Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia

References

• Atfi A, Dumont E, Colland F, Bonnier D, L’Helgoualc'h A, Prunier C, . 2007. The disintegrin and metalloproteinase ADAM12 contributes to TGF-ß signaling through interaction with the type II receptor. J Cell Biol 178: 201–208.
   PubMed Web of Science ®Google Scholar
• Akanji AO, Ohaeri JU, Al-Shammri SA, Fatania HR. 2007. Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects. Clin Chem Lab Med 45:1229–1231.
   PubMedGoogle Scholar
• Arndt M, Lendeckel U, Röcken C, Nepple K, Wolke C, Spiess A, . 2002. Altered expression of ADAMs (A Disintegrin and Metalloproteinase) in fibrillating human atria. Circulation 105:720–725.
   PubMed Web of Science ®Google Scholar
• Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, . 2002. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med 8:35–40.
   PubMed Web of Science ®Google Scholar
• Bernstein H-G, Stanarius A, Baumann B, Henning H, Krell D, Danos P, . 1998. Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 83:967–875.
   Google Scholar
• Bernstein H-G, Baumann B, Danos P, Diekmann S, Bogerts B, Gundelfinger ED, Braunewell K-H. 1999. Regional and cellular distribution of neural visinin–like protein immunoreactivities (VILIP-1 and vilip-3) in human brain. J Neurocytol 28:655–662.
   PubMedGoogle Scholar
• Bernstein H-G, Keilhoff G, Bukowska A, Ziegeler A, Funke S, Dobrowolny H, . 2004. ADAM (a disintegrin and metal-loprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes. J Neurosci Res 75:353–60.
   PubMedGoogle Scholar
• Bernstein H-G, Lendeckel U, Dobrowolny H, Stauch R, Steiner J, Grecksch G, . 2008. Beacon-like/ubiquitin-5-like immuno-reactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophrenia. Psychoneuroendocrinology 33: 340–351.
   PubMedGoogle Scholar
• Bernstein H-G, Steiner J, Bogerts B. 2009. Glial cells in schizophrenia: Pathophysiological significance and possible consequences for therapy. Expert Rev Neurother 9:1059–1071.
   PubMed Web of Science ®Google Scholar
• Bulyaeva KB, Glatt SJ, Bulyaev OA, Pavlova TA, Tsuang MT. 2007. Genome-wide linkage scan of schizophrenia: a cross-isolate study. Genomics 89:167–177.
   PubMedGoogle Scholar
• Byne W, Kidkardnee S, Tatusov SA, Yiannoulos G, Buchsbaum MS, Haroutunian V. 2006. Schizophrenia-associated reduction of neuronal and oligodendrocyte numbers in the anterior principal thalamic nucleus. Schizophr Res 85:245–253.
   PubMed Web of Science ®Google Scholar
• Chissoe S, Ehm M, Jean St. P. 2008. Genes associated with schizophrenia. US Patent Application 20080176239:p.42.
   Google Scholar
• Cadet JL, McCoy MT, Ladenheim B. 2002. Distinct gene expression signatures in the striata of wild-type and heterozygous c-fos knockout mice following methamphetamine administration: Evidence from cDNA array analyses. Synapse 44:211–226.
   PubMedGoogle Scholar
• Cao Y, Zhao Z, Gruszczynska-Biegala J, Zolkiewska A. 2003. Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro. Mol Cell Biol 23:6725–6738.
   PubMedGoogle Scholar
• Chissoe S, Ehm MG, Jean St. P. 2008. Genes associated with schizophrenia. United States Patent Application 20080176239, p 42.
   Google Scholar
• Cruz DA, Weaver CL, Lovallo EM, Melchitzky DS, Lewis DA. 2009. Selective alterations in postsynaptic markers of Chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia. Neuropsychopharmacology 34:2112–24.
   PubMedGoogle Scholar
• Danos P, Baumann B, Krämer K, Bernstein H-G, Stauch R, Krell D, . 2003. Volumes of association thalamic nuclei in schizophrenia: a postmortem study. Schizophr Res 60:141–155.
   PubMedGoogle Scholar
• Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, . 2003. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry 60: 443–456.
   PubMed Web of Science ®Google Scholar
• Dyczynska E, Sun D, Yi H, Sehara-Fujisawa A, Blobel CP, Zolkiewska A. 2007. proteolytic processing of delta-like 1 by ADAM proteases. J Biol Chem 282:436–444.
