2,535
Views
123
CrossRef citations to date
0
Altmetric
Research Article

Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring

, , , , , , , , , , & show all
Pages 486-500 | Received 15 Dec 2010, Accepted 26 Apr 2011, Published online: 08 Jun 2011

References

  • Baan R, Straif K, Grosse Y, Secretan B, El GF, Cogliano V. 2006. Carcinogenicity of carbon black, titanium dioxide, and talc. Lancet Oncol 7:295–296.
  • Barton HA, Cogliano VJ, Flowers L, Valcovic L, Setzer RW, Woodruff TJ. 2005. Assessing susceptibility from early-life exposure to carcinogens. Environ Health Perspect 113:1125–1133.
  • Borm PJ, Cakmak G, Jermann E, Weishaupt C, Kempers P, Van Schooten FJ, Oberdörster G, Schins RP. 2005. Formation of PAH-DNA adducts after in vivo and vitro exposure of rats and lung cells to different commercial carbon blacks. Toxicol Appl Pharmacol 205:157–167.
  • Borm PJ, Schins RP, Albrecht C. 2004. Inhaled particles and lung cancer, part B: Paradigms and risk assessment. Int J Cancer 110:3–14.
  • Bornholdt J, Saber AT, Sharma AK, Savolainen K, Vogel U, Wallin H. 2007. Inflammatory response and genotoxicity of seven wood dusts in the human epithelial cell line A549. Mutat Res 632:78–88.
  • Brauer M, Lencar C, Tamburic L, Koehoorn M, Demers P, Karr C. 2008. A cohort study of traffic-related air pollution impacts on birth outcomes. Environ Health Perspect 116:680–686.
  • Brauner EV, Forchhammer L, Moller P, Simonsen J, Glasius M, Wahlin P, Raaschou-Nielsen O, Loft S. 2007. Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage. Environ Health Perspect 115:1177–1182.
  • Brown DM, Stone V, Findlay P, MacNee W, Donaldson K. 2000. Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components. Occup Environ Med 57:685–691.
  • Brunborg G, Soderlund EJ, Holme JA, Dybing E. 1996. Organ-specific and transplacental DNA damage and its repair in rats treated with 1,2-dibromo-3-chloropropane. Chem Biol Interact 101:33–48.
  • Brunekreef B, Beelen R, Hoek G, Schouten L, Bausch-Goldbohm S, Fischer P, Armstrong B, Hughes E, Jerrett M, van den BP. 2009. Effects of long-term exposure to traffic-related air pollution on respiratory and cardiovascular mortality in the Netherlands: The NLCS-AIR study. Res Rep Health Eff Inst 5–71.
  • Calderon-Garciduenas L, Villarreal-Calderon R, Valencia-Salazar G, Henriquez-Roldan C, Gutierrez-Castrellon P, Torres-Jardon R, Osnaya-Brizuela N, Romero L, Torres-Jardon R, Solt A. 2008. Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants. Inhal Toxicol 20:499–506.
  • Carr KE, Hazzard RA, Reid S, Hodges GM. 1996. The effect of size on uptake of orally administered latex microparticles in the small intestine and transport to mesenteric lymph nodes. Pharm Res 13:1205–1209.
  • Cindrova-Davies T, Yung HW, Johns J, Spasic-Boskovic O, Korolchuk S, Jauniaux E, Burton GJ, Charnock-Jones DS. 2007. Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol 171:1168–1179.
  • Collins AR. 2009. Investigating oxidative DNA damage and its repair using the comet assay. Mutat Res 681:24–32.
  • Danielsen PH, Loft S, Jacobsen NR, Jensen KA, Autrup H, Ravanat JL, Wallin H, Moller P. 2010. Oxidative stress, inflammation and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter. Toxicol Sci 118:574–585.
  • Danielsen PH, Risom L, Wallin H, Autrup H, Vogel U, Loft S, Moller P. 2008. DNA damage in rats after a single oral exposure to diesel exhaust particles. Mutat Res 637:49–55.
  • Dejmek J, Selevan SG, Benes I, Solansky I, Sram RJ. 1999. Fetal growth and maternal exposure to particulate matter during pregnancy. Environ Health Perspect 107:475–480.
  • Delfino RJ, Sioutas C, Malik S. 2005. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ Health Perspect 113:934–946.
