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Original Article

Implications of in vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials

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Pages 871-885 | Received 08 Apr 2014, Accepted 07 Nov 2014, Published online: 12 Feb 2015

References

  • Ahmad Khanbeigi R, Kumar A, Sadouki F, Lorenz C, Forbes B, Dailey LA, Collins H. 2012. The delivered dose: applying particokinetics to in vitro investigations of nanoparticle internalization by macrophages. J Control Release 162:259–66
  • Anderson W, Kozak D, Coleman VA, Jamting AK, Trau M. 2013. A comparative study of submicron particle sizing platforms: accuracy, precision and resolution analysis of polydisperse particle size distributions. J Colloid Interface Sci 405:322–30
  • Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol 28:41–50
  • Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, et al. 2008. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential – a workshop report and consensus statement. Inhal Toxicol 20:75–99
  • Baisch B, Corson N, Wade-Mercer P, Gelein R, Kennell A, Oberdorster G, Elder A. 2014. Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation. Part Fibre Toxicol 11:5
  • Bello D, Hsieh S-F, Schmidt D, Rogers E. 2009. Nanomaterials properties vs. biological oxidative damage: implications for toxicity screening and exposure assessment. Nanotoxicology 3:249–61
  • Bihari P, Vippola M, Schultes S, Praetner M, Khandoga AG, Reichel CA, et al. 2008. Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Part Fibre Toxicol 5:14
  • Buford MC, Hamilton RF Jr, Holian A. 2007. A comparison of dispersing media for various engineered carbon nanoparticles. Part Fibre Toxicol 4:6
  • Cohen J, DeLoid G, Pyrgiotakis G, Demokritou P. 2013. Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry. Nanotoxicology 7:417–31
  • Cohen JM, Derk R, Wang L, Godleski J, Kobzik L, Brain J, Demokritou P. 2014a. Tracking translocation of industrially relevant engineered nanomaterials (ENMs) across alveolar epithelial monolayers in vitro. Nanotoxicology 8:216–25
  • Cohen JM, Teeguarden JG, Demokritou P. 2014b. An integrated approach for the in vitro dosimetry of engineered nanomaterials. Part Fibre Toxicol 11:20
  • DeLoid G, Cohen JM, Darrah T, Derk R, Rojanasakul L, Pyrgiotakis G, et al. 2014. Estimating the effective density of engineered nanomaterials for in vitro dosimetry. Nat Commun 5:3514
  • Demokritou P, Deloid G, Cohen J. 2012. Novel methods of measuring effective density of nanoparticles in fluids. US Provisional Patent Application No. 61/661,895
  • Demokritou P, Gass S, Pyrgiotakis G, Cohen JM, Goldsmith W, Mckinney W, et al. 2013. An in vivo and in vitro toxicological characterisation of realistic nanoscale CeO(2) inhalation exposures. Nanotoxicology 7:1338–50
  • Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdorster G. 2005. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci 88:614–29
  • Hinderliter PM, Minard KR, Orr G, Chrisler WB, Thrall BD, Pounds JG, Teeguarden JG. 2010. ISDD: a computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies. Part Fibre Toxicol 7:36
  • Hsieh SF, Bello D, Schmidt DF, Pal AK, Stella A, Isaacs JA, Rogers EJ. 2013. Mapping the biological oxidative damage of engineered nanomaterials. Small 9:1853–65
  • Jan E, Byrne SJ, Cuddihy M, Davies AM, Volkov Y, Gun'ko YK, Kotov NA. 2008. High-content screening as a universal tool for fingerprinting of cytotoxicity of nanoparticles. ACS Nano 2:928–38
  • Jones CF, Grainger DW. (2009). In vitro assessments of nanomaterial toxicity. Adv Drug Deliv Rev 61:438–56
  • Keller AA, Wang H, Zhou D, Lenihan HS, Cherr G, Cardinale BJ, et al. 2010. Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices. Environ Sci Technol 44:1962–7
  • Khatri M, Bello D, Pal AK, Cohen JM, Woskie S, Gassert T, et al. 2013. Evaluation of cytotoxic, genotoxic and inflammatory responses of nanoparticles from photocopiers in three human cell lines. Part Fibre Toxicol 10:42
  • Krewski D, Acosta D, Jr Andersen M, Anderson H, Bailar JC III, Boekelheide K, et al. (2010). Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Crit Rev 13:51–138
