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REVIEW ARTICLE

Exposure to ototoxic agents and hearing loss: A review of current knowledge

, , , , , & show all
Pages 166-175 | Accepted 09 Sep 2014, Published online: 07 Oct 2014

References

  • Martines F, Maira E, Ferrara S. Age related hearing impairment (ARHI): a common sensory deficit in the elderly. Acta Medica Mediterr. 2011;27:47–52.
  • Martines F, Dispenza F, Gagliardo C, Martines E, Bentivegna D. Sudden sensorineural hearing loss as prodromal symptom of anterior inferior cerebellar artery infarction. ORL. 2011;73:137–40.
  • Martines F, Bentivegna D, Martines E, Sciacca V, Martinciglio G. Assessing audiological, pathophysiological and psychological variables in tinnitus patients with or without hearing loss. Eur Arch Otorhinolaryngol. 2010; 267:1685–93.
  • Martines F, Bentivegna D, Martines E, Sciacca V, Martinciglio G. Characteristics of tinnitus with or without hearing loss: clinical observations in Sicilian tinnitus patients . Auris Nasus Larynx. 2010;37:685–93.
  • Martines F, Pangaro A, Martines E. Ménière's disease and neurovascular cross-compression: case report. Otorinolaringologia. 2009;59:65–70.
  • Henderson D, Bielefeld EC, Harris KC, Hu B. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006;27:1–19.
  • Chen GD, Chi LH, Kostyniak PJ, Henderson D. Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss. Toxicol Sci. 2007;98:167–77.
  • McNeil PL. Cellular and molecular adaptations to injurious mechanical stress. Trends Cell Biol. 1993;3:302–7.
  • Waters C. Molecular mechanisms of cell death in the ear. Ann N Y Acad Sci. 1999;884:41–51.
  • Hutchin T, Cortopassi G. Proposed molecular and cellular mechanism for aminoglycoside ototoxicity. Antimicrob Agents Chemother. 1994;38:2517–20.
  • Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res. 2007;226:157–67.
  • Hadi U, Nuwayhid N, Hasbini AS. Chloroquine ototoxicity: an idiosyncratic phenomenon. Otolaryngol Head Neck Surg. 1996;114:491–3.
  • Jiang H, Sha SH, Forge A, Schacht J. Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death Differ. 2006;13:20–30.
  • Ohlemiller KK, Wright JS, Dugan LL. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol. 1999;4:229–36.
  • Suzuki M, Yamasoba T, Ishibashi T, Miller JM, Kaga K. Effect of noise exposure on blood-labyrinth barrier in guinea pigs. Hear Res. 2002;164:12–8.
  • Henderson, DH, Hu B, Bielefeld EC. Patterns and mechanisms of noise induced cochlear pathology. In: Schacht TS, Popper AN, Fay RR, editors. Auditory trauma, protection and repair. New York: Springer; 2008. p. 195–217.
  • Cannizzaro G, Cannizzaro C, Cannizzaro E, Gagliano M, Giammona G, Martire M, Provenzano G. Variabilità nella risposta ai farmaci. In: I. G., editor. Principi di Farmacologia Generale. Napoli, Italy: 2002. p. 93–107.
  • Annunziato L, Di Renzo G. Interazioni farmacologiche. In: I. G. , editor. Trattato di Farmacologia. Napoli, Italy: 2010. p. 145–55.
  • Mukherjea D, Rybak LPPharmacogenomics of cisplatin induced ototoxicity. Pharmacogenomics. 2011;12:1039–50.
  • Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, et al. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. Nat Genet. 2009;41:1345–9.
  • Riedemann L, Lanvers C, Deuster D, Peters U, Boos J, Jürgens H, et al. Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics. 2008;8:23–8.
  • Tang HY, Hutcheson E, Neill S, Drummond-Borg M, Speer M, Alford RL. Genetic susceptibility to aminoglycoside ototoxicity: how many are at risk? Genet Med. 2002;4:336–45.
  • Zimmerman E, Lahav A. Ototoxicity in preterm infants: effects of genetics, aminoglycosides, and loud environmental noise. J Perinatol. 2013;33:3–8.
  • Salvago P, Martines E, Martines F. Prevalence and risk factors for sensorineural hearing loss: Western Sicily overview. Eur Arch Otorhinolaryngol. 2013;270:3049–56.
  • Martines F, Martines E, Mucia M, Sciacca V, Salvago P. Prelingual sensorineural hearing loss and infants at risk: Western Sicily report. Int J Pediatr Otorhinolaryngol. 2013;77:513–8.
  • Tabuchi K, Nishimura B, Nakamagoe M, Hayashi K, Nakayama M, Hara A. Ototoxicity: mechanisms of cochlear impairment and its prevention. Curr Med Chem. 2011; 18:4866–71.
