Effects of ORL1 Receptor Agonists and Antagonists in Nociception

REFERENCES

• Abdulla FA, Smith PA (1998). Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. J Neurosci 18:9685–9694.
   PubMed Web of Science ®Google Scholar
• Andoh T, Itoh M, Kuraishi Y (1997). Nociceptin gene expression in rat dorsal root ganglia induced by peripheral inflammation. NeuroReport 8:2793–2796.
   PubMed Web of Science ®Google Scholar
• Becker JA, Wallace A, Garzon A, Ingallinella P, Bianchi E, Cortese R, Simonin F, Kieffer BL, Pessi A (1999). Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library. JBiol Chem274(39): 27513–27522.
   Google Scholar
• Berger H, Calo’ G, Albrecht E, Guerrini R, Bienert M (2000). [Nphe(1)]NC(1-13)NH(2) selectively antagonizes nociceptin/orphanin FQ-stimulated G-protein activation in rat brain. J Pharmacol Exp Ther 294(2): 428–433.
   PubMed Web of Science ®Google Scholar
• Bertorelli R, Bastia E, Citterio F, Corradini L, Forlani A, Ongini E (2002). Lack of the nociceptin receptor does not affect acute or chronic nociception in mice. Peptides 23(9):1589–1596.
   PubMed Web of Science ®Google Scholar
• Bertorelli R, Corradini L, Rafiq K, Tupper J, Calo G, Ongini E (1999). Nociceptin and the ORL-1 ligand [Phe1psi (CH2-NH)Gly2]nociceptin(1-13)NH2 exert anti-opioid effects in the Freund’s adjuvant-induced arthritic rat model of chronic pain. Br J Pharmacol 128(6):1252–1258.
   PubMed Web of Science ®Google Scholar
• Bigoni R, Giuliani S, Calo’ G, Rizzi A, Guerrini R, Salvadori S, Regoli D, Maggi CA (1999). Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies. Naunyn Schmiedebergs Arch Pharmacol 359:160–167.
   PubMed Web of Science ®Google Scholar
• Bigoni R, Rizzi A, Rizzi D, Becker JA, Kieffer BL, Simonin F, Regoli D, Calo G (2000). In vitro pharmacological profile of peptide III-BTD: a novel ligand for nociceptin/orphanin FQ and opioid receptors. Life Sci 68(2):233–239.
   PubMed Web of Science ®Google Scholar
• Boom A, Mollereau C, Meunier JC, Vassart G, Parmentier M, Vanderhaeghen JJ, Schiffmann SN (1999). Distribution of the nociceptin and nocistatin precursor transcript in the mouse central nervous system. Neuroscience 91(3):991–1007.
   PubMed Web of Science ®Google Scholar
• Briscini L, Corradini L, Ongini E, Bertorelli R (2002). Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury. Eur J Pharmacol 447:59–65.
   PubMed Web of Science ®Google Scholar
• Calo’ G, Guerrini R, Bigoni R, Rizzi A, Marzola G, Okawa H, Bianchi C, Lambert DG, Salvadori S, Regoli D (2000a). Characterization of [Nphe(1)] nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br JPharmacol 129(6):1183–1193.
   PubMed Web of Science ®Google Scholar
• Calo’ G, Guerrini R, Rizzi A, Salvadori S, Regoli D (2000b). Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol 129(7): 1261–1283.
   PubMed Web of Science ®Google Scholar
• Calo G, Rizzi A, Marzola G, Guerrini R, Salvadori S, Beani L, Regoli D, Bianchi C (1998). Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay. Br J Pharmacol 125(2):373–378.
   PubMed Web of Science ®Google Scholar
• Candeletti S, Guerrini R, Calo G, Romualdi P, Ferri S (2000). Supraspinal and spinal effects of [Phe1psi (CH2-NH)Gly2]-nociceptin(1-13)-NH2 on nociception in the rat. Life Sci 66(3):257–264.
   PubMed Web of Science ®Google Scholar
• Chen LX, Wang ZZ, Wu H, Fang Q, Chen Y, Wang R. (2002). Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. Neurosci Lett 31(2): 95–98.
   Google Scholar
• Ciccocioppo R, Angeletti S, Sanna PP, Weiss F, Massi M (2000). Effect of nociceptin/orphanin FQ on the rewarding properties of morphine. Eur J Pharmacol 404(1-2):153-159.
