Assessment of the developmental toxicity of nanoparticles in an ex vivo 3D model, the murine limb bud culture system

References

• Agashe HB, Dutta T, Garg M, Jain NK. 2006. Investigations on the toxicological profile of functionalized fifth-generation poly(propylene imine) dendrimer. J Pharm Pharmacol 58:1491–8
   PubMed Web of Science ®Google Scholar
• Akiyama H, Chaboissier MC, Martin JF, Schedl A, De Crombrugghe B. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16:2813–28
   PubMed Web of Science ®Google Scholar
• Albertazzi L, Gherardini L, Brondi M, Sulis Sato S, Bifone A, Pizzorusso T, et al. 2012. In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry. Mol Pharm 10:249–60
   PubMedGoogle Scholar
• Al-Hajaj NA, Moquin A, Neibert KD, Soliman GM, Winnik FM, Maysinger D. 2011. Short ligands affect modes of QD uptake and elimination in human cells. ACS Nano 5:4909–18
   PubMed Web of Science ®Google Scholar
• Alivisatos AP, Gu W, Larabell C. 2005. Quantum dots as cellular probes. Annu Rev Biomed Eng 7:55–76
   PubMed Web of Science ®Google Scholar
• Alles AJ, Sulik KK. 1989. Retinoic-acid-induced limb-reduction defects: perturbation of zones of programmed cell death as a pathogenetic mechanism. Teratology 40:163–71
   PubMedGoogle Scholar
• Beyerle A, Irmler M, Beckers J, Kissel T, Stoeger T. 2010. Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications. Mol Pharm 7:727–37
   PubMed Web of Science ®Google Scholar
• Bi W, Huang W, Whitworth DJ, Deng JM, Zhang Z, Behringer RR, et al. 2001. Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci USA 98:6698–703
   PubMed Web of Science ®Google Scholar
• Blum JL, Xiong JQ, Hoffman C, Zelikoff JT. 2012. Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth. Toxicol Sci 126:478–86
   PubMed Web of Science ®Google Scholar
• Calderón M, Quadir MA, Sharma SK, Haag R. 2010. Dendritic polyglycerols for biomedical applications. Adv Mater 22:190–218
   PubMed Web of Science ®Google Scholar
• Chan W-H, Shiao N-H. 2008. Cytotoxic effect of CdSe quantum dots on mouse embryonic development. Acta Pharmacol Sin 29:259–66
   PubMed Web of Science ®Google Scholar
• Chatterjee K, Sarkar S, Jagajjanani Rao K, Paria S. 2014. Core/shell nanoparticles in biomedical applications. Adv Colloid Interface Sci 209:8–39
   PubMed Web of Science ®Google Scholar
• Chen N, He Y, Su Y, Li X, Huang Q, Wang H, et al. 2012. The cytotoxicity of cadmium-based quantum dots. Biomaterials 33:1238–44
   PubMed Web of Science ®Google Scholar
• Choi AO, Brown SE, Szyf M, Maysinger D. 2008. Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells. J Mol Med (Berl) 86:291–302
   PubMed Web of Science ®Google Scholar
• Choi AO, Cho SJ, Desbarats J, Lovrić J, Maysinger D. 2007. Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells. J Nanobiotechnol 5:1
   PubMedGoogle Scholar
• Chu M, Wu Q, Yang H, Yuan R, Hou S, Yang Y, et al. 2010. Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small 6:670–8
   PubMed Web of Science ®Google Scholar
• Crick EW, Osorio I, Frei M, Mayer AP, Lunte CE. 2014. Correlation of 3-mercaptopropionic acid induced seizures and changes in striatal neurotransmitters monitored by microdialysis. Eur J Pharm Sci 57:25–33
   PubMed Web of Science ®Google Scholar
• Derfus AM, Chan WCW, Bhatia SN. 2003. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18
   Web of Science ®Google Scholar
• Dernedde J, Rausch A, Weinhart M, Enders S, Tauber R, Licha K, et al. 2010. Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation. Proc Natl Acad Sci USA 107:19679–84
   PubMed Web of Science ®Google Scholar
• Ding M, Lu Y, Abbassi S, Li F, Li X, Song Y, et al. 2012. Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. J Cell Physiol 227:3446–56
   PubMed Web of Science ®Google Scholar
• Ding R, Tsunekawaa N, Obata K. 2004. Cleft palate by picrotoxin or 3-MP and palatal shelf elevation in GABA-deficient mice. Neurotoxicol Teratol 26:587–92
   PubMed Web of Science ®Google Scholar
• Duncan R, Izzo L. 2005. Dendrimer biocompatibility and toxicity. Adv Drug Deliver Rev 57:2215–37
   PubMed Web of Science ®Google Scholar
• Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi J. 2010. Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol 30:343–52
   PubMed Web of Science ®Google Scholar
• Frey H, Haag R. 2002. Dendritic polyglycerol: a new versatile biocompatible material. Rev Mol Biotechnol 90:257–67
   Google Scholar
• Friedman, L. 1987. Teratological research using in vitro systems. II. Rodent limb bud culture system. Environ Health Perspect 72:211–19
   PubMed Web of Science ®Google Scholar
