Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems

References

• Aiso S, Yamazaki K, Umeda Y, Asakura M, Kasai T, Takaya M, Toya T, 2010. Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 rats. Ind Health 48:783–795.
   PubMed Web of Science ®Google Scholar
• Asakura M, Sasaki T, Sugiyama T, Takaya M, Koda S, Nagano K, 2010. Genotoxicity and cytotoxicity of multi-wall carbon nanotubes in cultured Chinese hamster lung cells in comparison with chrysotile A fibers. J Occup Health 52:155–166.
   PubMed Web of Science ®Google Scholar
• Aust A. 1994. The role of iron in asbestos induced cancer. In: Davis JMG, Jaurand M-C, editors. Cellular and Molecular Effects of Mineral and Syntheticn Dusts and Fibers. NATO ASI Series. Vol. H85. Berlin: Springer-Verlag. pp 53–61.
   Google Scholar
• Burrows CJ, Muller JG, Kornyushyna O, Luo W, Duarte V, Leipold MD, 2002. Structure and potential mutagenicity of new hydantoin products from guanosine and 8-oxo-7,8-dihydroguanine oxidation by transition metals. Environ Health Perspect 110(Suppl 5):713–717.
   PubMed Web of Science ®Google Scholar
• Cadet J, Berger M, Buchko GW, Joshi PC, Raoul S, Ravanat JL. 1994. 2,2-Diamino-4-[(3,5-di-O-acetyl-2-deoxy-.beta.-D-erythro- pentofuranosyl)amino]-5-(2H)-oxazolone: a novel and predominant radical oxidation product of 3',5'-di-O-acetyl-2'-deoxyguanosine. J Am Chem Soc 116:7403–7404.
   Web of Science ®Google Scholar
• Carr GJ, Gorelick NJ. 1996. Mutational spectra in transgenic animal research: data analysis and study design based upon the mutant or mutation frequency. Environ Mol Mutagen 28:405–413.
   PubMedGoogle Scholar
• Chen CH, Su HC, Chuang SC, Yen SJ, Chen YC, Lee YT, 2010. Hydrophilic modification of neural microelectrode arrays based on multi-walled carbon nanotubes. Nanotechnology 21:485501.
   PubMed Web of Science ®Google Scholar
• Deng ZJ, Liang M, Monteiro M, Toth I, Minchin RF. 2011. Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nat Nanotechnol 6:39–44.
   PubMed Web of Science ®Google Scholar
• Ellinger-Ziegelbauer H, Pauluhn J. 2009. Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period. Toxicology 266:16–29.
   PubMed Web of Science ®Google Scholar
• Fenoglio I, Greco G, Tomatis M, Muller J, Raymundo-Piñero E, Béguin F, 2008. Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: physicochemical aspects. Chem Res Toxicol 21:1690–1697.
   PubMed Web of Science ®Google Scholar
• Ghosh M, Chakraborty A, Bandyopadhyay M, Mukherjee A. 2011. Multi-walled carbon nanotubes (MWCNT): induction of DNA damage in plant and mammalian cells. J Hazard Mater. 197:327–36.
   PubMed Web of Science ®Google Scholar
• Goyal RN, Jain N, Garg DK. 1997. Electrochemical and enzymic oxidation of guanosine and 8-hydroxyguanosine and the effects of oxidation products in mice. Bioelectrochemistry Bioenerg 43:105–114.
   Google Scholar
• Jacobsen NR, White PA, Gingerich J, Møller P, Saber AT, Douglas GR, 2011. Mutation spectrum in FE1-MUTA(TM) Mouse lung epithelial cells exposed to nanoparticulate carbon black. Environ Mol Mutagen 52:331–337.
   PubMed Web of Science ®Google Scholar
• Kino K, Ito N, Sugasawa K, Sugiyama H, Hanaoka F. 2004. Translesion synthesis by human DNA polymerase eta across oxidative products of guanine. Nucleic Acids Symp Ser 48:171–172.
   Google Scholar
• Kino K, Sugiyama H. 2001. Possible cause of G-C–>C-G transversion mutation by guanine oxidation product, imidazolone. Chem Biol 8:369–378.
   PubMed Web of Science ®Google Scholar
• Kino K, Sugiyama H. 2005. UVR-induced G-C to C-G transversions from oxidative DNA damage. Mutat Res 571:33–42.
   PubMedGoogle Scholar
• Kornyushyna O, Berges AM, Muller JG, Burrows CJ. 2002. In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment). Biochemistry 41:15304–15314.
