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Research Article

Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes

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Pages 338-352 | Received 01 Nov 2010, Accepted 24 Mar 2011, Published online: 16 May 2011

References

  • Alvarez-Roman R, Naik A, Kalia YN, Guy RH, Fessi H. 2004. Skin penetration and distribution of polymeric nanoparticles. J Control Release 99:53–62.
  • Arora S, Jain J, Rajwade JM, Paknikar KM. 2008. Cellular responses induced by silver nanoparticles: In vitro studies. Toxicol Lett 179:93–100.
  • Baroli B, Ennas MG, Loffredo F, Isola M, Pinna R, Lopez-Quintela MA. 2007. Penetration of metallic nanoparticles in human full-thickness skin. J Invest Dermatol 127:1701–1712.
  • Barry BW. 2001. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 14:101–114.
  • Baudouin C, Charveron M, Tarroux R, Gall Y. 2002. Environmental pollutants and skin cancer. Cell Biol Toxicol 18:341–348.
  • Breitner S, Stölzel M, Cyrys J, Pitz M, Wölke G, Kreyling W, Küchenhoff H, Heinrich J, Wichmann HE, Peters A. 2009. Short-term mortality rates during a decade of improved air quality in Erfurt, Germany. Environ Health Perspect 117(3):448–454.
  • Brisson P. 1974. Percutaneous absorption. Can Med Assoc J 110:1182–1185.
  • Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. 2001. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 175:191–199.
  • Bruno A, Minutolo P, de Lisio C, D'Alessio A. 2007. Evidence of fluorescent carbon nanoparticles produced in premixed flames by time-resolved fluorescence polarization anisotropy. Combust Flame 151:472–481.
  • Burd A, Kwok CH, Hung SC, Chan HS, Gu H, Lam WK, Huang L. 2007. A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models. Wound Repair Regen 15:94–104.
  • Castranova V, Ma JYC, Yang HM, Antonini JM, Butterworth L, Barger MW, Roberts J, Ma JKH. 2001. Effect of exposure to diesel exhaust particles on the susceptibility of the lung to infection. Environ Health Perspect 109:609–612.
  • Cecere D, Sgro LA, Basile G, D'Alessio A, D'Anna A, Minutolo P. 2002. Evidence and characterization of nanoparticles produced in nonsooting premixed flames. Combust Sci Tech 174 (11–12):377–398.
  • Cheng YW, Lee WW, Li CH, Lee CC, Kang JJ. 2004. Genotoxicity of motorcycle exhaust particles in vivo and in vitro. Toxicol Sci 81:103–111.
  • Chou CC, Riviere JE, Monteiro-Riviere NA. 2002. Differential relationship between the carbon chain length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity vs. interleukin-8 release in huan epidermal keratinocytes. Toxicol Sci 69:226–233.
  • Contet-Audonneau JL, Danoux L, Gauche D, Pauly G. 2000. Stress, apoptosis and ageing in human skin. 21st IFSCC International Congress, Berlin.
  • Cormier SA, Lomnicki S, Backes W, Barry D. 2006. Origin and health impacts of emissions of toxic by-products and fine particles from combustion and thermal treatment of hazardous wastes and materials. Environ Health Perspect 114:810–817.
  • Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P, Bagley ST. 2007. Human skin penetration of sunscreen nanoparticles: In vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol 20:148–154.
  • D'Alessio A, D'Anna A, D'Orsi A, Minutolo P, Barbella R, Ciajolo A. 1992. Precursor formation and soot inception in premixed ethylene flames. Proc Combust Inst 24:973–980.
  • D'Alessio A, D'Anna A, Minutolo P, Sgro LA. 2009. Nanoparticles of organic carbon (NOC) formed in flames and their effects in urban atmospheres. In: Bockhorn , editors. Combustion generated fine carbonaceous particles. Karlsruhe, Germany: Karlsruhe University Press. pp 205–230.
  • D'Anna A. 2009. Combustion formed nanoparticles. Proc Comb Inst 32:593–613.
  • D'Errico MR, Teson M, Calcagnile AS, Proietti De Santis L, Nikaido O, Botta E, Zambruno G, Stefanini M, Dogliotti E. 2003. Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVB. Cell Death Differentiat 10:754–756.
  • De Filippo A, Maricq MM. 2008. Diesel nucleation mode particles: Semivolatile or solid? Environ Sci Technol 42:7957–7962.
  • Donaldson K, Beswick PH, Gilmour PS. 1996. Free radical activity associated with the surface of particles: A unifying factor in determining biological activity? Toxicol Lett 88:293–298.
  • Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V. 2005. Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. Part Fibre Toxicol 21:2–10.
