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Review

Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity

, , , , , , , , , , & show all
Pages 167-193 | Received 03 Jun 2015, Accepted 11 Nov 2015, Published online: 06 Feb 2016

References

  • Rosenblatt MA, Abel M, Fischer GW, et al. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology. 2006;105:217–218.
  • AAGBI. AAGBI Safety Guideline – Management of Severe Local Anaesthetic Toxicity 2010. [cited 2015 May 20]. Available from: http://www.aagbi.org/sites/default/files/la_toxicity_2010_0.pdf.
  • American College of Medical Toxicology. ACMT position statement: interim guidance for the use of lipid resuscitation therapy. J Med Toxicol. 2011;7:81–82.
  • ASRA. Checklist for treatment of local anesthetic systemic toxicity 2011. [cited 2015 May 20]. Available from: https://www.asra.com/advisory-guidelines/article/3/checklist-for-treatment-of-local-anesthetic-systemic-toxicity.
  • Cao D, Heard K, Foran M, et al. Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. J Emerg Med. 2015;48:387–397.
  • Cave G, Harvey M, Graudins A. Intravenous lipid emulsion as antidote: a summary of published human experience. Emerg Med Australas. 2011;23:123–141.
  • Corman SL, Skledar SJ. Use of lipid emulsion to reverse local anesthetic-induced toxicity. Ann Pharmacother. 2007;41:1873–1877.
  • Jamaty C, Bailey B, Larocque A, et al. Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies. Clin Toxicol (Phila). 2010;48:1–27.
  • Gosselin S, Morris M, Nesbitt-Miller A, et al. Methodology for AACT evidence-based recommendations on the use of lipid emulsion therapy in poisoning. Clin Toxicol (Phila). 2015;53:557–564.
  • Dureau P, Charbit B, Benhamou D, et al. La toxicité systémique des anesthésiques locaux peut-elle être prévenue par l’Intralipide®? Une étude pharmacocinétique [Abstract]. Ann Fr Anesth Reanim. 2014;33(suppl 2): A7.
  • Dureau P, Mazoit JX, Navarro V, et al. La toxicité systémique des anesthésiques locaux peut-elle être prévenue par l Intralipide®? [Abstract]. Ann Fr Anesth Reanim. 2014;33(suppl 2):A7–A8.
  • Admani B, Essajee F. Successful resuscitation of a three month old child with intralipid infusion, presumed to have bupivacaine induced seizures and cardiovascular complications: case report. East Afr Med J. 2010;87:354–356.
  • Al-Alami AA. Successful treatment of early ropivacaine toxicity with intralipid in a patient with attention deficit hyperactivity disorder. Middle East J Anesthesiol. 2011;21:427–429.
  • Aveline C, Cognet F, Bonnet F. Ineffectiveness of intralipid infusion for central nervous toxicity following ultrasound-guided sciatic nerve block with lidocaine-ropivacaine solution: interaction between carbamazepine, local anaesthetic and intralipid? Eur J Anaesthesiol. 2010;27:1070–1072.
  • Bazerbachi F, Rank K, Chan A. Intravenous lipid rescue and ropivacaine systemic toxicity. J Anesth. 2014;28:139.
  • Bilotta F, Titi L, Rosa G. Local anesthetic-induced complete atrioventricular block during awake craniotomy. J Neurosurg Anesthesiol. 2012;24:238.
  • Buckenmaier ICC, Capacchione J, Mielke AR, et al. The effect of lipid emulsion infusion on postmortem ropivacaine concentrations in swine: endeavoring to comprehend a soldier's death. Anesth Analg. 2012;114:894–900.
  • Calenda E, Dinescu SA. Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine. J Anesth. 2009;23:472–473.
  • Cave G, Harvey M, Willers J, et al. LIPAEMIC report: results of clinical use of intravenous lipid emulsion in drug toxicity reported to an online lipid registry. J Med Toxicol. 2014;10:133–142.
  • Charbonneau H, Marcou TAP, Mazoit JX, et al. Early use of lipid emulsion to treat incipient mepivacaine intoxication. Reg Anesth Pain Med. 2009;34:277–278.
