Sexual dimorphism in ALS: Exploring gender-specific neuroimaging signatures

References

• Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, et al. The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population based study. J Neurol Neurosurg Psychiatry. 2012;83:102–8.
   PubMed Web of Science ®Google Scholar
• Chiò A, Mora G, Calvo A, Mazzini L, Bottacchi E, Mutani R, et al. Epidemiology of ALS in Italy: A 10-year prospective population based study. Neurology. 2009;72: 725–31.
   PubMed Web of Science ®Google Scholar
• Wijesekera LC, Mathers S, Talman P, Galtrey C, Parkinson MH, Ganesalingam J, et al. Natural history and clinical features of the flail arm and flail leg ALS variants. Neurology. 2009;72:1087–94.
   PubMed Web of Science ®Google Scholar
• del Aguila MA, Longstreth WT Jr, McGuire V, Koepsell TD, van Belle G. Prognosis in amyotrophic lateral sclerosis: a population based study. Neurology. 2003;60:813–9.
   PubMed Web of Science ®Google Scholar
• Portet F, Cadilhac C, Touchon J, Camu W. Cognitive impairment in motor neuron disease with bulbar onset. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001;2:23–9.
   PubMed Web of Science ®Google Scholar
• Logroscino G, Traynor BJ, Hardiman O, Chio’ A, Couratier P, Mitchell JD, et al. Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry. 2008;79:6–11.
   PubMed Web of Science ®Google Scholar
• Manjaly ZR, Scott KM, Abhinav K, Wijesekera L, Ganesalingam J, Goldstein LH, et al. The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotroph Lateral Scler. 2010;11:439–42.
   PubMed Web of Science ®Google Scholar
• Chio A, Meineri P, Tribolo A, Schiffer D. Risk factors in motor neuron disease: a case-control study. Neuroepidemiology. 1991;10:174–84.
   PubMed Web of Science ®Google Scholar
• de Jong S, Huisman M, Sutedja N, van der Kooi A, de Visser M, Schelhaas J, et al. Endogenous female reproductive hormones and the risk of amyotrophic lateral sclerosis. J Neurol. 2013;260:507–12.
   PubMed Web of Science ®Google Scholar
• Vivekananda U, Manjalay ZR, Ganesalingam J, Simms J, Shaw CE, Leigh PN, et al. Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability. J Neurol Neurosurg Psychiatry. 2011; 82:635–7.
   PubMed Web of Science ®Google Scholar
• Veldink JH, Bär PR, Joosten EA, Otten M, Wokke JH, van den Berg LH.Sexual differences in onset of disease and response to exercise in a transgenic model of ALS. Neuromuscul Disord. 2003;13:737–43.
   PubMed Web of Science ®Google Scholar
• Islamov RR, Hendricks WA, Jones RJ, Lyall GJ, Spanier NS, Murashov AK. 17Beta-estradiol stimulates regeneration of sciatic nerve in female mice. Brain Res. 2002;943:283–6.
   PubMed Web of Science ®Google Scholar
• Verstraete E, van den Heuvel MP, Veldink JH, Blanken N, Mandl RC, Hulshoff Pol HE, et al. Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study. PLoS One. 2010;5:e13664.
   PubMed Web of Science ®Google Scholar
• Verstraete E, Veldink JH, van den Berg LH, van den Heuvel MP. Structural brain network imaging shows expanding disconnection of the motor system in amyotrophic lateral sclerosis. Hum Brain Mapp. 2013 Mar 1. doi: 10.1002/hbm.22258. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Chen X, Sachdev PS, Wen W, Anstey KJ. Sex differences in regional grey matter in healthy individuals aged 44–48 years: a voxel based morphometric study. Neuroimage. 2007;36: 691–9.
   PubMed Web of Science ®Google Scholar
• Kanaan RA, Allin M, Picchioni M, Barker GJ, Daly E, Shergill SS, et al. Gender differences in white matter microstructure. PLoS One. 2012;7:e38272.
   PubMed Web of Science ®Google Scholar
• Menzler K, Belke M, Wehrmann E, Krakow K, Lengler U, Jansen A, et al. Males and females are different: diffusion tensor imaging reveals sexual dimorphism in the microstructure of the thalamus, corpus callosum and cingulum. Neuroimage. 2011;54:2557–62.
   PubMed Web of Science ®Google Scholar
• Szabó CA, Lancaster JL, Xiong J, Cook C, Fox P. MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons. Am J Neuroradiol. 2003;24: 644–7.
