Review of the effect of intravenous lipid emulsion on laboratory analyses

References

• Rosenblatt MA, Abel M, Fischer GW, et al. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006;105:217–218.
   PubMed Web of Science ®Google Scholar
• Litz RJ, Popp M, Stehr SN, et al. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 2006;61:800–801.
   PubMed Web of Science ®Google Scholar
• Taftachi F, Sanaei-Zadeh H, Sepehrian B, et al. Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning–a randomized controlled trial. Eur Rev Med Pharmacol Sci. 2012;16:38–42.
   PubMed Web of Science ®Google Scholar
• Smith SW. Drugs and pharmaceuticals: management of intoxication and antidotes. In: Luch A, editor. Molecular, clinical and environmental toxicology. Experientia Supplementum. 100: Birkhäuser Basel; 2010. p. 397-460.
   Google Scholar
• Downes MA, Calver LA, Isbister GK. Intralipid therapy does not improve level of consciousness in overdoses with sedating drugs: A case series. Emerg Med Australas. 2014;26:286–290.
   PubMed Web of Science ®Google Scholar
• Neal JM, Mulroy MF, Weinberg GL. American Society of Regional Anesthesia and Pain Medicine checklist for managing local anesthetic systemic toxicity: 2012 version. Reg Anesth Pain Med. 2012;37:16–18.
   PubMed Web of Science ®Google Scholar
• American College of Medical Toxicology. ACMT position statement: interim guidance for the use of lipid resuscitation therapy. J Med Toxicol. 2011;7:81–82.
   PubMedGoogle Scholar
• Agarwala R, Ahmed SZ, Wiegand TJ. Prolonged use of intravenous lipid emulsion in a severe tricyclic antidepressant overdose. J Med Toxicol. 2014;10:210–214.
   PubMedGoogle Scholar
• Bucklin MH, Gorodetsky RM, Wiegand TJ. Prolonged lipemia and pancreatitis due to extended infusion of lipid emulsion in bupropion overdose. Clin Toxicol. 2013;51:896–898.
   PubMed Web of Science ®Google Scholar
• Levine M, Skolnik AB, Ruha AM, et al. Complications following antidotal use of intravenous lipid emulsion therapy. J Med Toxicol. 2014;10:10–14.
   PubMedGoogle Scholar
• Rhoads DD, Sivak RA, Palmer OM. Plasma abnormalities following overdose. Clin Chem. 2014;60:1020–1021.
   PubMed Web of Science ®Google Scholar
• Burtis CA, Bruns DE. Tietz fundamentals of clinical chemistry and molecular diagnostics. 7th ed. St Louis, Missouri: Elsevier/Saunders; 2015. 1079 p.
   Google Scholar
• Nikolac N. Lipemia: causes, interference mechanisms, detection and management. Biochem. 2014;24:57–67.
   Google Scholar
• Grunbaum AM, Gilfix BM, Gosselin S, et al. Analytical interferences resulting from intravenous lipid emulsion. Clin Toxicol. 2012;50:812–817.
   Web of Science ®Google Scholar
• Brady J, Oleary N. Interference due to lipemia in routine photometric analysis - survey of an underrated problem. Ann Clin Biochem. 1994;31:281–288.
   PubMed Web of Science ®Google Scholar
• Gosselin S, Morris M, Miller-Nesbitt A, et al. Methodology for AACT evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol. 2015;53:557–564.
   PubMed Web of Science ®Google Scholar
• Bornhorst JA, Roberts RF, Roberts WL. Assay-specific differences in lipemic interference in native and intralipid-supplemented samples. Clin Chem. 2004;50:2197–2201.
   PubMed Web of Science ®Google Scholar
• Kroll MH. Evaluating interference caused by lipemia. Clin Chem. 2004;50:1968–1969.
   PubMed Web of Science ®Google Scholar
• Twomey PJ, Don-Wauchope AC, McCullough D. Unreliability of triglyceride measurement to predict turbidity induced interference. J Clin Pathol. 2003;56:861–862.