  • Arslan E, Orzan E, Santarelli R.Global problem of drug induced hearing loss. Ann N Y Acad Sci. 1999;884:1–14.
  • Marcotti W, van Netten SM, Kros CJ. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005;567:505–21.
  • Dulon D, Hiel H, Aurousseau C, Erre JP, Aran JM. Pharmacokinetics of gentamycin in the sensory hair cells of the organ of Corti: rapid uptake and long-term persistence. C R Acad Sci III. 1993;316:682–7.
  • Rybak LP, Ramkumar V. Ototoxicity. Kidney Int. 2007; 72:931–5.
  • Collins PW. Synergistic interactions of gentamycin and pure tones causing cochlear hair cell loss in pigmented guinea pigs. Hear Res. 1988;36:249–59.
  • Ryan AF, Bone RC. Non-simultaneous interaction of exposure to noise and kanamycin intoxication in the chinchilla. Am J Otolaryngol. 1982;3:264–72.
  • Xie J, Talaska AE, Schacht J. New developments in aminoglycoside therapy and ototoxicity. Hear Res. 2011; 281:28–37.
  • Martines F, Martinciglio G. VEMPs: clinical applications and personal experience. Otorinolaringologia. 2008;58: 137–40.
  • Hirose K, Hockenbery DM, Rubel EW. Reactive oxygen species in chick hair cells after gentamycin exposure in vitro. Hear Res. 1997;104:1–14.
  • Ward DT, McLarnon SJ, Riccardi D. Aminoglycosides increase intracellular calcium levels and ERK activity in proximal tubular OK cells expressing the extracellular calcium-sensing receptor. J Am Soc Nephrol. 2002;13:1481–9.
  • Forge A, Schacht J. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res. 2000;139:97–115.
  • Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 2000;103:239–52.
  • Chen Y, Huang WG, Zha DJ, Qiu JH, Wang JL, Sha SH, et al. Aspirin attenuates gentamycin ototoxicity: from the laboratory to the clinic. Hear Res. 2007;226:178–88.
  • Prezant TR, John V, Agapian JV, Bohlman MC, Bu X, Öztas S, et al. Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet. 1993;4:289–94.
  • Zhao H, Li R, Wang Q, Yan Q, Deng JH, Han D, et al. Maternally inherited aminoglycoside-induced and non- syndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese family. Am J Hum Genet. 2004;74:139–52.
  • Hobbie SN, Akshay S, Kalapala SK, Bruell CM, Shcherbakov D, Böttger EC. Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity. Proc Natl Acad Sci U S A. 2008;105:2088–93.
  • Tauris J, Christensen EI, Nykjaer A, Jacobsen C, Petersen CM, Ovesen T. Cubilin and megalin colocalize in the neonatal inner ear. Audiol Neurootol. 2009;14:267–78.
  • Bentivegna D, Salvago P, Agrifoglio M, Ballacchino A, Ferrara S, Mucia M, et al. The linkage between upper respiratory tract infections and otitis media: evidence of the ‘united airways’ concept. Acta Medica Mediterranea. 2012;28:287–90.
  • Martines F, Bentivegna D, Maira E, Sciacca V, Martines E. Risk factors for otitis media with effusion: case-control study in Sicilian schoolchildren. Int J Pediatr Otorhinolaryngol. 2011;75:754–9.
  • Martines F, Martinciglio G, Martines E, Bentivegna D. The role of atopy in otitis media with effusion among primary school children: audiological investigation. Eur Arch Otorhinolaryngol. 2010;267:1673–8.
  • Martines F, Martines E, Sciacca V, Bentivegna D. Otitis media with effusion with or without atopy: audiological findings in primary school children. Am J Otolaryngol. 2011;32:601–3.
  • Martines F, Bentivegna D. Audiological investigation of otitis media in children with atopy. Curr Allergy Asthma Rep. 2011;11:513–20.
  • Page F. Treatment of lupus erythematosus with mepacrine. The Lancet. 1951;2:755–8.
  • Johansen PB, Gran JT. Ototoxicity due to hydroxychloroquine: report of two cases. Clin Exp Rheumatol. 1998; 16:472–4.
  • Rynes RI. Anti-malarial drugs in the treatment of rheumatological diseases. Br J Rheumatol. 1997;36:799–805.
  • Scherbel AL, Harrison JW, Atdjian M. Further observations on the use of 4-aminoquinoline compounds in patients with rheumatoid arthritis or related diseases. Cleve Clin Q. 1958;25:95–111.
  • Nielsen-Abbring FW, Perenboom RM, van der Hulst RJ. Quinine-induced hearing loss. ORL J Otorhinolaryngol Relat Spec. 1990;52:65–8.
