Nontoxic impact of PEG-coated gold nanospheres on functional pulmonary surfactant-secreting alveolar type II cells

References

• Alkilany AM, Murphy CJ. 2010. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanopart Res 12:2313–2333.
   PubMed Web of Science ®Google Scholar
• Arruebo M, Fernández-Pacheco R, Ibarra MR, Santamaría J. 2007. Magnetic nanoparticles for drug delivery. Nano Today 2:22–32.
   Web of Science ®Google Scholar
• Bachand G, Allen A, Bachand M, Achyuthan K, Seagrave J, Brozik S. 2012. Cytotoxicity and inflammation in human alveolar epithelial cells following exposure to occupational levels of gold and silver nanoparticles. J Nanopart Res 14:1–10.
   Google Scholar
• Beck-Broichsitter M, Schmehl T, Seeger W, Gessler T. 2010. Evaluating the controlled release properties of inhaled nanoparticles using isolated, perfused, and ventilated lung models. J Nanomaterials 2011.
   Google Scholar
• Borm PJA, Kreyling W. 2004. Toxicological hazards of inhaled nanoparticles - Potential implications for drug delivery. J Nanomaterials 163791.
   Google Scholar
• Card JW, Zeldin DC, Bonner JC, Nestmann ER. 2008. Pulmonary applications and toxicity of engineered nanoparticles. Am J Physiol Lung Cell Mol Physiol 295:L400–L411.
   PubMed Web of Science ®Google Scholar
• Cavaliere R, Ciocatto EC, Giovanella BC, Heidelberger C, Johnson RO, Margottini M, et al. 1967. Selective heat sensitivity of cancer cells. Biochemical and clinical studies. Cancer 20:1351–1381.
   PubMed Web of Science ®Google Scholar
• Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD. 2005. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1:325–327.
   PubMed Web of Science ®Google Scholar
• Chander A, Johnson RG, Reicherter J, Fisher AB. 1986. Lung lamellar bodies maintain an acidic internal pH. J Biol Chem 261:6126–6131.
   Google Scholar
• Chithrani BD, Ghazani AA, Chan WCW. 2006. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 6:662–668.
   PubMed Web of Science ®Google Scholar
• Denekamp J. 1986. Cell kinetics and radiation biology. Int J Radiat Biol 49:357–380.
   Web of Science ®Google Scholar
• Dietl P, Haller T, Mair N, Frick M. 2001. Mechanisms of surfactant exocytosis in alveolar type II cells in vitro and in vivo. News Physiol Sci 16:239–243.
   PubMedGoogle Scholar
• Dobbs LG, Gonzalez R, Williams MC. 1986. An improved method for isolating type II cells in high yield and purity. Am Rev Respir Dis 134:141–145.
   PubMed Web of Science ®Google Scholar
• Dobrovolskaia MA, Patri AK, Zheng J, Clogston JD, Ayub N, Aggarwal P, et al. 2009. Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles. Nanomedicine 5:106–117.
   PubMed Web of Science ®Google Scholar
• Dreaden EC, Alkilany AM, Huang X, Murphy CJ, El-Sayed MA. 2012. The golden age: gold nanoparticles for biomedicine. Chem Soc Rev 41:2740–2779.
   PubMed Web of Science ®Google Scholar
• Enustun BV, Turkevich J. 1963. Coagulation of colloidal gold. J Am Chem Soc 85:3317–3328.
   Web of Science ®Google Scholar
• Fehrenbach H. 2001. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res 2:33–46.
   PubMed Web of Science ®Google Scholar
• Fernandez-Lopez C, Mateo-Mateo C, Alvarez-Puebla RA, Perez-Juste J, Pastoriza-Santos I, Liz-Marzan LM. 2009. Highly controlled silica coating of PEG-capped metal nanoparticles and preparation of SERS-encoded particles. Langmuir 25:13894–13899.
   Google Scholar
• Freundt EC, Czapiga M, Lenardo MJ. 2007. Photoconversion of lysotracker red to a green fluorescent molecule. Cell Res 17(11):956–957.
