Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice

References

• Gibbons S. ‘Legal highs’–novel and emerging psychoactive drugs: a chemical overview for the toxicologist. Clin Toxicol (Phila) 2012; 50:15–24.
   PubMed Web of Science ®Google Scholar
• EMCDDA – Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA. Available at: http://www.emcdda.europa.eu/attachements.cfm/att_132857_EN_EMCDDA-Europol%20Annual%20Report%202010A.pdf. Accessed on 16 December 2013.
   Google Scholar
• Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L. The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. PLos One 2013; 8:e59334.
   PubMed Web of Science ®Google Scholar
• 2012 Global Drug Survey. Available at: http://www.globaldrugsurvey.com/run-my-survey/2012-global-drug-survey. Accessed on 16 December 2013.
   Google Scholar
• Wood DM, Hunter L, Measham F, Dargan PI. Limited use of novel psychoactive substances in South London nightclubs. QJM 2012; 105:959–964.
   PubMed Web of Science ®Google Scholar
• Archer JR, Dargan PI, Chan WL, Hitchings A, Hudson S, Wood DM. Trend analysis of novel psychoactive substances detected in pooled urine samples from street urinals over six months. Clin Toxicol (Phila) 2013; 51:666.
   Web of Science ®Google Scholar
• Wood DM, Archer JRH, Measham F, Hudson S, Dargan PI. Detection of use of novel psychoactive substances by attendees at a music festival in the North West of England. Clin Toxicol (Phila) 2013; 51:340–341.
   Web of Science ®Google Scholar
• Archer JR, Dargan PI, Hudson S, Wood DM. Analysis of anonymous pooled urine from portable urinals in central London confirms the significant use of novel psychoactive substances. QJM 2013; 106:147–152.
   PubMed Web of Science ®Google Scholar
• Ward J, Rhyee S, Plansky J, Boyer E. Methoxetamine: a novel ketamine analog and growing health-care concern. Clin Toxicol (Phila) 2011; 49:874–875.
   PubMed Web of Science ®Google Scholar
• Hofer KE, Grager B, Müller DM, Rauber-Lüthy C, Kupferschmidt H, Rentsch KM, Ceschi A. Ketamine-like effects after recreational use of methoxetamine. Ann Emerg Med 2012; 60:97–99.
   PubMed Web of Science ®Google Scholar
• Wood DM, Davies S, Puchnarewicz M, Johnston A, Dargan PI. Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine. Eur J Clin Pharmacol 2012; 68:853–856.
   PubMed Web of Science ®Google Scholar
• Shields JE, Dargan PI, Wood DM, Puchnarewicz M, Davies S, Waring S. Methoxetamine associated cerebellar toxicity: Three cases with analytical confirmation. Clin Toxicol (Phila) 2012; 50:438–440.
   PubMed Web of Science ®Google Scholar
• Yeung LY, Rudd JA, Lam WP, Mak YT, Yew DT. Mice are prone to kidney pathology after prolonged ketamine addiction. Toxicol Lett 2009; 191:275–278.
   PubMed Web of Science ®Google Scholar
• Tan S, Chan WM, Wai MS, Hui LK, Hui VW, James AE, et al. Ketamine effects on the urogenital system–changes in the urinary bladder and sperm motility. Microsc Res Tech 2011; 74: 1192–1198.
   PubMed Web of Science ®Google Scholar
• Wai MS, Chan WM, Zhang AQ, Wu Y, Yew DT. Long-term ketamine and ketamine plus alcohol treatments produced damages in liver and kidney. Hum Exp Toxicol 2012; 31:877–886.
   PubMed Web of Science ®Google Scholar
• Chu PS, Kwok SC, Lam KM, Chu TY, Chan SW, Man CW, Ma WK. ‘Street ketamine’-associated bladder dysfunction: a report of ten cases. Hong Kong Med J 2007; 13:311–313.
   PubMedGoogle Scholar
• Tsai TH, Cha TL, Lin CM, Tsao CW, Tang SH, Chuang FP, et al. Ketamine-associated bladder dysfunction. Int J Urol 2009; 16: 826–829.
   PubMed Web of Science ®Google Scholar
• Morris H (11-February-2011). Interview with a ketamine chemist: or to be more precise, an arylcyclohexylamine chemist. Vice Magazine. Available at: http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2. Accessed on 16 December 2013.
   Google Scholar
• Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, et al. Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine. Hum Psychopharmacol 2012; 27: 145–149.
   PubMed Web of Science ®Google Scholar
• Chu PS, Ma WK, Wong SCW, Chu RWH, Cheng CH, Wong S, et al. The destruction of the lower urinary tract by ketamine abuse: a new syndrome?BJU Int 2008; 102:1616–1622.
   PubMed Web of Science ®Google Scholar
• Andersson KE, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysioogy. Physiol Rev 2004; 84: 935–986.
   PubMed Web of Science ®Google Scholar
• Poon TL, Wong KF, Chan MY, Fung KW, Chu SK, Man CW, et al. Upper gastrointestinal problems in inhalational ketamine abusers. J Dig Dis 2010; 11:106–110.
   PubMed Web of Science ®Google Scholar
• Wong SW, Lee KF, Wong J, Ng WW, Cheung YS, Lai PB. Dilated common bile ducts mimicking choledochal cysts in ketamine abusers. Hong Kong Med J 2009; 15:53–56.
   PubMedGoogle Scholar
• Morgan CJ, Curran HV. Acute and chronic effects of ketamine upon human memory: a review. Psychopharmacol [Berl] 2006; 188: 408–424.
   PubMed Web of Science ®Google Scholar
• Liao Y, Tang J, Ma M, Wu Z, Yang M, Wang X, et al. Frontal white matter abnormalities following chronic ketamine use: a diffusion tensor imaging study. Brain 2010;133:2115–2122.
   PubMed Web of Science ®Google Scholar
• Edward Roberts R, Curran HV, Friston KJ, Morgan CJ. Abnormalities in white matter microstructure associated with chronic ketamine use. Neuropsychopharmacology 2014;39:329–338.
   PubMed Web of Science ®Google Scholar