   PubMed Web of Science ®Google Scholar
• Glick MR, Ryder KW, Jackson SA. Graphical comparisons of interferences in clinical chemistry instrumentation. Clin Chem. 1986;32:470–475.
   PubMed Web of Science ®Google Scholar
• Sonntag O, Scholer A. Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies.[Erratum appears in Ann Clin Biochem 2001 Nov;38(Pt 6):731]. Ann Clin Biochem. 2001;38:376–385.
   PubMed Web of Science ®Google Scholar
• Dimeski G, Jones BW. Lipaemic samples: effective process for lipid reduction using high speed centrifugation compared with ultracentrifugation. Biochem. 2011;21:86–92.
   Google Scholar
• Fleming JJ, Swaminathan S. Interference in autoanalyzer analysis. Indian J. 2001;16:22–30.
   Google Scholar
• Nikolac N, Simundic AM, Miksa M, et al. Heterogeneity of manufacturers' declarations for lipemia interference–an urgent call for standardization. Clinica Chimica Acta. 2013;426:33–40.
   PubMed Web of Science ®Google Scholar
• Saracevic A, Nikolac N, Simundic AM. The evaluation and comparison of consecutive high speed centrifugation and LipoClear (R) reagent for lipemia removal. Clin Biochem. 2014;47:309–314.
   PubMed Web of Science ®Google Scholar
• Murphy L, Mullen H, Frost S, et al. An evaluation of interference by hemolysis, lipemia and icterus on the new au 5800® clinical chemistry system. Clin Chem. 2012;58:A20–A1.
   Google Scholar
• Agarwal S, Vargas G, Nordstrom C, et al. Effect of interference from hemolysis, icterus and lipemia on routine pediatric clinical chemistry assays. Clin Chim Acta. 2015;438:241–245.
   PubMed Web of Science ®Google Scholar
• Bailey D, Martens P, Mah W, et al. A next generation enzymatic magnesium assay on the Abbott ARCHITECT chemistry system meets performance goals based on biological variation. Clin Biochem. 2014;47:142–144.
   PubMed Web of Science ®Google Scholar
• Doyle K, Bach P. The effect of hemolysis and lipemia on 23 analyte values measured on an Abbott c16000 chemistry analyzer. Clin Chem. 2014;60:S68.
   PubMed Web of Science ®Google Scholar
• Elecsys and cobas analyzers [Product information]. Roche Diagnostics. Indianapolis, IN; 2014.
   Google Scholar
• Siemens Dimension Vista System [Product information]. Siemens Healthcare Diagnostics Inc. Newark, DE; 2013.
   Google Scholar
• Synchron Clinical Systems [Product information]. Beckman Coulter Inc. Brea, California; 2011.
   Google Scholar
• Simundic AM, Nikolac N, Ivankovic V, et al. Comparison of visual vs. automated detection of lipemic, icteric and hemolyzed specimens: can we rely on a human eye? Clin Chem Lab Med. 2009;47:1361–1365.
   PubMed Web of Science ®Google Scholar
• Meaney CJ, Sareh H, Hayes BD, Gonzales JP. Intravenous Lipid Emulsion in the Management of Amlodipine Overdose. Hospital Pharmacy. 2013;48:848–854.
   PubMedGoogle Scholar
• Oakes JA, Piquette C, Barthold CL. Successful use of intravenous lipid as adjunctive therapy in a severe calcium channel antagonist poisoning. Clin Toxicol. 2009;47:755–756.
   Web of Science ®Google Scholar
• Johnson-Arbor K, Salinger L. Prolonged laboratory interference after intravenous lipid emulsion therapy. Clin Toxicol. 2014;52:747–748.
   Web of Science ®Google Scholar
• Punja M, Neill SG, Wong S. Caution with interpreting laboratory results after lipid rescue therapy. Am J Emerg Med. 2013;31:1536.e1–2.
   PubMed Web of Science ®Google Scholar
• Wang J, Fan L, Ma C, et al. Effects of parenteral lipid emulsions on Leukocyte numerical and morphological parameters determined by LH750 hematology analyzer. Spurious counts and spurious results on haematology analysers: a review. Part II: white blood cells, red blood cells, haemoglobin, red cell indices and reticulocytes. Int J Lab Hematol. 2013;35:e4–e7.