   PubMed Web of Science ®Google Scholar
• Frohlich E, Meindl C, Roblegg E, Griesbacher A, Pieber TR. 2012. Cytotoxity of nanoparticles is influenced by size, proliferation and embryonic origin of the cells used for testing. Nanotoxicology 6:424–439.
   PubMed Web of Science ®Google Scholar
• Gill S, Benberg R, Ku T, Azarmi S, Roa W, Prenner EJ. 2007. Nanoparticles: characteristics, mechanisms of action, and toxicity in pulmonary drug deliverya review. J Biomed Nanotechnol 3:107–119.
   Web of Science ®Google Scholar
• Grzelczak M, Perez-Juste J, Mulvaney P, Liz-Marzan LM. 2008. Shape control in gold nanoparticle synthesis. Chem Soc Rev 37:1783–1791.
   PubMed Web of Science ®Google Scholar
• Hainfeld JF, Dilmanian FA, Slatkin DN, Smilowitz HM. 2008. Radiotherapy enhancement with gold nanoparticles. J Pharm Pharmacol 60:977–985.
   PubMed Web of Science ®Google Scholar
• Haller T, Dietl P, Deetjen P, Völkl H. 1996. The lysosomal compartment as intracellular calcium store in MDCK cells: a possible involvement in InsP3-mediated Ca2+ release. Cell Calcium 19:157–165.
   Google Scholar
• Haller T, Ortmayr J, Friedrich F, Volkl H, Dietl P. 1998. Dynamics of surfactant release in alveolar type II cells. Proc Natl Acad Sci USA 95:1579–1584.
   PubMed Web of Science ®Google Scholar
• Hamid R, Rotshteyn Y, Rabadi L, Parikh R, Bullock P. 2004. Comparison of alamar blue and MTT assays for high through-put screening. Toxicol In Vitro 18:703–710.
   PubMed Web of Science ®Google Scholar
• Hu M, Chen J, Li Z-Y, Au L, Hartland GV, Li X, et al. 2006. Gold nanostructures: engineering their plasmonic properties for biomedical applications. Chem Soc Rev 35:1084–1094.
   PubMed Web of Science ®Google Scholar
• Huang X, Jain PK, El-Sayed IH, El-Sayed MA. 2007. Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine 2:681–693.
   PubMed Web of Science ®Google Scholar
• Jain PK, El-Sayed MA. 2010. Plasmonic coupling in noble metal nanostructures. Chem Phys Lett 487:153–164.
   Web of Science ®Google Scholar
• Jain PK, Lee KS, El-Sayed IH, El-Sayed MA. 2006. Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 110:7238–7248.
   PubMed Web of Science ®Google Scholar
• Jana NR, Gearheart L, Murphy CJ. 2001. Wet chemical synthesis of high aspect ratio cylindrical gold nanorods. J Phys Chem B 105:4065–4067.
   Web of Science ®Google Scholar
• Jennings P, Koppelstaetter C, Pfaller W, Morin JP, Hartung T, Ryan MP. 2004. Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 2: toxicological evaluation. ALTEX 21:61–66.
   PubMedGoogle Scholar
• Jiang W, Kim BYS, Rutka JT, Chan WCW. 2008. Nanoparticle-mediated cellular response is size-dependent. Nat Nanotechnol 3:5.
   Google Scholar
• Kemp SJ, Thorley AJ, Gorelik J, Seckl MJ, O'Hare MJ, Arcaro A, et al. 2008. Immortalization of human alveolar epithelial cells to investigate nanoparticle uptake. Am J Respir Cell Mol Biol 39:591–597.
   PubMed Web of Science ®Google Scholar
• Kolber MA, Quinones RR, Gress RE, Henkert PA. 1988. Measurement of cytotoxicity by target cell release and retention of the fluorescent dye bis-carboxyethyl-carboxyfluorescein (BCECF). J Immunol Methods 108:255–264.
