129
Views
70
CrossRef citations to date
0
Altmetric
REVIEW ARTICLE

Autoimmune-associated hemophagocytic syndrome

, , , , &
Pages 205-215 | Received 28 Mar 2003, Accepted 16 Feb 2004, Published online: 02 Jan 2014

References

  • Scott RB, Rob-Smith AHT. Histiocytic medullary reticulosis. Lancet 1939;ii:194–8.
  • Rappaport H. Tumors of the hematopoietic systems. In: Rappaport, editor. Atlas of tumor pathology. Washington, DC: Armed Forces Institutes of Pathology; 1966. p. 49–63.
  • Farquhar JW, Claireaux AF. Familial hemophagocytic reticulosis. Arch Dis Child 1952;27:519–25.
  • Ftisdall RJ, McKenna RW, Nesbit ME, Krivit W, Balfour HH Jr, Simmons RL, et al. Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histio-cytosis. Cancer 1979;44:993–1002.
  • Ftisdall RJ, Brunning RD, Hernandez JI, Gordon DH. Bacteria-associated hemophagocytic syndrome. Cancer 1984;54:2968–72.
  • Weintraub M, Siegman-Igra Y, Josiphov J, Rahmani R, Liron M. Histiocytic hemophagocytosis in miliary tuberculosis. Arch Intern Med 1984;144:2055–6.
  • Campo E, Condom E, Miro MJ, Cid MC, Romagosa V. Tubercu-losis-associated hemophagocytic syndrome. A systemic process. Cancer 1986;58:2640–5.
  • Browett PJ, Varcoe AR, Fraser AG, Ellis-Pegler RB. Dissemi-nated tuberculosis complicated by the hemophagocytic syn-drome. Aust NZ J Med 1988;18:79–80.
  • Mascort Vaca G, Palomera Bernal L, Barcia Ruiz JM, de la Cruz Morgado D, Calvo-Rubio Romero-Portocarrero R, Garcia Diez I, et al. Histiocytic hemophagocytic syndrome associated with leishmaniasis. An Esp Pediatr 1991;35:273–5.
  • Ohno T, Shirasaka A, Sugiyama T, Furukawa H. Hemophago-cytic syndrome induced by Plasmodium falciparum malaria infection. Int J Hematol 1996;64:263–6.
  • Keller FG, Kurtzberg J. Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. Am J Pediatr Hematol Oncol 1994;16:368–71.
  • Blanche P, Robert F, Dupouy-Camet J, Sicard D. Toxoplasmosis-associated hemophagocytic syndrome in a patient with AIDS: diagnosis by the polymerase chain reaction. Clin Infect Dis 1994;19:989–90.
  • Takami A, Yamauchi H, Asakura H, Ishiyama K, Nakao S. Tsut-sugamushi disease (scrub typhus)-associated hemophagocytic syndrome. Int J Hematol 2002;75:337–8.
  • Kadin ME, Kamoun M, Lamberg J. Erythrophagocytic T gamma lymphoma: a clinicopathologic entity resembling malignant his-tiocytosis. N Engl J Med 1981;304:648–53.
  • Jaffe ES, Costa J, Fauci AS, Cossman J, Tsokos M. Malignant lymphoma and erythrophagocytosis simulating malignant histio-cytosis. Am J Med 1983;75:741–9.
  • Ng CS, Chan JK, Cheng PN, Szeto SC. Nasal T-cell lymphoma associated with hemophagocytic syndrome. Cancer 1986;58:67–71.
  • Invernizzi R, Paulli M, Rosso R, De Fazio P, Perugini 0, Kindl S, et al. Reactive hemophagocytosis in Ki-l-positive large cell lym-phoma: a case study. Haematologica 1989;74: 155–9.
  • Chan EY, Pi D, Chan GT, Todd D, Ho FC. Peripheral T-cell lymphoma presenting as hemophagocytic syndrome. Hematol Oncol 1989;7:275–85.
  • Falini B, Pileri S, De Solas I, Martelli MF, Mason DY, Delsol G, et al. Peripheral T-cell lymphoma associated with hemophago-cytic syndrome. Blood. 1990;75:434–44.
  • Su IJ, Hsu YH, Lin MT, Cheng AL, Wang CH, Weiss LM. Epstein-Barr virus-containing T-cell lymphoma presents with hemophagocytic syndrome mimicking malignant histiocytosis. Cancer 1993;72:2019–27.
  • Takahashi N, Chubachi A, Miura I, Nakamura S, Miura AB. Lymphoma-associated hemophagocytic syndrome in Japan (in Japanese). Rinsho Ketsueki 1999;40:542–9.
  • Takahashi N, Chubachi A, Kume M, Hatano Y, Komatsuda A, Kawabata Y, et al. A clinical analysis of 52 adult patients with hemophagocytic syndrome: the prognostic significance of the underlying diseases. Int J Hematol 2001;74:209–13.
  • Prokocimer M, Inbal A, Gelber M, Shohat B, Ben Basat M, Shaklai M. Hemophagocytosis simulating malignant histiocytosis: a terminal event of the myelodysplastic syndrome. Acta Haematol 1985;74:164–7.
  • Okuda T, Sakamoto S, Deguchi T, Misawa S, Kashima K, Yoshihara T, et al. Hemophagocytic syndrome associated with aggressive natural killer cell leukemia. Am J Hematol 1991;38: 321–3.
