Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies

References

• Bronstein AC, Spyker DA, Cantilena JR, Green JL, Rumack BH, Heard SE. 2007 annual report of the American Association of Poison Control Centers National Poison Data System (NPDS): 25th annual report. Clin Toxicol 2008; 46(10):927–1057.
   PubMed Web of Science ®Google Scholar
• LipidRescue. Guy Weinberg. http://www.lipidrescue.org. Accessed 1 June 2009.
   Google Scholar
• Jadad A, Moore A, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996; 17:1–12.
   PubMedGoogle Scholar
• von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. (STROBE Initiative). The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 2008; 61(4):344–349.
   PubMed Web of Science ®Google Scholar
• Weinberg G, Ripper R, Feinstein DL, Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003; 28(3):198–202.
   PubMed Web of Science ®Google Scholar
• Weinberg G, Hertz P, Newman J, Mayr VD, Raedler C, Wenzel V, Luckner G, Lindner KH, Strohmenger HU. A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg 2008; 106(5):1566–1571.
   PubMed Web of Science ®Google Scholar
• Weinberg G, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwick MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88(4):1071–1075.
   PubMed Web of Science ®Google Scholar
• Bania T, Chu J. Hemodynamic effect of intralipid in amitriptyline toxicity. Acad Emerg Med 2006; 13:S177.
   Google Scholar
• Yoav G, Odelia G, Shaltiel C. A lipid emulsion reduces mortality from clomipramine overdose in rats. Vet Hum Toxicol 2002; 44(1):30.
   PubMedGoogle Scholar
• Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med 2007; 49(2):178–185.
   PubMed Web of Science ®Google Scholar
• Tebbutt S, Harvey M, Nicholson T, Cave G. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med 2006; 13(2): 134–139.
   PubMed Web of Science ®Google Scholar
• Bania TC, Chu J, Perez E, Su M, Hahn IH. Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium, and saline. Acad Emerg Med 2007; 14(2):105–111.
   PubMed Web of Science ®Google Scholar
• Perez E, Bania T, Medlej K, Chu J, Mouravev R. Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model. Acad Emerg Med 2008; 15(5 Suppl. 1): S92–93.
   Google Scholar
• Medlej K, Bania T, Chu J, Perez E, Mouravev R, Yang J. Delayed effects of intravenous fat emulsion on verapamil toxicity. Acad Emerg Med 2008; 15(5 Suppl. 1):S93.
   Google Scholar
• Bania T, Chu J, Perez E, Medlej K, Rosselli M, Mouravev R, Yang J, Lee D. Hemodynamic effects of intravenous fat emulsion versus high dose insulin euglycemia in a model of severe verapamil toxicity. Acad Emerg Med 2008; 15(5 Suppl. 1):S93.
   Google Scholar
• Chu J, Medlej K, Bania T, Perez E, Mouravev R. The effect of intravenous fat emulsions in nifedipine toxicity. Acad Emerg Med 2009; 16(1):S226.
   PubMedGoogle Scholar
• Cave G, Harvey M, Castle C. The role of fat emulsion therapy in a rodent model of propranolol toxicity: a preliminary study. J Med Toxicol 2006; 2(1):4–7.
   PubMedGoogle Scholar
• Krieglstein J, Meffert A, Niemeyer D. Influence of emulsified fat on chlopromazine availability in rabbit blood. Experimentia 1974; 30(8): 924–926.
   PubMedGoogle Scholar
• Litz R, Popp M, Stehr S, Koch T. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 2006; 61(8): 800–801.
   PubMed Web of Science ®Google Scholar
• Rosenblatt M, Abel M, Fischer G, Itzkovich CJ, Eisenkraft J. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006; 105(1): 217–218.
   PubMed Web of Science ®Google Scholar
• Warren J, Thoma R, Georgescu A, Shah S. Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. Anesth Analg 2008; 106(5):1578–1580.
   PubMed Web of Science ®Google Scholar
• Marwick P, Levin A, Coetzee A. Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. Anesth Analg 2009; 108(4):1344–1346.
   PubMed Web of Science ®Google Scholar
• Smith HM, Jacob AK, Segura LG, Dilger JA, Torsher LC. Simulation education in anesthesia training: A case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training. Anesth Analg 2008; 106(5):1581–1584.
   PubMed Web of Science ®Google Scholar
• Sonsino DH, Fischler M. Immediate intravenous lipid infusion in the successful resuscitation of ropivacaine-induced cardiac arrest after infraclavicular brachial plexus block. Reg Anesth Pain Med 2009; 34(3): 276–277.
