3,593
Views
21
CrossRef citations to date
0
Altmetric
REVIEW

Applications of nanoparticle systems in gene delivery and gene therapy

, , , &
Pages 581-587 | Received 07 Sep 2014, Accepted 29 Sep 2014, Published online: 03 Nov 2014

References

  • Abdallah B, Hassan A, Benoist C, Goula D, Behr JP, Demeneix BA. 1996. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther. 7:1947–1954.
  • Akiyoshi K, Kobayashi S, Shichibe S, Mix D, Baudys M, Kim SW, Sunamoto J. 1998. Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin. J Control Release. 54:313–320.
  • Almeida AJ, Souto E. 2007. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev. 59:478–490.
  • Anajwala CC, Jani GK, Swamy SV. 2010. Current trends of nanotechnology for cancer therapy. Int J Pharm Sci Nanotechnol. 3: 1043–1056.
  • Bangham A, Horne R. 1964. Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. J Mol Biol. 8:660–IN10.
  • Bengali Z, Pannier AK, Segura T, Anderson BC, Jang JH, Mustoe TA, Shea LD. 2005. Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol Bioeng. 90:290–302.
  • Brem H, Gabikian P. 2001. Biodegradable polymer implants to treat brain tumors. J Control Release. 74:63–67.
  • Burke RS, Pun SH. 2008. Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver. Bioconjug Chem. 19:693–704.
  • Caplan AI. 2005. Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng. 11:1198–1211.
  • Chen PC, Mwakwari SC, Oyelere AK. 2008. Gold nanoparticles: from nanomedicine to nanosensing. Nanotechnol Sci Appl. 1:45.
  • Choi YH, Liu F, Choi JS, Kim SW, Park JS. 1999. Characterization of a targeted gene carrier, lactose-polyethylene glycol-grafted poly-L-lysine, and its complex with plasmid DNA. Hum Gene Ther. 10:2657–2665.
  • Coll JL, Chollet P, Brambilla E, Desplanques D, Behr JP, Favrot M. 1999. In vivo delivery to tumors of DNA complexed with linear polyethylenimine. Hum Gene Ther. 10:1659–1666.
  • Dang JM, Leong KW. 2006. Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev. 58:487–499.
  • Daniel M-C, Astruc D. 2004. Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev. 104:293–346.
  • Eldem T, Speiser P, Hincal A. 1991. Optimization of spray-dried and-congealed lipid micropellets and characterization of their surface morphology by scanning electron microscopy. Pharm Res. 8:47–54.
  • Eliyahu H, Barenholz Y, Domb A. 2005. Polymers for DNA delivery. Molecules. 10:34–64.
  • Ensign LM, Cone R, Hanes J. 2012. Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliv Rev. 64:557–570.
  • Fahr A, Liu X. 2007. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv. 4:403–416.
  • Fajac I, Allo JC, Souil E, Merten M, Pichon C, Figarella C, et al. 2000. Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells. J Gene Med. 2:368–378.
  • Ferrari S, Moro E, Pettenazzo A, Behr JP, Zacchello F, Scarpa M. 1997. ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther. 4:1100–1106.
  • Fischer M, Vögtle F. 1999. Dendrimers: from design to application—a progress report. Angew Chem Int Ed. 38:884–905.
  • Frechet JM. 1994. Functional polymers and dendrimers: reactivity, molecular architecture, and interfacial energy. Science. 263: 1710–1715.
  • Gasco MR. 1993. Method for producing solid lipid microspheres having a narrow size distribution. Google Patents.
  • Ghosh P, Han G, De M, Kim CK, Rotello VM. 2008. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 60:1307–1315.
  • Glover DJ, Lipps HJ, Jans DA. 2005. Towards safe, non-viral therapeutic gene expression in humans. Nat Rev Genet. 6:299–310.
  • Gyawali D, Palmer M, Tran RT, Yang I. 2012. for Theranostic Systems. Biomedical Materials and Diagnostic Devices, p. 435.
  • Han G, Martin CT, Rotello VM. 2006. Stability of gold nanoparticle‐bound DNA toward biological, physical, and chemical agents. Chem Biol Drug Des. 67:78–82.
  • Han S-o, Mahato RI, Sung YK, Kim SW. 2000. Development of biomaterials for gene therapy. Mol Ther. 2:302–317.
  • Harada-Shiba M, Yamauchi K, Harada A, Takamisawa I, Shimokado K, Kataoka K. 2002. Polyion complex micelles as vectors in gene therapy–pharmacokinetics and in vivo gene transfer. Gene Ther. 9:407–414.