  • Limbach LK, Li Y, Grass RN, Brunner TJ, Hintermann MA, Muller M, et al. 2005. Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations. Environ Sci Technol 39:9370–6
  • Luyts K, Napierska D, Nemery B, Hoet PHM. 2013. How physico-chemical characteristics of nanoparticles cause their toxicity: complex and unresolved interrelations. Environ Sci Process Impacts 15:23–38
  • Ma JY, Zhao H, Mercer RR, Barger M, Rao M, Meighan T, et al. 2011. Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats. Nanotoxicology 5:312–25
  • Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, Zhang H. 2013a. Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res 46:607–21
  • Nel AE, Nasser E, Godwin H, Avery D, Bahadori T, Bergeson L, et al. 2013b. A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment. ACS Nano 7:6422–33
  • Pal AK, Bello D, Budhlall B, Rogers E, Milton DK. 2012. Screening for oxidative stress elicited by engineered nanomaterials: evaluation of acellular DCFH assay. Dose Response 10:308–30
  • Pal AK, Aalaei I, Gadde S, Gaines P, Schmidt D, Demokritou P, Bello D. 2014a. High resolution characterization of engineered nanomaterial dispersions in complex media using tunable resistive pulse sensing technology. ACS Nano 8:9003–15
  • Pal AK, Hsieh S-F, Khatri M, Isaacs JA, Demokritou P, Gaines P, et al. 2014b. Screening for oxidative damage by engineered nanomaterials: a comparative evaluation of FRAS and DCFH. J Nanopart Res 16:1–20
  • Pirela S, Molina R, Watson C, Cohen JM, Bello D, Demokritou P, Brain J. 2013. Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model. Inhal Toxicol 25:498–508
  • Powers KW, Brown SC, Krishna VB, Wasdo SC, Moudgil BM, Roberts SM. 2006. Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci 90:296–303
  • Roberts GS, Kozak D, Anderson W, Broom MF, Vogel R, Trau M. 2010. Tunable nano/micropores for particle detection and discrimination: scanning ion occlusion spectroscopy. Small 6:2653–8
  • Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, et al. 2010. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ Health A 73:445–61
  • Sager TM, Castranova V. 2009. Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide. Part Fibre Toxicol 6:15
  • Sager TM, Porter DW, Robinson VA, Lindsley WG, Schwegler-Berry DE, Castranova V. 2007. Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity. Nanotoxicology 1:118–29
  • Sharma G, Kodali V, Gaffrey M, Wang W, Minard KR, Karin NJ, et al. 2014. Iron oxide nanoparticle agglomeration influences dose rates and modulates oxidative stress-mediated dose-response profiles in vitro. Nanotoxicology 8:663–75
  • Summers HD, Rees P, Holton MD, Brown MR, Chappell SC, Smith PJ, Errington RJ. 2011. Statistical analysis of nanoparticle dosing in a dynamic cellular system. Nat Nanotechnol 6:170–4
  • Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. 2007. Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol Sci 95:300–12
  • Thomas CR, George S, Horst AM, Ji Z, Miller RJ, Peralta-Videa JR, et al. 2011. Nanomaterials in the environment: from materials to high-throughput screening to organisms. ACS Nano 5:13–20
  • Vanwinkle BA, de Mesy Bentley KL, Malecki JM, Gunter KK, Evans IM, Elder A, et al. 2009. Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response. Nanotoxicology 3:307–18
  • Vippola M, Falck GC, Lindberg HK, Suhonen S, Vanhala E, Norppa H, et al. 2009. Preparation of nanoparticle dispersions for in-vitro toxicity testing. Hum Exp Toxicol 28:377–85
  • Warheit DB, Borm PJ, Hennes C, Lademann J. 2007. Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop. Inhal Toxicol 19:631–43
  • Watson C, Ge J, Cohen J, Pyrgiotakis G, Engelward B, Demokritou P. 2014. A high throughput screening platform for engineered nanoparticle mediated genotoxicity using cometchip technology. ACS Nano 8:2118–33
  • Willmott GR, Vogel R, Yu SS, Groenewegen LG, Roberts GS, Kozak D, et al. 2010. Use of tunable nanopore blockade rates to investigate colloidal dispersions. J Phys Condens Matter 22:454116
  • Zhou EH, Watson C, Pizzo R, Cohen J, Dang Q, de Barros PM, et al. 2014. Assessing the impact of engineered nanoparticles on wound healing using a novel in-vitro bioassay. Nanomedicine. Doi: 10.2217/nnm.14.40

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