  • Driscoll KE, Carter JM, Howard BW, Hassenbein DG, Pepelko W, Baggs RB, Oberdörster G. 1996. Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black. Toxicol Appl Pharmacol 136:372–380.
  • Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdörster G, Salem H, Schlesinger RB. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations. Toxicol Sci 55:24–35.
  • Driscoll KE, Deyo LC, Carter JM, Howard BW, Hassenbein DG, Bertram TA. 1997. Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis 18:423–430.
  • Dybdahl M, Risom L, Bornholdt J, Autrup H, Loft S, Wallin H. 2004. Inflammatory and genotoxic effects of diesel particles in vitro and in vivo. Mutat Res 562:119–131.
  • Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L. 2008. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol 38:57–67.
  • Folkmann JK, Loft S, Moller P. 2007. Oxidatively damaged DNA in aging dyslipidemic ApoE-/- and wild-type mice. Mutagenesis 22:105–110.
  • Folkmann JK, Risom L, Jacobsen NR, Wallin H, Loft S, Moller P. 2009. Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes. Environ Health Perspect 117:703–708.
  • Gallagher J, Sams R, Inmon J, Gelein R, Elder A, Oberdörster G, Prahalad AK. 2003. Formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine in rat lung DNA following subchronic inhalation of carbon black. Toxicol Appl Pharmacol 190:224–231.
  • Hougaard KS, Fadeel B, Gulumian M, Kagan VE, Savolainen K. 2011. Developmental toxicity of engineered nanoparticles. In: Gupta RC, editor. Reproductive and developmental toxicology. Chapter 21 Amsterdam: Academic Press, pp 269–290.
  • Hougaard KS, Jackson P, Jensen KA, Sloth JJ, Loschner K, Larsen EH, Birkedal RK, Vibenholt A, Boisen AM, Wallin H. 2010. Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol 7:16.
  • Hougaard KS, Jensen KA, Nordly P, Taxvig C, Vogel U, Saber AT, Wallin H. 2008. Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity, and inflammation in mice. Part Fibre Toxicol 5:3.
  • Jackson P, Lund SP, Kristiansen G, Andersen O, Vogel U, Wallin H, Hougaard KS. 2011. An experimental protocol for maternal pulmonary exposure in developmental toxicology. Basic Clin Pharmacol Toxicol 108:202–207.
  • Jacobsen NR, Moller P, Cohn CA, Loft S, Vogel U, Wallin H. 2008a. Diesel exhaust particles are mutagenic in FE1-MutaMouse lung epithelial cells. Mutat Res 641:54–57.
  • Jacobsen NR, Moller P, Jensen KA, Vogel U, Ladefoged O, Loft S, Wallin H. 2009. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice. Part Fibre Toxicol 6:2.
  • Jacobsen NR, Pojana G, White P, Moller P, Cohn CA, Korsholm KS, Vogel U, Marcomini A, Loft S, Wallin H. 2008b. Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells. Environ Mol Mutagen 49:476–487.
  • Jacobsen NR, Saber AT, White P, Moller P, Pojana G, Vogel U, Loft S, Gingerich J, Soper L, Douglas GR. 2007. Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells. Environ Mol Mutagen 48:451–461.
  • Jacobsen NR, White PA, Gingerich J, Moller P, Saber AT, Douglas GR, Vogel U, Wallin H. 2010. Mutation spectrum in FE1-MUTA(TM)Mouse lung epithelial cells exposed to nanoparticulate carbon black. Environ Mol Mutagen 52:331–337.
  • Jonakait GM. 2007. The effects of maternal inflammation on neuronal development: Possible mechanisms. Int J Dev Neurosci 25:415–425.
  • Knaapen AM, Borm PJ, Albrecht C, Schins RP. 2004. Inhaled particles and lung cancer. Part A: Mechanisms. Int J Cancer 109:799–809.
  • Krewski D, Jerrett M, Burnett RT, Ma R, Hughes E, Shi Y, Turner MC, Pope CA III, Thurston G, Calle EE. 2009. Extended follow-up and spatial analysis of the American Cancer Society study linking particulate air pollution and mortality. Res Rep Health Eff Inst 5–114.
  • Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdörster G, Ziesenis A. 2002. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health A 65:1513–1530.
  • Kreyling WG, Semmler-Behnke M, Seitz J, Scymczak W, Wenk A, Mayer P, Takenaka S, Oberdörster G. 2009. Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol 21(Suppl. 1):55–60.
