268
Views
22
CrossRef citations to date
0
Altmetric
Original Investigations

The first- and second-generation antipsychotic drugs affect ADP-induced platelet aggregation

, PhD , MD, , &
Pages 268-275 | Received 18 Feb 2008, Accepted 17 Sep 2008, Published online: 10 Mar 2010

References

  • Allebeck P. Schizophrenia: A life-shortening illness. Schizophr Bull 1989; 15: 81–89
  • Abrams CS, Brass LF. Platelet signal transduction. Hemostasis and thrombosis, basic principles and clinical practice. Chapter 31, RW Colman, et al. Lippincott Williams and Wilkins, Philadelphia, PA 2001; 541–559
  • Bakken AM, Staeffler A, Jorgensen HA, Holmsen H. Glycerophospholipid molecular species in platelets and brain tissues – are platelets a good model for neurons?. Platelets 2006; 17: 484–492
  • Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927–929
  • Brown S. Excess mortality of schizophrenia: meta-analysis. Br J Psychiatry 1997; 171: 502–508
  • Brydon L, Magid K, Steptoe A. Platelets, coronary heart disease, and stress. Brain Behav Immun 2006; 20: 113–119
  • Cadet JL, Lohr J.B. Possible involvement of free radicals in neuroleptic-induced movement disorders. Evidence from treatment of tardive dyskinesia with vitamin E. Ann NY Acad Sci 1989; 570: 176–185
  • De Clerk F. The role of serotonin in thrombogenesis. Clin Physiol Biochem 1990; 8(Suppl 3)40–49
  • De Clerck F, Somers Y, Mannaert E, Greenspan A, Eerdekens M. In vitro effects of risperidone and 9-hydroxyrisperidone on human platelet function, plasma coagulation, and fibrynolysis. Clin Ther 2004; 26: 1261–1273
  • Dietrich-Muszalska A. Evaluation of the effects of different concentrations of risperidone, corresponding to the drug doses used in treatment of schizophrenic patients, on lipid peroxidation in plasma and blood platelets at in vitro studies. Psychiatr Psychol Klin 2004; 4: 215–223
  • Dietrich-Muszalska A. The impact of different concentrations of clozapine on changes of lipid peroxidation in human plasma – in vitro studies. Psychiatr Psychol Klin 2005; 1: 18–25
  • Dietrich-Muszalska A, Olas B. Isoprostanes as indicators of oxidative stress in schizophrenia. World J Biol Psychiatry 2007a; 11: 1–7
  • Dietrich-Muszalska A, Olas B. The changes of aggregability of blood platelets in schizophrenia. World J Biol Psychiatry 2007b; 14: 1–6
  • Dietrich-Muszalska A, Rabe-Jablonska J, Zgirski A. The effects of olanzapine (Zolafren) on lipid peroxidation in human blood platelets and plasma: in vitro studies. Psychiatr Psychol Klin 2004; 4: 13–19
  • Dietrich-Muszalska A, Olas B, Rabe-Jablonska J. Oxidative stress in blood platelets from schizophrenic patients. Platelets 2005; 16: 386–391
  • Dinan TG. Neuroleptic effects on platelet aggregation: a study in normal volunteers and schizophrenics. Psychol Med 1987; 17: 875–881
  • Doolittle RF, Watt KWK, Cottrell BA, Strong DD, Riley M. The amino acid sequence of the alpha-chain of human fibrinogen. Nature 1979; 280: 464–468
  • Eerdekens M, Hove IV, Remmerie B, Mannaert E. Pharmacokinetics and tolerability of long-acting risperidone in schizophrenia. Schizophr Res 2004; 70: 91–100
  • Falkai P, Wobrock T, Lieberman J, Glenthoj B, Gattaz WF, Möller HJ. WFSBP Task Force on Treatment Guidelines for Schizophrenia. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: acute treatment of schizophrenia. World J Biol Psychiatry 2005; 6: 132–191
  • Falkai P, Wobrock T, Lieberman J, Glenthoj B, Gattaz WF, Möller HJ. WFSBP Task Force on Treatment Guidelines for Schizophrenia. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: long-term treatment of schizophrenia. World J Biol Psychiatry 2006; 7: 5–40
  • Farrel DH, Thiagarajan P, Chung DW, Davie EW. Role of fibrinogen and chain sites in platelet aggregation. Proc Natl Acad Sci USA 1992; 89: 10729–10732
  • Feinbloom D, Bauer KA. Assessment of hemostatic risk factors in predicting arterial thrombotic events. Arterioscler Thromb Vasc Biol 2005; 25: 2043–2053
  • Frolich KW, Aarbakke GM, Holmsen H. Chlorpromazine increases the turnover of metabolically active phosphoinositides and elevates the steady state level of phosphatidylinositol-4-phosphate in human platelets. Biochem Pharmacol 1992; 44: 2013–2020
  • Gachet C, Cazenave JP. Platelet receptors: ADP. Platelets in thrombotic and non-thrombotic disorders, P Gresele, CP Page, V Fuster, J Vermylen. Cambridge University Press, Cambridge 2002; 127–139
  • Haslam RJ. Interaction of the pharmacological receptors of blood platelets with adenylate cyclase. Ser Haematol 1973; 6: 333–350
  • Ishigooka J, Shizu Y, Wakatabe H, Tanaka K, Miura S. Different effects of centrally acting drugs on rabbit platelet aggregation; with special reference to selective inhibitory effects of antipsychotic and antidepressants. Biol Psychiatry 1985; 20: 866–873