   PubMed Web of Science ®Google Scholar
• Howdieshell TR, Sussman A, Dipiro J, et al. Reliability of invivo mixed venous oximetry during experimental hypertriglyceridemia. Crit Care Med. 1992;20:999–1004.
   PubMed Web of Science ®Google Scholar
• Rouillon JD, Toubin G, Moussard C, et al. Methemoglobinemia - analytical absorbance errors in patients receiving intravenous lipid emulsions. Pathol Biol. 1985;33:57–60.
   PubMed Web of Science ®Google Scholar
• Vermeer HJ, Steen G, Naus AJ, et al. Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach. Clin Chem Lab Med. 2007;45:114–119.
   PubMed Web of Science ®Google Scholar
• Arambarri M, Oriol A, Sancho JM, et al. [Interference in blood coagulation tests on lipemic plasma. Correction using n-hexane clearing]. Sangre (Barc). 1998;43:13–19.
   PubMedGoogle Scholar
• Leary NO, Pembroke A, Duggan PF. Single stable reagent (Arsenazo-III) for optically robust measurement of calcium in serum and plasma. Clin Chem. 1992;38:904–908.
   PubMed Web of Science ®Google Scholar
• Dimeski G. Interference testing. Clin. 2008;29:S43–S48.
   Google Scholar
• Guder WG, da Fonesca-Wolheim F, Heil W, et al. The haemolytic, icteric and lipemic sample recommendations regarding their recognition and prevention of clinically relevant interferences: recommendations of the Working Group on Preanalytical Variables of the German Society for Clinical Chemistry and the German Society for Laboratory Medicine. J Lab Med/Lab Medizin. 2000;24:357–364.
   Google Scholar
• Fliser E, Jerkovic K, Vidovic T, et al. Detecting paraproteins with measurements of serum index on Siemens analysers Dimension. Biochem. 2011;21:A5–A6.
   Google Scholar
• Bustin SA, Benes V, Garson JA, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55:611–622.
   PubMed Web of Science ®Google Scholar
• Andersson A, Strandberg K, Becker C, et al. Interference testing of the creatinine sensor in the ABL87 FLEX analyzer. Point Care. 2007;6:139–143.
   Google Scholar
• Aulesa C, Pastor I, Naranjo D, et al. Validation of the Coulter LH 750 in a hospital reference laboratory. Lab Hematol. 2003;9:15–28.
   PubMedGoogle Scholar
• Beneteau-Burnat B, Baudin B, Vaubourdolle M. Evaluation of Stratus CS stat fluorimetric analyser for measurement of cardiac markers Troponin I (cTnI), creatine kinase MB (CK-MB), and myoglobin. J Clin Lab Anal. 2001;15:314–318.
   PubMed Web of Science ®Google Scholar
• Cantero M, Conejo JR, Jimenez A. Interference from lipemia in cell count by hematology analyzers. Clin Chem. 1996;42:987–988.
   PubMed Web of Science ®Google Scholar
• Datta P, Scurlock D, Dasgupta A. Analytic performance evaluation of a new turbidimetric immunoassay for phenytoin on the ADVIA 1650 analyzer: effect of phenytoin metabolite and analogue. Therapeutic Drug Monitoring. 2005;27:305–308.
   PubMed Web of Science ®Google Scholar
• Datta P, Dasgupta A. New method for calcium on the ADVIA analyzer is free from interference of gadolinium-type contrast agents. J Clin Lab Anal. 2009;23:399–403.
   PubMed Web of Science ®Google Scholar
• Dempfle C, Schraml M, Besenthal I, et al. Multicentre evaluation of a new point-of-care test for the quantitative determination of D-dimer. Clinica Chimica Acta. 2001;307:211–218.
   PubMed Web of Science ®Google Scholar
• Dimeski G. A commentary on the effect of lipid emulsions on pathology tests. Anaesthesia. 2009;64:1033–1035.