  • Bortoli R, Santiago M. Chloroquine ototoxicity. Clin Rheumatol. 2007;26:1809–10.
  • Gonçalves MS, Silveira AF, Teixeira AR, Hyppolito MA.Mechanisms of cisplatin ototoxicity: theoretical review. J Laryngol Otol. 2013;127:536–41.
  • Bokemeyer C, Berger CC, Hartmann JT, Kollmannsberger C, Schmoll HJ, Kuczyk MA, et al. Analysis of risk factors for cisplatin induced ototoxicity in patients with testicular cancer. Br J Cancer. 1998;77:1355–62.
  • Rybak LP, Mukherjea D, Jajoo S, Ramkumar V. Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J Exp Med. 2009;219:177–86.
  • Oishi N, Talaska AE, Schacht J. Ototoxicity in dogs and cats. Vet Clin North Am Small Anim Pract. 2012;42:1259–71.
  • Yildirim M, Inançli HM, Samanci B, Oktay MF, Enöz M, Topçu I. Preventing cisplatin induced ototoxicity by N-acetylcysteine and salicylate. Kulak Burun Bogaz Ihtis Derg. 2010;20:173–83.
  • Greenlee H, Hershman DL, Jacobson JS. Use of antioxidant supplements during breast cancer treatment: a comprehensive review. Breast Cancer Res Treat. 2009;115:437–52.
  • Oldenburg J, Kraggerud SM, Cvancarova M, Lothe RA, Fossa SD. Cisplatin induced long-term hearing impairment is associated with specific glutathione S-transferase genotypes in testicular cancer survivors. J Clin Oncol. 2007; 25:708–14.
  • Rais-Bahrami K, Majd M, Veszelovszky E, Short BL. Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004;21:329–32.
  • Abbasi AH, Ramadan R, Hoffman A, Abassi Z. Kidney-ear axis. Isr Med Assoc J. 2007;9:814–8.
  • Johnson AC. Auditory sensitivity in rats exposed to toluene and/or acetyl salicylic acid. Neuroreport. 1992;3:1141–4.
  • Cazals Y. Auditory sensorineural alterations induced by salicylate. Prog Neurobiol. 2000;62:583–631.
  • Johnson AC, Morata TC. Occupational exposure to chemicals and hearing impairment. The Nordic Expert Group for Criteria Documentation of Health Risks of Chemicals. Arbete och Hälsa. 2010;44:1–177.
  • Lataye R, Campo P, Pouyatos B, Cossec B, Blachère V, Morel G. Solvent ototoxicity in the rat and guinea pig. Neurotoxicol Teratol. 2003;25:39–50.
  • Gagnaire F, Marignac B, Blachère V, Grossmann S, Langlais C. The role of toxicokinetics in xylene induced ototoxicity in the rat and guinea pig. Toxicology. 2007; 231:147–58.
  • Hoet P, Lison D. Ototoxicity of toluene and styrene: state of current knowledge. Crit Rev Toxicol. 2008;38:127–70.
  • Lataye R, Campo P, Loquet G. Combined effects of noise and styrene exposure on hearing function in the rat. Hear Res. 2000;139:86–96.
  • Cappaert NL, Klis SF, Muijser H, Kulig BM, Smoorenburg GF. Simultaneous exposure to ethyl benzene and noise: synergistic effects on outer hair cells. Hear Res. 2001;162: 67–79.
  • Kopke R, Allen KA, Henderson D, Hoffer M, Frenz D, van de Water T. A radical demise. Toxins and trauma share common pathways in hair cell death. Ann N Y Acad Sci. 1999;884:171–91.
  • Fechter LD, Cheng GD, Rao D. Characterizing conditions that favour potentiation of noise induced hearing loss by chemical asphyxiants. Noise Health. 2000;3:11–21.
  • Muijser H, Lammers JH, Kullig BM. Effects of exposure to trichloroethylene and noise on hearing in rats. Noise Health. 2000;2:57–66.
  • Fechter LD, Chen GD, Rao D. Chemical Asphyxiants and Noise. Noise Health. 2002;4:49–61.
  • Lund SP, Kristiansen GB. Hazards to hearing from combined exposure to toluene and noise in rats. Int J Occup Med Environ Health. 2008;21:47–57.
  • Fechter LD, Klis SF, Shirwany NA, Moore TG, Rao DB. Acrylonitrile produces transient cochlear function loss and potentiates permanent noise-induced hearing loss. Toxicol Sci. 2003;75:117–23.
  • Pouyatos B, Gearhart CA, Fechter LD. Acrylonitrile potentiates hearing loss and cochlear damage induced by moderate noise exposure in rats. Toxicol Appl Pharmacol. 2005;204:46–56.