   PubMed Web of Science ®Google Scholar
• Clarke S, Zimmer A, Zimmer AM, Hill RG, Kitchen I (2003). Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor- like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience 22(2): 479–489.
   Google Scholar
• Connor M, Vaughan CW, Chieng B, Christie MJ (1996). Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro. Br J Pharmacol 119(8):1614–1618.
   PubMed Web of Science ®Google Scholar
• Connor M, Vaughan CW, Jennings EA, Allen RG, Christie MJ (1999). Nociceptin, Phe(1)psi-nociceptin (1-13), nocistatin and prepronociceptin(154-181) effects on calcium channel currents and a potassium current in rat locus coeruleus in vitro. Br J Pharmacol 128(8):1779–1787.
   PubMed Web of Science ®Google Scholar
• Courteix C, Coudore-Civiale MA, Privat AM, Pelissier T, Eschalier A, Fialip J (2004). Evidence for an exclusive antinociceptive effect of nociceptin/orphanin FQ, an endogenous ligand for the ORL1 receptor, in two animal models of neuropathic pain. Pain 110(1-2): 236–245 Danielson PB, Dores RM (1999). Molecular evolution of the opioid/orphanin gene family. Gen Comp Endocrinol 113(2):169–186.
   Google Scholar
• Danielson PB, Hoversten MT, Fitzpatrick M, Schreck C, Akil H, Dores RM (2001). Sturgeon orphanin, a molecular “fossil” that bridges the gap between the opioids and orphanin FQ/nociceptin. J Biol Chem 276(25):22114–22119.
   PubMed Web of Science ®Google Scholar
• Darland T, Heinricher MM, Grandy DK (1998). Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more. Trends Neurosci 21(5):215–221.
   PubMed Web of Science ®Google Scholar
• Dautzenberg FM, Wichmann J, Higelin J, Py-Lang G, Kratzeisen C, Malherbe P, Kilpatrick GJ, Jenck F (2001). Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo. J Pharmacol Exp Ther 298:812–819.
   PubMed Web of Science ®Google Scholar
• Depner UB, Reinscheid RK, Takeshima H, Brune K, Zeilhofer HU (2003). Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor. Eur J Neurosci 17(11):2381–2387.
   PubMed Web of Science ®Google Scholar
• Devine DP, Reinscheid RK, Monsma FJ Jr, Civelli O, Akil H (1996). The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion. Brain Res 727(1-2):225–229.
   PubMed Web of Science ®Google Scholar
• Dooley CT, Spaeth CG, Berzetei-Gurske IP, Craymer K, Adapa ID, Brandt SR, Houghten RA, Toll L (1997). Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther 283(2):735–741.
   PubMed Web of Science ®Google Scholar
• Erb K, Liebel JT, Tegeder I, Zeilhofer HU, Brune K, Geisslinger G (1997). Spinally delivered nociceptin/ orphanin FQ reduces flinching behavior in the rat formalin test. Neuroreport 8(8):1967–1970.
   PubMed Web of Science ®Google Scholar
• Fukuda K, Kato S, Mori K, Nishi M, Takeshima H, Iwabe N, Miyata T, Houtani T, Sugimoto T (1994). cDNA cloning and regional distribution of a novel member of the opioid receptor family. FEBS Lett 343:42–46.
   PubMed Web of Science ®Google Scholar
• Grisel JE, Mogil JS (2000). Effects of supraspinal orphanin FQ/nociceptin. Peptides 21(7):1037–1045.
   PubMed Web of Science ®Google Scholar
• Grisel JE, Mogil JS, Belknap JK, Grandy DK (1996). Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuroreport 7(13):2125–2129.
   PubMed Web of Science ®Google Scholar
• Guerrini R, Calo G, Rizzi A, Bigoni R, Bianchi C, Salvadori S, Regoli D (1998). A new selective antagonist of the nociceptin receptor. Br J Pharmacol 123:163–165.
   PubMed Web of Science ®Google Scholar
• Guerrini R, Calo’ G, Bigoni R, Rizzi D, Regoli D, Salvadori S (2001). Structure-activity relationship of [Nphe1]-NC-(1-13)-NH2, a pure and selective nociceptin/ orphanin FQ receptor antagonist. J Pept Res 57(3):215–222.
   PubMedGoogle Scholar
• Hao JX, Xu IS, Wiesenfeld-Hallin Z, Xu XJ (1998). Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation. Pain 76:385–393.
