22
Views
5
CrossRef citations to date
0
Altmetric
Research Article

The Toxic Effects of Alcohol on Folate Metabolism

, &
Pages 407-411 | Published online: 25 Sep 2008

References

  • Sullivan L. W., Herbert V. Mechanisms of hematosuppression by ethanol. Am. J. Clin. Nutr. 1964; 14: 238
  • Lindenbaum J., Hargrove R. L. Thrombocytopenia in alcoholics. Ann. Intern. Med. 1968, (58): 526
  • Eichner E. R., Hillman R. S. The evolution of anemia in alcoholic patients. Am. J. Med. 1971; 50: 218
  • Eichner E. R., Pierce H. I., Hillman R. S. Folate balance in dietary‐induced megaloblastic anemia. N. Engl. J. Med. 1971; 284: 933
  • Halsted C. H., Robles E. A., Mezey E. Intestinal malabsorption induced by feeding a folate‐deficient diet and ethanol to alcoholic patients. Am. J. Clin. Nutr. 1972; 25: 449
  • Eichner E. R., Hillman R. S. Effect of alcohol on serum folate level. J. Clin. Invest. 1973; 52: 584
  • McGuffin R., Goff P., Hillman R. S. The effect of diet and alcohol on the development of folate deficiency in the rat. Br. J. Haematol. 1975; 31: 185
  • Paine C. J., Eichner E. R., Dickson V. Concordance of radio‐assay and microbiological assay in the study of the ethanol‐induced fall in serum folate level. Am. J. Med. Sci. 1973; 266: 135
  • Halsted C. H., Griggs R. C., Harris J. W. The effect of alcoholism on the absorption of folic acid (3H PGA) evaluated by plasma levels and urine excretion. J. Lab. Clin. Med. 1967; 69: 116
  • Halsted C. H., Robles E. A., Mezey E. Decreased jejunal uptake of labeled folic acid (3H PGA) in alcoholic patients: Roles of alcohol and nutrition. N. Engl. J. Med. 1971; 285: 701
  • Lane F., Goff P., McGuffin R., Eichner E. R., Hillman R. S. Folic acid metabolism in normal, folate deficient and alcoholic man. Br. J. Haematol. 1976; 34: 489
  • Hillman R. S., McGuffin R., Campbell C. Alcohol interference with the folate enterohepatic cycle. Trans. Assoc. Am. Physicians 1978; 91: 145–156
  • Chanarin I., Hutchinson M., McLean A., Moule M. Hepatic folate in man. Br. Med. J., J. 1966; 396
  • Pratt R. F., Cooper B. A. Folates in plasma and bile of man after feeding folic acid‐3H and 5‐formyltetrahydrofolate (folinic acid). J. Clin. Invest. 1971; 50: 455
  • Lavoie A., Cooper B. A. Rapid transfer of folic acid from blood to bile in man, and its conversion into folate coenzymes and into a pteroylglutamate with little biological activity. Clin. Sci. Mol. Med. 1974; 46: 729
  • Steinberg S. E., Campbell T. T.L., Hillman R. S. The kinetics of the normal folate enterohepatic cycle. J. Clin. Invest. 1979; 64: 83–88
  • Home D. W., Briggs W. T., Wagner C. Ethanol stimulates 5‐methyltetrahydrofolate accumulation in isolated rat liver cells. Biochem. Pharmacol. 1978; 27(16)2059
  • Steinberg S. E., Campbell C. L., Hillman R. S. The effect of alcohol on hepatic secretion of methylfolate. Am. J. Clin. Nutr. 1999, Submitted
  • Hoffbrand A. V., Tripp E., Lavoie A. Synthesis of folate polyglutamates in human cells. Clin. Sci. Mol. Med. 1976; 50: 61
  • Coward J. K., Parameswaran K. W., Cashmore A. R., Bertino J. R. 7,8‐Dihydropterol oligo‐γ‐L‐glutamates: Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources. Biochemistry 1977; 13: 3899–3904
  • Lieber C. S. Liver adaptation and injury in alcoholism. N. Engl. J. Med. 1973; 288: 356
  • Home D. W., Briggs W. T., Wagner C. A functional active transport system for methotrexate in freshly isolated hepatocytes. Biochem. Biophys. Res. Commun. 1976; 68: 70
  • Goldman I. D. The characteristics of the membrane transport of amethopterin and the naturally occurring folates. Ann. N. Y. Acad. Sci. 1971; 186: 400

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.