  • Hawker CJ, Frechet JM. 1992. Unusual macromolecular architectures: The convergent growth approach to dendritic polyesters and novel block copolymers. J Am Chem Soc. 114:8405–8413.
  • Jeong JH, Kim SW, Park TG. 2007. Molecular design of functional polymers for gene therapy. Prog Polym Sci. 32:1239–1274.
  • Jin R, Wu G, Li Z, Mirkin CA, Schatz GC. 2003. What controls the melting properties of DNA-linked gold nanoparticle assemblies? J Am Chem Soc. 125:1643–1654.
  • Jin S, Leach JC, Ye K. 2009. Nanoparticle-mediated gene delivery In: Lee IW, Foote RS, Eds. Micro and Nano Technologies in Bioanalysis. Berlin: Springer, pp. 547–557.
  • Jores K, Haberland A, Wartewig S, Mäder K, Mehnert W. 2005. Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and Raman spectroscopy. Pharm Res. 22: 1887–1897.
  • Junghans M, Kreuter J, Zimmer A. 2000. Antisense delivery using protamine–oligonucleotide particles. Nucleic Acids Res. 28: e45–e45.
  • Kakkar V, Singh S, Singla D, Kaur IP. 2011. Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol Nutr Food Res. 55:495–503.
  • Kasyanenko N, Lysyakova LA, Dribinskii BA, Zolotova YuI, Nazarova OV, Panarin EF. 2012. DNA-polymer complexes for gene therapy. Polym Sci Ser C. 54:57–68.
  • Kaul G, Amiji M. 2005. Cellular interactions and in vitro DNA transfection studies with poly (ethylene glycol)‐modified gelatin nanoparticles. J Pharm Sci. 94:184–198.
  • Kaul G. 2005. Amiji M. Tumor-targeted gene delivery using poly (ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies. Pharm Res. 22:951–961.
  • Kievit FM, Veiseh O, Bhattarai N, Fang C, Gunn JW, Lee D, et al. 2009. PEI–PEG–chitosan‐copolymer‐coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection. Adv Funct Mater. 19:2244–2251.
  • Kim WJ, Yockman JW, Lee M, Jeong JH, Kim YH, Kim SW. 2005. Soluble Flt-1 gene delivery using PEI- g-PEG-RGD conjugate for anti-angiogenesis. J Control Release. 106:224–234.
  • Klajnert B. Bryszewska M. 2000. Dendrimers: properties and applications. Acta Biochim Polonica. 48:199–208.
  • Kneuer C, Sameti M, Bakowsky U, Schiestel T, Schirra H, Schmidt H, Lehr CM. 2000a. A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug Chem. 11:926–932.
  • Kneuer C, Sameti M, Haltner EG, Schiestel T, Schirra H, Schmidt H, Lehr CM. 2000b. Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA. Int J Pharm. 196:257–261.
  • Knowles MR, Hohneker KW, Zhou Z, Olsen JC, Noah TL, Hu PC, et al. 1995. A controlled study of adenoviral-vector–mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med. 333:823–831.
  • Krebs MD, Salter E, Chen E, Sutter KA, Alsberg E. 2010. Calcium phosphate‐DNA nanoparticle gene delivery from alginate hydrogels induces in vivo osteogenesis. J Biomed Mater Res Part A. 92:1131–1138.
  • Lai SK, Wang Y-Y, Hanes J. 2009. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 61:158–171.
  • Ledley FD. 1996. Pharmaceutical approach to somatic gene therapy. Pharm Res. 13:1595–1614.
  • Lee M, Kim SW. 2005. Polyethylene glycol-conjugated copolymers for plasmid DNA delivery. Pharm Res. 22:1–10.
  • Lucas P, Milroy DA, Thomas BJ, Moss SH, Pouton CW. 1999. Pharmaceutical and biological properties of poly (amino acid)/DNA polyplexes. J Drug Target. 7:143–156.
  • Ma Y, Kolotuchin SV, Zimmerman SC. 2002. Supramolecular Polymer Chemistry: Self-Assembling Dendrimers Using the DDA⊙ AAD (GC-like) Hydrogen Bonding Motif. J Am Chem Soc. 124: 13757–13769.
  • Malafaya PB, Silva GA, Reis RL. 2007. Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev. 59:207–233.
  • McIntosh CM, Esposito EA III3rd, Boal AK, Simard JM, Martin CT, Rotello VM. 2001. Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters. J Am Chem Soc. 123: 7626–7629.
  • Mehnert W, Mäder K. 2001. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 47: 165–196.
  • Melo LG, Pachori AS, Kong D, Gnecchi M, Wang K, Pratt RE, Dzau VJ. 2004. Gene and cell-based therapies for heart disease. FASEB J. 18:648–663.