  • Lacasana M, Esplugues A, Ballester F. 2005. Exposure to ambient air pollution and prenatal and early childhood health effects. Eur J Epidemiol 20:183–199.
  • Lamoureux DP, Kobzik L, Fedulov AV. 2010. Customized PCR-array analysis informed by gene-chip microarray and biological hypothesis reveals pathways involved in lung inflammatory response to titanium dioxide in pregnancy. J Toxicol Environ Health A 73:596–606.
  • Landsiedel R, Kapp MD, Schulz M, Wiench K, Oesch F. 2008. Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations – many questions, some answers. Mutat Res 681:241–258.
  • McArt DG, McKerr G, Saetzler K, Howard CV, Downes CS, Wasson GR. 2010. Comet sensitivity in assessing DNA damage and repair in different cell cycle stages. Mutagenesis 25:299–303.
  • McNamee JP, McLean JR, Ferrarotto CL, Bellier PV. 2000. Comet assay: Rapid processing of multiple samples. Mutat Res 466:63–69.
  • Mohr U, Ernst H, Roller M, Pott F. 2006. Pulmonary tumor types induced in Wistar rats of the so-called “19-dust study”. Exp Toxicol Pathol 58:13–20.
  • Møller P, Friis G, Christensen PH, Risom L, Plesner G, Kjaersgaard J, Vinzents P, Loft S, Jensen A, Tved M. 2004. Intra-laboratory comet assay sample scoring exercise for determination of formamidopyrimidine DNA glycosylase sites in human mononuclear blood cell DNA. Free Radic Res 38:1207–1214.
  • Møller P, Jacobsen NR, Folkmann JK, Danielsen PH, Mikkelsen L, Hemmingsen JG, Vesterdal LK, Forchhammer L, Wallin H, Loft S. 2010. Role of oxidative damage in toxicity of particulates. Free Radic Res 44:1–46.
  • Morfeld P, McCunney RJ. 2007. Carbon black and lung cancer: Testing a new exposure metric in a German cohort. Am J Ind Med 50:565–567.
  • Myllynen PK, Loughran MJ, Howard CV, Sormunen R, Walsh AA, Vahakangas KH. 2008. Kinetics of gold nanoparticles in the human placenta. Reprod Toxicol 26:130–137.
  • Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. 2002. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A 65:1531–1543.
  • Osier M, Oberdörster G. 1997. Intratracheal inhalation vs intratracheal instillation: Differences in particle effects. Fundam Appl Toxicol 40:220–227.
  • Pedersen M, Wichmann J, Autrup H, Dang DA, Decordier I, Hvidberg M, Bossi R, Jakobsen J, Loft S, Knudsen LE. 2009. Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ Res 109:1012–1020.
  • Percy DH, Barthold SW. 2001. Pathology of laboratory rodents and rabbits. 2nd edition. Ames, Iowa: Iowa State Press, A Blackwell Publishing Company.
  • Pope CA III, Dockery DW. 2006. Health effects of fine particulate air pollution: Lines that connect. J Air Waste Manag Assoc 56:709–742.
  • Pope DP, Mishra V, Thompson L, Siddiqui AR, Rehfuess EA, Weber M, Bruce NG. 2010. Risk of low birth weight and stillbirth associated with indoor air pollution from solid fuel use in developing countries. Epidemiol Rev 32:70–81.
  • Puntoni R, Ceppi M, Reggiardo G, Merlo F. 2001. Occupational exposure to carbon black and risk of bladder cancer. Lancet 358:562.
  • Ramanakumar AV, Parent ME, Latreille B, Siemiatycki J. 2008. Risk of lung cancer following exposure to carbon black, titanium dioxide and talc: Results from two case-control studies in Montreal. Int J Cancer 122:183–189.
  • Randerath E, Zhou GD, Randerath K. 1996. Organ-specific oxidative DNA damage associated with normal birth in rats. Carcinogenesis 17:2563–2570.
  • Reliene R, Hlavacova A, Mahadevan B, Baird WM, Schiestl RH. 2005. Diesel exhaust particles cause increased levels of DNA deletions after transplacental exposure in mice. Mutat Res 570:245–252.
  • Renwick LC, Brown D, Clouter A, Donaldson K. 2004. Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup Environ Med 61:442–447.
  • Saber AT, Bornholdt J, Dybdahl M, Sharma AK, Loft S, Vogel U, Wallin H. 2005. Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation. Arch Toxicol 79:177–182.