   PubMed Web of Science ®Google Scholar
• Bede P, Bokde ALW, Byrne S, Elamin M, McLaughlin R, Kenna K, et al. A multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology. epub2013 Jun 14.
   Google Scholar
• Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, et al. Tract based spatial statistics: voxelwise analysis of multisubject diffusion data. Neuroimage. 2006;31:1487–505.
   PubMed Web of Science ®Google Scholar
• Fischl B. FreeSurfer. Neuroimage. 2012;62:774–1.
   PubMed Web of Science ®Google Scholar
• Douaud G, Smith S, Jenkinson M, Behrens T, Johansen-Berg H, Vickers J, et al.Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. Brain. 2007;130:2375–86.
   PubMed Web of Science ®Google Scholar
• Zhou J, Gennatas ED, Kramer JH, Miller BL, Seeley WW. Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron. 2012;73:1216–27.
   PubMed Web of Science ®Google Scholar
• Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron. 2009;62:42–2.
   PubMed Web of Science ®Google Scholar
• Ravits JM, La Spada AR. ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration. Neurology. 2009;73:805–11.
   PubMed Web of Science ®Google Scholar
• Agosta F, Pagani E, Rocca MA, Caputo D, Perini M, Salvi F, et al. Voxel based morphometry study of brain volumetry and diffusivity in amyotrophic lateral sclerosis patients with mild disability. Hum Brain Mapp. 2007;28: 1430–8.
   PubMed Web of Science ®Google Scholar
• Huster RJ, Westerhausen R, Kreuder F, Schweiger E, Wittling W. Hemispheric and gender-related differences in the midcingulum bundle: a DTI study. Hum Brain Mapp. 2009;30:383–91.
   PubMed Web of Science ®Google Scholar
• Tamura I, Kitagawa M, Otsuki M, Kikuchi S, Tashiro K, Dubois B. Pure topographical disorientation following a right forceps major of the splenium lesion: a case study. Neurocase. 2007;13:178–84.
   PubMed Web of Science ®Google Scholar
• Binder JR, Mohr JP. The topography of callosal reading pathways: a case-control analysis. Brain. 1992;115:1807–26.
   PubMed Web of Science ®Google Scholar
• Verstraete E, Veldink JH, Hendrikse J, Schelhaas HJ, van den Heuvel MP, van den Berg LH. Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2012;83:383–8.
   PubMed Web of Science ®Google Scholar
• Filippini N, Douaud G, Mackay CE, Knight S, Talbot K, Turner MR. Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology. 2010;75: 1645–52.
   PubMed Web of Science ®Google Scholar
• Verstraete E, van den Heuvel MP, Veldink JH, Blanken N, Mandl RC, Hulshoff Pol HE, et al. Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study. PLoS One. 2010;5: e13664.
   PubMed Web of Science ®Google Scholar
• Olney RK, Murphy J, Forshew D, Garwood E, Miller BL, Langmore S, et al. The effects of executive and behavioural dysfunction on the course of ALS. Neurology. 2005;65: 1774–7.
   PubMed Web of Science ®Google Scholar
• Elamin M, Phukan J, Bede P, Jordan N, Byrne S, Pender N, et al. Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia. Neurology. 2011; 76:1263–9.
   PubMed Web of Science ®Google Scholar
• Bede P, Bokde A, Elamin M, Byrne S, McLaughlin RL, Jordan N, et al. Grey matter correlates of clinical variables in amyotrophic lateral sclerosis: a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. J Neurol Neurosurg Psychiatry. 2013;84:766–73.
   PubMed Web of Science ®Google Scholar
• Girardi A, Macpherson SE, Abrahams S. Deficits in emotional and social cognition in amyotrophic lateral sclerosis. Neuropsychology. 2011;25:53–65.
   PubMed Web of Science ®Google Scholar
• Taylor LJ, Brown RG, Tsermentseli S, Al-Chalabi A, Shaw CE, Ellis CM, et al. Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?. J Neurol Neurosurg Psychiatry. 2013;84:494–8.
   PubMed Web of Science ®Google Scholar
• Elamin M, Pender N, Hardiman O, Abrahams S. Social cognition in neurodegenerative disorders: a systematic review. J Neurol Neurosurg Psychiatry. 2012;83:1071–9.
   PubMed Web of Science ®Google Scholar