   PubMed Web of Science ®Google Scholar
• Edwards DR, Handsley MM, Pennington CJ. 2008. The ADAM metalloproteinases, Mol Aspects Med 29:258–289.
   PubMed Web of Science ®Google Scholar
• Ewald H, Flint TJ, Jorgensen TH, Wang AG, Jensen P, Vang M, . 2002. Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands. Am J Med Genet 114:196–204.
   PubMed Web of Science ®Google Scholar
• Fornito Y, Yücel M, Wood SJ, Pantelis C. 2009. Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology. Schizophr Bull 35:973–993.
   PubMed Web of Science ®Google Scholar
• Futamura T, Toyooka K, Iritani S, Niizato S, Nakamura R, Tsuchiya K, . 2002. Abnormal epression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients, Mol Psychiatry 7: 673–682.
   PubMedGoogle Scholar
• Gregg JR, Herring NR, Naydenov AV, Hanlin RP, Konradi C. 2009. Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex functions in rats. Schizophr Res 113: 277–87
   PubMed Web of Science ®Google Scholar
• Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, . 2001. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci USA 98: 4746–4751.
   PubMed Web of Science ®Google Scholar
• Harold D, Jehu L, Turic D, Hollingworth P, Moore P, Summerhaves P, . 2007. Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 144: 448–452.
   Google Scholar
• Hänninen K, Katila H, Anttila S, Rontu R, Maaskola J, Hurme M, Lehtimäki T. 2007. Epidermal grwoth factor a61g polymorphism is associated with the age of onset of schizophrenia in male patients. J Psychiatry Res 41: 8–14.
   PubMedGoogle Scholar
• Hof PR, Haroutunian V, Copland C, Davis KL, Buxbaum JD. 2002. Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia. Neurochem Res 27: 1193–1200.
   PubMed Web of Science ®Google Scholar
• Hof PR, Haroutunian V, Friedrich VL Jr, Byne W, Buitron C, Perl DP, Davis KL. 2003. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol Psychiatry 53:1075–1085.
   PubMed Web of Science ®Google Scholar
• Höistad M, Segal D, Takahashi N, Sakurai T, Buxbaum JD, Hof PR. 2009. Linking white and grey matter in schizophrenia: oligodendrcyte and neuron pathology in the prefrontal cortex. Front Neuroanat 3:9.
   PubMedGoogle Scholar
• Horiuchi K, Le Gall S, Schulte M, Yamaguchi T, Reiss K, Murphy G, . 2007. Substrate selectivity of epidermal growth factor-receptor ligand sheddases by phorbol esters and calcium influx. Mol Biol Cell 18:176–188.
   PubMedGoogle Scholar
• Hung CC, Chen YH, Tsai MT, Chen CH. 2001. Systematic search for mutations in the human tissue inhibitors of metalloproteinases-3 (TIMP-3) gene on chromosome 22 and association study with schizophrenia. Am J Med Genet 105: 275–278.
   PubMedGoogle Scholar
• Iossifov J, Zheng T, Baron M, Gilliam TC, Rzhetsky A. 2008. Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network, Genome Res 18:1150–1161.
   PubMed Web of Science ®Google Scholar
• Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, . 2004. ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase. Biochem Biophys Res Commun 314:1008–1013.
   PubMed Web of Science ®Google Scholar
• Ivo R, Schulze TG, Schumacher J, Kesper K, Müller DJ, Kremer I, . 2006. No evidence for association between Notch4 and schizophrenia in a large family-based and case-control association analysis. Psychiatr Genet 16:197–203.
   PubMedGoogle Scholar
• Jacobsen J, Wewer UM. 2009. Targeting ADAM12 in human disease: head, body or tail? Curr Pharm Des 15:2300–2310.
   PubMed Web of Science ®Google Scholar
• Jacobsen J, Visse R, Sørensen HP, Enghild JJ, Brew K, Wewer UM, Nagase H. 2007. Catalytic properties of ADAM12 and its domain deletion mutants. Biochemistry 47:537–547.
   PubMedGoogle Scholar
• Kalkman HO. 2009. Altered growth factor signalling pathways as the basis of aberrant stem cell maturation in schizophrenia. Pharmacol Ther 121: 115–121.