   PubMed Web of Science ®Google Scholar
• Li S, He P, Dong J, Guo Z, Dai L. 2005. DNA-directed self-assembling of carbon nanotubes. J Am Chem Soc. 127:14–5.
   PubMed Web of Science ®Google Scholar
• Ma-Hock L, Treumann S, Strauss V, Brill S, Luizi F, Mertler M, 2009. Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol Sci 112:468–481.
   PubMed Web of Science ®Google Scholar
• Migliore L, Saracino D, Bonelli A, Colognato R, D'Errico MR, Magrini A, 2010. Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells. Environ Mol Mutagen 51(4):294–303.
   PubMedGoogle Scholar
• Monteiro-Riviere NA, Inman AO, Wang YY, Nemanich RJ. 2005. Surfactant effects on carbon nanotube interactions with human keratinocytes. Nanomedicine 1:293–299.
   PubMed Web of Science ®Google Scholar
• Morimoto Y, Hirohashi M, Ogami A, Oyabu T, Myojo T, Todoroki M, 2011. Pulmonary toxicity of well-dispersed multi-wall carbon nanotubes following inhalation and intratracheal instillation. Nanotoxicology; doi: 10.3109/17435390.2011.594912, 29 June 2011.
   Web of Science ®Google Scholar
• Moriya M. 1993. Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G.C–>T.A transversions in simian kidney cells. Proc Natl Acad Sci USA 90:1122–1126.
   PubMed Web of Science ®Google Scholar
• Mossman BT, Gee BL. 1993. Pulmonary reactions and mechanisms of toxicity of inhaled fibers. In: Gardner DE, editors. Toxicology of the Lung. 2nd ed. New York: Raven Press. pp 371–387.
   Google Scholar
• Muller J, Decordier I, Hoet PH, Lombaert N, Thomassen L, Huaux F, 2008. Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis 29:427–433.
   PubMed Web of Science ®Google Scholar
• Nohmi T, Masumura K. 2005. Molecular nature of intrachromosomal deletions and base substitutions induced by environmental mutagens. Environ Mol Mutagen 45:150–161.
   PubMedGoogle Scholar
• Nohmi T, Suzuki T, Masumura K. 2000. Recent advances in the protocols of transgenic mouse mutation assays. Mutat Res 455:191–215.
   PubMedGoogle Scholar
• Pacurari M, Castranova V, Vallyathan V. 2010. Single- and multi-wall carbon nanotubes versus asbestos: are the carbon nanotubes a new health risk to humans? J Toxicol Environ Health A 73:378–395.
   PubMed Web of Science ®Google Scholar
• Patlolla A, Hussain SM, Schlager JJ, Patlolla S, Tchounwou PB. 2010c. Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice. Environ Toxicol 25:608–621.
   PubMed Web of Science ®Google Scholar
• Patlolla A, Knighten B, Tchounwou P. 2010a. Multi-walled carbon nanotubes induce cytotoxicity, genotoxicity and apoptosis in normal human dermal fibroblast cells. Ethn 20(Suppl 1):S1-65–S1-72.
   Google Scholar
• Patlolla A, Patlolla B, Tchounwou P. 2010b. Evaluation of cell viability, DNA damage, and cell death in normal human dermal fibroblast cells induced by functionalized multiwalled carbon nanotube. Mol Cell Biochem 338:225–232.
   PubMed Web of Science ®Google Scholar
• Pauluhn J. 2010a. Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci 113:226–242.
   PubMed Web of Science ®Google Scholar
• Pauluhn J. 2010b. Multi-walled carbon nanotubes (Baytubes): approach for derivation of occupational exposure limit. Regul Toxicol Pharmacol 57:78–89.
   PubMed Web of Science ®Google Scholar
• Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, 2008. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3:423–428.
   PubMed Web of Science ®Google Scholar
• Pollack M, Oe T, Lee SH, Silva Elipe MV, Arison BH, Blair IA. 2003. Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product. Chem Res Toxicol 16:893–900.
   PubMed Web of Science ®Google Scholar
• Pollack M, Yang IY, Kim HY, Blair IA, Moriya M. 2006. Translesion DNA Synthesis across the heptanone–etheno-2'-deoxycytidine adduct in cells. Chem Res Toxicol 19:1074–1079.
   PubMedGoogle Scholar
• Porter DW, Hubbs AF, Mercer RR, Wu N, Wolfarth MG, Sriram K, 2010. Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269:136–147.
   PubMed Web of Science ®Google Scholar
• Porter DW, Millecchia LL, Robinson VA, Hubbs A, Willard P, Pack D, 2002. Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica. Am J Physiol Lung Cell Mol Physiol 283:L485–L493.