  • Saber AT, Halappanavar S, Folkmann JK, Bornholdt J, Boisen AM, Moller P, Williams A, Yauk C, Vogel U, Loft S. 2009. Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation. Part Fibre Toxicol 6:12.
  • Saber AT, Jensen KA, Jacobsen NR, Birkedal RK, Mikkelsen L, Møller P, Loft S, Wallin H, Vogel U. 2011. Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers. Nanotoxicology (DOI 10.3109/17435390.2011.587900).
  • Sadauskas E, Danscher G, Stoltenberg M, Vogel U, Larsen A, Wallin H. 2009a. Protracted elimination of gold nanoparticles from mouse liver. Nanomedicine 5:162–169.
  • Sadauskas E, Jacobsen NR, Danscher G, Stoltenberg M, Vogel U, Larsen A, Kreyling W, Wallin H. 2009b. Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation. Chem Cent J 3:16.
  • Sadauskas E, Wallin H, Stoltenberg M, Vogel U, Doering P, Larsen A, Danscher G. 2007. Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol 4:10.
  • Sager TM, Castranova V. 2009. Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: Comparison to ultrafine titanium dioxide. Part Fibre Toxicol 6:15.
  • Schins RP, Knaapen AM. 2007. Genotoxicity of poorly soluble particles. Inhal Toxicol 19(Suppl. 1):189–198.
  • Sláma R, Morgenstern V, Cyrys J, Zutavern A, Herbarth O, Wichmann HE, Heinrich J. 2007. Traffic-related atmospheric pollutants levels during pregnancy and offspring's term birth weight: A study relying on a land-use regression exposure model. Environ Health Perspect 115:1283–1292.
  • Sorahan T, Harrington JM. 2007. A “lugged” analysis of lung cancer risks in UK carbon black production workers, 1951–2004. Am J Ind Med 50:555–564.
  • Šrám RJ, Binkova B, Dejmek J, Bobak M. 2005. Ambient air pollution and pregnancy outcomes: A review of the literature. Environ Health Perspect 113:375–382.
  • Švecová V, Rossner P Jr, Dostal M, Topinka J, Solansky I, Sram RJ. 2009. Urinary 8-oxodeoxyguanosine levels in children exposed to air pollutants. Mutat Res 662:37–43.
  • Takahashi S, Matsuoka O. 1981. Cross placental transfer of 198Au-colloid in near term rats. J Radiat Res (Tokyo) 22:242–249.
  • The Danish Working Environment Authority. 2007. At-vejledning. Stoffer og Materialer - C.0.1. Grænseværdier for stoffer og materialer. pp 1–55.
  • Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, Masuda S, Kinae N, Hiyoshi K, Ogo S. 2009. Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems. Part Fibre Toxicol 6:23.
  • Tripathi DN, Pawar AA, Vikram A, Ramarao P, Jena GB. 2008. Use of the alkaline comet assay for the detection of transplacental genotoxins in newborn mice. Mutat Res 653:134–139.
  • Utsunomiya S, Jensen KA, Keeler GJ, Ewing RC. 2004. Direct identification of trace metals in fine and ultrafine particles in the Detroit urban atmosphere. Environ Sci Technol 38:2289–2297.
  • van Ravenzwaay B, Landsiedel R, Fabian E, Burkhardt S, Strauss V, Ma-Hock L. 2008. Comparing fate and effects of three particles of different surface properties: Nano-TiO(2), pigmentary TiO(2) and quartz. Toxicol Lett 152–159.
  • Weichenthal S, Dufresne A, Infante-Rivard C. 2007. Indoor ultrafine particles and childhood asthma: Exploring a potential public health concern. Indoor Air 17:81–91.
  • Wick P, Malek A, Manser P, Meili D, Maeder-Althaus X, Diener L, Diener PA, Zisch A, Krug HF, von MU. 2010. Barrier capacity of human placenta for nanosized materials. Environ Health Perspect 118:432–436.
  • Wilson MR, Lightbody JH, Donaldson K, Sales J, Stone V. 2002. Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol Appl Pharmacol 184:172–179.
  • Yang H, Liu C, Yang D, Zhang H, Xi Z. 2009. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: The role of particle size, shape and composition. J Appl Toxicol 29:69–78.
  • Yoshida S, Hiyoshi K, Oshio S, Takano H, Takeda K, Ichinose T. 2010. Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring. Fertil Steril 93:1695–1699.