials 2013; 34:3559–3570.
   PubMed Web of Science ®Google Scholar
• Parry MC, Bhabra G, Sood A, Machado F, Cartwright L, Saunders M, et al. Thresholds for indirect DNA damage across cellular barriers for orthopaedic biomaterials. Biomaterials 2010; 31:4477–4483.
   PubMed Web of Science ®Google Scholar
• Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, et al. Nanoparticles can cause DNA damage across a cellular barrier. Nature Nanotechnol 2009; 4:876–883.
   PubMed Web of Science ®Google Scholar
• Germain MA, Hatton A, Williams S, Matthews JB, Stone MH, Fisher J, Ingham E. Comparison of the cytotoxicity of clinically relevant cobalt–chromium and alumina ceramic wear particles in vitro. Biomaterials 2003; 24:469–479.
   PubMed Web of Science ®Google Scholar
• Doorn PF, Campbell PA, Worrall J, Benya PD, McKellop HA, Amstutz HC. Metal wear particle characterization from metal on metal total hip replacements: Transmission electron microscopy study of periprosthetic tissues and isolated particles. J Biomed Mater Res 1998; 42:103–111.
   PubMed Web of Science ®Google Scholar
• Goode AE, Perkins JM, Sandison A, Karunakaran C, Cheng H, Wall D, et al. Chemical speciation of nanoparticles surrounding metal-on-metal hips. Chem Commun 2012; 48:8335–8337.
   PubMed Web of Science ®Google Scholar
• Pourzal R, Catelas I, Theissmann R, Kaddick C, Fischer A. Characterization of wear particles generated from CoCrMo alloy under sliding wear conditions. Wear 2011; 271:1658–1666.
   PubMed Web of Science ®Google Scholar
• Lewis AC, Heard PJ. The effects of calcium phosphate deposition upon corrosion of CoCr alloys and the potential for implant failure. J Biomed Mater Res Part A 2005; 75:365–373.
   PubMed Web of Science ®Google Scholar
• Lewis AC, Kilburn MR, Papageorgiou I, Allen GC, Case CP. Effect of synovial fluid, phosphate-buffered saline solution, and water on the dissolution and corrosion properties of CoCrMo alloys as used in orthopedic implants. J Biomed Mater Res Part A 2005; 73A:456–467.
   Web of Science ®Google Scholar
• Hokin B, Adams M, Ashton J, Louie H. Comparison of the dietary cobalt intake in three different Australian diets. Asia Pac J Clin Nutr 2004; 13:289–291.
   PubMed Web of Science ®Google Scholar
• Hokin B, Adams M, Ashton J, Louie H. Analysis of the cobalt content in Australian foods. Asia Pac J Clin Nutr 2004; 13: 284–288.
   PubMed Web of Science ®Google Scholar
• EGVM (Expert Group on Vitamins and Minerals). Safe Upper Levels for Vitamins and Minerals. London: Food Standards Agency; 2003.
   Google Scholar
• EFSA (European Food Safety Authory). Assessment of the safety of cobalt(II) chloride hexahydrate added for nutritional purposes as a source of cobalt in food supplements and the bioavailability of cobalt from this source. EFSA J 2009; 7:1–8.
   Google Scholar
• Mineralife. Cobalt - Liquid Ionic Supplement. Retrieved on July 31, 2012, from: http://www.ionicliquidminerallife.com/ionic/Cobalt-Trace-Mineral—b-1029.asp. Colorado Springs, CO: Mineralife; 2012.
   Google Scholar
• Mineralife. Cobalt 8oz -120 Day Supply. Retrieved on December 6, 2012, from: <http://www.mineralifeonline.com/pd-cobalt-8oz-60-day-supply.cfm>. Colorado Springs, CO: Mineralife; 2012.
   Google Scholar
• Meltzer HM, Brantsaeter AL, Borch-Iohnsen B, Ellingsen DG, Alexander J, Thomassen Y, et al. Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study. Environ Res 2010; 110:497–504.
   PubMed Web of Science ®Google Scholar
• Reuber S, Kreuzer M, Kirchgessner M. Interactions of cobalt and iron in absorption and retention. J Trace Elem Electrolytes Health Dis 1994; 8:151–158.
   PubMed Web of Science ®Google Scholar
• Bar-Or D, Rael LT, Bar-Or R, Slone DS, Mains CW, Rao NK, Curtis CG. The cobalt-albumin binding assay: insights into its mode of action. Clin Chim Acta 2008; 387:120–127.
