Can low-intensity extracorporeal shockwave therapy improve erectile dysfunction? A prospective, randomized, double-blind, placebo-controlled study

References

• Montorsi F, Adaikan G, Becher E, Giuliano F, Khoury S, Lue TF, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med 2010;7:3572–88.
   PubMed Web of Science ®Google Scholar
• Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol 2010;57:804–8.
   PubMed Web of Science ®Google Scholar
• Cunningham G, Rosen R. Overview of male sexual dysfunction. Uptodate. January 2013. Available from http://www.uptodate.com/contents/overview-of-male-sexual-dysfunction.
   Google Scholar
• Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Urol 2000;163:460–3.
   PubMed Web of Science ®Google Scholar
• Chaussy C, Brendel W, Schmiedt E. Extracorporeally induced destruction of kidney stones by shock waves. Lancet 1980;ii:1265–8.
   Google Scholar
• Chaussy C, Schmiedt E, Jocham D, Brendel W, Forssmann B, Walther M. First clinical experience with extracorporeally induced destruction of kidney stones by shock waves. J Urol 1982;127:417–20.
   PubMed Web of Science ®Google Scholar
• Chaussy C, Schmiedt E. Shock wave treatment for stones in the upper urinary tract. Urol Clin North Am 1983;10:743–50.
   PubMed Web of Science ®Google Scholar
• Sackmann M, Delius M, Sauerbruch T, Holl J, Weber W, Ippisch E, et al. Shock wave lithotripsy of gallbladder stones. N Engl J Med 1988;318:393–7.
   PubMed Web of Science ®Google Scholar
• Sauter G, Kullak-Ublick GA, Schumacher R, Janssen J, Greiner L, Brand B, et al. Safety and efficacy of repeated shockwave lithotripsy of gallstones with and without adjuvant bile acid therapy. Gastroenterology 1997;112:1603–9.
   PubMed Web of Science ®Google Scholar
• Palmieri A, Imbimbo C, Longo N, Fusco F, Verze P, Mangiapia F, et al. A first prospective, randomized, double-blind, placebo-controlled clinical trial evaluating extracorporeal shock wave therapy for the treatment of Peyronie’s disease. Eur Urol 2009;56:363–70.
   PubMed Web of Science ®Google Scholar
• Nishida T, Shimokawa H, Oi K, Tatewaki H, Uwatoku T, Abe K, et al. Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo. Circulation 2004;110:3055–61.
   PubMed Web of Science ®Google Scholar
• Yan X, Zeng B, Chai Y, Luo C, Li X. Improvement of blood flow, expression of nitric oxide, and vascular endothelial growth factor by low-energy shockwave therapy in random-pattern skin flap model. Ann Plast Surg 2008;61:646–53.
   PubMed Web of Science ®Google Scholar
• Lund L, Pedersen DV, Højer S, Hanna M. Can extracorporal shock-wave therapy (ESWT) improves erectile tissues and induces angiogenesis in an animal model of streptozotocin induced diabetes. J Urol 2014; submitted.
   PubMedGoogle Scholar
• Qui X, Lin G, Xin Z, Ferretti L, Zhang H, Lue TF, et al. Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model. J Sex Med 2013;10:738–46.
   PubMedGoogle Scholar
• Vardi Y, Appel B, Jacob G, Massarwi O, Gruenwald I. Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction. Eur Urol 2010;58:243–8.
   PubMed Web of Science ®Google Scholar
• Gruenwald I, Appel B, Vardi Y. Low-intensity extracorporeal shock wave therapy: a novel effective treatment for erectile dysfunction in severe ED patients who respond poorly to PDE5 inhibitor therapy. J Sex Med 2012;9:259–64.
   PubMed Web of Science ®Google Scholar
• Vardi Y, Appel B, Kilchevsky A, Gruenwald I. Does low intensity extracorporeal shock wave therapy have a physiological effect on erectile function? Short-term results of a randomized, double-blind, sham controlled study. J Urol 2012;187:1769–75.
   PubMed Web of Science ®Google Scholar
• Haahr M, Salling M, Pedersen DV, Hanna M, Lund L. Low-intensity extracorporeal shock wave therapy improves erectile dysfunction – a pilot study with 2-year follow-up. J Androl Gynecol 2014; in press.
   Google Scholar
• Fukumoto Y, Ito A, Uwatoku T, Matoba T, Kishi T, Tanaka H, et al. Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease. Coron Artery Dis 2006;17:63–70.
   PubMedGoogle Scholar
• He Y, He W, Qin G, Luo J, Xaio M. Transplantation KCNMA1 modified bone marrow–mesenchymal stem cell therapy for diabetes mellitus-induced erectile dysfunction. Andrologia 2014;46:479–86.
   PubMed Web of Science ®Google Scholar