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Review Article

Spatial clustering of amyotrophic lateral sclerosis and the potential role of BMAA

, , , , &
Pages 25-32 | Received 03 Jun 2011, Accepted 04 Sep 2011, Published online: 03 Jan 2012

References

  • Fang F, Valdimarsdottir U, Bellocco R, Ronnevi LO, Sparen P, Fall K, . Amyotrophic lateral sclerosis in Sweden, 1991–2005. Arch Neurol. 2009;66:515–9.
  • Noonan CW, White MC, Thurman D, Wong LY. Temporal and geographic variation in the United States motor neuron disease mortality, 1969–1998. Neurology. 2005;64: 1215–21.
  • Cronin S, Hardiman O, Traynor BJ. Ethnic variation in the incidence of ALS: a systematic review. Neurology. 2007;68: 1002–7.
  • Fang F, Kamel F, Lichtenstein P, Bellocco R, Sparen P, Sandler DP, . Familial aggregation of amyotrophic lateral sclerosis. Ann Neurol. 2009;66:94–9.
  • Banack SA, Cox PA. Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam. Neurology. 2003;61:387–9.
  • Cox PA, Sacks OW. Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. Neurology. 2002;58:956–9.
  • Spencer PS, Nunn PB, Hugon J, Ludolph A, Roy DN. Motor neuron disease on Guam: possible role of a food neurotoxin. Lancet. 1986;1:965.
  • Bradley WG, Cox PA. Beyond Guam: cyanobacteria, BMAA and sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009;10:5–6.
  • Waller LA. Statistical power and design of focused clustering studies. Stat Med. 1996;15:765–82.
  • Openshaw S. The Modifiable Areal Unit Problem. Norwich, UK: Geo Books; 1984.
  • Marin B, Gil J, Preux PM, Funalot B, Couratier P. Incidence of amyotrophic lateral sclerosis in the Limousin region of France, 1997–2007. Amyotroph Lateral Scler. 2009;10:216–20.
  • Waller LA, Gotway CA. Applied Spatial Statistics for Public Health Data. Hoboken, NJ: Wiley; 2004.
  • Jacquez GM, Greiling DA. Local clustering in breast, lung and colorectal cancer in Long Island, New York. Int J Health Geogr. 2003;2:3.
  • Garruto RM, Gajdusek C, Chen KM. Amyotrophic lateral sclerosis among Chamorro migrants from Guam. Ann Neurol. 1980;8:612–9.
  • Garruto RM, Gajdusek DC, Chen KM. Amyotrophic lateral sclerosis and Parkinsonism-dementia among Filipino migrants to Guam. Ann Neurol. 1981;10:341–50.
  • Sabel CE, Boyle PJ, Loytonen M, Gatrell AC, Jokelainen M, Flowerdew R, . Spatial clustering of amyotrophic lateral sclerosis in Finland at place of birth and place of death. Am J Epidemiol. 2003;157:898–905.
  • Logroscino G, Traynor BJ, Hardiman O, Chio A, Couratier P, Mitchell JD, . Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry. 2008;79:6–11.
  • Chad D, Mitsumoto H, Adelman LS, Bradley WG, Munsat TL, Zieper I. Conjugal motor neuron disease. Neurology. 1982;32:306–7.
  • Maloo JC, Radhakrishnan K, Poddar SK, Thacker AK. Conjugal motor neuron disease. J Assoc Physicians India. 1987;35:303–4.
  • Maloo JC, Radhakrishnan K, Poddar SK, Thacker AK. Conjugal motor neuron disease. J Assoc Physicians India. 1989;37:789–90.
  • Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, . A clustering of conjugal amyotrophic lateral sclerosis in south-eastern France. Arch Neurol. 2003;60:553–7.
  • Camu W, Cadilhac J, Billiard M. Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France. Neurology. 1994;44:547–8.
  • Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F, Giagheddu M. Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy. Ital J Neurol Sci. 1998;19:97–100.
  • Gajdusek DC. Motor neuron disease in natives of New Guinea. N Engl J Med. 1963;268:474–6.