• Gao X, Yang L, Petros JA, Marshall FF, Simons JW, Nie S. 2005. In vivo molecular and cellular imaging with quantum dots. Curr Opin Biotechnol 16:63–72
   PubMed Web of Science ®Google Scholar
• Gnanabakthan N, Hales BF. 2009. The oxidative stress response is region specific in organogenesis stage mouse embryos exposed to 5-bromo-2′-deoxyuridine. Birth Defects Res A Clin Mol Teratol 85:202–10
   PubMed Web of Science ®Google Scholar
• Hong J-S, Kim S, Lee SH, Jo E, Lee B, Yoon J, et al. 2014. Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test. Nanotoxicology 8:349–62
   PubMed Web of Science ®Google Scholar
• Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Ohta T, et al. 2004. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4:2163–9
   Web of Science ®Google Scholar
• Huang C, Hales BF. 2002. Role of caspases in murine limb bud cell death induced by 4-hydroperoxycyclophosphamide, an activated analog of cyclophosphamide. Teratology 66:288–99
   PubMedGoogle Scholar
• Jaiswal JK, Mattoussi H, Mauro JM, Simon SM. 2003. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat Biotechnol 21:47–51
   PubMed Web of Science ®Google Scholar
• Jiang W, Kim BY, Rutka JT, Chan WCW. 2008. Nanoparticle-mediated cellular response is size-dependent. Nat Nanotechnol 3:145–50
   PubMed Web of Science ®Google Scholar
• Kainthan RK, Janzen J, Levin E, Devine DV, Brooks DE. 2006. Biocompatibility testing of branched and linear polyglycidol. Biomacromolecules 7:703–9
   PubMed Web of Science ®Google Scholar
• Kannan RM, Nance E, Kannan S, Tomalia DA. 2014. Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications. J Intern Med [Epub ahead of print]. DOI: 10.1111/joim.12280
   PubMed Web of Science ®Google Scholar
• Kauffer FA, Merlin C, Balan L, Schneider R. 2014. Incidence of the core composition on the stability, the ROS production and the toxicity of CdSe quantum dots. J Hazard Mater 268:246–55
   PubMed Web of Science ®Google Scholar
• Khandare J, Calderón M, Dagia NM, Haag R. 2012. Multifunctional dendritic polymers in nanomedicine: opportunities and challenges. Chem Soc Rev 41:2824–48
   PubMed Web of Science ®Google Scholar
• King Heiden TC, Dengler E, Kao WJ, Heideman W, Peterson RE. 2007. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol Appl Pharmacol 225:70–9
   PubMed Web of Science ®Google Scholar
• Kochhar DM. (1983). Embryonic organs in culture. In: Johnson EM, Kochhar D, eds. Teratogenesis and Reproductive Toxicology. Berlin Heidelberg: Springer, 301–14
   Google Scholar
• Kolhatkar RB, Kitchens KM, Swaan PW, Ghandehari H. 2007. Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability. Bioconjug Chem 18:2054–60
   PubMed Web of Science ®Google Scholar
• Kreyling WG, Semmler-Behnke M, Takenaka S, Möller W. 2013. Differences in the biokinetics of inhaled nano- versus micrometer-sized particles. Acc Chem Res 46:714–22
   PubMed Web of Science ®Google Scholar
• Kurishita A. 1989. Histological study of cell death in digital malformations induced by 5-azacytidine: suppressive effect of caffeine. Teratology 39:163–72
   PubMedGoogle Scholar
• Lin P, Chen J-W, Chang LW, Wu J-P, Redding L, Chang H, et al. 2008. Computational and ultrastructural toxicology of a nanoparticle, quantum dot 705, in mice. Environ Sci Technol 42:6264–70
   PubMed Web of Science ®Google Scholar
• Lovrić J, Cho SJ, Winnik FM, Maysinger D. 2005. Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death. Chem Biol 12:1227–34
   PubMed Web of Science ®Google Scholar
• Magdolenova Z, Collins AR, Kumar A, Dhawam A, Stone V, Dusinska M. 2014. Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles. Nanotoxicology 8:233–78
   PubMed Web of Science ®Google Scholar
• Manke A, Wang L, Rojanasakul Y. 2013. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int 2013:942916
   PubMed Web of Science ®Google Scholar
• Menjoge AR, Rinderknecht AL, Navath RS, Faridnia M, Kim CJ, Romero R, et al. 2011. Transfer of PAMAM dendrimers across human placenta: prospects of its use as drug carrier during pregnancy. J Control Release 150:326–38
   PubMed Web of Science ®Google Scholar
• Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, et al. 2005. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307:538–44
   PubMed Web of Science ®Google Scholar
• Neubert D, Barrach H-J. (1977). Techniques applicable to study morphogenetic differentiation of limb buds in organ culture. In: Neubert D, Merker H-J, Kwasigroch TE, et al, eds. Methods in Pre-Natal Toxicology: Evaluation of Embryotoxic Effects in Experimental Animals. Stuttgart: Georg Thieme Publishers, 241–51
   Google Scholar