  • Contargyris C, Bourgoin A, Guilhaumou R, et al. Local anesthetics toxicity during a post caesarian transverse abdominis plane block. Prat Anesth Reanim. 2012;16:308–310.
  • Cordell CL, Schubkegel T, Light TR, et al. Lipid infusion rescue for bupivacaine-induced cardiac arrest after axillary block. J Hand Surg. 2010;35:144–146.
  • Dacosta WP. Subcutaneous bupivacaine intoxication managed with lipid emulsion [Abstract]. Anestesia en Mexico. 2009;21:143–144.
  • Diaz J, Bernasinski M, Malinovsky JM. Reversal of neurologic symptoms related to lidocaine toxicity with a lipid emulsion administration [French]. Ann Fr Anesth Reanim. 2012;31:647.
  • Dix SK, Rosner GF, Nayar M, et al. Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion. Crit Care Med. 2011;39:872–874.
  • Egan T. Seizure post brachial plexus block in patient with remote history of seizures with non toxic dose of local anaesthetic [Abstract]. Reg Anesth Pain Med. 2013;38.
  • Espinet AJ, Emmerton MT. The successful use of intralipid for treatment of local anesthetic-induced central nervous system toxicity: some considerations for administration of intralipid in an emergency. Clin J Pain. 2009;25:808–809.
  • Etesse B, Letouzey V, Roger C, et al. Epidural analgesia is not the only cause of peripartum central neurologic symptoms. Report of one case of posterior reversible encephalopathy syndrome [French]. Ann Fr Anesth Reanim. 2011;30:57–60.
  • Fenten MGE, Rohrbach A, Wymenga AB, et al. Systemic local anesthetic toxicity after local infiltration analgesia following a polyethylene tibial insert exchange: a case report. Reg Anesth Pain Med. 2014;39:264–265.
  • Foxall G, McCahon R, Lamb J, et al. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid®. Anaesthesia. 2007;62:516–518.
  • French LK, Kusin S, Hendrickson RG. Pediatric lidocaine toxicity following intraosseous injection: a case series. Clin Toxicol (Phila). 2012;50:329–330.
  • Fuzaylov G, Ying B, Tang Y, Sethna NF. Successful resuscitation after inadvertent intravenous injection of bupivacaine in an adolescent. Paediatr Anaesth. 2010;20:958–959.
  • Gallagher C, Tan JM, Foster CG. Lipid rescue for bupivacaine toxicity during cardiovascular procedures. Heart Int. 2010;5:20–21.
  • Gnaho A, Eyrieux S, Gentili M. Cardiac arrest during an ultrasound-guided sciatic nerve block combined with nerve stimulation. Reg Anesth Pain Med. 2009;34:278.
  • Goyal R, Shukla RN, Kumar G, et al. Supraventricular tachycardia after an intercostal nerve block with bupivacaine treated with 10% intralipid. J Anaesthesiol Clin Pharmacol. 2011;27:564–565.
  • Grenc D, Sarc L, Knafelj R, et al. Successful lipid emulsion treatment for generalized seizures and cardiac arrest following epidural lidocaine administration. Clin Toxicol (Phila). 2011;49:268.
  • Hartley RA, Foster PN, Moore JA. Local anaesthetic toxicity with continuous local anaesthetic infusion following hepatic resection. Eur J Anaesthesiol. 2012;29:455–456.
  • Harvey M, Cave G, Chanwai G, et al. Successful resuscitation from bupivacaine-induced cardiovascular collapse with intravenous lipid emulsion following femoral nerve block in an emergency department. EMA. 2011;23:209–214.
  • Heavner J, Heavner M. Cardiac arrest following pleurodesis: lipid rescue for lidocaine overdose [Abstract]. Chest. 2012;142:291A.
  • Hurley WT, Hanlon P. Lipid emulsion as an antidote at the Washington Poison Center; use in carbamazepine, flecanide, hydroxychloroquine, bupivacaine, and bupropion. Clin Toxicol (Phila). 2009;47:729–730.
  • Jensen K, Borglum J. High volume nerve blocks and systemic toxicity of local anaesthetics. A case report [Abstract]. Reg Anesth Pain Med. 2011;36:E213.
