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Research Article

An Evidence-Based Systematic Review of Tongkat Ali (Eurycoma longifolia) by the Natural Standard Research Collaboration

, PharmD, , PhD, , BA, , , PharmD & , MPH
Pages 54-83 | Published online: 19 Feb 2013

REFERENCES

  • Ab Rahman AA, Al-Sadat N, Yun Low W. Help seeking behaviour among men with erectile dysfunction in primary care setting. J Men's Health 2011;8:894.
  • Abd Rahman K, Niiyama K, Azizi R, Species assembly and site preference of tree species in a primary seraya-ridge forest of Peninsular Malaysia. J Trop For Sci. 2002;14(3):287–303.
  • Adaikan PG. Phytoandrogen and sexual health. Phytoandrogen & sexual health 2004.
  • Adimoelja A. Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl. 2000;23 Suppl 2:82–84.
  • Ahmad S. Research and development on functional foods in Malaysia. Nutr Rev. 1996;54(11 Pt 2):S169–S171.
  • Al-Adhroey AH, Nor ZM, Al-Mekhlafi HM, Mahmud R. Ethnobotanical study on some Malaysian anti-malarial plants: a community based survey. J Ethnopharmacol. 10-28-2010;132(1):362–364.
  • Ang HH. An insight into Malaysian herbal medicines. Trends Pharmacol Sci 2004;25(6):297–298.
  • Ang HH, Chan KL, Gan EK, Enhancement of sexual motivation in sexually naive male mice by Eurycoma longifolia. Int J Pharmacogn. 1997;35:144–146.
  • Ang HH, Chan KL, Mak JW. Effect of 7-day daily replacement of culture medium containing Eurycoma longifolia Jack constituents on the Malaysian Plasmodium falciparum isolates. J Ethnopharmacol. 12-15-1995a;49(3):171–175.
  • Ang HH, Chan KL, Mak JW. In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates. Planta Med 1995b;61(2):177–178.
  • Ang HH, Cheang HS. Promotion of sexual activity in rats with Eurycoma longifolia Jack. Journal of Herbs, Spices, and Medicinal Plants 1999a;6:23–28.
  • Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999b;79(4):497–500.
  • Ang HH, Cheang HS. Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats. Arch Pharm. Res 2001;24(5):437–440.
  • Ang HH, Cheang HS. Effects of Eurycoma longifolia Jack on copulatory behavior in middle-aged male rats. J Herbs Spices Med Plants 2002;9(1):109–114.
  • Ang HH, Cheang HS, Yusof A P. Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Exp. Anim 2000;49(1):35–38.
  • Ang HH, Hitotsuyanagi Y, Fukaya, H, Takeya K. Quassinoids from Eurycoma longifolia. Phytochemistry. 2002;59(8):833–837.
  • Ang LH, Ho WM, Ang TB, Establishment of a high value timber production area on tin tailings - Tropical forestry research in the new millennium: meeting demands and challenges. 2001a;245–253.
  • Ang HH, Ikeda S, Gan EK. Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack. Phytother Res. 2001b;15(5):435–436.
  • Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats. Fundam. Clin. Pharmacol. 2002;16(6):479–483.
  • Ang HH, Lee KL. Contamination of mercury in tongkat Ali hitam herbal preparations. Food Chem Toxicol. 2006;44(8):1245–1250.
  • Ang HH, Lee KL, Kiyoshi M. Sexual arousal in sexually sluggish old male rats after oral administration of Eurycoma longifolia Jack. J Basic Clin. Physiol. Pharmacol. 2004;15(3-4):303–309.
  • Ang HH, Ngai TH. Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack. Fundam Clin Pharmacol. 2001;15(4):265–268.
  • Ang HH, Ngai TH, Tan TH. Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats. Phytomedicine. 2003;10(6–7):590–593.
  • Ang HH, Sim MK. Eurycoma longifolia Jack enhances libido in sexually experienced male rats. Exp. Anim 1997;46(4):287–290.
  • Ang HH, Sim MK. Eurycoma longifolia increases sexual motivation in sexually naive male rats. Arch Pharm Res 1998;21(6):779–781.