   PubMed Web of Science ®Google Scholar
• Hao JX, Wiesenfeld-Hallin Z, Xu XJ (1997). Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat. Neurosci Lett 223(1):49–52.
   PubMed Web of Science ®Google Scholar
• Hara N, Minami T, Okuda-Ashitaka E, Sugimoto T, Sakai M, Onaka M, Mori H, Imanishi T, Shingu K, Ito S (1997). Characterization of nociceptin hyperalgesia and allodynia in conscious mice. Br J Pharmacol 121(3):401–408.
   PubMed Web of Science ®Google Scholar
• Hashiba E, Harrison C, Galo’ G, Guerrini R, Rowbotham DJ, Smith G, Lambert DG (2001). Characterization and comparison of novel ligands for the nociceptin/ orphanin FQ receptor. Naunyn Schmiedebergs Arch Pharmacol 363(1):28–33.
   Google Scholar
• Heinricher MM, McGaraughty S, Grandy DK (1997). Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla. J Neurophysiol 78(6):3351–3358.
   PubMed Web of Science ®Google Scholar
• Helyes Z, Nemeth J, Pinter E, Szolcsanyi J (1997). Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals. Br J Pharmacol 121:613–615.
   PubMed Web of Science ®Google Scholar
• Houtani T, Nishi M, Takeshima H, Nukada T, Sugimoto T (1996). Structure and regional distribution of nociceptin/ orphanin FQ precursor. Biochem Biophys Res Commun 219(3):714–719.
   PubMed Web of Science ®Google Scholar
• Inoue M, Kobayashi M, Kozaki S, Zimmer A, Ueda H (1998). Nociceptin/ orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Proc Natl Acad Sci USA 95:10949–10953.
   PubMed Web of Science ®Google Scholar
• Inoue M, Shimohira I, YoshidaA, ZimmerA, Takeshima H, Sakurada T, Ueda H (1999). Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. J Pharmacol Exp Ther 291(1):308–313.
   PubMed Web of Science ®Google Scholar
• Itoh M, Takasaki I, Andoh T, Nojima H, Tominaga M, Kuraishi Y (2001). Induction by carrageenan inflammation of prepronociceptin mRNAin VR1-immunoreactive neurons in rat dorsal root ganglia. Neurosci Res 40:227–233.
   PubMed Web of Science ®Google Scholar
• Jenck F, Wichmann J, Dautzenberg FM, Moreau JL, Ouagazzal AM, Martin JR, Lundstrom K, Cesura AM, Poli SM, Roever S, Kolczewski S, Adam G, KilpatrickG(2000).Asynthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat. Proc Natl Acad Sci U S A 97:4938–4943.
   Google Scholar
• Jhamandas KH, Sutak M, Henderson G (1998). Antinociceptive and morphine modulatory actions of spinal orphanin FQ. Can J Physiol Pharmacol 76(3):314–324.
   PubMed Web of Science ®Google Scholar
• Jia Y, Linden DR, Serie JR, Seybold VS (1998). Nociceptin/ orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation. Neurosci Lett 250(1):21–24.
   PubMed Web of Science ®Google Scholar
• Kamei J, Ohsawa M, Kashiwazaki T, Nagase H (1999). Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice. Eur J Pharmacol 370:109–116.
   PubMed Web of Science ®Google Scholar
• Kapusta DR, Chang JK, Kenigs VA (1999). Central administration of [Phe1psi(CH2-NH)Gly2]nociceptin (1-13)-NH2 and orphanin FQ/nociceptin (OFQ/N) produce similar cardiovascular and renal responses in conscious rats. J Pharmacol Exp Ther 289(1): 173–180.
   PubMed Web of Science ®Google Scholar
• Kawamoto H, Ozaki S, Itoh Y, Miyaji M, Arai S, Nakashima H, Kato T, Ohta H, Iwasawa Y (1999). Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4- piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397). J Med Chem 42(25):5061–5063.
   PubMed Web of Science ®Google Scholar
• Ko MC, Naughton NN, Traynor JR, Song MS, Woods JH, Rice KC, McKnight AT (2002). Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors. Br J Pharmacol 135:943–950.
   PubMed Web of Science ®Google Scholar
• Kolesnikov YA, Pasternak GW (1999). Peripheral orphanin FQ/nociceptin analgesia in the mouse. Life Sci 64(22):2021–2028.