  • Ekunwe SN, Hunter RD, Hwang HM. 2005. Ultraviolet radiation increases the toxicity of pyrene, 1-aminopyrene and 1-hydroxypyrene to human keratinocytes. Int J Environ Res Public Health 2 (1):58–62.
  • Gilhar A, Ullman Y, Karry R, Shalaginov R, Assy B, Serafimovich S, Kalish RS. 2004. Aging of human epidermis: The role of apoptosis, Fas and telomerase. Br J Derm 150:56–63.
  • Hiura TS, Kaszubowski MP, Li N, Nel A. 1999. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 163:5582–5591.
  • Hu X, Zhang Y, Zhao X, Huey-Min H. 2007. Biodegradation of benzo[a]pyrenewith immobilized laccase: Genotoxicity of the products in HaCaT and A3 cells. Environ Molec Mutagen 48:106–113.
  • Ibald-Mulli A, Wichmann HE, Kreyling W, Peters A. 2002. Epidemiological evidence on health effects of ultrafine particles. J Aerosol Med 15:189–201.
  • Imhof D, Weingartner E, Ordonez C, Gehrig R, Hill M, Buchmann B, Baltensperger U. 2005. Real-world emission factors of fine and ultrafine aerosol particles for different traffic situations in Switzerland. Environ Sci Technol 39:8341–8350.
  • Jonaitis TS, Card JW, Magnuson B. 2010. Concerns regarding nano-sized titanium dioxide dermal penetration and toxicity study. Toxicol Lett 192:268–269.
  • Kennedy C, Bastiaens MT, Bajdik CD, Willemze R, Westendorp RG, Bouwes Bawinck JN. 2003. Effect of smoking and sun on the aging skin. J Invest Dermatol 120:548–554.
  • Kiss B, Biro T, Czifra G, Toth BI, Kertesz Z, Szikszai Z, Kiss AZ, Juhasz I, Zouboulis CC, Hunyadi J. 2008. Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells. Exp Derm 17:659–667.
  • Kittelson DB. 1998. Engines and nanoparticles: A review. J Aerosol Sci 29:575–588.
  • Lademann J, Richter H, Teichmann A, Otberg N, Blume-Peytavi U, Luengo J, Weib B, Schaefer UF, Lehr CM, Wept R, Sterry W. 2007. Nanoparticles – an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 66:159–164.
  • Larese FF, D'Agostino F, Crosera M, Adami G, Renzi N, Bovenzi M. 2009. Human skin penetration of silver nanoparticles through intact and damaged skin. Toxicol 255:33–37.
  • Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455–460.
  • Liu YQ, Keane M, Ensell M, Mille W, Kashon M, Ong T M, Mauderly J, Lawson D, Gautam M, Zielinska B, Whitney K, Eberhardt, Wallace W. 1990. In vitro genotoxicity of exhaust emissions of diesel and gasoline engine vehicles operated on a unified driving cycle. J Environ Monitor 7:60–66.
  • Ma C, Wang J, Luo J. 2004. Activation of nuclear factor kappa B by diesel exhaust particles in mouse epidermal cells through phosphatidylinositol 3-kinase/Akt signaling pathway. Biochem Pharmacol 67:1975–1983.
  • McGahon AJ, Martin SJ, Bissonnette RP, Mahboubi A, Shi Y, Mogil RJ, Nishioka WK, Green DR. 1995. The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol 46:153–185.
  • Minutolo P, D'Anna A, Commodo M, Pagliara R, Toniato G, Accordini C. 2008. Emission of ultrafine particles from natural gas domestic burners. Env Eng Sci 25:1357–1363.
  • Minutolo P, Sgro LA, Bruno A, D'Anna A, D'Alessio A. 2009. In: Bockhorn , editors. Karlsruhe: Karlsruhe University Press. pp 231–246.
  • Montiere-Riviere NA, Inman AO. 2006. Challenges for assessing carbon nanomaterial toxicity to the skin. Carbon 44:1070–1078.
  • Nohynek GJ, Lademann J, Ribaud C, Roberts MS. 2007. Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety. Crit Rev Toxicol 37:251–277.
  • Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839.
  • Osunsanya T, Prescott G, Seaton A. 2000. Acute respiratory effects of particles: Mass or number? Occup Environ Med 58:154–159.
  • Peters A, Breitner S, Cyrys J, Stölzel M, Pitz M, Wölke G, Heinrich J, Kreyling W, Küchenhoff H, Wichmann HE. 2009. The influence of improved air quality on mortality risks in Erfurt, Germany. Boston, MA, Health Effects Institute.
  • Peters A, Wichmann HE, Tuch T, Heinrich J, Heyder J. 1997. Respiratory effects are associated with the number of ultrafine particles. Am J Respir Crit Care Med 155:1376–1383.
  • Pirjola L, Parviainen H, Hussein T, Valli A, Hameri K, Aaalto P, Virtanen A, Keskinen J, Pakkanen TA, Makela T, Hillameo RE. 2004. ‘Sniffer’ – a novel tool for chasing vehicles and measuring traffic pollutants. Atmos Environ 38:3625–3635.
  • Rolland A, Wagner N, Chatelus A, Shroot B, Schaefer H. 1993. Site-specific drug delivery to pilosebaceous structures using polymeric microspheres. Pharm Res 10:1738–1744.