   PubMed Web of Science ®Google Scholar
• Ku T, Gill S, Lobenberg R, Azarmi S, Roa W, Prenner EJ. 2008. Size dependent interactions of nanoparticles with lung surfactant model systems and the significant impact on surface potential. J Nanosci Nanotechnol 8:2971–2978.
   Google Scholar
• Lewinski N, Colvin V, Drezek R. 2008. Cytotoxicity of nanoparticles. Small 4:26–49.
   PubMed Web of Science ®Google Scholar
• Liz-Marzán LM. 2005. Tailoring surface plasmons through the morphology and assembly of metal nanoparticles. Langmuir 22:32–41.
   Google Scholar
• Maynard RL, Donaldson K, Tetley TD. 2013. Type 1 pulmonary epithelial cells: a new compartment involved in the slow phase of particle clearance from alveoli. Nanotoxicology 7:350–351.
   PubMed Web of Science ®Google Scholar
• Mironava T, Hadjiargyrou M, Simon M, Jurukovski V, Rafailovich MH. 2010. Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time. Nanotoxicology 4:120–137.
   PubMed Web of Science ®Google Scholar
• Moros M, Hernáez B, Garet E, Dias JT, Sáez B, Grazú V, et al. 2012. Monosaccharides versus PEG-functionalized NPs: influence in the cellular uptake. ACS Nano 6:1565–1577.
   PubMed Web of Science ®Google Scholar
• Muhlfeld C, Gehr P, Rothen-Rutishauser B. 2008a. Translocation and cellular entering mechanisms of nanoparticles in the respiratory tract. Swiss Med Wkly 138:387–391.
   PubMed Web of Science ®Google Scholar
• Muhlfeld C, Rothen-Rutishauser B, Blank F, Vanhecke D, Ochs M, Gehr P. 2008b. Interactions of nanoparticles with pulmonary structures and cellular responses. Am J Physiol Lung Cell Mol Physiol 294:L817–L829.
   PubMed Web of Science ®Google Scholar
• Mulvaney P. 1996. Surface plasmon spectroscopy of nanosized metal particles. Langmuir 12:788–800.
   Web of Science ®Google Scholar
• Murphy CJ, Gole AM, Stone JW, Sisco PN, Alkilany AM, Goldsmith EC, et al. 2008. Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc Chem Res 41:1721–1730.
   PubMed Web of Science ®Google Scholar
• Nativo P, Prior IA, Brust M. 2008. Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano 2:1639–1644.
   PubMed Web of Science ®Google Scholar
• Neely A, Perry C, Varisli B, Singh AK, Arbneshi T, Senapati D, et al. 2009. Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon rayleigh scattering properties of gold nanoparticle. ACS Nano 3:2834–2840.
   PubMed Web of Science ®Google Scholar
• Niidome T, Yamagata M, Okamoto Y, Akiyama Y, Takahashi H, Kawano T, et al. 2006. PEG-modified gold nanorods with a stealth character for in vivo applications. J Control Release 114:343–347.
   PubMed Web of Science ®Google Scholar
• Oberdorster G, Oberdorster E, Oberdorster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839.
   PubMed Web of Science ®Google Scholar
• O'Brien J, Wilson I, Orton T, Pognan F. 2000. Investigation of the alamar blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 267:5421–5426.
   PubMedGoogle Scholar
• Olmeda B, Villén L, Cruz A, Orellana G, Perez-Gil J. 2010. Pulmonary surfactant layers accelerate O2 diffusion through the air-water interface. Biochim Biophys Acta 1798:1281–1284.
   Google Scholar
• Pan Y, Neuss S, Leifert A, Fischler M, Wen F, Simon U, et al. 2007. Size-dependent cytotoxicity of gold nanoparticles. Small 3:1941–1949.
   PubMed Web of Science ®Google Scholar
• Papadopoulos NG, Dedoussis GV, Spanakos G, Gritzapis AD, Baxevanis CN, Papamichail M. 1994. An improved fluorescence assay for the determination of lymphocyte-mediated cytotoxicity using flow cytometry. J Immunol Methods 177:101–111.
