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ORIGINAL ARTICLE

Effects of titanium dioxide nanoparticles on α-synuclein aggregation and the ubiquitin-proteasome system in dopaminergic neurons

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Pages 690-694 | Received 09 Oct 2014, Accepted 21 Oct 2014, Published online: 11 Nov 2014

References

  • Auluck PK, Caraveo G, Lindquist S. 2010. α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol. 26:211–233.
  • Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, et al. 2004. α-Synuclein locus duplication as a cause of familial Parkinson's disease. Lancet. 364:1167–1169.
  • Ebrahimi-Fakhari D, Cantuti-Castelvetri I, Fan Z, Rockenstein E, Masliah E, Hyman BT, et al. 2011. Distinct roles in vivo for the ubiquitin–proteasome system and the autophagy–lysosomal pathway in the degradation of α-synuclein. J Neurosci. 31: 14508–14520.
  • Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, et al. 2006. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 114: 1172–1178.
  • Esteve-Rudd, J, Campello, L, Herrero, MT, Cuenca, N, & Martín-Nieto, J. 2010. Expression in the mammalian retina of parkin and UCH-L1, two components of the ubiquitin-proteasome system. Brain Res. 1352:70–82.
  • Hastings TG. 2009. The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease. J Bioenerg Biomembr. 41:469–472.
  • Li JJ, Hartono D, Ong CN, Bay BH, Yung LY. 2010. Autophagy and oxidative stress associated with gold nanoparticles. Biomaterials. 31:5996–6003.
  • Nel A, Xia T, Mädler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science. 311:622–627.
  • Pan Y, Leifert A, Ruau D, Neuss S, Bornemann J, Schmid G, et al. 2009. Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage. Small. 5:2067–2076.
  • Petrucelli L, Dawson TM. 2004. Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system. Ann Med. 36:315–320.
  • Pisanic TR II, Blackwell JD, Shubayev VI, Fiñones RR, Jin S. 2007. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials. 28:2572–2581.
  • Rakovic A, Grünewald A, Kottwitz J, Brüggemann N, Pramstaller PP, Lohmann K, Klein C. 2011. Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One. 6:e16746.
  • Reynolds AD, Glanzer JG, Kadiu I, Ricardo-Dukelow M, Chaudhuri A, et al. 2008. Nitrated alpha‐synuclein‐activated microglial profiling for Parkinson's disease. J Neurochem. 104: 1504–1525.
  • Shang F, Taylor A. 2011. Ubiquitin–proteasome pathway and cellular responses to oxidative stress. Free Radic Biol Med. 51: 5–16.
  • Trojanowski JQ, Lee VM. 1998. Aggregation of neurofilament and α-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia. Arch Neurol. 55:151–152.
  • Uversky VN. 2007. α-Synuclein Aggregation and Parkinson's Disease. Protein Misfolding, Aggregation, and Conformational Diseases. Springer US, 61–110.
  • Wu J, Sun J, Xue Y. 2010. Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells. Toxicol Lett. 199:269–276.
  • Wu J, Wang C, Sun J, Xue Y. 2011. Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways. ACS Nano. 5:4476–4489.

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