  • Ronkko T, Virtanen A, Kannosto J, Keskinen J, Lappi M, Pirjola L. 2007. Nucleation mode particles with a nonvolatile core in the exhaust of a heavy duty diesel vehicle. Environ Sci Technol 41:6384–6389.
  • Rusciano G, Cerrone G, Sasso A, Bruno A, Minutolo P. 2006. Infrared analysis of nano organic particles produced in laminar flames. Appl Phys B: Lasers Optics 82:155–160.
  • Rusciano G, De Luca AC, D'Alessio A, Minutolo P, Pesce G, Sasso A. 2008. Surface-enhanced Raman scattering study of nano-sized organic carbon particles produced in combustion processes. Carbon 46:335–341.
  • Samberg ME, Oldenburg SJ, Monteiro-Riviere NA. 2009. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environ Health Perspect 118:407–413.
  • Schröder P, Schieke SM, Morita A. 2006. Premature skin aging by infrared radiation, tobacco smoke and ozone. In: Gilchrest BA, Krutmann J, editors. Skin aging. New York: Springer-Verlag. pp 45–55.
  • Seagrave JC, McDonald JD, Gigliotti AP, Nikula KJ, Seilkop SK, Gurevich M, Mauderly JL. 2002. Mutagenicity and in vivo toxicity of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions. Toxicol Sci 70:212–226.
  • Sgro LA, De Filippo A, Lanzuolo G, D'Alessio A. 2007. Characterization of Nanoparticles of Organic Carbon (NOC) produced in rich premixed flames by differential mobility analysis Proc Combust Inst 31:631–638.
  • Sgro LA, Borghese A, Speranza L, Barone A, Minutolo P, Bruno A, D'Anna A, D'Alessio A. 2008. Measurement of nanoparticles of organic carbon and soot in flames and vehicle exhausts. Environ Sci Technol 42(3):859–863.
  • Sgro LA, Simonelli A, Pascarella L, Minutolo P, Guarnieri D, Netti P, D'Anna A. 2009a. Toxicological properties of nanoparticles of organic compounds (NOC) from flames and vehicle exhausts. Env Sci Technol 43:608–613.
  • Shvedova A, Castranova V, Kisin ER, Schwegler-Berry D, Murray AR, Gandelsman VZ, Maynard A, Baron P. 2003. Exposure to carbon nanotube material: Assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 66:1909–1926.
  • Stojicic N, Baumstark-Khan C, Hellweg CE, Grotheer HH., Reitz G, Kolanus W, Hemmersbach R. 2010. Toxicity of ethylene combustion condensates is directly proportional to their carbon content. Toxicol Lett 269:35–40.
  • Toll R, Jacobi U, Richter H, Lademann J, Schaefer H, Blume-Peytavi U. 2004. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol 123:168–176.
  • Ushio H, Nohara K, Fujimaki H. 1999. Effect of environmental pollutants on the production of pro-inflammatory cytokines by normal human dermal keratinocytes. Toxicol Lett 105:17–24.
  • Vierkötter A, Schikowski T, Ranft U, Sugiri D, Matsui M, Krämer U, Krutmann J. 2010. Airborne particle exposure and extrinsic skin aging. J Investigat Dermatol 130:2719–2726.
  • Wang H. 2011. Formation of nascient soot and other condensed-phase materials in flames. Proc Comb Inst 33:41–67.
  • Wang S, Sheng Y, Feng M, Leszczynski J, Wang L, Tachikawa H, Yu H. 2007. Light-induced cytotoxicity of 16 polycyclic aromatic hydrocarbons on the US EPA priority pollutant list in human skin HaCaT keratinocytes: Relationship between phototoxicity and excited state properties. Environ Toxicol 22:318–327.
  • Wichmann HE, Spix C, Tuch T, Wölke G, Peters A, Heinrich J, Kreyling WG, Heyder J. 2000. Daily mortality and fine and ultrafine particles in Erfurt, Germany part I: Role of particle number and particle mass. Res Rep Health Eff Inst 98:5–94.
  • Wörle-Knirsch JM, Pulskamp K, Krug HF. 2006. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett 6:1261–1268.
  • Wu J, Wei L, Xue C, Zhou S, Lan F, Bi L, Xu H, Yang X, Zeng FD. 2010. Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 191:1–8.
  • Xia XR, Monteiro-Riviere NA, Riviere JE. 2010. Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol 242:29–37.
  • Yang X, Liu J, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L, Zhang B, Zhuang Z. 2010. SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Particle Fibre Toxicol 7:1.
  • Zhang LW, Monteiro-Riviere NA. 2008. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacol Physiol 21:166–180.
  • Zheng B, Hwang HM, Yu H, Ekunwe SN. 2004. DNA damage produced in HaCaT cells by combined fluoranthene exposure and ultraviolent A irradiation. Environ Mol Mutagen 44:151–155.
  • Zhu Y, Hinds C, Kim S, Shen S, Sioutas C. 2002. Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmos Env 36:4323–4335.

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