  • Merdan T, Kunath K, Fischer D, Kopecek J, Kissel T. 2002. Intracellular processing of poly (ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments. Pharm Res. 19:140–146.
  • Mirkin CA, Letsinger RL, Mucic RC, Storhoff JJ. 1996. A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature. 382:607–609.
  • Mourey TH, Turner SR, Rubinstein M, Frechet JMJ, Hawker CJ, Wooley KL. 1992. Unique behavior of dendritic macromolecules: intrinsic viscosity of polyether dendrimers. Macromolecules. 25:2401–2406.
  • Müller R, Maaen S, Weyhers H, Specht F, Lucks JS. 1996. Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles. Int J Pharm. 138:85–94.
  • Müller RH, Mäder K, Gohla S. 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. Eur J Pharm Biopharm. 50:161–177.
  • Ogris M, Brunner S, Schüller S, Kircheis R, Wagner E. 1999. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6:595–605.
  • Panyam J, Labhasetwar V. 2003. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev. 55:329–347.
  • Park TG, Jeong JH, Kim SW. 2006. Current status of polymeric gene delivery systems. Adv Drug Deliv Rev. 58:467–486.
  • Partridge KA, Oreffo RO. 2004. Gene delivery in bone tissue engineering: progress and prospects using viral and nonviral strategies. Tissue Eng. 10:295–307.
  • Petersen H, Fechner PM, Martin AL, Kunath K, Stolnik S, Roberts CJ. 2002. Polyethylenimine-graft-poly (ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. Bioconjug Chem. 13:845–854.
  • Phillips SC. 1995. Receptor-mediated DNA delivery approaches to human gene therapy. Biologicals. 23:13–16.
  • Pissuwan D, Niidome T, Cortie MB. 2011. The forthcoming applications of gold nanoparticles in drug and gene delivery systems. J Control Release. 149:65–71.
  • Rosenberg SA, Aebersold P, Cornetta K, Kasid A, Morgan RA, Moen R, et al. 1990. Gene transfer into humans—immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med. 323: 570–578.
  • Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AK, Han MS, Mirkin CA. 2006. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science. 312:1027–1030.
  • Sandhu KK, McIntosh CM, Simard JM, Smith SW, Rotello VM. 2002. Gold nanoparticle-mediated transfection of mammalian cells. Bioconjug Chem. 13:3–6.
  • Schaffert D, Wagner E. 2008. Gene therapy progress and prospects: synthetic polymer-based systems. Gene Ther. 15:1131–1138.
  • Schmidt P. 1997. Pharmazeutische Technologie: Moderne Arzneiformen. Lehrbuch für Studierende der Pharmazie, Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung. Von RH Müller und GE Hildebrand. 348 Seiten, 117 Abbildungen, 57 Tabellen. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart 1997. DM 64,‐, ISBN 3‐8047‐1504‐4. Pharm Unserer Zeit. 26:323–323.
  • Schwarz C, Mehnert W, Lucks JS, Müller RH. 1994. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J Control Release. 30: 83–96.
  • Smith A. 1986. Evaluation of poly (lactic acid) as a biodegradable drug delivery system for parenteral administration. Int J Pharm. 30: 215–220.
  • Suh W, Han SO, Yu L, Kim SW. 2002. An angiogenic, endothelial-cell-targeted polymeric gene carrier. Mol Ther. 6:664–672.
  • Thomas M, Klibanov AM. 2003. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci. 100:9138–9143.
  • Westesen K, Siekmann B. 1997. Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles. Int J Pharm. 151:35–45.
  • Wightman L, Kircheis R, Rössler V, Carotta S, Ruzicka R, Kursa M, Wagner E. 2001. Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J Gene Med. 3:362–372.
  • Wissing S, Kayser O, Müller R. 2004. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev. 56:1257–1272.
  • Wivel NA, Wilson JM. 1998. Methods of gene delivery. Hematol Oncol Clin North Am. 12:483–501.
  • Wolfert MA, Dash PR, Nazarova O, Oupicky D, Seymour LW, Smart S, et al. 1999. Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA. Bioconjug Chem. 10:993–1004.
  • Xiao Y, Qian H, Young WG, Bartold PM. 2003. Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Eng. 9:1167–1177.
  • Yang S, Leong KF, Du Z, Chua CK. 2001. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng. 7:679–689.
  • Yin Y, Alivisatos AP. 2004. Colloidal nanocrystal synthesis and the organic–inorganic interface. Nature. 437:664–670.
  • zur Mühlen A, Schwarz C, Mehnert W. 1998. Solid lipid nanoparticles (SLN) for controlled drug delivery–drug release and release mechanism. Eur J Pharm Biopharm. 45:149–155.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.