Characteristics of analytically confirmed 3-MMC-related intoxications from the Swedish STRIDA project

References

• Gibbons S.‘Legal highs’ - novel and emerging psychoactive drugs: a chemical overview for the toxicologist. Clin Toxicol (Phila) 2012; 50:15–24.
   PubMed Web of Science ®Google Scholar
• Spiller HA, Ryan ML, Weston RG, Jansen J. Clinical experience with and analytical confirmation of “bath salts” and “legal highs” (synthetic cathinones) in the United States. Clin Toxicol (Phila) 2011; 49:499–505.
   PubMed Web of Science ®Google Scholar
• EMCDDA. European Drug Report 2014: Trends and developments. European Monitoring Centre for Drugs and Drug Addiction. 2014. http://www.emcdda.europa.eu/publications/annual-report.
   Google Scholar
• UNODC. The challenge of new psychoactive substances 2013. http://www.unodc.org/documents/scientific/NPS_2013_SMART.pdf.
   Google Scholar
• Baron M, Elie M, Elie L. An analysis of legal highs: do they contain what it says on the tin? Drug Test Anal 2011; 3:576–581.
   PubMed Web of Science ®Google Scholar
• Davies S, Wood DM, Smith G, Button J, Ramsey J, Archer R, et al. Purchasing ‘legal highs’ on the Internet–is there consistency in what you get? QJM 2010; 103:489–493.
   PubMed Web of Science ®Google Scholar
• EMCDDA. Risk assessments of a various psychoactive substances 1999–2014. http://www.emcdda.europa.eu/publications/searchresults?action = list&type = PUBLICATIONS&SERIES_PUB = w12.
   Google Scholar
• Gustavsson D, Escher C. [Mephedrone–Internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance]. Läkartidningen 2009; 106:2769–2771.
   PubMedGoogle Scholar
• Lindeman E, Hultén P, Ström S, Enlund M, Al-Saffar Y, Helander A. [Increased abuse of the Internet drug MDPV in Vastmanland. Severe cases of poisoning have given health care major problems]. Läkartidningen 2012; 109:1954–1957.
   PubMedGoogle Scholar
• Miotto K, Striebel J, Cho AK, Wang C. Clinical and pharmacological aspects of bath salt use: a review of the literature and case reports. Drug Alcohol Depend 2013; 132:1–12.
   PubMed Web of Science ®Google Scholar
• Murray BL, Murphy CM, Beuhler MC. Death following recreational use of designer drug “bath salts” containing 3,4-Methylenedioxypyrovalerone (MDPV). J Med Toxicol 2012; 8:69–75.
   PubMedGoogle Scholar
• Al-Saffar Y, Stephanson NN, Beck O. Multicomponent LC-MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine-experience from the Swedish population. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 930:112–120.
   PubMed Web of Science ®Google Scholar
• Elliott SP, Brandt SD, Freeman S, Archer RP. AMT (3-(2-aminopropyl)indole) and 5-IT (5-(2-aminopropyl)indole): an analytical challenge and implications for forensic analysis. Drug Test Anal 2013; 5:196–202.
   PubMed Web of Science ®Google Scholar
• Helander A, Beck O, Hägerkvist R, Hultén P. Identification of novel psychoactive drug use in Sweden based on laboratory analysis–initial experiences from the STRIDA project. Scand J Clin Lab Invest 2013; 73:400–406.
   PubMed Web of Science ®Google Scholar
• Helander A, Bäckberg M, Hultén P, Al-Saffar Y, Beck O. Detection of new psychoactive substance use among emergency room patients: Results from the Swedish STRIDA project. Forensic Sci Int 2014; 243C:23–29.
   Web of Science ®Google Scholar
• EMCDDA. Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances. 2011. http://www.emcdda.europa.eu/attachements.cfm/att_116646_EN_TDAK11001ENC_WEB-OPTIMISED%20FILE.pdf.
   Google Scholar
• Lusthof KJ, Oosting R, Maes A, Verschraagen M, Dijkhuizen A, Sprong AG. A case of extreme agitation and death after the use of mephedrone in The Netherlands. Forensic Sci Int 2011; 206:e93–95.