  • Kurland LT, Mulder DW. Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution and special reference to the Mariana Islands, including clinical and pathologic observations. Neurology. 1954;4:438–48.
  • Zimmerman HM, editor. Monthly report to the medical officer in command. United States Navy Medical Research Unit No 2; 1945.
  • Araki S, Iwahashi Y, Kuroiwa Y. Epidemiological study of amyotrophic lateral sclerosis and allied disorders in the Kii Peninsula (Japan). J Neurol Sci. 1967;4:279–87.
  • Reed DM, Brody JA. Amyotrophic lateral sclerosis and Parkinsonism-dementia on Guam, 1945–1972. I. Descriptive epidemiology. Am J Epidemiol. 1975;101:287–301.
  • Spencer PS, Hugon J, Ludolph A, Nunn PB, Ross SM, Roy DN, . Discovery and partial characterization of primate motor-system toxins. Ciba Found Symp. 1987;126: 221–38.
  • Yase Y. The pathogenetic role of metals in motor neuron disease: the participation of aluminum. Adv Exp Med Biol. 1987;209:89–96.
  • Kilness AW, Hichberg FH. Amyotrophic lateral sclerosis in a high selenium environment. JAMA. 1977;237:2843–4.
  • Melmed C, Krieger C. A cluster of amyotrophic lateral sclerosis. Arch Neurol. 1982;39:595–6.
  • Sanders M. Clustering of amyotrophic lateral sclerosis. JAMA. 1980;244:435.
  • Sienko DG, Davis JP, Taylor JA, Brooks BR. Amyotrophic lateral sclerosis. A case-control study following detection of a cluster in a small Wisconsin community. Arch Neurol. 1990;47:38–41.
  • Taylor JA, Davis JP. Evidence for clustering of amyotrophic lateral sclerosis in Wisconsin. J Clin Epidemiol. 1989;42:569–75.
  • Kusui K. Epidemiological study on amyotrophic lateral sclerosis (ALS) and other neighboring motor neuron diseases in Kii Peninsula. Folia Psychiatr Neurol Jpn. 1962;64:85–99.
  • Spencer PS, Kisby GE, Ludolph AC. Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region. Neurology. 1991;41:62–6; discussion 6–8.
  • Kuzuhara S, Kokubo Y. Atypical Parkinsonism of Japan: amyotrophic lateral sclerosis-Parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease): an update. Mov Disord. 2005;20 (Suppl 12):S108–13.
  • Gunnarsson LG, Lygner PE, Veiga-Cabo J, de Pedro-Cuesta J. An epidemic-like cluster of motor neuron disease in a Swedish county during the period 1973–1984. Neuroepidemiology. 1996;15:142–52.
  • Neilson S, Gunnarsson LG, Robinson I. Rising mortality from motor neuron disease in Sweden, 1961–1990: the relative role of increased population life expectancy and environmental factors. Acta Neurol Scand. 1994;90: 150–9.
  • Proctor SP, Feldman RG, Wolf PA, Brent B, Wartenberg D. A perceived cluster of amyotrophic lateral sclerosis cases in a Massachusetts community. Neuroepidemiology. 1992;11: 277–81.
  • Uccelli R, Binazzi A, Altavista P, Belli S, Comba P, Mastrantonio M, . Geographic distribution of amyotrophic lateral sclerosis through motor neuron disease mortality data. Eur J Epidemiol. 2007;22:781–90.
  • Caller TA, Doolin JW, Haney JF, Murby AJ, West KG, Farrar HE, . A cluster of amyotrophic lateral sclerosis in New Hampshire: a possible role for toxic cyanobacteria blooms. Amyotroph Lateral Scler. 2009;10 (Suppl 2):101–8.
  • Cox PA, Richer R, Metcalf JS, Banack SA, Codd GA, Bradley WG. Cyanobacteria and BMAA exposure from desert dust: a possible link to sporadic ALS among Gulf War veterans. Amyotroph Lateral Scler. 2009;10 (Suppl 2): 109–17.