   PubMed Web of Science ®Google Scholar
• Kerger BD, Gerads R, Gurleyuk H, Thuett KA, Finley BL, Paustenbach DJ. Cobalt speciation assay for human serum. Part I. Method for measuring large and small molecular cobalt and albumin-binding capacity using size exclusion chromatography with inductively-coupled plasma-mass spectroscopy detection. Toxicol Environ Chem 2013; 95:687–708.
   Web of Science ®Google Scholar
• Kerger BD, Tvermoes B, Unice K, Finley BL, Paustenbach DJ, Galbraith D. Cobalt speciation assay for human serum. Part II. Method validation in a study of human volunteers ingesting Cobalt (II) Chloride Dietary Supplement for 90 days. Toxicol Environ Chem 2013; 95:709–718.
   Web of Science ®Google Scholar
• Bar-Or D, Bar-Or R, Rael LT, Gardner DK, Slone DS, Craun ML. Heterogeneity and oxidation status of commercial human albumin preparations in clinical use. Crit Care Med 2005; 33:1638–1641.
   PubMed Web of Science ®Google Scholar
• Bar-Or D, Winkler JV, Vanbenthuysen K, Harris L, Lau E, Hetzel FW. Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I. Am Heart J 2001; 141:985–991.
   PubMed Web of Science ®Google Scholar
• Mothes E, Faller P. Evidence that the principal CoII-binding site in human serum albumin is not at the N-terminus: Implication on the albumin cobalt binding test for detecting myocardial ischemia. Biochemistry (Mosc). 2007; 46:2267–2274.
   Web of Science ®Google Scholar
• Sadler PJ, Tucker A, Viles JH. Involvement of a lysine residue in the N-terminal Ni2 + and Cu2 + binding site of serum albumins. Comparison with Co2+, Cd2 + and Al3+. Eur J Biochem 1994; 220:193–200.
   PubMedGoogle Scholar
• Unice K, Monnot A, Gaffney SH, Tvermoes B, Thuett K, Paustenbach D, et al. Inorganic cobalt supplementation: Prediction of cobalt levels in whole blood and urine using a biokinetic model. Food Chem Toxicol 2012; 50:2456–2461.
   PubMed Web of Science ®Google Scholar
• Tvermoes BE, Finley BL, Unice KM, Otani JM, Paustenbach DJ, Galbraith DA. Cobalt whole blood concentrations in healthy adult male volunteers following two-weeks of ingesting a cobalt supplement. Food Chem Toxicol 2013; 53:432–439.
   PubMed Web of Science ®Google Scholar
• Tevetoglu F. The treatment of common anemias in infancy and childhood with a cobalt-iron mixture; including a case report of iron deficiency anemia due to geophagia. J Pediatr 1956; 49: 46–55.
   PubMed Web of Science ®Google Scholar
• Alexander CS. Cobalt-beer cardiomyopathy: a clinical and pathologic study of twenty-eight cases. Am J Med 1972; 53:395–417.
   PubMed Web of Science ®Google Scholar
• Steens W, von Foerster G, Katzer A. Severe cobalt poisoning with loss of sight after ceramic-metal pairing in a hip–a case report. Acta Orthop 2006;77:830–832.
   PubMed Web of Science ®Google Scholar
• Oldenburg M, Wegner R, Baur X. Severe cobalt intoxication due to prosthesis wear in repeated total hip arthroplasty. J Arthroplasty 2009;24:825.e815–825.e820.
   Google Scholar
• Rizzetti MC, Liberini P, Zarattini G, Catalani S, Pazzaglia U, Apostoli P, Padovani A. Loss of sight and sound. Could it be the hip?Lancet 2009; 373:1052–1052.
   PubMed Web of Science ®Google Scholar
• Ikeda T, Takahashi K, Kabata T, Sakagoshi D, Tomita K, Yamada M. Polyneuropathy caused by cobalt–chromium metallosis after total hip replacement. Muscle Nerve 2010; 42:140–143.
   PubMed Web of Science ®Google Scholar
• Pelclova D, Sklensky M, Janicek P, Lach K. Severe cobalt intoxication following hip replacement revision: clinical features and outcome. Clin Toxicol 2012; 50:262–265.
   PubMed Web of Science ®Google Scholar
• Zywiel MG, Brandt JM, Overgaard CB, Cheung AC, Turgeon TR, Syed KA. Fatal cardiomyopathy after revision total hip replacement for fracture of a ceramic liner. J Bone Joint Surg Br 2013; 95:31–37.