  • Jeding I, Evans PJ, Akanmu D, Dexter D, Spencer JD, Arunoma OI, et al. Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs. Biochem Pharmacol 1995; 49: 359–365
  • Kamath S, Blann AD, Lip GYH. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 1561–1571
  • Laasvatn KO, Holmsen H. Chlorpromazine and human platelet glycerolipid metabolism: precursor specificity and significance of drug–platelet interaction time. Biochem Pharmacol 1999; 44: 1113–1123
  • Lohr JB, Kuczenski R, Bracha HS, Moir M, Jeste DV. Increased indices of free radical activity in the cerebrospinal fluid of patients with tardive dyskinesia. Biol Psychiatry 1990; 15: 535–539
  • McNicol A. Platelet preparation and estimation of functional responses. Platelets. A practical approach, SP Watson, KS Authi. Oxford University Press, Oxford, New YorkTokyo 1995; 1–6
  • McNicol A, Israels SJ. Platelets and anti-platelet therapy. J Pharmacol Sci 2003; 93: 381–396
  • Meltzer HY. Role of serotonin in the action of atypical antipsychotic drugs. Clin Neurosci 1995; 3: 64–75
  • Michelson AD. How platelets work: platelet function and dysfunction. J Thromb 2003; 16: 7–12
  • Möller HJ. Novel antipsychotics in the long-term treatment of schizophrenia. World J Biol Psychiatry 2004; 5: 9–19
  • Numata S, Kato O, Misawa H, Tokuda H, Kasahara T, Ohmori T. Left atrial thrombosis associated with antipsychotic drugs. Prog Neuro-Psychopharmacol Biol Psychiatry 2005; 29: 153–155
  • Nowak P, Wachowicz B. Peroxynitrite-mediated modification of fibrinogen affects platelet aggregation and adhesion. Platelets 2002; 13: 293–299
  • Offermanns G. Activation of platelet function through G-protein-coupled receptors. Circ Res 2006; 99: 1293–1304
  • Peet M, Laugharne J, Rangarajan N, Reynolds GP. Tardive dyskinesia, lipid peorxidation, and sustained amelioration with vitamin E treatment. Int Clin Psychophamacol 1993; 8: 151–153
  • Plein H, Berk M. The platelet as a peripheral marker in psychiatric illness. Hum Psychopharmacol Clin Exp 2001; 16: 229–236
  • Ruschena D, Mullen PE, Burgess P, Codner SM, Barry-Walsh J, Drummer OH, et al. Sudden death in psychiatric patients. Br J Psychiatry 1998; 172: 331–336
  • Sheehan DV, Lecrubier Y, Sheenhan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59(Supp 20)22–33
  • Taylor D, Paton C, Kerwin R. The South London and Maudsley NHS Trust. Prescribing guidelines7th ed. Martin Dunitz, Taylor & Francis Group, London, New York 2003
  • Thomassen R, Vandenbroucke JP, Rosendaal FR. Antipsychotic medication and venous thrombosis. Br J Psychiatry 2001; 179: 63–66
  • The United States Pharmacopoeia Drug Information. 2000. Drug Information for the Health Care Professional. Vol I20th ed. Greenwood Village, CO, Thomson Micromedex
  • von Kanel R. Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: how strong is the evidence?. Acta Psychiatr Scand 2004; 110: 163–177
  • Wallaschofski H, Donne M, Eigenthaler M, Hentschel R, Faber R, Stepan H, et al. PRL as a novel potent cofactor for platelet aggregation. J Clin Endocrinol Metab 2001; 86: 5912–5919
  • Wallaschofski H, Eigenthaler M, Kiefer M, Donne M, Betina H, Gertz H, et al. Hyperprolactinemia in patients on antipsychotic drags causes ADP-stimulated platelet activation that might explain the increased risk for venous thromboembolism: pilot study. J Clin Psychopharmacol 2003; 23: 479–483
  • Walsh MT, Ryan M, Hillmann A, Condren R, Kenny D, Dinan T, et al. Elevated expression of integrin αIIbβIIIa in drug-naive, first episode schizophrenic patients. Biol Psychiatry 2002; 52: 874–879
  • Wu K. Platelet activation mechanisms and marker in arterial thrombosis. J Intern Med 1996; 239: 17–34
  • Yang TY, Chung KJ, Huang TL, Te-Kung CH. Massive pulmonary embolism in a young patient on clozapine therapy. J Emergency Med 2004; 27: 27–29
  • Yao JK, Yasaei P, van Kammen DP. Increased turnover of platelet phosphatidylinositol in schizophrenia. Prostaglandins Leukotrienes Essent Fatty Acids 1992; 46: 39–46
  • Yao JK, van Kammen DP, Gurklis JA, Peters JL. Platelet aggregation and dense granule secretion in schizophrenia. Psychiatry Res 1994; 54: 13–24
  • Yao JK, van Kammen DP, Moss HB, Sokulski DE. Decreased serotonic responsivity in platelet of drug-free patients with schizophrenia. Psychiatr Res 1996; 63: 123–132
  • Yao JK, Magan S, Sonel AF, Gurklis JA, Sanders R, Reddy RD. Effects of omega-3 fatty acid on platelet serotonin responsivity in patients with schizophrenia. Prostaglandins Leukotriens Essent Fatty Acids 2004; 71: 171–176
  • Zornberg GL, Jick H. Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism: a case-control study. Lancet 2000; 356: 1219–1223

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.