  • Miranda ML, Alicia Overstreet Galeano M, Tassone E, Allen KD, Horner RD. Spatial analysis of the etiology of amyotrophic lateral sclerosis among 1991 Gulf War veterans. Neurotoxicology. 2008;29:964–70.
  • Scott KM, Abhinav K, Stanton BR, Johnston C, Turner MR, Ampong MA, . Geographical clustering of amyotrophic lateral sclerosis in south-east England: a population study. Neuroepidemiology. 2009;32:81–8.
  • Kurtzke JF. On statistical testing of prevalence studies. J Chronic Dis. 1966;19:909–22.
  • Armon C, Daube JR, O'Brien PC, Kurland LT, Mulder DW. When is an apparent excess of neurologic cases epidemiologically significant? Neurology. 1991;41:1713–8.
  • Horner RD, Grambow SC, Coffman CJ, Lindquist JH, Oddone EZ, Allen KD, . Amyotrophic lateral sclerosis among 1991 Gulf War veterans: evidence for a time-limited outbreak. Neuroepidemiology. 2008;31:28–32.
  • Haley RW. Excess incidence of ALS in young Gulf War veterans. Neurology. 2003;61:750–6.
  • Coffman CJ, Horner RD, Grambow SC, Lindquist J. Estimating the occurrence of amyotrophic lateral sclerosis among Gulf War (1990–1991) veterans using capture-recapture methods. Neuroepidemiology. 2005;24:141–50.
  • Mitchell JD, Borasio GD. Amyotrophic lateral sclerosis. Lancet. 2007;369:2031–41.
  • McGuire V, Longstreth WT Jr, Nelson LM, Koepsell TD, Checkoway H, Morgan MS, . Occupational exposures and amyotrophic lateral sclerosis: a population-based case-control study. Am J Epidemiol. 1997;145:1076–88.
  • Johnson FO, Atchison WD. The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis. Neurotoxicology. 2009;30: 761–5.
  • Kamel F, Umbach DM, Hu H, Munsat TL, Shefner JM, Taylor JA, . Lead exposure as a risk factor for amyotrophic lateral sclerosis. Neurodegener Dis. 2005;2: 195–201.
  • Kamel F, Umbach DM, Lehman TA, Park LP, Munsat TL, Shefner JM, . Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes. Environ Health Perspect. 2003;111:1335–9.
  • Kamel F, Umbach DM, Munsat TL, Shefner JM, Hu H, Sandler DP. Lead exposure and amyotrophic lateral sclerosis. Epidemiology. 2002;13:311–9.
  • Kamel F, Umbach DM, Stallone L, Richards M, Hu H, Sandler DP. Association of lead exposure with survival in amyotrophic lateral sclerosis. Environ Health Perspect. 2008;116:943–7.
  • Morahan JM, Pamphlett R. Amyotrophic lateral sclerosis and exposure to environmental toxins: an Australian case-control study. Neuroepidemiology. 2006;27:130–5.
  • Weisskopf MG, Morozova N, O'Reilly EJ, McCullough ML, Calle EE, Thun MJ, . Prospective study of chemical exposures and amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2009;80:558–61.
  • Hakansson N, Gustavsson P, Johansen C, Floderus B. Neurodegenerative diseases in welders and other workers exposed to high levels of magnetic fields. Epidemiology. 2003;14:420–8.
  • Li CY, Sung FC. Association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis: a review. Am J Ind Med. 2003;43: 212–20.
  • Weisskopf MG, Ascherio A. Cigarettes and amyotrophic lateral sclerosis: only smoke or also fire? Ann Neurol. 2009;65:361–2.
  • Kamel F, Umbach DM, Munsat TL, Shefner JM, Sandler DP. Association of cigarette smoking with amyotrophic lateral sclerosis. Neuroepidemiology. 1999;18:194–202.
  • Alonso A, Logroscino G, Jick SS, Hernan MA. Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study. BMC Neurol. 2010;10:6.
  • Armon C. Smoking may be considered an established risk factor for sporadic ALS. Neurology. 2009;73:1693–8.