  • Landy C, Gagnon N, Boulland P, et al. Seizures associated with local anaesthetic intoxication. Br J Anaesth. 2012;109:463–464.
  • Landy C, Schaeffer E, Raynaud L, et al. Convulsions after normal dose of lidocaine: a probable drug interaction. Br J Anaesth. 2012;108:701.
  • Lange DB, Schwartz D, DaRoza G, et al. Use of intravenous lipid emulsion to reverse central nervous system toxicity of an iatrogenic local anesthetic overdose in a patient on peritoneal dialysis [Erratum appears in Ann Pharmacother 2013;47:139]. Ann Pharmacother. 2012;46:e37.
  • Larson A, Stidham T, Banerji S, et al. Seizures and methemoglobinemia in an infant after excessive EMLA application. Pediatr Emerg Care. 2013;29:377–379.
  • Levine M, Skolnik AB, Ruha AM, et al. Complications following antidotal use of intravenous lipid emulsion therapy. J Med Toxicol. 2014;10:10–14.
  • Li J, Wardhan R. Local anesthetic systemic toxicity (LAST) in an ESKD patient upon receiving an axillary brachial plexus block along with blocks of the musculocutaneous & intercostobrachial nerves [Abstract]. Reg Anesth Pain Med. 2013;38:A218.
  • Lin EP, Aronson LA. Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate. Paediatr Anaesth. 2010;20:955–957.
  • Litz RJ, Popp M, Stehr SN, et al. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia. 2006;61:800–801.
  • Litz RJ, Roessel T, Heller AR, et al. Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesth Analg. 2008;106:1575–1577.
  • Liu SK, Ou Yang HH, Chen KB, et al. Successful treatment of highly potential local anesthetic systemic toxicity by “staged prevention strategy” with intravenous lipid emulsion [Abstract]. Eur J Anaesth. 2012;29:129.
  • Ludot H, Tharin JY, Belouadah M, et al. Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg. 2008;106:1572–1574.
  • Markowitz S, Neal JM. Immediate lipid emulsion therapy in the successful treatment of bupivacaine systemic toxicity [Abstract]. Reg Anesth Pain Med. 2009;34:276–277.
  • Marraffa JM, Stork CM. Delayed cardiovascular toxicity after inadvertent subcutaneous injection of bupivacaine successfully treated with intravenous fat emulsion. Clin Toxicol (Phila). 2013;51:652–653.
  • Marwick PC, Levin AI, Coetzee AR. Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. Anesth Analg. 2009;108:1344–1346.
  • Mazoit JX. Cardiac arrest and local anaesthetics. [French]. Presse Med. 2013;42:280–286.
  • McCutchen T, Gerancher JC. Early intralipid therapy may have prevented bupivacaine-associated cardiac arrest. Reg Anesth Pain Med. 2008;33:178–180.
  • Mizutani K, Oda Y, Sato H. Successful treatment of ropivacaine-induced central nervous system toxicity by use of lipid emulsion: effect on total and unbound plasma fractions. J Anesth. 2011;25:442–445.
  • Nguyen VH, White JL. Further support for the early administration of lipid emulsion in the treatment of ropivacaine-induced central nervous system toxicity. J Anesth. 2012;26:479–480.
  • Ogugua CS, Savel RH, Keene A, et al. Prevention of catastrophic outcomes in systemic bupivacaine toxicity: early recognition and aggressive management [Abstract]. Chest. 2009;136:38S–39S.
  • Reddy JG, Lahm T. Intravenous lipid emulsion rescue for severe central nervous system local anesthetic toxicity [Abstract]. Chest. 2010;138:76A.
  • Sakai T, Manabe W, Kamitani T, et al. Ropivacaine-induced late-onset systemic toxicity after transversus abdominis plane block under general anesthesia: successful reversal with 20% lipid emulsion. Masui. 2010;59:1502–1505.
  • Schaeffer E, Rayaud L, Landy C, et al. Local anaesthetics intoxication, during ultrasound-guided axillary plexus block, treated by Intralipide®. Ann Fr Anesth Reanim. 2010;29:929–930.