   PubMed Web of Science ®Google Scholar
• Kotlinska J, Dylag T, Rafalski P, Talarek S, Kosior M, Silberring J (2004). Influence of nociceptin(1-17) fragments and its tyrosine-substituted derivative on morphine-withdrawal signs in rats. Neuropeptides 38(5):277–282.
   PubMed Web of Science ®Google Scholar
• Kotlinska J, Wichmann J, Rafalski P, Talarek S, Dylag T, Silberring J (2003). Non-peptidergic OP4 receptor agonist inhibits morphine antinociception but does not influence morphine dependence. Neuroreport 14: 601–604.
   PubMed Web of Science ®Google Scholar
• Kuzmin A, Sandin J, Terenius L, Ogren SO (2003). Acquisition, expression, and reinstatement of ethanolinduced conditioned place preference in mice: Effects of opioid receptor-like 1 receptor agonists and naloxone. J Pharmacol Exp Ther 304(1):310–318.
   PubMed Web of Science ®Google Scholar
• Krowicki ZK, Kapusta DR, Hornby PJ (2000). Orphanin FQ/nociceptin and [Phe(1)Psi(CH(2)-NH)Gly(2)] nociceptin(1-13)-NH(2) stimulate gastric motor function in anaesthetized rats. Br J Pharmacol 130(7): 1639–1645.
   PubMed Web of Science ®Google Scholar
• Labuz D, Chocyk A, Wedzony K, Toth G, Przewlocka B (2003). Endomorphin-2, deltorphin II and their analogs suppress formalin-induced nociception and c-Fos expression in the rat spinal cord. Life Sci 73(4):403–412.
   PubMed Web of Science ®Google Scholar
• Lapalu S, Moisand C, Mazarguil H, Cambois G, Mollereau C, Meunier JC (1997). Comparison of the structure-activity relationships of nociceptin and dynorphin Ausing chimeric peptides. FEBS Lett 417(3): 333–336.
   PubMed Web of Science ®Google Scholar
• Laughlin TM, Vanderah TW, Lashbrook J, Nichols ML, Ossipov M, Porreca F, Wilcox GL (1997). Spinally administered dynorphin A produces long-lasting allodynia: Involvement of NMDA but not opioid receptors. Pain 72(1-2):253-260.
   Web of Science ®Google Scholar
• Lutfy K, Eitan S, Bryant C, et al. (2003). Buprenorphine- induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. J Neurosci 23:10331–10337.
   PubMed Web of Science ®Google Scholar
• Luo C, Kumamoto E, Furue H, Chen J, Yoshimura M (2002). Nociceptin inhibits excitatory but not inhibitory transmission to substantia gelatinosa neurones of adult rat spinal cord. Neuroscience 109:349–358.
   PubMed Web of Science ®Google Scholar
• Ma F, Xie H, Dong ZQ, Wang YQ, Wu GC (2005). Expression of ORL1 mRNA in some brain nuclei in neuropathic pain rats. Brain Res 1043(1-2):214-217.
   Web of Science ®Google Scholar
• Mabuchi T, Matsumura S, Okuda-Ashitaka E, Kitano T, Kojima H, Nagano T, Minami T, Ito S (2003). Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. Eur J Neurosci 17(7): 1384–1392.
   PubMed Web of Science ®Google Scholar
• McDougall JJ, Pawlak M, Hanesch U, SchmidtRF (2000). Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ. Neurosci Lett 288(2):123–126.
   PubMed Web of Science ®Google Scholar
• Menzies JR, Glen T, Davies MR, Paterson SJ, Corbett AD (1999). In vitro agonist effects of nociceptin and [Phe(1)psi(CH(2)-NH)Gly(2)]nociceptin(1-13)NH(2) in the mouse and rat colon and the mouse vas deferens. Eur J Pharmacol 385(2-3):217-223.
   Web of Science ®Google Scholar
• Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B, et al. (1995). Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377(6549):532–535.
   PubMed Web of Science ®Google Scholar
• Meunier J, Mouledous L, Topham CM (2000). The nociceptin (ORL1) receptor: Molecular cloning and functional architecture. Peptides 21(7):893–900.
   PubMed Web of Science ®Google Scholar
• Mika J, Li Y, Weihe E, Schafer MK (2003). Relationship of pronociceptin/orphanin FQ and the nociceptin receptor ORL1 with substance P and calcitonin gene-related peptide expression in dorsal root ganglion of the rat. Neurosci Lett 348(3):190–194.