  • Asiah O, Nurhanan MY, Mohd IA. Determination of bioactive peptide (4.3 kDa) as an aphrodisiac marker in six Malaysian plants. J Trop For Sci. 2007;19(1):61–63.
  • Athimulam A, Kumaresan S, Foo DCY, Modelling and optimization of Eurycoma longifolia water extract production. Food Bioprod Process. 2006;84(C2):139–149.
  • Aziz S, Akeng G, Kandasamy KI. Induction of somatic embryos from cotyledonary tissue of Tongkat Ali (Eurycoma longifolia). Journal of Tropical Medicinal Plants 2000;53–59.
  • Aziz LMS, Keng ChanLai, Lim BoeyPeng. Effects of medium constituents on growth and canthinone accumulation in cell suspension cultures of Eurycoma longifolia Jack. Hayati Journal of Biosciences 2009;16(2).
  • Baharuddin S, Adenan J, Mashhor M. Some medicinal plants from Sungai Kinchin, Pahang, Malaysia. Malayan Nature Journal 1990;43(4).
  • Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull. (Tokyo) 2003;51(11):1301–1303.
  • Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010;81(7):669–679.
  • Carratu B, Boniglia C, Ciarrocchi M, Gargiulo R, Sanzini E. Convenient TLC for the detection of a herbal ingredient in a food supplement. Nat Prod Res 2010;24(20):1954–1960.
  • Chan KL, Choo CY, Abdullah NR. Semisynthetic 15-O-acyl- and 1,15-di-O-acyleurycomanones from Eurycoma longifolia as potential antimalarials. Planta. Med 2005;71(10):967–969.
  • Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004;92(2–3):223–227.
  • Chan KL, Choo CY, Morita H, Itokawa H. High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia. Planta. Med 1998;64(8):741–745.
  • Chan K, Iitaka Y, Noguchi H, et al. 6a-Hydroxyeurycomalactone, a quassinoid from Eurycoma longifolia. Phytochemistry. 1992;31(12):4295–4298.
  • Chan KL, Lee SP, Sam TW, et al. 13ß,18-dihydroeurycomanol, a quassinoid from Eurycoma longifolia. Phytochemistry. 1991;30(9):3138–3141.
  • Chan KL, Lee SP, Sam TW, et al. A quassinoid glycoside from the roots of Eurycoma longifolia. Phytochemistry. 2012;28(10):2857–2859.
  • Chan KL., Low BS, Teh CH, Das PK. The effect of Eurycoma longifolia on sperm quality of male rats. Nat Prod Commun. 2009;4(10):1331–1336.
  • Chan KL, O'Neill MJ, Phillipson JD, Warhurst DC. Plants as sources of antimalarial drugs. Part 3. Eurycoma longifolia. Planta Med. 1986;(2):105–107.
  • Choo CY, Chan KL. High performance liquid chromatography analysis of canthinone alkaloids from Eurycoma longifolia. Planta. Med 2002;68(4):382–384.
  • Chua LSL, Kamarudin S, Markandan S, et al. A preliminary checklist of vascular plants from the Machinchang Range, Pulau Langkawi, Peninsular Malaysia. Malayan Nature Journal 2005;57(2):155–172.
  • Chua GLS, Koh BL, Lau SC, et al. The nutrient status of the plateau heath forest on Gunung Keriong, Pahang, Peninsular Malaysia. J Trop For Sci. 1995;8(2):240–246.
  • Chye LHP. Traditional Asian folklore medicines in sexual health. Indian J Urol. 2006;22(3):241–245.
  • Cyranoski D. Malaysian researchers bet big on home-grown Viagra. Nat Med 2005;11(9):912.
  • Danial M, Keng CL, Syarifah RSA, et al. Seed histology of recalcitrant Eurycoma longifolia plants during germination and its beneficial attribute for hairy roots production. J Med Plants Res. 2005;5(1):93–98.
  • Darise M, Kohda H, Mizutani K, et al. Eurycomanone and eurycomanol, quassinoids from the roots of Eurycoma longifolia [from Indonesia. Phytochemistry. 1982;21(8):2091–2093.