• Oberdörster G. 2010. Safety assessment for nanotoxicology and nanomedicine: concepts of nanotoxicology. J Intern Med 267:89–105
   PubMed Web of Science ®Google Scholar
• Ornoy, A. 2006. Neuroteratogens in man: an overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy. Reprod Toxicol 22:214–26
   PubMed Web of Science ®Google Scholar
• Paradis F-H, Hales BF. 2013. Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs. Toxicol Sci 131:234–41
   PubMed Web of Science ®Google Scholar
• Paradis F-H, Huang C, Hales BF. (2012). The murine limb bud in culture as an in vitro teratogenicity test system. In: Harris C, Hansen JM, eds. Developmental Toxicology. New York: Humana Press, Springer, 197–213
   Google Scholar
• Pelaz B, Jaber S, De Aberasturi DJ, Wulf V, Aida T, De La Fuente JM, et al. 2012. The state of nanoparticle-based nanoscience and biotechnology: progress, promises, and challenges. ACS Nano 6:8468–83
   PubMed Web of Science ®Google Scholar
• Ritter EJ, Scott WJ, Wilson JG. 1973. Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis. Teratology 7:219–25
   PubMedGoogle Scholar
• Stacey A, Bateman J, Choi T, Mascara T, Cole W, Jaenisch R. 1988. Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene. Nature 332:131–6
   PubMed Web of Science ®Google Scholar
• Stoccoro A, Karlsson HL, Coppedè F, Migliore L. 2013. Epigenetic effects of nano-sized materials. Toxicology 313:3–14
   PubMed Web of Science ®Google Scholar
• Su Y, Peng F, Jiang Z, Zhong Y, Lu Y, Jiang X, et al. 2011. In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots. Biomaterials 32:5855–62
   PubMed Web of Science ®Google Scholar
• Sun J, Zhang Q, Wang Z, Yan B. 2013. Effects of nanotoxicity on female reproductivity and fetal development in animal models. Int J Mol Sci 14:9319–37
   PubMed Web of Science ®Google Scholar
• Sunder A, Hanselmann R, Frey H, Mülhaupt R. 1999. Controlled synthesis of hyperbranched polyglycerols by ring-opening multibranching polymerization. Macromolecules 32:4240–6
   Web of Science ®Google Scholar
• Sunder A, Mülhaupt R, Haag R, Frey H. 2000. Hyperbranched polyether polyols: a modular approach to complex polymer architectures. Adv Mater 12:235–9
   Web of Science ®Google Scholar
• Tiwari DK, Jin T, Behari J. 2011. Bio-distribution and toxicity assessment of intravenously injected anti-HER2 antibody conjugated CdSe/ZnS quantum dots in Wistar rats. Int J Nanomedicine 6:463–75
   PubMed Web of Science ®Google Scholar
• Tung EWY, Winn LM. 2011. Valproic acid increases formation of reactive oxygen species and induced apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects. Mol Pharmacol 80:979–87
   PubMed Web of Science ®Google Scholar
• Ucciferri N, Collnot EM, Gaiser BK, Tirella A, Stone V, Domenici C, et al. 2014. In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response. Nanotoxicology 8:697–708
   PubMed Web of Science ®Google Scholar
• Verma A, Stellacci F. 2010. Effect of surface properties on nanoparticle–cell interactions. Small 6:12–21
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen L. 2011. Quantum dots, lighting up the research and development of nanomedicine. Nanomed Nanotech Biol Med 7:385–402
   PubMed Web of Science ®Google Scholar
• Wick P, Malek A, Manser P, Meili D, Maeder-Althaus X, Diener L, et al. 2010. Barrier capacity of human placenta for nanosized materials. Environ Health Perspect 118:432–6
   PubMed Web of Science ®Google Scholar
• Winnik FM, Maysinger D. 2012. Quantum dot cytotoxicity and ways to reduce it. Acc Chem Res 46:672–80
   PubMed Web of Science ®Google Scholar
• Yang E, Korsmeyer SJ. 1996. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 88:386–401
   PubMed Web of Science ®Google Scholar
• Yang H, Sun C, Fan Z, Tian X, Yan L, Du L, et al. 2012. Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy. Sci Rep 2:847
   PubMed Web of Science ®Google Scholar
• Yang RS, Chang LW, Wu JP, Tsai MH, Wang HJ, Kuo YC, et al. 2007. Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment. Environ Health Perspect 115:1339–43
   PubMed Web of Science ®Google Scholar
• Yeh TK, Wu JP, Chang LW, Tsai MH, Chang WH, Tsai HT, et al. 2011. Comparative tissue distributions of cadmium chloride and cadmium-based quantum dot 705 in mice: safety implications and applications. Nanotoxicology 5:91–7
   PubMed Web of Science ®Google Scholar
• Youle RJ, Strasser A. 2008. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9:47–59
   PubMed Web of Science ®Google Scholar
• Ziemba B, Janaszewska A, Ciepluch K, Krotewicz M, Fogel WA, Appelhans D, et al. 2011. In vivo toxicity of poly(propyleneimine) dendrimers. J Biomed Mater Res A 99:261–8
   PubMedGoogle Scholar