  • Vyskocil A, Truchon G, Leroux T, Lemay F, Gendron M, Gagnon F, et al. A weight of evidence approach for the assessment of the ototoxic potential of industrial chemicals. Toxicol Ind Health. 2012;28:796–819.
  • Morata TC. Chemical exposure as a risk factor for hearing loss. J Occup Environ Med. 2003;45:676–82.
  • Crawford JM, Hoppin JA, Alavanja MC, Blair A, Sandler DP, Kamel F. Hearing loss among licensed pesticide applicators in the agricultural health study. J Occup Environ Med. 2008;50:817–26.
  • Vyskocil A, Truchon G, Leroux T, Lemay F, Gendron M, Gagnon F, et al. A weight of evidence approach for the assessment of the ototoxic potential of industrial chemicals. Toxicol Ind Health. 2012;28:796–819.
  • Rabinowitz PM, Sircar KD, Tarabar S, Galusha D, Slade MD. Hearing loss in migrant agricultural workers. J Agromedicine. 2005;10:9–17.
  • Chang SJ, Chen CJ, Lien CH, Sung FC. Hearing loss in workers exposed to toluene and noise. Environ Health Perspect. 2006;114:1283–6.
  • Burr H, Lund SP, Sperling BB, Kristensen TS, Poulsen OM. Smoking and height as risk factors for prevalence and five-year incidence of hearing loss. A questionnaire based follow-up study of employees in Denmark aged 18–59 years exposed and unexposed to noise. Int J Audiol. 2005; 44:531–9.
  • Osman K, Pawlas K, Schütz A, Gazdzik M, Sokal JA, Vahter M. Lead exposure and hearing effects in children in Katowice, Poland. Environ Res. 1999;80:1–8.
  • Abbate C, Giorgianni C, Munaò F, Brecciaroli R. Neurotoxicity induced by exposure to toluene. An electrophysiologic study. Int Arch Occup Environ Health. 1993; 64:389–92.
  • Fuente A, McPherson B. Central auditory processing effects induced by solvent exposure. Int J Occup Med Environ Health. 2007;20;271–9.
  • Campo P, Maguin K, Lataye R. Effects of aromatic solvents on acoustic reflexes mediated by central auditory pathways. Toxicol Sci. 2007;99:582–90.
  • Otto DA, Fox DA. Auditory and visual dysfunction following lead exposure. Neurotoxicology. 1993;14:191–207.
  • Discalzi G, Fabbro D, Meliga F, Mocellini A, Capellaro F.Effects of occupational exposure to mercury and lead on brainstem auditory evoked potentials. Int J Psychophysiol. 1993;14:21–5.
  • Evans P, Halliwell B. Free radicals and hearing. Cause, consequence, and criteria. Ann N Y Acad Sci. 1999;884: 19–40.
  • Rao DB, Moore DR, Reinke LA, Fechter LD. Free radical generation in the cochlea during combined exposure to noise and carbon monoxide: an electrophysiological and an EPR study. Hear Res. 2001;161:113–22.
  • Fechter LD, Gearhart C, Fulton S, Campbell J, Fisher J, Na K, et al. Promotion of noise induced cochlear injury by toluene and ethyl benzene in the rat. Toxicol Sci. 2007;98:542–51.
  • Fechter LD, Gearhart C, Fulton S, Campbell J, Fisher J, Na K, et al. JP-8 jet fuel can promote auditory impairment resulting from subsequent noise exposure in rats. Toxicol Sci. 2007;98;510–25.
  • Toppila E, Pyykkö I, Starck J, Kaksonen R, Ishizaki H. Individual risk factors in the development of noise induced hearing loss. Noise Health. 2000;2:59–70.
  • Davis RR, Murphy WJ, Snawder JE, Striley CA, Henderson D, Khan A, et al.Susceptibility to the ototoxic properties of toluene is species specific. Hear Res. 2002; 166:24–32.
  • Szanto C, Ionesco M. Influence of age and gender on hearing threshold levels in workers exposed to different intensity levels of occupational noise. Audiology. 1983; 22:339–56.
  • Kujawa SG, Liberman MC. Acceleration of age related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci. 2006;26:2115–23.
  • Mizoue T, Miyamoto T, Shimizu T. Combined effect of smoking and occupational exposure to noise on hearing loss in steel factory workers. Occup Environ Med. 2003;60:56–9.
  • Bohne BA, Harding GW, Lee SC. Death pathways in noise-damaged outer hair cells. Hear Res. 2007;223:61–70.
  • Fridberger A, Flock, Ulfendahl M, Flock B. Acoustic overstimulation increases outer hair cell Ca+ concentration and causes dynamic contraction of the hearing organ. Proc Natl Acad Sci U S A. 1998;95:7127–32.

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