  • Darise M, Kohda H, Mizutani K, et al. Revision of configuration of the 12-hydroxyl group of eurycomanone and eurycomanol, quassinoids from Eurycoma longifolia. Phytochemistry 1983;22(6):1514.
  • Doustjalali SR, Marzalina, Datiakma MAN. A gel-based proteomic kit to screen the quality of water-soluble root extracts of Eurycoma longifolia. J Trop For Sci. 2005;479–480.
  • Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007;28(9):1422–1424.
  • Frydrychova S, Opletal L, Macakova K, Lustykova A, Rozkot M, Lipensky J. Effects of herbal preparation on libido and semen quality in boars. Reprod. Domest Anim 2011;46(4):573–578.
  • Hamzah S, Yusof A. The ergogenic effects of Eurycoma longifolia Jack: a pilot study. Brit J Sport Med. 2003;37(5):465–466.
  • Hanapi NA, Azizi J, Ismail S, et al. Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro. IJP - Int J Pharmacol. 2010;6(4):494–499.
  • Hasnida HN, Aziah MY, Salbiah M, et al. Multiplication of shoots from in vitro germinated seedlings of Eurycoma longifolia and Aquilaria malaccensis. Forest Research Institute Malaysia (FRIM) 2001;269–276.
  • Hassali MA, Hassali MA, Khan TM, et al. Public knowledge about herbal beverages in Penang, Malaysia. Australasian Medical Journal 2009;1–11.
  • Hout S, Chea A, Bun SS, Elias R, Gasquet M, Timon-David P, Balansard G, Azas N. Screening of selected indigenous plants of Cambodia for antiplasmodial activity. J Ethnopharmacol. 8-11-2006;107(1):12–18.
  • Husen R, Pihie AH, Nallappan M. Screening for antihyperglycaemic activity in several local herbs of Malaysia. J Ethnopharmacol. 2004;95(2-3):205–208.
  • Hussein S, Rusli I, Kiong ALP, et al. Micropropagation of Eurycoma longifolia Jack via formation of somatic embryogenesis. Asian J Plant Sci. 2005;4(5):472–485.
  • Hussein S, Rusli Ibrahim, Kiong LingPick. Adventitious shoots regeneration from root and stem explants of Eurycoma longifolia Jack - an important tropical medicinal plants. Int J Agric Res 2006;183–193.
  • Hussein S, Rusli I, Kiong LPA. A summary of reported chemical constituents and medicinal uses of Eurycoma longifolia. J Trop Med Plants. 2007;8(1):103–110.
  • Itokawa H, Kishki E, Morita H, et al. Cytotoxic quassinoids and tirucallane-type triterpenes from the woods of Eurycoma longifolia. Chemical and Pharmaceutical Bulletin 1992;40(4):1053–1055.
  • Itokawa H, Qin XR, Morita H, et al. C18 and C19 quassinoids from Eurycoma longifolia. J Nat Prod. 1993;56(10):1766–1771.
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clinical Trials 1996;17(1):1–12.
  • Jantan I, Zaki ZM, Ahmad AR, et al. Evaluation of smoke from mosquito coils containing Malaysian plants against Aedes aegypti. Fitoterapia. 1999;70(3):327.
  • Jiwajinda S, Santisopasri V, Murakami A, Hirai N, Ohigashi H. Quassinoids from Eurycoma longifolia as plant growth inhibitors. Phytochemistry. 2001;58(6):959–962.
  • Jiwajinda S, Santisopasri V, Murakami A, Sugiyama H, Gasquet M, Riad E, Balansard G, Ohigashi H. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol. 2002;82(1):55–58.
  • Kardono LB, Angerhofer CK, Tsauri S, Padmawinata K, Pezzuto JM, Kinghorn AD. Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia. J Nat Prod. 1991;54(5):1360–1367.
  • Kulip J. Medicinal plants of Sabah, Malaysia: potential for agroforestry. JIRCAS Working Report 2009;47–48.