   PubMed Web of Science ®Google Scholar
• Mika J, Schafer MK, Obara I, Weihe E, Przewlocka B (2004). Morphine and endomorphin-1 differently influence pronociceptin/orphanin FQ system in neuropathic rats. Pharmacol Biochem Behav 78:171–178.
   PubMed Web of Science ®Google Scholar
• Mogil JS, Grisel JE, Reinscheid RK, Civelli O, Belknap JK, Grandy DK (1996). Orphanin FQ is a functional anti-opioid peptide. Neuroscience 75(2):333–337.
   PubMed Web of Science ®Google Scholar
• Mogil JS, Pasternak GW (2001). The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. Pharmacol Rev 53(3): 381–415.
   PubMed Web of Science ®Google Scholar
• Mollereau C, Mouledous L (2000). Tissue distribution of the opioid receptor-like (ORL1) receptor. Peptides 21(7):907–917.
   PubMed Web of Science ®Google Scholar
• Mollereau C, Mouledous L, Lapalu S, Cambois G, Moisand C, Butour JL, Meunier JC (1999). Distinct mechanisms for activation of the opioid receptor-like 1 and kappa-opioid receptors by nociceptin and dynorphin A. Mol Pharmacol 55(2):324–331.
   PubMed Web of Science ®Google Scholar
• Mollereau C, Parmentier M, Mailleux P, Butour JL, Moisand C, Chalon P, Caput D, Vassart G, Meunier JC (1994). ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett 341(1):33–38.
   PubMed Web of Science ®Google Scholar
• Morgan MM, Grisel JE, Robbins CS, GrandyDK(1997). Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. Neuroreport 8(16): 3431–3434.
   Google Scholar
• Murphy NP, Ly HT, Maidment NT (1996). Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats. Neuroscience 75(1):1–4.
   PubMed Web of Science ®Google Scholar
• Nishi M, Houtani T, Noda Y, Mamiya T, Sato K, Doi T, Kuno J, Takeshima H, Nukada T, Nabeshima T, Yamashita T, Noda T, Sugimoto T (1997). Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/ orphaninFQ receptor. EMBO J 16(8):1858–1864.
   PubMed Web of Science ®Google Scholar
• Nothacker HP, Reinscheid RK, Mansour A, Henningsen RA, Ardati A, Monsma FJ Jr, Watson SJ, Civelli O (1996). Primary structure and tissue distribution of the orphanin FQ precursor. Proc Natl Acad Sci U S A 93(16):8677–8682.
   PubMed Web of Science ®Google Scholar
• Nozaki-Taguchi N, Yamamoto T (2005). Spinal opioid receptor like1 receptor agonist, but not N-methyl- D-aspartic acid antagonist, reverses the secondary mechanical allodynia induced by intradermal injection of capsaicin in rats. Anesth Analg 100(4): 1087–1092.
   PubMed Web of Science ®Google Scholar
• Obara I, Przewlocki R, Przewlocka B (2005). Spinal and local peripheral antiallodynic activity of Ro64-6198 in neuropathic pain in the rat. Pain 116(1-2):17-25.
   Web of Science ®Google Scholar
• Ogawa M, Hatano K, Kawasumi Y, Wichmann J, Ito K (2001). Synthesis and in vivo evaluation of [11C] methyl-Ro 64-6198 as an ORL1 receptor imaging agent. Nucl Med Biol 28:941–947.
   PubMed Web of Science ®Google Scholar
• Ozaki S, Kawamoto H, Itoh Y, Miyaji M, Azuma T, Ichikawa D, Nambu H, Iguchi T, Iwasawa Y, Ohta H (2000). In vitro and in vivo pharmacological characterization of J-113397, a potent and selective nonpeptidyl ORL1 receptor antagonist. Eur J Pharmacol 402(1-2):45-53.
   Web of Science ®Google Scholar
• Pettersson LM, Sundler F, Danielsen N (2002). Expression of orphanin FQ/nociceptin and its receptor in rat peripheral ganglia and spinal cord. Brain Res 945: 266–275.
   PubMed Web of Science ®Google Scholar
• Pheng LH, Calo G, Guerrini R, Regoli D (2000). [Nphe(1)] nociceptin-(1-13)NH(2) selectively antagonizes nociceptin effects in the rabbit isolated ileum. Eur J Pharmacol 397(2-3):383-388.
