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Original Articles

Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

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Pages 297-304 | Received 31 Dec 2015, Accepted 22 Jan 2016, Published online: 28 Feb 2016

References

  • Aggarwal BB, Kumar A, Bharti AC. 2003. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 23:363–398.
  • Aggarwal BB, Sundaram C, Malani N, Ichikawa H. 2007. Curcumin: the Indian solid gold. Adv Exp Med Biol. 595:1–75.
  • Aggarwal BB, Sung B. 2009. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 30:85–94.
  • Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. 2007. Bioavailability of curcumin: problems and promises. Mol Pharm. 4:807–818.
  • Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB. 2010. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol. 79:330–338.
  • Anitha A, Deepa N, Chennazhi KP, Lakshmanan VK, Jayakumar R. 2014. Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment. Biochim Biophys Acta. 1840:2730–2743.
  • Bansal SS, Goel M, Aqil F, Vadhanam MV, Gupta RC. 2011. Advanced drug delivery systems of curcumin for cancer chemoprevention. Cancer Prev Res (Phila). 4:1158–1171.
  • Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, et al. 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21:2895–2900.
  • Dewar AM, Clark RA, Singer AJ, Frame MD. 2011. Curcumin mediates both dilation and constriction of peripheral arterioles via adrenergic receptors. J Invest Dermatol. 131:1754–1760.
  • Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, et al. 2008. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res. 14:4491–4499.
  • Dhule SS, Penfornis P, Frazier T, Walker R, Feldman J, Tan G, et al. 2012. Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma. Nanomedicine. 8:440–451.
  • Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glockner-Pagel J, et al. 2004. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science. 304:600–602.
  • Fang XD, Yang F, Zhu L, Shen YL, Wang LL, Chen YY. 2009. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 36:1177–1182.
  • Gao W, Bian Y, Chang TMS. 2013. Novel nanodimension artificial red blood cells that act as O2 and CO2 carrier with enhanced antioxidant activity: PLA-PEG nanoencapsulated polySFHb-superoxide dismutase-catalase-carbonic anhydrase. Artif Cells Nanomed Biotechnol. 41:232–239.
  • Gao X, Zheng F, Guo G, Liu X, Fan R, Qian Z, et al. 2013. Improving the anti-colon cancer activity of curcumin with biodegradable nano-micelles. J Mater Chem B. 1:5778–5790.
  • Goel A, Kunnumakkara AB, Aggarwal BB. 2008. Curcumin as “Curecumin: from kitchen to clinic. Biochem Pharmacol. 75:787–809.
  • Gref R, Luck M, Quellec P, Marchand M, Dellacherie E, Harnisch S, Blunk T, Muller RH. 2000. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B Biointerfaces. 18:301–313.
  • Krausz AE, Adler BL, Cabral V, Navati M, Doerner J, Charafeddine RA, et al. 2015. Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine. 11:195–206.
  • Kumar SS, Mahesh A, Mahadevan S, Mandal AB. 2014. Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. Biochim Biophys Acta. 1840:1913–1922.
  • Kurien BT, Singh A, Matsumoto H, Scofield RH. 2007. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol. 5:567–576.
  • Lao CD, Ruffin MTT, Normolle D, Heath DD, Murray SI, Bailey JM, et al. 2006. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 6:10.
  • Ma Z, Haddadi A, Molavi O, Lavasanifar A, Lai R, Samuel J. 2008. Micelles of poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed Mater Res A. 86:300–310.
  • Meng FT, Ma GH, Qiu W, Su ZG. 2003. W/O/W double emulsion technique using ethyl acetate as organic solvent: effects of its diffusion rate on the characteristics of microparticles. J Control Rel. 91:407–416.
  • Mirakabad FST, Akbarzadeh A, Milani M, Zarghami N, Taheri-Anganeh M, Zeighamian V, Badrzadeh F, Rahmati-Yamchi M. 2016. A Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line. Artif Cells Nanomed Biotechnol. 44:423–430.
  • Mohanty C, Acharya S, Mohanty AK, Dilnawaz F, Sahoo SK. 2010. Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy. Nanomedicine (Lond). 5:433–449.
  • Narayanan A, Kehn-Hall K, Senina S, Lundberg L, Van Duyne R, Guendel I, et al. 2014. Curcumin inhibits Rift Valley fever virus replication in human cells. J Biol Chem. 287:33198–33214.
  • Nurullahoglu-Atalik KE, Okudan N, Belviranli M, Gokbel H, Simsek L. 2012. Curcumin increases vasodilatory effect of cilostazol in diabetic rat aorta. Indian J Exp Biol. 50:128–132.
  • Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S. 2010. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med. 10:57.
  • Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, et al. 2004. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 10:6847–6854.
  • Shi M, Cai Q, Yao L, Mao Y, Ming Y, Ouyang G. 2006. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol Int. 30:221–226.
  • Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. 2002. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res. 62:3868–3875.
  • Song Q, Wang X, Hu Q, Huang M, Yao L, Qi H, et al. 2013. Cellular internalization pathway and transcellular transport of pegylated polyester nanoparticles in Caco-2 cells. Int J Pharm. 445:58–68.
  • Thu HP, Quang DT, Trang MTT, Ha TTH, Nam NH, Phuc NX, et al. 2013. Vitro apoptosis enhancement of Hep-G2 cells by PLA–TPGS and PLA–PEG block copolymer encapsulated curcumin nanoparticles. Chem Lett. 42:255–257.
  • Tian B, Wang Z, Zhao Y, Wang D, Li Y, Ma L, et al. 2008. Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model. Cancer Lett. 264:299–308.
  • Tiyaboonchai W, Tungpradit W, Plianbangchang P. 2007. Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. Int J Pharm. 337:299–306.
  • Tonnesen HH, Karlsen J. 1985. Studies on curcumin and curcuminoids. VI. Kinetics of curcumin degradation in aqueous solution. Z Lebensm Unters Forsch. 180:402–404.
  • Vila A, Gill H, McCallion O, Alonso MJ. 2004. Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density. J Control Rel. 98:231–244.
  • Xia H, Gao X, Gu G, Liu Z, Hu Q, Tu Y, et al. 2012. Penetratin-functionalized PEG-PLA nanoparticles for brain drug delivery. Int J Pharm. 436:840–850.
  • Yang C, Chen H, Zhao J, Pang X, Xi Y, Zhai G. 2014. Development of a folate-modified curcumin loaded micelle delivery system for cancer targeting. Colloids Surf B Biointerfaces. 121:206–213.

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