  • Kuo PC, Damu AG, Lee KH, Wu TS. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg Med Chem. 2-1-2004;12(3):537–544.
  • Kuo PC, Damu AG, Wu TS. Characterization of the water soluble fraction from the root extract of Eurycoma longifolia. Chin Pharmaceut J 2003;55:257–265.
  • Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003;66(10):1324–1327.
  • Le VT, Nguyen NS. Constituents of Eurycoma longifolia Jack. J Org Chem. 1970;35(4):1104–1109.
  • Lin KW. Ethnobotanical study of medicinal plants used by the Jah Hut peoples in Malaysia. Indian J Med Sci. 2005;59(4):156–161.
  • Lin LC, Peng CY, Wang HS, et al. Reinvestigation of the constituents of Eurycoma longifolia. Chinese Pharmaceutical Journal 2011;53:97–106.
  • Ling PKA, Phua ATG, Tee CS, et al. Optimization of protoplast isolation protocols from callus of Eurycoma longifolia. J Med Plants Res. 2010;4(17):1778–1785.
  • Low BS, Ng BH, Choy WP, Yuen KH, Chan KL. Bioavailability and pharmacokinetic studies of eurycomanone from Eurycoma longifolia. Planta Med 2005;71(9):803–807.
  • Low BS, Teh CH, Yuen KH, Chan KL. Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity. Nat Prod Commun. 2011;6(3):337–341.
  • Lufthi MS, Chan LK, Boey PL. Effect of cell source and pH of culture medium on the production of canthin-6-one alkaloids from the cell cultures of Tongkat Ali (Eurycoma longifolia Jack). Plant Biotechnol 2004;6(2):125–130.
  • Lugnataweepon I, Pleuktivorapongkul A, Sirithunyalug J, et al. Effects of herbal powder composition on flow and compaction properties. Proceedings of the Kasetsart University Annual Conference 2011;1:113–120.
  • Mahanem MN, Abu Hassan SMN, Lukman CH. The effect of Eurycoma longifolia Jack (Tongkat Ali) on sexual behaviour and sperm quality in rats. Malayas J Pharm Sci 2004;2(1):53–60.
  • Malviya N, Jain S, Gupta VB, Vyas S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction–a review. Acta Pol Pharm. 2011;68(1):3–8.
  • Maziah M, Rosli N. The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali. Methods Mol Biol. 2009;547:359–369.
  • Maziah M, Rosli N, Sreeramanan S. Optimization of suitable auxin application in a recalcitrant woody forest plant of Eurycoma longifolia (Tongkat Ali) for callus induction. Afr J Biotechnol. 2010;9(49):8417–8428.
  • Mitsunaga K, Koike K, Tanaka T, et al. Canthin-6-one alkaloids from Eurycoma longifolia. Phytochemistry. 1994;35(3):799–802.
  • Miyake K, Tezuka Y, Awale S, Li F, Kadota S. Quassinoids from Eurycoma longifolia. J Nat Prod. 2009;72(12):2135–2140.
  • Miyake K, Tezuka Y, Awale S, Li F, Kadota S. Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat Prod Commun. 2010;5(1):17–22.
  • Mohamad M, Li MW, Hmad A. Modelling for Extraction of Major Phytochemical Components from Eurycoma longifolia. J Appl Sci. 2010;10(21):2572–2577.
  • Mohd I. Opportunities on the planting of medicinal and herbal plants in Malaysia. Planter 1998;74(867):339–342.
  • Mohd NAG, Amran M, Mohd HT. Sustainable production of medicinal plants through cultivation: the golden hope experience. Towards modernisation of research and technology in herbal industries 2001.
  • Mohd-Fuat AR, Kofi EA, Allan GG. Mutagenic and cytotoxic properties of three herbal plants from Southeast Asia. Trop. Biomed. 2007;24(2):49–59.
  • Mohd Ridzuan MA, Noor Rain A, Zhari I, Zakiah I. Effect of Eurycoma longifolia extract on the Glutathione level in Plasmodium falciparum infected erythrocytes in vitro. Trop Biomed. 2005;22(2):155–163.