   PubMedGoogle Scholar
• Katsel P, Davis KL, Li C, Tan W, Greenstein E, Kleiner Hoffman LG, Haroutunian V. 2008. Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes. Neuropsychopharmacology 33:2993–3009.
   PubMed Web of Science ®Google Scholar
• Kirkpatrick B, Messias NC, Conley RR, Roberts RC. 2003. Interstitial cells of the white matter in the dorsolateral prefrontal cortex in deficient and nondeficient schizophrenia. J Nerv Ment Dis 191: 563–567.
   PubMed Web of Science ®Google Scholar
• Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T ,. 2004. ADAM12 Is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol 165:1743–1753.
   PubMed Web of Science ®Google Scholar
• Kompus K, Hugdahl K, Marklund P, Nyberg L. 2009. Distinct control networks for cognition and emotion in the prefrontal cortex. Neurosci Lett 467:76–80.
   PubMedGoogle Scholar
• Konopaske GT, Dorph-Petersen KA, Sweet RA, Pierri JN, Zhang W, Sampson AR, Lewis DA. 2008. Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol Psychiatry 63:759–765.
   PubMed Web of Science ®Google Scholar
• Kurisaki T, Masuda A, Sudo K, Sakagami J, Higashiyama S, Matsuda Y, . 2003. Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrinalpha in adipogenesis and myogenesis. Mol Cell Biol 23:55–61.
   PubMed Web of Science ®Google Scholar
• Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM. 2008. Cellular roles of ADAM12 in health and disease. Int J Biochem Cell Biol 40:1685–1702.
   PubMed Web of Science ®Google Scholar
• Laigaard J, Sørensen T, Fröhlich C, Pedersen BN, Christiansen M, Schiøtt K, . 2003. ADAM12: a novel first-trimester maternal serum marker for Down syndrome. Prenat Diagn 23:1086–1091.
   PubMed Web of Science ®Google Scholar
• Lin J, Luo J, Redies C. 2008. Differential expression of five members of the ADAM family in the developing chicken brain. Neuroscience 157: 360–375.
   PubMedGoogle Scholar
• Maier O, van der Heide T, Johnson R, de Vries H, Baron W, Hoekstra D. 2006. The function of neurofascin155 in oligodendrocytes is regulated by metalloprotease-mediated cleavage and ectodomain shedding. Exp Cell Res 312:500–511.
   PubMedGoogle Scholar
• Loechel F, Fox JW, Murphy G, Albrechtsen R, Wewer UM. 2000. ADAM-12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3. Biochem Biophys Res Commun 278:511–515.
   PubMed Web of Science ®Google Scholar
• Mai JK, Assheuer J, Paxinos G. 2003. Atlas of the human brain. San Diego, CA: Academic Press.
   Google Scholar
• Manoach DS, Ketwaroo GA, Polli FE, Thakkar KN, Barton JJS, Goff DC, . 2007. Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia. Neuroimage 37:599–610.
   PubMedGoogle Scholar
• Malinin NL, Wright S, Seubert P, Schenk D, Griswold-Prenner I. 2005. Amyloid-beta neurotoxicity is mediated by FISH-adapter protein and ADAM12 metalloprotease activity. Proc Natl Acad Sci USA 22: 3058–3063.
   PubMedGoogle Scholar
• Martins-de-Souza D, Gattaz WF, Schmitt A, Maccarone G, Hunyadi-Gulýas E, Eberlein MN, . 2009. Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia. J Psychiatr Res 43:978–986.
   PubMed Web of Science ®Google Scholar
• Mayhew MH. 1992. A review of recent advances in stereology for quantifying neural structure. J Neurocytol 21: 313–328.
   PubMedGoogle Scholar
• Moon HJ, Yim SV, Lee WK, Jeon YW, Kim YH, Ko YJ, . 2006. Identification of DNA copy–number aberrations by array-comparative genomic hybridization in patients with schizophrenia. Biochem Biophys Res Commun 344:531–539.
   PubMedGoogle Scholar
• Nadri C, Bersudsky Y, Belmaker RH, Agam G. 2007. Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients. J Neural Transm 114:473–477.
   PubMedGoogle Scholar
• Park N, Juo SH, Cheng R, Liu L, Loth JE, Lilliston B, . 2004. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry 9:1091–1099.