  • Schellhammer F, Milde A. Lipid rescue therapy of toxic effects from local anesthetics in interventional radiology. RöFo. 2011;183:73–74.
  • Scherrer V, Compere V, Loisel C, et al. Cardiac arrest from local anesthetic toxicity after a field block and transversus abdominis plane block: a consequence of miscommunication between the anesthesiologist and surgeon. A A Case Rep. 2013;1:75–76.
  • Schwarzkopf P, Ruffert H, Pracht K. Psoas compartment block: how to limit systemic side effects? [Abstract]. Reg Anesth Pain Med. 2011;36:E261.
  • Shah S, Gopalakrishnan S, Apuya J, et al. Use of Intralipid in an infant with impending cardiovascular collapse due to local anesthetic toxicity. J Anesth. 2009;23:439–441.
  • Shenoy U, Paul J, Antony D. Lipid resuscitation in pediatric patients – need for caution? Paediatr Anaesth. 2014;24:332–334.
  • Shih YH, Chen CH, Wang YM, et al. Successful reversal of bupivacaine and lidocaine-induced severe junctional bradycardia by lipid emulsion following infraclavicular brachial plexus block in a uremic patient. Acta Anaesthesiol Taiwan. 2011;49:72–74.
  • Smith HM, Jacob AK, Segura LG, et al. Simulation education in anesthesia training: a case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training. Anesth Analg. 2008;106:1581–1584.
  • Sonsino DH, Fischler M. Immediate intravenous lipid infusion in the successful resuscitation of ropivacaine-induced cardiac arrest after infraclavicular brachial plexus block. Reg Anesth Pain Med. 2009;34:276–277.
  • Sorrenti D, Peverini M, Casalena S, et al. Late onset local anaesthetic systemic toxicity (last) after ENS guided axillary brachial plexus block with mepivacaine 1.5%: successful reversal with early 20% lipid emulsion therapy [Abstract]. Reg Anesth Pain Med. 2014;39:e260.
  • Spence AG. Lipid reversal of central nervous system symptoms of bupivacaine toxicity. Anesthesiology. 2007;107:516–517.
  • Sturini E, Saporito A, Tomasetti R, et al. Mepivacaine neurologic toxicity after an erroneous administration for intravenous regional anesthesia treated with lipid emulsion: new solutions for old mistakes [Abstract]. Reg Anesth Pain Med. 2010;35:E179–E180.
  • Süzer MA, Özhan MO, Eşkin MB, et al. Local anesthetic toxicity managed successfully with lipid infusion (case report). Türk Anest Rean Der Dergisi. 2011;39:159–163.
  • Ter Horst MT, Tjiang GCH, Luitwieler RL, et al. Antidote for intoxication due to local anesthetics: new application of fat emulsion for intravenous administration. Ned Tijdschr Geneeskd. 2010;154:1822–1825.
  • Varela H, Bums SM. Use of lipid emulsions for treatment of local anesthetic toxicity: a case report. AANA J. 2010;78:359–364.
  • Warren JA, Thoma RB, Georgescu A, et al. Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. Anesth Analg. 2008;106:1578–1580.
  • Whiteman DM, Kushins SI. Successful resuscitation with intralipid after marcaine overdose. Aesthet Surg J. 2014;34:738–740.
  • Whiteside J. Reversal of local anaesthetic induced CNS toxicity with lipid emulsion Anaesthesia. 2008;63:203–204.
  • Widfeldt N, Kolmodin L. CNS symptoms of ropivacaine in bloodless field disappeared with Intralipid. [Norwegian]. Lakartidningen. 2014;111:742–743.
  • Wong GK, Joo DT, McDonnell C. Lipid resuscitation in a carnitine deficient child following intravascular migration of an epidural catheter. Anaesthesia. 2010;65:192–195.
  • Zhurda T, Muzha D, Caushi GJ, et al. Usefulness of lipidic solution for the treatment of systemic toxicity related to bupivacaine injected in a sub-coracoid brachial plexus block. [French]. Ann Fr Anesth Reanim. 2010;29:592–593.