   PubMed Web of Science ®Google Scholar
• Patra HK, Banerjee S, Chaudhuri U, Lahiri P, Dasgupta AK. 2007. Cell selective response to gold nanoparticles. Nanomedicine 3:111–119.
   PubMed Web of Science ®Google Scholar
• Perez-Gil J, Weaver TE. 2010. Pulmonary surfactant pathophysiology: current models and open questions. Physiology (Bethesda) 25:132–141.
   PubMed Web of Science ®Google Scholar
• Pison U, Welte T, Giersig M, Groneberg DA. 2006. Nanomedicine for respiratory diseases. Eur J Pharmacol 533:341–350.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Fernández J, Pérez-Juste J, García De Abajo FJ, Liz-Marzán LM. 2006. Seeded growth of submicron au colloids with quadrupole plasmon resonance modes. Langmuir 22:7007–7010.
   PubMed Web of Science ®Google Scholar
• Rojanathanes R, Sereemaspun A, Pimpha N, Buasorn V, Ekawong P, Wiwanitkit V. 2008. Gold nanoparticle as an alternative tool for a urine pregnancy test. Taiwan J Obstet Gynecol 47:296–299.
   PubMed Web of Science ®Google Scholar
• Ruge CA, Kirch J, Canadas O, Schneider M, Perez-Gil J, Schaefer UF, et al. 2011. Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A. Nanomedicine 7:690–693.
   PubMed Web of Science ®Google Scholar
• Ruge CA, Schaefer UF, Herrmann J, Kirch J, Canadas O, Echaide M, et al. 2012. The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLoS One 7:e40775.
   PubMed Web of Science ®Google Scholar
• Schurch S, Gehr P, Im Hof V, Geiser M, Green F. 1990. Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol 80:17–32.
   PubMedGoogle Scholar
• Sham JO, Zhang Y, Finlay WH, Roa WH, Lobenberg R. 2004. Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung. Int J Pharm 269:457–467.
   PubMed Web of Science ®Google Scholar
• Soenen SJ, Rivera-Gil P, Montenegro J-M, Parak WJ, De Smedt SC, Braeckmans K. 2011. Cellular toxicity of inorganic nanoparticles: common aspects and guidelines for improved nanotoxicity evaluation. Nano Today 6:446–465.
   Web of Science ®Google Scholar
• Sperling RA, Parak WJ. 2010. Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos Transact A Math Phys Eng Sci 368:1333–1383.
   PubMed Web of Science ®Google Scholar
• Stone KC, Mercer RR, Gehr P, Stockstill B, Crapo JD. 1992. Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 6:235–243.
   PubMed Web of Science ®Google Scholar
• Sung JC, Pulliam BL, Edwards DA. 2007. Nanoparticles for drug delivery to the lungs. Trends Biotechnol 25:563–570.
   PubMed Web of Science ®Google Scholar
• Uboldi C, Bonacchi D, Lorenzi G, Hermanns MI, Pohl C, Baldi G, et al. 2009. Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441. Part Fibre Toxicol 6:1743–8977.
   Google Scholar
• Wemhoner A, Frick M, Dietl P, Jennings P, Haller T. 2006. A fluorescent microplate assay for exocytosis in alveolar type II cells. J Biomol Screen 11:286–295.
   Google Scholar
• Wemhoner A, Hackspiel I, Hobi N, Ravasio A, Haller T, Rudiger M. 2010. Effects of perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells. Respir Res 11:52.
   PubMedGoogle Scholar
• Whitsett JA. 2010. Review: the intersection of surfactant homeostasis and innate host defense of the lung: lessons from newborn infants. Innate Immun 16:138–142.
   Google Scholar
• Wirkes A, Jung K, Ochs M, Muhlfeld C. 2010. Allometry of the mammalian intracellular pulmonary surfactant system. J Appl Physiol 109:1662–1669.
   PubMed Web of Science ®Google Scholar
• Yang W, Peters JI, Williams RO 3rd. 2008. Inhaled nanoparticles_a current review. Int J Pharm 356:239–247.
   PubMed Web of Science ®Google Scholar