   Web of Science ®Google Scholar
• Przewlocki R, Labuz D, Mika J, Przewlocka B, Tomboly C, Toth G (1999). Pain inhibition by endomorphins. Ann N Y Acad Sci 897:154–164.
   PubMed Web of Science ®Google Scholar
• Przewlocka B, Mika J, Labuz D, Toth G, Przewlocki R (1999). Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats. Eur J Pharmacol 367(2-3):189-96.
   Web of Science ®Google Scholar
• Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ Jr, Civelli O (1995). Orphanin FQ: A neuropeptide that activates an opioid-like G protein- coupled receptor. Science 270(5237):792–794.
   PubMed Web of Science ®Google Scholar
• Reinscheid RK, Higelin J, Henningsen RA, Monsma FJ Jr, CivelliO(1998). Structures that delineate orphanin FQ and dynorphin A pharmacological selectivities. J Biol Chem 273(3):1490–1495.
   Google Scholar
• Rizzi A, Bigoni R, Calo G, Guerrini R, Salvadori S, Regoli D (1999). [Nphe(1)]nociceptin-(1-13)-NH(2) antagonizes nociceptin effects in the mouse colon. Eur J Pharmacol 385(2-3):R3–5.
   Web of Science ®Google Scholar
• Schulz S, Schreff M, Nuss D, Gramsch C, Hollt V (1996). Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions. Neuroreport 7(18):3021–3025.
   PubMed Web of Science ®Google Scholar
• Shinkai H, Ito T, Iida T, Kitao Y, Yamada H, Uchida I (2000). 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J Med Chem 43(24): 4667–4677.
   PubMed Web of Science ®Google Scholar
• Suaudeau C, Florin S, Meunier JC, Costentin J (1998). Nociceptin-induced apparent hyperalgesia in mice as a result of the prevention of opioid autoanalgesic mechanisms triggered by the stress of an intracerebroventricular injection. Fundam Clin Pharmacol 12(4):420–425.
   PubMed Web of Science ®Google Scholar
• Suyama H, Kawamoto M, Gaus S, Yuge O (2003). Effect of JTC-801 (nociceptin antagonist) on neuropathic pain in a rat model. Neurosci Lett 351(3):133–136.
   PubMed Web of Science ®Google Scholar
• Tamai H, Sawamura S, Takeda K, Orii R, Hanaoka K (2005). Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation. Eur J Pharmacol 510(3):223–228.
   PubMed Web of Science ®Google Scholar
• Tian JH, Xu W, Fang Y, Mogil JS, Grisel JE, Grandy DK, Han JS (1997a). Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: Antagonism in brain and potentiation in spinal cord of the rat. Br J Pharmacol 120(4):676–680.
   PubMed Web of Science ®Google Scholar
• Tian JH, Xu W, Zhang W, Fang Y, Grisel JE, Mogil JS, Grandy DK, Han JS (1997b). Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia. Neuroreport 8(2):497–500.
   PubMed Web of Science ®Google Scholar
• Ueda H, Yamaguchi T, Tokuyama S, Inoue M, Nishi M, Takeshima H (1997). Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene. Neurosci Lett 237(2-3):136-138.
   Web of Science ®Google Scholar
• Wang H, Zhu CB, Cao XD, Wu GC (1998). Effect of orphanin FQ on acupuncture analgesia and noxious Novel Analgesia 43 stimulation in the periaqueductal gray. Sheng Li Xue Bao 50(3):263–267.
   PubMedGoogle Scholar
• Wang YQ, Zhu CB, Cao XD, Wu GC (1999a). Supraspinal hyperalgesia and spinal analgesia by [Phe1psi (CH2-NH)Gly2]nociceptin-(1-13)-NH2 in rat. Eur J Pharmacol 376:R1–3.
   PubMed Web of Science ®Google Scholar
• Wang JL, Zhu CB, Cao XD, Wu GC (1999b). Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test. Regul Pept 79(2-3):159-163.
   Google Scholar
• Wichmann J, Adam G, Rover S, Hennig M, Scalone M, Cesura AM, Dautzenberg FM, Jenck F (2000). Synthesis of (1S,3aS)-8-(2,3,3a,4,5, 6-hexahydro-1Hphenalen- 1-yl)-1-phenyl-1,3,8-triaza-spiro[4. 5]decan- 4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties. Eur J Med Chem 35:839–851.