  • Mohd Ridzuan MA, Sow A, Noor Rain A, Mohd Ilham A, Zakiah I. Eurycoma longifolia extract-artemisinin combination: parasitemia suppression of Plasmodium yoelii-infected mice. Trop Biomed. 2007;24(1):111–118.
  • Morita H, Kishi E, Takeya K, et al. New quassinoids from the roots of Eurycoma longifolia. Planta Med. 1990;56(6).
  • Morita H, Kishi E, Takeya K, Itokawa H. Biphenylneolignans from wood of Eurycoma longifolia. Phytochemistry. 1992;31(11):3993–3995.
  • Morita H, Kishi E, Takeya K, et al. Highly oxygenated quassinoids from Eurycoma longifolia. Phytochemistry. 1993;33(3):691–696.
  • Muhamad AS, Chen CK, Ooi FK, et al. Eurycoma longifolia Jack: Medicinal properties and its effect on endurance exercise performance. Asian Journal of Exercise & Sports Science 2009;6(1).
  • Muhamad AS, Chen CK, Ooi FK, et al. Effects of Eurycoma longifolia Jack Supplementation on Recreational Athletes’ Endurance Running Capacity and Physiological Responses in the Heat. International Journal of Applied Sports Sciences 2010;22(1):119.
  • Muhammed IMA, Haron Norini. Supply and demand of Eurycoma longifolia (Tongkat Ali) plants with few others. Journal of Trop Med Plants 2001;2(1):145–154.
  • Nowroji K, Rahmah N, Chan KL, et al. Cytotoxicity activity of root extract/fractions of Eurycoma longifolia Jack root against vero and Hs27cells. J Med Plants Res. 2012;4(22):2383–2387.
  • Nurhanan MY, Azimahtol HLP, Azizol AK. Cytotoxicity studies of Eurycoma longifolia extracts against a panel of human cancer cell lines. Proceedings of the Seminar on Medicinal and Aromatic Plants 2002;124–127.
  • Nurhanan MY, Azimahtol Hawariah LP, Mohd, Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005;19(11):994–996.
  • Oei-Koch A, Kraus L. Substances in Eurycoma longifolia. I. Sterols, saponins. / Inhaltsstoffe von Eurycoma longifolia Jack. I. Sterols, Saponine. Planta Medica 1978;34(3):339–340.
  • Oei-Koch A, Kraus L. Constituents of Eurycoma longifolia Jack. Part 3. Bitter principles (eurycomalacton). Scientia Pharmaceutica (Austria) 1980;48:110–117.
  • Osman A, Jordan B, Lessard PA, Muhammad N, Haron MR, Riffin NM, Sinskey AJ, Rha C, Housman DE. Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms. Plant Physiol. 2003;131(3):1294–1301.
  • Qinna N, Taha H, Matalka KZ, Badwan AA. A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals. Int J Impot Res 2009;21(5):315–320.
  • Reddy KRN, Nurdijati SB, Salleh B. Efficacy of aqueous medicinal plant extracts on growth and citrinin production by Penicillium citrinum isolated from rice grains. Afr J Microbiol Res. 2010;4(23):2562–2565.
  • Remli R, Chan SC. Use of complementary medicine amongst diabetic patients in a public primary care clinic in Ipoh. Med J Malaysia. 2003;58(5):688–693.
  • Rosli N, Maziah M, Chan KL, et al. Factors affecting the accumulation of 9-methoxycanthin-6-one in callus cultures of Eurycoma longifolia. J Forest Res 2009;20(1):54–58.
  • Said MM, Gibbons S, Zloh M. Chemometrics analysis of solid herbal products and development of spectral databases. J Pharm Pharmacol. 2010;62:1203–1204.
  • Salman SA, Amrah S, Wahab MS, Ismail Z, Ismail R, Yuen KH, and Gan SH. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35(6):691–696.
  • Sareena HH, Ashril Y. 12th commonwealth international sport conference. 2002. Manchester.
  • Sholikhah EN, Wijayanti MA, Nurani LH, Mustofa. Stage specificity of pasak bumi root (Eurycoma longifolia Jack) isolate on Plasmodium falciparum cycles. Med J Malaysia. 2008;63 Suppl A:98–99.