  • Zimmer C, Piepenbrink K, Riest G, et al. Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion [German]. Anaesthesist. 2007;56:449–453.
  • Bonfim MR, De Simone Melo M, Dreyer E, et al. Lipid therapy with two agents in ropivacaine-induced toxicity: experimental study in swine. Rev Bras Anestesiol. 2012;62:685–695.
  • Bushey BA, Auld VH, Volk JE, et al. Combined lipid emulsion and ACLS resuscitation following bupivacaine- and hypoxia-lnduced cardiovascular collapse in unanesthetized swine. AANA J. 2011;79:129–138.
  • Candela D, Louart G, Bousquet PJ, et al. Reversal of bupivacaine-induced cardiac electrophysiologic changes by two lipid emulsions in anesthetized and mechanically ventilated piglets. Anesth Analg. 2010;110:1473–1479.
  • De Queiroz M, Rhondali O, Leveneur O, et al. Resuscitation with lipid or with epinephrine in levobupivacaine-induced cardiac toxicity in piglets. Br J Anaesth. 2012;108:ii292–ii293.
  • de Queiroz Siqueira M, Chassard D, Musard H, et al. Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets. Br J Anaesth. 2014;112:729–734.
  • de Simone Melo M, Bonfm MR, Dreyer E, et al. Hemodynamic changes in lipid emulsion therapy (SMOFlipid) for bupivacaine toxicity in swines. Acta Cir Bras. 2012;27:318–324.
  • Di Gregorio G, Kessler C, Weinberg G. Lipid emulsion in treatment of sodium channel blocker overdose. Ann Emerg Med. 2008;51:489.
  • Di Gregorio G, Schwartz D, Ripper R, et al. Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest [Erratum appears in Crit Care Med 2009;37:2329]. Crit Care Med. 2009;37:993–999.
  • Fettiplace MR, Akpa BS, Ripper R, et al. Resuscitation with lipid emulsion: dose dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology. 2014;120:915–925.
  • Fettiplace MR, Ripper R, Lis K, et al. Intraosseous lipid emulsion: an effective alternative to IV delivery in emergency situations. Crit Care Med. 2014;42:e157–e160.
  • Gokahmetoglu G, Aksu R, Bicer C, et al. The effect of levosimendan combined with 20% lipid emulsion treatment on survival from bupivacaine induced toxicity in experiment. Bratisl Lek Listy. 2014;115:275–279.
  • Hicks SD, Salcido DD, Logue ES, et al. Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology. 2009;111:138–146.
  • Hiller DB, Gregorio GD, Ripper R, et al. Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology. 2009;111:498–505.
  • Karci A, Aykac Ibisoglu A, Oransay K, et al. The effects of lipid treatment on levobupivacaine induced cardiotoxicity in rats [Abstract]. Eur J Anaesthesiol. 2009;26:108.
  • Karcioğlu M, Tuzcu K, Sefil F, et al. Efficacy of resuscitation with intralipid in a levobupivacaine-induced cardiac arrest model. Turk J Med Sci. 2014;44:330–336.
  • Li Z, Xia Y, Dong X, et al. Lipid resuscitation of bupivacaine toxicity: long-chain triglyceride emulsion provides benefits over long-and medium-chain triglyceride emulsion. Anesthesiology. 2011;115:1219–1228.
  • Litonius ES, Niiya T, Neuvonen PJ, et al. Intravenous lipid emulsion only minimally influences bupivacaine and mepivacaine distribution in plasma and does not enhance recovery from intoxication in pigs. Anesth Analg. 2012;114:901–906.
  • Mauch J, Jurado OM, Spielmann N, et al. Resuscitation strategies from bupivacaine-induced cardiac arrest. Paediatr Anaesth. 2012;22:124–129.
  • Mauch J, Martin Jurado O, Spielmann N, et al. Comparison of epinephrine vs lipid rescue to treat severe local anesthetic toxicity – an experimental study in piglets. Paediatr Anaesth. 2011;21:1103–1108.
  • Mauch JY, Martin-Jurado O, Spielmann N, et al. Comparison of four different rescue regimens to treat cardiac arrest due to bupivacaine intoxication – An experimental study in neonatal pig [Abstract]. Eur J Anaesthesiol. 2011;28:118.
