917
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Accelerated fracture healing in mice lacking the 5-lipoxygenase gene

&
Pages 748-755 | Received 22 Feb 2010, Accepted 08 Jul 2010, Published online: 11 Nov 2010

  • Baron R, Vigney A, Neff L, Silvergate A, Santa Maria A. Processing of undecalcified bone specimens for bone histomorphometry. In: Bone histomorphometry: Techniques and hnterpretation. (Ed Recker RR). Boca Raton: CRC Press, Inc.; 1983: 13-35.
  • Bonewald LF, Flynn M, Qiao M, Dallas MR, Mundy GR, Boyce BF. Mice lacking 5-lipoxygenase have increased cortical bone thickness. Adv Exp Med Biol 1997; 433:299-302.
  • Burd TA, Hughes MS, Anglen JO. Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion. J Bone Joint Surg (Br) 2003; 85:700-5.
  • Byrum RS, Goulet JL, Griffiths RJ, Koller BH. Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. J Exp Med 1997; 185:1065-75.
  • Capper EA, Marshall LA. Mammalian phospholipases A(2): mediators of inflammation, proliferation and apoptosis. Prog Lipid Res 2001; 40:167-97.
  • Chan C-C, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther 1999; 290:551-60.
  • Chen XS, Sheller JR, Johnson EN, Funk CD. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 1994; 372:179-82.
  • Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation. Biochem Biophys Res Commun 2005; 328:764-76.
  • Cottrell JA, O'Connor JP. Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing. J Bone Joint Surg (Am) 2009; 91:2653-65.
  • Cottrell JA, Meyenhofer M, Medicherla S, Higgins L, O'Connor JP. Analgesic effects of p38 kinase inhibitor treatment on bone fracture healing. Pain 2009; 142:116-26.
  • Dabrowski S, Kur J. Cloning and expression in Escherichia coli of the recombinant his-tagged DNA polymerases from Pyrococcus furiosus and Pyrococcus woesei. Protein Expr Purif 1998; 14:131-8.
  • Flynn MA, Qiao M, Garcia C, Dallas M, Bonewald LF. Avian osteoclast cells are stimulated to resorb calcified matrices by and possess receptors for leukotriene B4. Calcif Tissue Int 1999; 64:154-9.
  • Form DM, Auerbach R. PGE2 and angiogenesis. Proc Soc Exp Biol Med 1983; 172:214-8.
  • Gallwitz WE, Mundy GR, Lee CH, Qiao M, Roodman GD, Raftery M, 5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices. J Biol Chem 1993; 268:10087-94.
  • Garcia C, Boyce BF, Gilles J, Dallas M, Qiao M, Mundy GR, Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo. J Bone Miner Res 1996; 11:1619-27.
  • Hudson N, Balsitis M, Everitt S, Hawkey CJ. Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut 1993; 34: 742-7.
  • Jakob M, Demarteau O, Suetterlin R, Heberer M, Martin I. Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. Rheumatology (Oxford) 2004; 43:852-7.
  • Kennedy BP, Payette P, Mudgett J, Vadas P, Pruzanski W, Kwan M, A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains. J Biol Chem 1995; 270:22378-85.
  • Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 1995; 83:483-92.
  • Li M, Ke HZ, Qi H, Healy DR, Li Y, Crawford DT, A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J Bone Miner Res 2003; 18:2033-42.
  • Li M, Healy DR, Li Y, Simmons HA, Crawford DT, Ke HZ, Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice. Bone 2005; 37:46-54.
  • Lowe GN, Fu YH, McDougall S, Polendo R, Williams A, Benya PD, Effects of prostaglandins on deoxyribonucleic acid and aggrecan synthesis in the RCJ 3.1C5.18 chondrocyte cell line: role of second messengers. Endocrinology 1996; 137:2208-16.
  • Maniatopoulos C, Rodriguez A, Deporter DA, Melcher AH. An improved method for preparing histological sections of metallic implants. Int J Oral Maxillofac Implants 1986; 1:31-7.
  • Manigrasso MB, O'Connor JP. Characterization of a closed femur fracture model in mice. J Orthop Trauma 2004; 18:687-95.
  • Manigrasso MB, O'Connor JP. Comparison of fracture healing among different inbred mouse strains. Calcif Tissue Int 2008; 82:465-74.
  • Marcouiller P, Pelletier JP, Guevremont M, Martel-Pelletier J, Ranger P, Laufer S, Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis. J Rheumatol 2005; 32:704-12.
  • Martel-Pelletier J, Mineau F, Fahmi H, Laufer S, Reboul P, Boileau C, Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids. Arthritis Rheum 2004; 50:3925-33.
  • Maxis K, Delalandre A, Martel-Pelletier J, Pelletier JP, Duval N, Lajeunesse D. The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein. Arthritis Res Ther 2006; 8:R181.
  • Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995; 83:473-82.
  • Mountziaris PM, Mikos AG. Modulation of the inflammatory response for enhanced bone tissue regeneration. Tissue Eng Part B Rev 2008; 14:179-86.
  • Murphy RC, Gijon MA. Biosynthesis and metabolism of leukotrienes. Biochem J 2007; 405:379-95.
  • Paralkar VM, Borovecki F, Ke HZ, Cameron KO, Lefker B, Grasser WA, An EP2 receptor-selective prostaglandin E2 agonist induces bone healing. Proc Natl Acad Sci U S A 2003; 100:6736-40.
  • Raisz LG. Prostaglandins and bone: physiology and pathophysiology. Osteoarthritis Cartilage 1999; 7:419-21.
  • Ren W, Dziak R. Effects of leukotrienes on osteoblastic cell proliferation. Calcif Tissue Int 1991; 49:197-201.
  • Seno H, Oshima M, Ishikawa TO, Oshima H, Takaku K, Chiba T, Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res 2002; 62:506-11.
  • Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 2004; 56:387-437.
  • Simon AM, Manigrasso MB, O'Connor JP. Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 2002; 17:963-76.
  • Simon AM, O'Connor JP. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg (Am) 2007; 89:500-11.
  • Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Measurement of protein using bicinchoninic acid. Anal Biochem 1985; 150:76-85.
  • Smith CJ, Zhang Y, Koboldt CM, Muhammad J, Zweifel BS, Shaffer A, Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 1998; 95:13313-8.
  • Steinhilber D. 5-Lipoxygenase: enzyme expression and regulation of activity. Pharm Acta Helv 1994; 69:3-14.
  • Tanaka M, Sakai A, Uchida S, Tanaka S, Nagashima M, Katayama T, Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats. Bone 2004; 34:940-8.
  • Traianedes K, Dallas MR, Garrett IR, Mundy GR, Bonewald LF. 5-Lipoxygenase metabolites inhibit bone formation in vitro. Endocrinology 1998; 139:3178-84.
  • Wientroub S, Wahl LM, Feuerstein N, Winter CC, Reddi AH. Changes in tissue concentration of prostaglandins during endochondral bone differentiation. Biochem Biophys Res Commun 1983; 117:746-50.
  • Yu Y, Fan J, Chen XS, Wang D, Klein-Szanto AJ, Campbell RL, Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nat Med 2006; 12:699-704.
  • Yuan C, Rieke CJ, Rimon G, Wingerd BA, Smith WL. Partnering between monomers of cyclooxygenase-2 homodimers. Proc Natl Acad Sci U S A 2006; 103:6142-7.
  • Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 2002; 109:1405-15.
  • Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone 2004; 34:809-17.