  • Shuid AN, Abu Bakar MF, Abdul Shukor TA, Muhammad N, Mohamed N, Soelaiman IN. The anti-osteoporotic effect of Eurycoma Longifolia in aged orchidectomised rat model. Aging Male. 2011;14(3):150–154.
  • Siregar LAM, Keng CL. In vitro shoot organogenesis of Eurycoma longifolia. Planter. 2002;78(915):289–300.
  • Sobri H, Marziah M, Azizol AK. Tissue culture of Tongkat Ali (Eurycoma longifolia) for mass production. Towards modernisation of research and technology in herbal industries. 2002;18–21.
  • Sriwilaijaroen N, Kondo S, et al. Antiplasmodial effects of Brucea javanica (L.) Merr. and Eurycoma longifolia Jack extracts and their combination with chloroquine and quinine on Plasmodium falciparum in culture. Tropical Medicine and Health 2010;38(2):61–68.
  • Suppakan N, Suriyapananont S. Thai crude drugs: preparations and specifications. Part 16. Eurycoma longifolia Jack. Mahidol University Journal of Pharmaceutical Sciences 1983;10:43–48.
  • Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010;12(3):376–380.
  • Tan S, Yuen KH, Chan KL. HPLC analysis of plasma 9-methoxycanthin-6-one from Eurycoma longifolia and its application in a bioavailability/pharmacokinetic study. Planta Med 2002;68(4):355–358.
  • Tee TT, Azimahtol HL. Induction of apoptosis by Eurycoma longifolia jack extracts. Anticancer. Res. 2005;25(3B):2205–2213.
  • Tee TT, Cheah YH, Hawariah LP. F16, a fraction from Eurycoma longifolia jack extract, induces apoptosis via a caspase-9-independent manner in MCF-7 cells. Anticancer. Res. 2007;27(5A):3425–3430.
  • Teh CH, Abdulghani M, Morita H, Shiro M, Hussin AH, Chan KL. Comparative X-ray and conformational analysis of a new crystal of 13alpha,21-dihydroeurycomanone with eurycomanone from Eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay. Planta Med 2011;77(2):128–132.
  • Teh CH, Teoh SC, Yeap CS, Chan KL, Fun HK. 4,5,7,8,17-Penta-hydr-oxy-14,18-dimethyl-6-methyl-ene-3,10-dioxapenta-cyclo-[9.8. 0.0.0.0]nona-dec-14-ene-9,16-dione methanol solvate dihydrate. Acta Crystallogr. Sect E Struct Rep Online. 2009;65(Pt 4):o898–o899.
  • Tnah LH, Lee CT, Lee SL, Ng KK, Ng CH, Hwang SS. Microsatellite markers of an important medicinal plant, Eurycoma longifolia (Simaroubaceae), for DNA profiling. Am J Bot. 2011;98(5):e130–e132.
  • Tzar M, Hamidah Y, Hartini M, etal. The Antibacterial or Antifungal Effects of Eurycoma longifolia Root Extract. The Internet Journal of Herbal and Plant Medicine 2011;1(1).
  • Ueda JY, Tezuka Y, Banskota AH, Le Tran Q, Tran QK, Harimaya Y, Saiki I, Kadota S. Antiproliferative activity of Vietnamese medicinal plants. Biol Pharm Bull. 2002;25(6):753–760.
  • Vittachi N. Flower power. Far Eastern Economic Review 1994;157(18).
  • Wahab NA, Mokhtar NM, Halim WN, Das S. The effect of eurycoma longifolia Jack on spermatogenesis in estrogen-treated rats. Clinics (Sao Paulo) 2010;65(1):93–98.
  • Wernsdorfer WH, Ismail S, Chan KL, Congpuong, K, Wernsdorfer G. Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro. Wien Klin Wochenschr. 2009;121 Suppl 3:23–26.
  • Zanoli P, Zavatti M, Montanari C, Baraldi M. Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats. J Ethnopharmacol. 11-12-2009;126(2):308–313.

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