   PubMed Web of Science ®Google Scholar
• McCullough C, Keane MG, Hillman T, Elkhodair S. Pneumomediastinum secondary to mephedrone inhalation. BMJ Case Rep 2013; 2013.
   Google Scholar
• Rhidian R, Babu A. Acute kidney injury requiring haemodialysis following ingestion of mephedrone. BMJ Case Rep 2013; 2013.
   Google Scholar
• Wood DM, Davies S, Greene SL, Button J, Holt DW, Ramsey J, Dargan PI. Case series of individuals with analytically confirmed acute mephedrone toxicity. Clin Toxicol (Phila) 2010; 48:924–927.
   PubMed Web of Science ®Google Scholar
• Wood DM, Davies S, Puchnarewicz M, Button J, Archer R, Ovaska H, et al. Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity. J Med Toxicol 2010; 6:327–330.
   PubMedGoogle Scholar
• Wood DM, Greene SL, Dargan PI. Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone. Emerg Med J 2011; 28:280–282.
   PubMed Web of Science ®Google Scholar
• Dargan PI, Sedefov R, Gallegos A, Wood DM. The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone). Drug Test Anal 2011; 3:454–463.
   PubMed Web of Science ®Google Scholar
• Schifano F, Albanese A, Fergus S, Stair JL, Deluca P, Corazza O, et al.; Psychonaut Web Mapping; ReDNet Research Groups. Mephedrone (4-methylmethcathinone; ‘meow meow’): chemical, pharmacological and clinical issues. Psychopharmacology (Berl) 2011; 214:593–602.
   PubMed Web of Science ®Google Scholar
• Wood DM, Dargan PI. Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicity. Prog Neuropsychopharmacol Biol Psychiatry 2012; 39:227–233.
   PubMed Web of Science ®Google Scholar
• Schifano F, Corkery J, Ghodse AH. Suspected and confirmed fatalities associated with mephedrone (4-methylmethcathinone, “meow meow”) in the United Kingdom. J Clin Psychopharmacol 2012; 32:710–714.
   PubMed Web of Science ®Google Scholar
• Svensk Författningssamling [Swedish codes of Statues]. Förordning om ändring i förordningen (1992:1554) om kontroll av narkotika [Regulation of changing the regulation of Narcotics]. 2013.
   Google Scholar
• Bluelight. http://www.bluelight.org/vb/content/ (Accessed on August, 2014).
   Google Scholar
• Erowid. http://www.erowid.org/ (Accessed on August, 2014).
   Google Scholar
• Flashback. https://www.flashback.org/t1880193 (Accessed on August, 2014).
   Google Scholar
• Dal Cason TA, Young R, Glennon RA. Cathinone: an investigation of several N-alkyl and methylenedioxy-substituted analogs. Pharmacol Biochem Behav 1997; 58:1109–1116.
   PubMed Web of Science ®Google Scholar
• Kelly JP. Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. Drug Test Anal 2011; 3:439–453.
   PubMed Web of Science ®Google Scholar
• Lopez-Arnau R, Martinez-Clemente J, Carbo M, Pubill D, Escubedo E, Camarasa J. An integrated pharmacokinetic and pharmacodynamic study of a new drug of abuse, methylone, a synthetic cathinone sold as “bath salts”. Prog Neuropsychopharmacol Biol Psychiatry 2013; 45:64–72.
   PubMed Web of Science ®Google Scholar
• Bäckberg M, Beck O, Hultén P, Rosengren-Holmberg J, Helander A. Intoxications of the new psychoactive substance 5-(2-aminopropyl)indole (5-IT): A case series from the Swedish STRIDA project. Clin Toxicol (Phila) 2014; 52:618–624.
   PubMed Web of Science ®Google Scholar
• EMCDDA. New drugs in Europe 2012. 2013. http://www.emcdda.europa.eu/attachements.cfm/att_212366_EN_EMCDDA-Europol%202012%20Annual%20Report_final.pdf.