   Web of Science ®Google Scholar
• Janicek P, Tomas T, Klepac L, Pelclova D, Sklensky M. Chronic intoxication with cobalt following revision total hip arthroplasty. Hip Int 2012;[Online] Available at: http://www.hip-int.com/article/chronic-intoxication-with-cobalt-following-revision-total-hip-arthroplasty. Accessed 1 November 2012.
   Google Scholar
• Apel W, Stark D, Stark A, O’Hagan S, Ling J. Cobalt-chromium toxic retinopathy case study. Doc Ophthalmol 2013; 126:69–78.
   PubMed Web of Science ®Google Scholar
• Pazzaglia UE, Apostoli P, Congiu T, Catalani S, Marchese M, Zarattini G. Cobalt, chromium and molybdenum ions kinetics in the human body: Data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication. Arch Orthop Trauma Surg 2011; 131:1299–1308.
   PubMed Web of Science ®Google Scholar
• Tower SS. Arthroprosthetic cobaltism: Neurological and cardiac manifestations in two patients with metal-on-metal arthroplasty: a case report. J Bone Joint Surg Am 2010; 92:2847–2851.
   PubMed Web of Science ®Google Scholar
• Mao X, Wong AA, Crawford RW. Cobalt toxicity—an emerging clinical problem in patients with metal-on-metal hip prostheses?Med J Aust 2011; 194:649–651.
   PubMed Web of Science ®Google Scholar
• Machado C, Appelbe A, Wood R. Arthroprosthetic cobaltism and cardiomyopathy. Heart Lung Circ 2012; 21:759–760.
   PubMed Web of Science ®Google Scholar
• Ng SK, Ebneter A, Gilhotra JS. Hip-implant related chorio-retinal cobalt toxicity. Indian J Ophthalmol 2013; 61:35–37.
   PubMed Web of Science ®Google Scholar
• Sotos JG, Tower SS. Systemic disease after hip replacement: Aeromedical implications of arthroprosthetic cobaltism. Aviat Space Environ Med 2013; 84:242–245.
   PubMed Web of Science ®Google Scholar
• Leikin JB, Karydes HC, Whiteley PM, Wills BK, Cumpston KL, Jacobs JJ. Outpatient toxicology clinic experience of patients with hip implants. Clin Toxicol 2013; 51:230–236.
   Web of Science ®Google Scholar
• Moretti B, Pesce V, Maccagnano G, Vicenti G, Lovreglio P, Soleo L, Apostoli P. Peripheral neuropathy after hip replacement failure: is vanadium the culprit?Lancet 2012; 379:1676.
   PubMed Web of Science ®Google Scholar
• Angell M. Shattuck Lecture–Evaluating the health risks of breast implants: The interplay of medical science, the law, and public opinion. N Engl J Med 1996; 334:1513–1518.
   PubMed Web of Science ®Google Scholar
• Palcheff-Wiemer M, Concannon MJ, Conn VS, Puckett CL. The impact of the media on women with breast implants. Plast Reconstr Surg 1993; 92:779–785.
   PubMed Web of Science ®Google Scholar
• Prentice JR, Clark MJ, Hoggard N, Morton AC, Tooth C, Paley MN, et al. Metal-on-metal hip prostheses and systemic health: a cross-sectional association study 8 years after implantation. PLoS One 2013; 8:e66186–e66195.
   PubMed Web of Science ®Google Scholar
• Alimonti A, Bocca B, Mannella E, Petrucci F, Zennaro F, Cotichini R, et al. Assessment of reference values for selected elements in a healthy urban population. Ann Ist Super Sanita 2005; 41:181–187.
   PubMedGoogle Scholar
• Minoia C, Sabbioni E, Apostoli P, Pietra R, Pozzoli L, Gallorini M, et al. Trace element reference values in tissues from inhabitants of the European community. I. A study of 46 elements in urine, blood and serum of Italian subjects. Sci Total Environ 1990; 95:89–105.
   PubMed Web of Science ®Google Scholar
• Anard D, Kirsch-Volders M, Elhajouji A, Belpaeme K, Lison D. In vitro genotoxic effects of hard metal particles assessed by alkaline single cell gel and elution assays. Carcinogenesis 1997; 18:177–184.
   PubMed Web of Science ®Google Scholar
• Van Goethem F, Lison D, Kirsch-Volders M. Comparative evaluation of the in vitro micronucleus test and the alkaline single cell gel electrophoresis assay for the detection of DNA damaging agents: Genotoxic effects of cobalt powder, tungsten carbide and cobalt-tungsten carbide. Mutat Res 1997; 392:31–43.