   PubMed Web of Science ®Google Scholar
• Gnaho A, Eyrieux S, Gentili M. Cardiac arrest during an ultrasound-guided sciatic nerve block combined with nerve stimulation. Reg Anesth Pain Med 2009; 34(3):278.
   PubMed Web of Science ®Google Scholar
• Markowitz S, Neal JM. Immediate lipid emulsion therapy in the successful treatment of bupivacaine systemic toxicity. Reg Anesth Pain Med 2009; 34(3):276.
   PubMed Web of Science ®Google Scholar
• Sirianni AJ, Osterhoudt KC, Calello DP, Muller AA, Waterhouse MR, Goodkin MB, Weinberg GL, Henretig, FM. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008; 51(4):412–415.
   PubMed Web of Science ®Google Scholar
• Weinberg G, Ripper R, Kelly K, DiGregorio G, Edelman LB. A rodent model comparing lipid and pressor treatment of bupivacaine-induced asystole. Anesthesiology 2007; 107:A23.
   Google Scholar
• Weinberg G, Gregorio GD, Ripper R, Kelly K, Massad M, Edelman L, Schwartz D, Shah N, Zheng S, Feinstein DL. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008; 108:907–913.
   PubMed Web of Science ®Google Scholar
• DiGregorio G, Schwartz D, Ripper R, Kelly K, Feinstein DL, Minshall RD, Massad M, Ori C, Weinberg GL. Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest. Crit Care Med 2009; 37(3):993–999.
   PubMed Web of Science ®Google Scholar
• Bania T, Chu J, Wesolowski M. The hemodynamic effect of intralipid on propranolol toxicity. Acad Emerg Med 2006; 13:S109.
   PubMedGoogle Scholar
• Harvey G, Cave G. Intralipid infusion ameliorates propranolol-induced hypotension in rabbits. J Med Toxicol 2008; 4(2):71–76.
   PubMedGoogle Scholar
• Harvey G, Cave G, Hoggett K. Correlation of plasma and peritoneal dialysate clomipramine concentration with hemodynamic recovery after intralipid infusion in rabbits. Acad Emerg Med 2009; 16(2):151–156.
   PubMed Web of Science ®Google Scholar
• Cave G, Harvey M. Lipid emulsion may augment early blood pressure recovery in a rabbit model of atenolol toxicity. J Med Toxicol 2009; 5(1):50–51.
   PubMedGoogle Scholar
• Foxall G, McCahon R, Lamb J, Hardman JG, Bedforth NM. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid (R). Anaesthesia. 2007; 62(5):516–518.
   PubMed Web of Science ®Google Scholar
• Litz RJ, Roessel T, Heller A, Stehr SN. Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesth Analg 2008; 106(5):1575–1577.
   PubMed Web of Science ®Google Scholar
• Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM. Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrythmia following posterior lumbar plexus block in a child. Anesth Analg 2008; 106(5): 1572–1574.
   PubMed Web of Science ®Google Scholar
• Harchelroad FP, Palma A. Efficacy and safety of intravenous lipid therapy in a B-blocker overdose. Clin Toxicol 2008; 46(7):620.
   Google Scholar
• Al-Duaij N, George M, O’Donnell K, Burns Ewald M. Lipid emulsion in massive imipramine overdose. Clin Toxicol 2009; 47:460.
   Web of Science ®Google Scholar
• Young AC, Velez LI, Kleinschmidt KC. Intravenous fat emulsion therapy for the intentional sustained-release verapamil overdose. Resuscitation 2009; 80:591–593.
   PubMed Web of Science ®Google Scholar
• Dolcourt B, Aaron C. Intravenous fat emulsion for refractory verapamil and atenolol induced-shock: a human case report. NACCT. Clin Toxicol 2008; 46:620.
   Google Scholar
• McCutchen T, Grenacher J. Early Intralipid therapy may have prevented bupivacaine-associated cardiac arrest. Reg Anesth Pain Med 2008; 33(2):178–180.
   PubMed Web of Science ®Google Scholar
• Zimmer C, Piepenbrink K, Riest G, Peters J. Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion. [German]. Anaesthesist 2007; 56(5):449–453.
   PubMed Web of Science ®Google Scholar
• Brooks C. Intralipid use in TCA overdose. In: LipidRescue. http://www.lipidrescue.org. Accessed May 2009.
   Google Scholar
• Russell R, Westfall B. Alleviation of barbiturate depression by fat emulsion. Anesth Analg 1962; 41:582–585.
   PubMed Web of Science ®Google Scholar
• Spence A. Lipid reversal of central nervous system symptoms of bupivacaine toxicity. Anesthesiology 2007; 107:516–517.