   PubMed Web of Science ®Google Scholar
• Erlandsen EJ, Randers E, Kristensen JH. Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System. Scand J Clin Lab Invest. 1999;59:1–8.
   PubMed Web of Science ®Google Scholar
• Erlandsen EJ, Randers E. Performance evaluation of the Roche Tina-quant Cystatin C assay and reference interval for cystatin C in healthy blood donors. Scand J Clin Lab Invest. 2010;70:300–304.
   PubMed Web of Science ®Google Scholar
• Farre J, Biosca C, Galimany R. Evaluation of the Jokoo-ION 150 AC: guidelines for the evaluation of analysers by ion-selective electrodes. J Automat Chem. 1990;12:116–128.
   PubMedGoogle Scholar
• Giacoia GP, Krasner J. Interference of intravenous lipid emulsion with the determination of calcium in serum. Am J Med Technol. 1979;45:767–768.
   PubMedGoogle Scholar
• Gobert De Paepe E, Munteanu G, Schischmanoff PO, et al. [Haemolysis and turbidity influence on three analysis methods of quantitative determination of total and conjugated bilirubin on ADVIA 1650]. Ann Biol Clin. 2008;66:175–182.
   PubMedGoogle Scholar
• Grimaldi E, Scopacasa F. Evaluation of the Abbott CELL-DYN 4000 hematology analyzer. Am J Clin Pathol. 2000;113:497–505.
   PubMed Web of Science ®Google Scholar
• Grimaldi E, Del Vecchio L, Scopacasa F, et al. Evaluation of the platelet counting by Abbott CELL-DYN SAPPHIRE haematology analyser compared with flow cytometry. Int J Lab Hematol. 2009;31:151–160.
   PubMed Web of Science ®Google Scholar
• La'ulu SL, Dominguez CM, Roberts WL. Performance characteristics of the AxSYM D-dimer assay. Clinica Chimica Acta. 2008;390:148–151.
   PubMed Web of Science ®Google Scholar
• Marx AM, Gressner AM. Evaluation of the Kodak Ektachem slide assays for iron and lactate. J Clin Lab Anal. 1991;5:86–89.
   PubMed Web of Science ®Google Scholar
• Moreno P, Ginel PJ. Effects of haemolysis, lipaemia and bilirubinaemia on prothrombin time, activated partial thromboplastin time and thrombin time in plasma samples from healthy dogs. Res Vet Sci. 1999;67:273–276.
   PubMed Web of Science ®Google Scholar
• Richard H, Bachmann L, Gin G. Development of a Free Phenytoin assay by modification of the Siemens ADVIA 1800 Total Phenytoin Method. Clin Chem. 2011;57:A53.
   Google Scholar
• Rosenman J, Garry E, Pesta M, et al. Effects of hemolysis, icterus, and lipemia on serum osmolality results using the Advanced® Model 3250 single-sample osmometer. Clin Chem. 2010;56:A15–A16.
   Google Scholar
• Ross RS, Paar D. Analytically and clinically significant interference effects in coagulation testing: lessons from MDA 180. [German]. Lab Medizin. 1998;22:90–4.
   Google Scholar
• Sehgal L, Sehgal H, Rosen A, Gould S, Moss G. Effect of Intralipid on measurements of total hemoglobin and oxyhemoglobin in whole blood. Crit Care Med. 1984;12:907–909.
   PubMed Web of Science ®Google Scholar
• Steinhauer JR, Hardy RW, Robinson CA, et al. Comparison of non-diglyceride- and diglyceride-based assays for pancreatic lipase activity. J Clin Lab Anal. 2002;16:52–55.
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Matsushita H, Tanaka Y, et al. Elimination of interference by lipids in the low WBC mode in the automated hematology analyzer XN-2000. Int J Lab Hematol. 2014;36:e50-e54.
   PubMed Web of Science ®Google Scholar
• Ver Elst KM, Chapelle JP, Boland P, et al. Analytic and clinical evaluation of the Abbott AxSYM cardiac troponin I assay. Am J Clin Pathol. 1999;112:745–752.
   PubMed Web of Science ®Google Scholar