   PubMed Web of Science ®Google Scholar
• Williams CA, Wu SY, Cook J, Dun NJ (1998). Release of nociceptin-like substances from the rat spinal cord dorsal horn. Neurosci Lett 244(3):141–144.
   PubMed Web of Science ®Google Scholar
• Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F (1998). Orphanin-FQ/nociceptin: Lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats. Eur J Pain 2(3):267–278.
   PubMed Web of Science ®Google Scholar
• Vaughan CW, Christie MJ (1996). Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones. Br J Pharmacol 117(8):1609–1611.
   PubMed Web of Science ®Google Scholar
• Xie GX, Meuser T, Pietruck C, Sharma M, Palmer PP (1999). Presence of opioid receptor-like (ORL1) receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia. Life Sci 64: 2029–2037.
   PubMed Web of Science ®Google Scholar
• Xu XJ, Hao JX, Wiesenfeld-Hallin Z (1996). Nociceptin or antinociception: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat. Neuroreport 7:2092–2094.
   PubMed Web of Science ®Google Scholar
• Xu IS, Grass S, Wiesenfeld-Hallin Z, Xu XJ (1999). Effects of intrathecal orphanin FQ on a flexor reflex in the rat after inflammation or peripheral nerve section. Eur J Pharmacol 370:17–22.
   PubMed Web of Science ®Google Scholar
• Xu X, Grass S, Hao J, Xu IS, Wiesenfeld-Hallin Z (2000). Nociceptin/orphanin FQ in spinal nociceptive mechanisms under normal and pathological conditions. Peptides 21(7):1031–1036.
   PubMed Web of Science ®Google Scholar
• Yamada H, Nakamoto H, Suzuki Y, Ito T, Aisaka K (2002). Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br J Pharmacol 135(2):323–332.
   Google Scholar
• Yamamoto T, Ohtori S, Chiba T (2000). Inhibitory effect of intrathecally administered nociceptin on the expression of Fos-like immunoreactivity in the rat formalin test. Neurosci Lett 284(3):155–158.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Nozaki-Taguchi N (1997). Effects of intrathecally administered nociceptin, an opioid receptor- like1 receptor agonist, and N-methyl-D-aspartate receptor antagonists on the thermal hyperalgesia induced by partial sciatic nerve injury in the rat. Anesthesiology 87:1145–1152.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Nozaki-Taguchi N, Kimura S (1997). Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat. Neurosci Lett 224:107–110.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Nozaki-Taguchi N, Sakashita Y, Kimura S (1999). Nociceptin/orphanin FQ: Role in nociceptive information processing. Prog Neurobiol 57: 527–535.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Sakashita Y, Nozaki-Taguchi N (2001). Antagonism of ORLI receptor produces an algesic effect in the rat formalin test. Neuroreport 12(7): 1323–1327.
   PubMed Web of Science ®Google Scholar
• Yuan L, Han Z, Chang JK, Han JS (1999). Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats. Brain Res 826(2): 330–334.
   PubMed Web of Science ®Google Scholar
• Zaveri N, Polgar WE, Olsen CM, et al. (2001). Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors. Eur J Pharmacol 428:29–36.
   PubMed Web of Science ®Google Scholar
• Zhang M, Wang X, Zhang D, Xu G, Dong H, Yu Y, Han J (2005). Orphanin FQ antagonizes the inhibition of Ca2+ currents induced by mu-opioid receptors. J Mol Neurosci 25(1):21–27.
   PubMed Web of Science ®Google Scholar
• Zhang XL, Zhu CB, Xu SF, Cao XD, Wu GC, Li MY, Cui DF, Chi CW (1997). Effect of intrathecal or intracerebroventricular administration of OFQ on pain threshold and acupuncture analgesia in rats. Sheng Li Xue Bao 49(5):575–580.
   PubMedGoogle Scholar
• Zhu CB, Cao XD, Xu SF, Wu GC (1997). Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats. Neurosci Lett 235(1-2):37-40.
   Web of Science ®Google Scholar
• Zhu CB, Zhang XL, Xu SF, Cao XD, Wu GC, Li MY, CuiDF, QiZW(1998).Antagonistic effect of orphanin FQ on opioid analgesia in rat. Zhongguo Yao Li Xue Bao 19(1):10–14.
   Google Scholar