   Google Scholar
• Google Trends. http://www.google.com/trends/explore#q = 3-mmc&geo = SE&cmpt = q (Accessed on August, 2014).
   Google Scholar
• Wood DM, Greene SL, Dargan PI. Emergency department presentations in determining the effectiveness of drug control in the United Kingdom: mephedrone (4-methylmethcathinone) control appears to be effective using this model. Emerg Med J 2013; 30:70–71.
   PubMed Web of Science ®Google Scholar
• Karinen R, Tuv SS, Rogde S, Peres MD, Johansen U, Frost J, et al. Lethal poisonings with AH-7921 in combination with other substances. Forensic Sci Int 2014. doi: 10.1016/j.forsciint.2014.08.013.
   Web of Science ®Google Scholar
• Burch HJ, Clarke EJ, Hubbard AM, Scott-Ham M. Concentrations of drugs determined in blood samples collected from suspected drugged drivers in England and Wales. J Forensic Leg Med 2013; 20:278–289.
   PubMed Web of Science ®Google Scholar
• Power JD, McGlynn P, Clarke K, McDermott SD, Kavanagh P, O’Brien J. The analysis of substituted cathinones. Part 1: chemical analysis of 2-, 3- and 4-methylmethcathinone. Forensic Sci Int 2011; 212:6–12.
   PubMed Web of Science ®Google Scholar
• van Amsterdam J, Nutt D, van den Brink W. Generic legislation of new psychoactive drugs. J Psychopharmacol 2013; 27:317–324.
   PubMed Web of Science ®Google Scholar
• Cosbey SH, Peters KL, Quinn A, Bentley A. Mephedrone (methylmethcathinone) in toxicology casework: a Northern Ireland perspective. J Anal Toxicol 2013; 37:74–82.
   PubMed Web of Science ®Google Scholar
• Meyer MR, Wilhelm J, Peters FT, Maurer HH. Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry. Anal Bioanal Chem 2010; 397:1225–1233.
   PubMed Web of Science ®Google Scholar
• Pedersen AJ, Reitzel LA, Johansen SS, Linnet K. In vitro metabolism studies on mephedrone and analysis of forensic cases. Drug Test Anal 2013; 5:430–438.
   PubMed Web of Science ®Google Scholar
• Sorensen LK. Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879:727–736.
   PubMed Web of Science ®Google Scholar
• Adamowicz P, Tokarczyk B, Stanaszek R, Slopianka M. Fatal mephedrone intoxication–a case report. J Anal Toxicol 2013; 37:37–42.
   PubMed Web of Science ®Google Scholar
• Aromatario M, Bottoni E, Santoni M, Ciallella C. New lethal highs: a case of a deadly cocktail of GHB and Mephedrone. Forensic Sci Int 2012; 223:e38–41.
   PubMed Web of Science ®Google Scholar
• Dickson AJ, Vorce SP, Levine B, Past MR. Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. J Anal Toxicol 2010; 34:162–168.
   PubMed Web of Science ®Google Scholar
• Elliott S, Evans J. A 3-year review of new psychoactive substances in casework. Forensic Sci Int 2014; 243C:55–60.
   Google Scholar
• Gerace E, Petrarulo M, Bison F, Salomone A, Vincenti M. Toxicological findings in a fatal multidrug intoxication involving mephedrone. Forensic Sci Int 2014; 243C:68–73.
   Google Scholar
• Maskell PD, De Paoli G, Seneviratne C, Pounder DJ. Mephedrone (4-methylmethcathinone)-related deaths. J Anal Toxicol 2011; 35:188–191.
   PubMed Web of Science ®Google Scholar
• Rojek S, Klys M, Maciow-Glab M, Kula K, Strona M. Cathinones derivatives-related deaths as exemplified by two fatal cases involving methcathinone with 4-methylmethcathinone and 4-methylethcathinone. Drug Test Anal 2014; 6:770–777.
   PubMed Web of Science ®Google Scholar
• Torrance H, Cooper G. The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland. Forensic Sci Int 2010; 202:e62–63.
   PubMed Web of Science ®Google Scholar