758
Views
110
CrossRef citations to date
0
Altmetric
Research Article

Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line

, , , , , , & show all
Pages 557-567 | Received 26 Mar 2010, Accepted 09 Nov 2011, Published online: 15 Dec 2010

References

  • Aillon KL, Xie Y, El-Gendy N, Berkland CJ, Forrest ML. 2009. Effects of nanomaterial physicochemical properties on in vivo toxicity. Adv Drug Deliv Rev 61(6):457–466.
  • AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S. 2009. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3(2):279–290.
  • Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. 1983. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation. J Immunol 130(4):1910–1917.
  • Bidere N, Lorenzo HK, Carmona S, Laforge M, Harper F, Dumont C, Senik A. 2003. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 278(33):31401–31411.
  • Bouchier-Hayes L, Munoz-Pinedo C, Connell S, Green DR. 2008. Measuring apoptosis at the single cell level. Methods 44(3):222–228.
  • Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. 1999. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 274(33):22932–22940.
  • Calderon-Garciduenas L, Solt AC, Henriquez-Roldan C, Torres-Jardon R, Nuse B, Herritt L, Villarreal-Calderon R, Osnaya N, Stone I, Garcia R, Brooks DM, Gonzalez-Maciel A, Reynoso-Robles R, Delgado-Chavez R, Reed W. 2008. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicol Pathol 36(2):289–310.
  • Casey JR, Grinstein S, Orlowski J. 2010. Sensors and regulators of intracellular pH. Nat Rev Mol Cell Biol 11(1):50–61.
  • Chiarugi A. 2005. “Simple but not simpler”: Toward a unified picture of energy requirements in cell death. Faseb J 19(13):1783–1788.
  • Chwieralski CE, Welte T, Buhling F. 2006. Cathepsin-regulated apoptosis. Apoptosis 11(2):143–149.
  • Ferri KF, Kroemer G. 2001. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3(11):E255–263.
  • Frohlich E, Samberger C, Kueznik T, Absenger M, Roblegg E, Zimmer A, Pieber TR. 2009. Cytotoxicity of nanoparticles independent from oxidative stress. J Toxicol Sci 34(4):363–375.
  • Germain M, Mathai JP, McBride HM, Shore GC. 2005. Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. Embo J 24(8):1546–1556.
  • Hotchkiss RS, Strasser A, McDunn JE, Swanson PE. 2009. Cell death. N Engl J Med 361(16):1570–1583.
  • Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T, Majima HJ. 2007. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 7(1–2):106–118.
  • Jagtap P, Szabo C. 2005. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 4(5):421–440.
  • Jellinger KA. 2009. Recent advances in our understanding of neurodegeneration. J Neural Transm 116(9):1111–1162.
  • Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P. 1997. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 185(8):1481–1486.
  • Li SD, Huang L. 2008. Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm 5(4):496–504.
  • Lv H, Zhang S, Wang B, Cui S, Yan J. 2006. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 114(1):100–109.
  • Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311(5761):622–627.
  • Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M. 2009. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8(7):543–557.
  • Plantin-Carrenard E, Bringuier A, Derappe C, Pichon J, Guillot R, Bernard M, Foglietti MJ, Feldmann G, Aubery M, Braut-Boucher F. 2003. A fluorescence microplate assay using yopro-1 to measure apoptosis: Application to HL60 cells subjected to oxidative stress. Cell Biol Toxicol 19(2):121–133.
  • Riedl SJ, Shi Y. 2004. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5(11):897–907.
  • Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA, Korsmeyer SJ. 2002. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell 2(1):55–67.
  • Watson P, Jones AT, Stephens DJ. 2005. Intracellular trafficking pathways and drug delivery: Fluorescence imaging of living and fixed cells. Adv Drug Deliv Rev 57(1):43–61.
  • Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. 2006. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6(8):1794–1807.
  • Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE. 2008a. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2(10):2121–2134.
  • Xia T, Kovochich M, Liong M, Zink JI, Nel AE. 2008b. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano 2(1):85–96.
  • Xiao AY, Wang XQ, Yang A, Yu SP. 2002. Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons. Brain Res 955(1–2):253–259.
  • Zamaraeva MV, Sabirov RZ, Maeno E, Ando-Akatsuka Y, Bessonova SV, Okada Y. 2005. Cells die with increased cytosolic ATP during apoptosis: A bioluminescence study with intracellular luciferase. Cell Death Differ 12(11):1390–1397.
  • Zhao M, Antunes F, Eaton JW, Brunk UT. 2003. Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis. Eur J Biochem 270(18):3778–3786.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.