   PubMed Web of Science ®Google Scholar
• Porter DW, Millecchia LL, Willard P, Robinson VA, Ramsey D, McLaurin J, 2006. Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation. Toxicol Sci 90(1):188–197.
   PubMed Web of Science ®Google Scholar
• Reddy AR, Reddy YN, Krishna DR, Himabindu V. 2012. Pulmonary toxicity assessment of multiwalled carbon nanotubes in rats following intratracheal instillation. Environ Toxicol 27:211–219.
   PubMed Web of Science ®Google Scholar
• Rindgen D, Lee SH, Nakajima M, Blair IA. 2000. Formation of a substituted 1,N(6)-etheno-2'-deoxyadenosine adduct by lipid hydroperoxide-mediated generation of 4-oxo-2-nonenal. Chem Res Toxicol 13:846–852.
   PubMedGoogle Scholar
• Rindgen D, Nakajima M, Wehrli S, Xu K, Blair IA. 1999. Covalent modifications to 2'-deoxyguanosine by 4-oxo-2-nonenal, a novel product of lipid peroxidation. Chem Res Toxicol 12:1195–1204.
   PubMed Web of Science ®Google Scholar
• Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, 2009. Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol 4:747–751.
   PubMed Web of Science ®Google Scholar
• Sakamoto Y, Nakae D, Fukumori N, Tayama K, Maekawa A, Imai K, 2009. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 34:65–76.
   PubMed Web of Science ®Google Scholar
• Sakamoto Y, Nakae D, Hagiwara Y, Satoh K, Ohashi N, Fukamachi K, 2010. Serum level of expressed in renal carcinoma (ERC)/mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT). J Toxicol Sci 35:265–270.
   PubMedGoogle Scholar
• Sargent LM, Shvedova AA, Hubbs AF, Salisbury JL, Benkovic SA, Kashon ML, 2009. Induction of aneuploidy by single-walled carbon nanotubes. Environ Mol Mutagen 50:708–717.
   PubMed Web of Science ®Google Scholar
• Shibutani S, Takeshita M, Grollman AP. 1991. Insertion of specific bases during DNA synthesis past the oxidation-damaged base8-oxodG. Nature 349:431–434.
   PubMed Web of Science ®Google Scholar
• Tabet L, Bussy C, Setyan A, Simon-Deckers A, Rossi MJ, Boczkowski J, 2011. Coating carbon nanotubes with a polystyrene-based polymer protects against pulmonary toxicity. Part Fibre Toxicol 8:3.
   PubMed Web of Science ®Google Scholar
• Takagi A, Hirose A, Nishimura T, Fukumori N, Ogata A, Ohashi N, 2008. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 33:105–116.
   PubMed Web of Science ®Google Scholar
• Takaya M, Serita F, Yamazaki K, Aiso S, Kubota H, Asakura M, 2010. Characteristics of multiwall carbon nanotubes for an intratracheal instillation study with rats. Ind Health 48:452–459.
   PubMed Web of Science ®Google Scholar
• Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, 2009. Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems. Part Fibre Toxicol 6:23.
   PubMed Web of Science ®Google Scholar
• Totsuka Y, Kato T, Masuda S, Ishino K, Matsumoto Y, Goto S, 2010. In vitro and in vivo genotoxicity induced by fullerene (C60) and kaolin. Genes Environ 33:14–20.
   Google Scholar
• Wick P, Manser P, Limbach LK, Dettlaff-Weglikowska U, Krumeich F, Roth S, 2007. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 168:121–131.
   PubMed Web of Science ®Google Scholar
• Wirnitzer U, Herbold B, Voetz M, Ragot J. 2009. Studies on the in vitro genotoxicity of baytubes, agglomerates of engineered multi-walled carbon-nanotubes (MWCNT). Toxicol Lett 186:160–165.
   PubMed Web of Science ®Google Scholar
• Wörle-Knirsch JM, Pulskamp K, Krug HF. 2006. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett 6:1261–1268.
   PubMed Web of Science ®Google Scholar
• Yang IY, Hashimoto K, de Wind N, Blair IA, Moriya M. 2009. Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells. J Biol Chem 284:191–198.
   PubMedGoogle Scholar
• Ye Y, Muller JG, Luo W, Mayne CL, Shallop AJ, Jones RA, 2003. Formation of 13C-, 15N-, and 18O-labeled guanidinohydantoin from guanosine oxidation with singlet oxygen. Implications for structure and mechanism. J Am Chem Soc 125:13926–13927.
   PubMed Web of Science ®Google Scholar