  • Fang F, Ye W. Smoking may be considered an established risk factor for sporadic ALS. Neurology. 2010;74:1927; author reply 8–9.
  • Weisskopf MJ, Gallo V, O'Reilly EJ, Vineis P, Ascherio A. Smoking may be considered an established risk factor for sporadic ALS. Neurology. 2010;74:1927–8; author reply 8–9.
  • Gallo V, Bueno-De-Mesquita HB, Vermeulen R, Andersen PM, Kyrozis A, Linseisen J, . Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort. Ann Neurol. 2009;65:378–85.
  • Mulder DW, Kurland LT. Motor neuron disease: epidemiologic studies. Adv Exp Med Biol. 1987;209:325–32.
  • Plato CC, Garruto RM, Galasko D, Craig UK, Plato M, Gamst A, . Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years. Am J Epidemiol. 2003;157: 149–57.
  • Bradley WG, Mash DC. Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases. Amyotroph Lateral Scler. 2009;10 (Suppl 2):7–20.
  • Marler TE, Snyder LR, Shaw CA. Cycas micronesica (Cycadales) plants devoid of endophytic cyanobacteria increase in beta-methylamino-L-alanine. Toxicon. 2010;56: 563–8.
  • Banack SA, Murch SJ, Cox PA. Neurotoxic flying foxes as dietary items for the Chamorro people, Marianas Islands. J Ethnopharmacol. 2006;106:97–104.
  • Murch SJ, Cox PA, Banack SA. A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam. Proc Natl Acad Sci U S A. 2004;101:12228–31.
  • Pablo J, Banack SA, Cox PA, Johnson TE, Papapetropoulos S, Bradley WG, . Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease. Acta Neurol Scand. 2009;120: 216–25.
  • Brand LE. Human exposure to cyanobacteria and BMAA. Amyotroph Lateral Scler. 2009;10 (Suppl 2):85–95.
  • Brand LE, Pablo J, Compton A, Hammerschlag N, Mash DC. Cyanobacterial blooms and the occurrence of the neurotoxin, beta-N-methylamino-L-alanine (BMAA), in South Florida aquatic food webs. Harmful Algae. 2010; doi:10.1016/j.hal.2010.05.002.
  • Jonasson S, Eriksson J, Berntzon L, Spacil Z, Ilag LL, Ronnevi LO, . Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure. Proc Natl Acad Sci U S A. 2010;107: 9252–7.
  • Bradley WG, Banack SA, Cox PA. The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology. 2009;72:473–4, 6; author reply 5–6.
  • Snyder LR, Cruz-Aguado R, Sadilek M, Galasko D, Shaw CA, Montine TJ. Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissue. Toxicol Appl Pharmacol. 2009;240:180–8.
  • Snyder LR, Cruz-Aguado R, Sadilek M, Galasko D, Shaw CA, Montine TJ. Lack of cerebral BMAA in human cerebral cortex. Neurology. 2009;72:1360–1.
  • Shen WB, McDowell KA, Siebert AA, Clark SM, Dugger NV, Valentino KM, . Environmental neurotoxin-induced progressive model of Parkinsonism in rats. Ann Neurol. 2010;68:70–80.
  • Lincoln EP, Wilkie AC, French BT. Cyanobacterial process for renovating dairy wastewater. Biomass and Bioenergy. 1996;10:63–8.
  • Dionysiou D. Overview: harmful algal blooms and natural toxins in fresh and marine waters. Exposure, occurrence, detection, toxicity, control, management and policy. Toxicon. 2010;55:907–8.
  • Aleksandrov SV. Biological production and eutrophication of Baltic Sea estuarine ecosystems: the Curonian and Vistula lagoons. Mar Pollut Bull. 2010;61:205–10.
  • Barros LS, de Souza FC, Tavares LH, Amaral LA. Microcystin-LR in Brazilian aquaculture production systems. Water Environ Res. 2010;82:240–8.
  • Nyenje PM, Foppen JW, Uhlenbrook S, Kulabako R, Muwanga A. Eutrophication and nutrient release in urban areas of sub-Saharan Africa: a review. Sci Total Environ. 2010;408:447–55.