   PubMed Web of Science ®Google Scholar
• Colognato R, Bonelli A, Ponti J, Farina M, Bergamaschi E, Sabbioni E, Migliore L. Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro. Mutagenesis 2008; 23:377–382.
   PubMed Web of Science ®Google Scholar
• Alarifi S, Ali D, Suliman Y AO, Ahamed M, Siddiqui MA, Al-Khedhairy AA. Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells. Int J Nanomedicine 2013; 8:189–199.
   PubMed Web of Science ®Google Scholar
• De Boeck M, Lombaert N, De Backer S, Finsy R, Lison D, Kirsch-Volders M. In vitro genotoxic effects of different combinations of cobalt and metallic carbide particles. Mutagenesis 2003; 18:177–186.
   PubMed Web of Science ®Google Scholar
• Stea S, Visentin M, Granchi D, Savarino L, Dallari D, Gualtieri G, et al. Sister chromatid exchange in patients with joint prostheses. J Arthroplasty 2000; 15:772–777.
   PubMed Web of Science ®Google Scholar
• Ladon D, Doherty A, Newson R, Turner J, Bhamra M, Case CP. Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty. J Arthroplasty 2004; 19:78–83.
   PubMed Web of Science ®Google Scholar
• Daley B, Doherty AT, Fairman B, Case CP. Wear debris from hip or knee replacements causes chromosomal damage in human cells in tissue culture. J Bone Joint Surg Br 2004; 86:598–606.
   PubMed Web of Science ®Google Scholar
• Davies AP, Sood A, Lewis AC, Newson R, Learmonth ID, Case CP. Metal-specific differences in levels of DNA damage caused by synovial fluid recovered at revision arthroplasty. J Bone Joint Surg Br 2005; 87:1439–1444.
   PubMedGoogle Scholar
• Collins A, Dusinska M, Franklin M, Somorovska M, Petrovska H, Duthie S, et al. Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ Mol Mutagen 1997; 30:139–146.
   PubMed Web of Science ®Google Scholar
• Olsen JH, McLaughlin JK, Nyren O, Mellemkjaer L, Lipworth L, Blot WJ, et al. Hip and knee implantations among patients with osteoarthritis and risk of cancer: a record-linkage study from Denmark. Int J Cancer 1999; 81:719–722.
   PubMed Web of Science ®Google Scholar
• Visuri T, Pukkala E, Pulkkinen P, Paavolainen P. Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis: A meta-analysis of 6 Nordic cohorts with 73,000 patients. Acta Orthop Scand 2003; 74:351–360.
   PubMed Web of Science ®Google Scholar
• Visuri TI, Pukkala E, Pulkkinen P, Paavolainen P. Cancer incidence and causes of death among total hip replacement patients: A review based on Nordic cohorts with a special emphasis on metal-on-metal bearings. Proc Inst Mech l Eng Part H J Eng Med 2006; 220:399–407.
   PubMed Web of Science ®Google Scholar
• Smith AJ, Dieppe P, Porter M, Blom AW. Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: Linkage study between the National Joint Registry of England and Wales and hospital episode statistics. BMJ 2012; 344:e2383–e2394.
   PubMed Web of Science ®Google Scholar
• Lalmohamed A, MacGregor AJ, de Vries F, Leufkens HGM, van Staa TP. Patterns of risk of cancer in patients with metal-on- metal hip replacements versus other bearing surface types: a record linkage study between a prospective joint registry and general practice electronic health records in England. PLoS One 2013; 8:e65891.
   PubMed Web of Science ®Google Scholar
• Paavolainen P, Pukkala E, Pulkkinen P, Visuri T. Cancer incidence after total knee arthroplasty: a nationwide Finnish cohort from 1980 to 1996 involving 9,444 patients. Acta Orthop Scand 1999; 70: 609–617.
   PubMed Web of Science ®Google Scholar
• Paavolainen P, Pukkala E, Pulkkinen P, Visuri T. Cancer incidence in Finnish hip replacement patients from 1980 to 1995: a nationwide cohort study involving 31,651 patients. J Arthroplasty 1999; 14:272–280.
   PubMed Web of Science ®Google Scholar
• Visuri T, Koskenvuo M. Cancer risk after McKee-Farrar total hip replacement. Orthopedics 1991; 14:137–142.
   PubMed Web of Science ®Google Scholar
• Visuri T, Pukkala E, Paavolainen P, Pulkkinen P, Riska EB. Cancer risk after metal on metal and polyethylene on metal total hip arthroplasty. Clin Orthop 1996; 329 :S280–S289.