   PubMed Web of Science ®Google Scholar
• Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, . 2006. The human obesity gene map: the 2005 update. Obesity 14: 529–644
   PubMed Web of Science ®Google Scholar
• Schmitt A, Steyskal C, Bernstein H-G, Schneider-Axmann T, Parlapani E, Schaeffer EL, . 2009. Stereologic investigation of the posterior part of the hippocampus in schizophrenia. Acta Neuropathol 117:395–407.
   PubMedGoogle Scholar
• Schmitt A, Otto S, Jatzko A, Ruf M, Demirakca T, Tost H, . 2009. Parieto-prefrontal dysfunction during visuo-auditory information processing in elderly, chronic schizophrenic patients and medication effects. Rev Psiquiatr Clin 36:89–96.
   Google Scholar
• Segal D, Koschnick JR, Slegers LH, Hof PR. 2007. Oligodendrocyte pathophysiology: a new view of schizophrenia. Int J Neuropsychopharmacol 10: 503–511.
   PubMed Web of Science ®Google Scholar
• Segal D, Schmitz C, Hof PR. 2009. Spatial distribution and density of oligodendrocytes in the cingulum bundle are unaltered in schizophrenia. Acta Neuropathol 117:385–394.
   PubMedGoogle Scholar
• Selemon LD, Mrzljak J, Kleinman JE, Herman MM, Goldman-Rakic PS. 2003. Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9. Arch Gen Psychiatry 60:69–77.
   PubMed Web of Science ®Google Scholar
• Sherman DL, Tait S, Melrose S, Johnson R, Zonta B, Court FA, . 2005. Neurofascins are required to establish axonal domains for saltatory conduction. Neuron 48:737–42.
   PubMed Web of Science ®Google Scholar
• Stark AK, Uylings HBM, Sanz-Arigita E, Pakkenberg B. 2004. Glial cell loss in the anterior cingulate cortex, a subregion of the prefrontal cortex, in subjects with schizophrenia. Am J Psychiatry 161: 4882–888
   Google Scholar
• Steiner J, Mawrin C, Ziegeler A, Bielau H, Ullrich O, Bernstein H-G, Bogerts B. 2006. Distribution of HLA-DR positive microglia in schizophrenia reflects impaired cerebral lateralization. Acta Neuropathol 112:305–316.
   PubMed Web of Science ®Google Scholar
• Steiner J, Bernstein H-G, Bogerts B, Gos T, Richter-Landsberg C, Wunderlich MT, Keilhoff G. 2008. S100B is expressed in, and released from,OLN-93 oligodendrocytes: Influence of serum and glucose deprivation, Neuroscience 154:496–503.
   PubMedGoogle Scholar
• Uranova NA, Orlovskaya DD, Vikhreva OV, Zimina IS, Rakhmanova VI. 2001. Morphometric study of ultrastructural changes in oligodendroglial cells in the postmortem brain in endogenous psychoses. Vestn Ross Akad Med Nauk 7:42–48.
   Google Scholar
• Uranova NA, Vostrikov VM, Orlovskaya DD, Rachmanova VI. 2004. Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium. Schizophr Res 67:269–275.
   PubMed Web of Science ®Google Scholar
• Vostrikov VM, Uranova NA, Orlovskaya DD. 2007. Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders. Schizophr Res 94:273–280.
   PubMed Web of Science ®Google Scholar
• Wang Z, Wei J, Zhang X, Guo Y, Xu Q, Liu S, . 2006. A review and re-evaluation of an association between the Notch4 locus and schizophrenia (2006) Am J Med Genet B Neuropsychiatr Genet 141B:902–906.
   PubMed Web of Science ®Google Scholar
• Wewer UM, Albrechtsen R, Engvall E. 2005. ADAM12: The long and the short of it. In: Proteases in Health and Disease. The ADAM family of proteases. Nigel NM, Lendeckel U. New York: Springer. 123–146.
   Google Scholar
• Wu M-K, Wang C-K, Bai Y-A, Huang CY, Lee SD. 2007. Outcomes of obese, clozapine-treated inpatients with schizophrenia placed on a six-month diet and physical activity program. Psychiatr Serv 58:544–550.
   PubMed Web of Science ®Google Scholar
• Yamada Y, Esaki T, Mizutani T. 1999. Intracranial cavity volume can be accurately estimated from the weights of intracranial contents: confirmation by the dental plaster casting method. Neuropathol Appl Neurobiol 25:341–344.
   PubMedGoogle Scholar