   PubMed Web of Science ®Google Scholar
• Whiteside J. Reversal of local anesthetic induced CNS toxicity with lipid. Anesthesia 2008; 63:202–213.
   PubMed Web of Science ®Google Scholar
• Charbonneau H, Marcou T, Mazoit J, Zetlaoui P, Benhamou D. Early use of lipid emulsion to treat incipient mepivacaine intoxication. Reg Anesth Pain Med 2009; 34(3):277–278.
   PubMed Web of Science ®Google Scholar
• Finn SDH, Uncles DR, Willers J, Sable N. Early treatment of a quetiapine and sertraline overdose with Intralipid. Anesthesia 2009; 64(2): 191–194.
   PubMed Web of Science ®Google Scholar
• Uncles D. Intralipid for mirtazapine and quetiapine. In: LipidRescue. http://www.lipidrescue.org. Accessed 1 April 2009.
   Google Scholar
• Cave G, Harvey M, Castle C. Intralipid ameliorates thiopentone induced respiratory depression in rats: investigative pilot study. Emerg Med Australas 2005; 17(2):180–181.
   PubMedGoogle Scholar
• Collaboration. Clarke’s analysis of drugs and poisons. In: Anthony, ed., Pharmaceutical Press; 2004. http://www.medicinescomplete.com/mc/clarke/current/. Accessed 21 December 2009.
   Google Scholar
• Perez E, Medlej K, Bania T, Yang J, Chu J. Does the infusion rate of intravenous fat emulsion in severe verapamil toxicity affect survival and hemodynamic parameters? Acad Emerg Med 2009; 16(1):S154.
   Google Scholar
• Brull S. Lipid emulsion for the treatment of local anesthetic toxicity: patient safety implications. Anesth Analg 2008; 106(5):1337–1339.
   PubMed Web of Science ®Google Scholar
• Bania T, Medlej K, Chu J, Perez E, Mouravev R, Yang J. Does the pulmonary fat emboli syndrome occur with intravenous fat emulsion therapy? Acad Emerg Med 2008; 15:S94.
   Google Scholar
• Bania TC. Lipid therapy in drug toxicity. In: Toxicology AAoC, ed. North American Congress of Clinical Toxicology. New Orleans, LA: American Academy of Clinical Toxicology; 2007.
   Google Scholar
• Corman S, Skledar S. Use of lipid emulsion to reverse local anesthetic-induced toxicity. Ann Pharmacother 2007; 41(11):1873–1877.
   PubMed Web of Science ®Google Scholar
• Clark M. Lipid emulsion as rescue for local anesthetic-related cardiotoxicity. J Perianesth Nurs 2008; 23(2):111–117.
   PubMedGoogle Scholar
• Malinovsky JM, Mazoit JX, Sztark F, Estebe JP, Captlevila X, Samii K, Eledjam JJ, Benhamou D, Bonnet F, Bouaziz H, Weinberg G. Systemic toxicity of local anaesthetics and lipid emulsions: an interesting supplementary alternative. Ann Fr Anesth Reanim 2008; 27(2):132–134.
   PubMed Web of Science ®Google Scholar
• Rosenberg P. Lipid emulsion for the treatment of severe local anesthetic toxicity in adults – probably useful, but evidence is lacking. Rev Esp Anestesiol Reanim 2008; 55(2):67–68.
   PubMedGoogle Scholar
• Martin T. Intravenous lipid emulsion therapy for poisonings. Clin Toxicol 2008; 46(5):403.
   Web of Science ®Google Scholar
• Turner-Lawrence D, Kerns W. Intravenous fat emulsion: a potent novel antidote. J Med Toxicol 2008; 4(2):109–114.
   PubMedGoogle Scholar
• Felice K, Schumann H. Intravenous lipid emulsion for local anesthetic toxicity: a review of the literature. J Med Toxicol 2008; 4(3):184–191.
   PubMedGoogle Scholar
• Laboratories CoT. Application of parenteral lipid emulsions to therapy for poisonings (Japanese). Chudoku kenkyu (Japanese J of toxicol) 2009; 22(1):70–74.
   PubMedGoogle Scholar
• Juni P, Withschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trials for meta-analysis. JAMA 1999; 282:1054–1060.
   PubMed Web of Science ®Google Scholar
• Guidelines for the Management of Severe Local Anaesthetic Toxicity. Association of Anesthetists of Great Britain and Ireland. http://www.aagbi. org/publications/guidelines/docs/latoxicity07.pdf. Accessed 1 April 2009.
   Google Scholar