   PubMed Web of Science ®Google Scholar
• Visuri T, Borg H, Pulkkinen P, Paavolainen P, Pukkala E. A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up. BMC Musculoskel Dis 2010; 11:1–8.
   PubMed Web of Science ®Google Scholar
• Visuri T, Pulkkinen P, Paavolainen P, Pukkala E. Cancer risk is not increased after conventional hip arthroplasty. A nationwide study from the Finnish Arthroplasty Register with follow-up of 24,636 patients for a mean of 13 years. Acta Orthop 2010; 81:77–81.
   PubMed Web of Science ®Google Scholar
• Gillespie W, Frampton C, Henderson R, Ryan P. The incidence of cancer following total hip replacement. J Bone Joint Surg Br 1988; 70:539–542.
   PubMed Web of Science ®Google Scholar
• Mathiesen EB, Ahlbom A, Bermann G, Lindgren JU. Total hip replacement and cancer: a cohort study. J Bone Joint Surg Br 1995; 77:345–350.
   PubMedGoogle Scholar
• Nyren O, McLaughlin JK, Gridley G, Ekbom A, Johnell O, Fraumeni JF Jr, Adami HO. Cancer risk after hip replacement with metal implants: a population-based cohort study in Sweden. J Natl Cancer Inst 1995; 87:28–33.
   PubMed Web of Science ®Google Scholar
• Signorello LB, Ye W, Fryzek JP, Lipworth L, Fraumeni JF, Blot WJ, et al. Nationwide study of cancer risk among hip replacement patients in Sweden. J Natl Cancer Inst 2001; 93:1405–1410.
   PubMed Web of Science ®Google Scholar
• Holly RG. Studies on iron and cobalt metabolism. JAMA 1955; 158:1349–1352.
   PubMed Web of Science ®Google Scholar
• Jaimet CH, Thode HG. Thyroid function studies on children receiving cobalt therapy. JAMA 1955; 158:1353–1355.
   PubMed Web of Science ®Google Scholar
• Angerer J, Heinrich R, Szadkowski D, Lehnert G. Occupational exposure to cobalt powder and salts biological monitoring and health effects. In: Lekkas TD, ed. International Conference Heavy Metals in the Environment: Athens, September 1985, Volume 2. Edinburgh, Scotland, UK: CEP Consultants; 1985:11–13.
   Google Scholar
• Raffn E, Mikkelsen S, Altman DG, Christensen JM, Groth S. Health effects due to occupational exposure to cobalt blue dye among plate painters in a porcelain factory in Denmark. Scand J Work Environ Health 1988; 14:378–384.
   PubMed Web of Science ®Google Scholar
• Swennen B, Buchet JP, Stanescu D, Lison D, Lauwerys R. Epidemiological survey of workers exposed to cobalt oxides, cobalt salts, and cobalt metal. Br J Ind Med 1993; 50:835–842.
   PubMedGoogle Scholar
• Lantin AC, Mallants A, Vermeulen J, Speybroeck N, Hoet P, Lison D. Absence of adverse effect on thyroid function and red blood cells in a population of workers exposed to cobalt compounds. Toxicol Lett 2011; 201:42–46.
   PubMed Web of Science ®Google Scholar
• Jacquet M. Huit annes de cobaltotherapie en cardiologie. Arch Mal Coeur Vaiss 1949; 42:1095–1111.
   Google Scholar
• Mohiuddin SM, Taskar PK, Rheault M, Roy PE, Chenard J, Morin Y. Experimental cobalt cardiomyopathy. Am Heart J 1970; 80:532–543.
   PubMed Web of Science ®Google Scholar
• Domingo JL, Llobet JM, Bernat R. A study of the effects of cobalt administered orally to rats. Arch Farmacol Toxicol 1984; 10:13–20.
   PubMedGoogle Scholar
• Morvai V, Szakmary E, Tatrai E, Ungvary G, Folly G. The effects of simultaneous alcohol and cobalt chloride administration on the cardiovascular system of rats. Acta Physiol Hung 1993; 81:253–261.
   PubMedGoogle Scholar
• Haga Y, Cline N, Hatori N, Hoffmann-Bang C, Pehrsson SK, Ryden L. Impaired myocardial function following chronic cobalt exposure in an isolated rat heart model. Trace Elem Electrolyt 1996; 13:69–74.
   Web of Science ®Google Scholar
• Roche M, Layrisse M. Effect of cobalt on thyroidal uptake of I131. J Clin Endocrinol Metab 1956; 16:831–833.
   Web of Science ®Google Scholar