  • Mayr VD, Mitterschiffthaler L, Neurauter A, et al. A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg. 2008;106:1566–1571.
  • Shi K, Xia Y, Wang Q, et al. The effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats. Anesth Analg. 2013;116:804–809.
  • Wat CY, Yuen MK, Li RWS, et al. Lipid emulsion infusion vs standard cardiac resuscitation in management of ropivacaine cardiac toxicity in pigs. Anaesth Intensive Care. 2009;37:661–662.
  • Weinberg G, Paisanthasan C, Feinstein D, et al. The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. Anesth Analg. 2004;98:790–795.
  • Weinberg G, Ripper R, Feinstein DL, et al. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med. 2003;28:198–202.
  • Weinberg GL, Di Gregorio G, Ripper R, et al. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology. 2008;108:907–913.
  • Yan J, Shen Y, Li B, et al. Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats. Br J Anaesth. 2012;108:857–863.
  • Yoshimoto M, Horiguchi T, Nishikawa T. Efficacy of lipid resuscitation in cardiac arrest induced by bupivacaine-glucose mixture in rats. Eur J Anaesthesiol. 2014;31:210.
  • Callejo D, Sevilla R, Gonzalez J, et al. Analysis of the temporal regression of the QRS widening induced by bupivacaine after intralipid administration: study in an experimental porcine model. Eur J Anaesthesiol. 2014;31:65.
  • Cave G, Harvey M, Prince G, et al. Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid. Anaesthesia. 2010;65:792–798.
  • Weinberg GL, VadeBoncouer T, Ramaraju GA, et al. Pretreatment or resuscitation with a lipid infusion shifts the dose – response to bupivacaine-induced asystole in rats. Anesthesiology. 1998;88:1071–1075.
  • Harvey M, Cave G, Prince G, et al. Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: transient circulatory return in rabbits. Anesth Analg. 2010;111:791–796.
  • Partownavid P, Umar S, Li J, et al. Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats. Crit Care Med. 2012;40:2431–2437.
  • Partownavid P, Umar S, Rahman S, et al. Intralipid rescue of bupivacaine-induced cardiotoxicity was abolished by fatty acid oxidation inhibitor CVT-4325 [Abstract]. Circulation. 2010;122.
  • Partownavid P, Umar S, Rahman S, et al. Intralipid fails to rescue bupivacaine-induced cardiotoxicity in the presence of the opioid antagonist naloxone [Abstract]. Circulation. 2012;126.
  • Yoshimoto M, Horiguchi T, Nishikawa T, et al. Comparative effects of lipid emulsion on the recovery from levobupivacaine-induced or from ropivacaine-induced cardiac arrest in rats. Br J Anaesth. 2012;108:ii105–ii106.
  • O'Brien TQ, Clark-Price SC, Evans EE, et al. Infusion of a lipid emulsion to treat lidocaine intoxication in a cat. J Am Vet Med Ass. 2010;237:1455–1458.
  • Balshem H, Helfand M, Schunemann HJ, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64:401–406.
  • Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines 6. Rating the quality of evidence – imprecision. J Clin Epidemiol. 2011;64:1283–1293.
  • Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines: 8. Rating the quality of evidence–indirectness. J Clin Epidemiol. 2011;64:1303–1310.
  • Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines: 7. Rating the quality of evidence – inconsistency. J Clin Epidemiol. 2011;64:1294–1302.
  • Guyatt GH, Oxman AD, Montori V, et al. GRADE guidelines: 5. Rating the quality of evidence – publication bias. J Clin Epidemiol. 2011;64:1277–1282.
  • Guyatt GH, Oxman AD, Sultan S, et al. GRADE guidelines: 9. Rating up the quality of evidence. J Clin Epidemiol. 2011;64:1311–1316.
  • Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines: 4. Rating the quality of evidence – study limitations (risk of bias). J Clin Epidemiol. 2011;64:407–415.
  • Chem Spider Search and Share Chemistry. 2015 [cited 2015 July 23]. Available from: http://www.chemspider.com.

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