  • Carpenter SR. Phosphorus control is critical to mitigating eutrophication. Proc Natl Acad Sci U S A. 2008;105: 11039–40.
  • Jeppesen E, Kronvang B, Meerhoff M, Sondergaard M, Hansen KM, Andersen HE, . Climate change effects on run-off, catchment phosphorus loading and lake ecological state, and potential adaptations. J Environ Qual. 2009;38:1930–41.
  • Paul VJ. Global warming and cyanobacterial harmful algal blooms. Adv Exp Med Biol. 2008;619:239–57.
  • Maasilta P, Jokelainen M, Loytonen M, Sabel CE, Gatrell AC. Mortality from amyotrophic lateral sclerosis in Finland, 1986–1995. Acta Neurol Scand. 2001;104:232–5.
  • Seljeseth YM, Vollset SE, Tysnes OB. Increasing mortality from amyotrophic lateral sclerosis in Norway? Neurology. 2000;55:1262–6.
  • Tysnes OB, Vollset SE, Aarli JA. Epidemiology of amyotrophic lateral sclerosis in Hordaland county, western Norway. Acta Neurol Scand. 1991;83:280–5.
  • Sabel CE, Gatrell AC, eds. Exploratory spatial data analysis of motor neuron disease in north-west England: beyond the address at diagnosis. Proceedings of the International Workshop on Geomedical Systems; 1998. Stutgartt: Teubner-Verlag.
  • Chi A, Magnani C, Schiffer D. Amyotrophic lateral sclerosis mortality in Italy, 1958–1987: a cross-sectional and cohort study. Neurology. 1993;43:927–30.
  • Lilienfeld DE, Chan E, Ehland J, Godbold J, Landrigan PJ, Marsh G, . Rising mortality from motor neuron disease in the USA, 1962–1984. Lancet. 1989;1:710–3.
  • Lilienfeld DE, Perl DP. Projected neurodegenerative disease mortality in the United States, 1990–2040. Neuroepidemiology. 1993;12:219–28.
  • Fleming LE, Rivero C, Burns J, Williams C, Beana JA, Shea KA, . Blue-green algae (cyanobacterial) toxins, surface drinking water, and liver cancer in Florida. Harmful Algae. 2002;1:157–68.
  • Nishiwaki-Matsushima R, Ohta T, Nishiwaki S, Suganuma M, Kohyama K, Ishikawa T, . Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J Cancer Res Clin Oncol. 1992;118:420–4.
  • Svircev Z, Krstic S, Miladinov-Mikov M, Baltic V, Vidovic M. Freshwater cyanobacterial blooms and primary liver cancer epidemiological studies in Serbia. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009; 27:36–55.
  • Yu SZ. Primary prevention of hepatocellular carcinoma. J Gastroenterol Hepatol. 1995;10:674–82.
  • Backer LC, McNeel SV, Barber T, Kirkpatrick B, Williams C, Irvin M, . Recreational exposure to microcystins during algal blooms in two California lakes. Toxicon. 2010;55:909–21.
  • Cheng YS, Zhou Y, Irvin CM, Kirkpatrick B, Backer LC. Characterization of aerosols containing microcystin. Mar Drugs. 2007;5:136–50.
  • Fleming LE, Kirkpatrick B, Backer LC, Bean JA, Wanner A, Reich A, . Aerosolized red-tide toxins (brevetoxins) and asthma. Chest. 2007;131:187–94.
  • Fleming LE, Bean JA, Kirkpatrick B, Cheng YS, Pierce R, Naar J, . Exposure and effect assessment of aerosolized red tide toxins (brevetoxins) and asthma. Environ Health Perspect. 2009;117:1095–100.
  • Neutra RR. Counterpoint from a cluster buster. Am J Epidemiol. 1990;132:1–8.
  • Carmichael W. A world overview: one hundred and twenty-seven years of research on toxic cyanobacteria: where do we go from here? Adv Exp Med Biol. 2008;619: 105–25.

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