  • Saeki A, Ogasawara Y, Otsubo H, Sekita T, Nishiwaki K, Masuoka H, et al. Acute myelomonocytic leukemia complicated with syndrome of inappropriate secretion of antidiuretic hor- mone, nephrotic syndrome, and hemophagocytic syndrome (in Japanese). Ftinsho Ketsueki 1995;36:665–71.
  • Kumar M, Boggino H, Hudnall SD, Velagaleti GV. Acute myeloid leukemia associated with hemophagocytic syndrome and t(4;7)(q21;q36). Cancer Genet Cytogenet 2000;122:26–9.
  • Kaito K, Ono M, Kobayashi M, Kawamoto S, Nishiwaki K, Masuoka H, et al. A case of hemophagocytic syndrome with multiple myeloma (in Japanese). Ftinsho Ketsueki 1992;33:1095–7.
  • Venizelosa ID, Garipidou V, Perifanis V. Hemophagocytic syndrome associated with multiple myeloma. Leuk Lymphoma 2002;43:897–9.
  • Lipsker D, Marquart-Elbaz C, Kurtz JE, Maloisel F, Heid E, Grosshans E. Macrophage activation syndrome disclosing leukemic transformation of mycosis fungoides. Ann Dermatol Venereol 1997;124:544–6.
  • Cordel N, Le Corvaisier-Pieto C, Young P, Lenormand B, Courville P, Soubrane J, et al. Hemophagocytic syndrome and metastatic melanoma: 3 cases. Ann Dermatol Venereol 2000;127: 1077–9.
  • Sakai T, Shiraki K, Deguchi M, Itoh N, Konishi T, Takase K, et al. Hepatocellular carcinoma associated with hemophagocytic syndrome. Hepatogastroenterology. 2001;48:1464–6.
  • Ohga S, Ooshima A, Fukushige J, Ueda K. Histiocytic haemo-phagocytosis in a patient with Kawasaki disease: changes in the hypercytokinaemic state. Eur J Pediatr 1995;154:539–41.
  • Kaneko K, Takahashi K, Fujiwara S, Maruyama T, Obinata K. Kawasaki disease followed by haemophagocytic syndrome. Eur J Pediatr 1998;157:610–1.
  • Chen JS, Chang KC, Cheng CN, Tsai WH, Su U. Childhood hemophagocytic syndrome associated with Kikuchi's disease. Haematologica 2000;85:998–1000.
  • Tochimoto A, Nishimagi E, Kawaguchi Y, Kobashigawa T, Okamoto H, Harigai M, et al. A case of recurrent hemophago-cytic syndrome complicated with systemic sclerosis: relationship between disease activity and serum level of IL-18 (in Japanese). Ryumachi 2001;41:659–64.
  • Wong KF, Hui PK, Chan JK, Chan YW, Ha SY. The acute lupus hemophagocytic syndrome. Ann Intern Med 1991;114:387–90.
  • Kumakura S, Ishikura H, Endo J, Kobayashi S. Autoimmune-associated hemophagocytosis. Am J Hematol 1995;50:148–9.
  • Kumakura S, Ishikura H, Umegae N, Yamagata S, Kobayashi S. Autoimmune-associated hemophagocytic syndrome. Am J Med 1997;102:113–5.
  • Kumakura S, Ishikura H, Munemasa S, Adachi T, Murakawa Y, Kobayashi S. Adult-onset Still's disease-associated hemopha-gocytosis. J Ftheumatol 1997;24:1645–8.
  • Stephan JL, Zeller J, Hubert P, Herbelin C, Dayer JM, Prieur AM. Macrophage activation syndrome and rheumatic disease in childhood: a report of four new cases. Clin Exp Ftheumatol 1993; 11:451–6.
  • Takahasi K, Kumakura S, Ishikura H, Murakawa Y, Yamauchi Y, Kobayashi S. Reactive hemophagocytosis in systemic lupus erythematosus. Intern Med 1998;37:550–3.
  • Yamanouchi J, Yamauchi Y, Yokota E, Matsumoto I. Hemoph-agocytic syndrome in a patient with rheumatoid arthritis (in Japanese). Ryumachi 1998;38:731–4.
  • Papo T, Andre MH, Amoura Z, Lortholary 0, Tribout B, Guillevin L, et al. The spectrum of reactive hemophagocytic syn-drome in systemic lupus erythematosus. J Rheumatol 1999;26: 927–30.
  • Wano Y, Ebata K, Masaki Y, Takeshita S, Ogawa N, Kim CG, et al. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto's disease) accompanied by hemophagocytosis and salivary gland swelling in a patient with systemic lupus erythematosus (in Japanese). Ftinsho Ketsueki 2000;41:54–60.
  • Mori Y, Sugiyama T, Chiba R, Sugimoto T, Furukawa M, Sueishi M, et al. A case of systemic lupus erythematosus with hemoph-agocytic syndrome and cytophagic histiocytic panniculitis (in Japanese). Ryumachi 2001;41:31–6.
  • Koseto M, Murakami A, Tatekawa T, Fujii T, Suzuki T. Hemoph-agocytic syndrome in a patient with systemic lupus erythematosus (in Japanese). Nippon Naika Gakkai Zasshi 2001;90:696–8.
  • Suzuki J, Nawata M, Koike M, Wada R, Sekigawa I, Iida N, et al. Two cases of reactive hemophagocytic syndrome: a patient with adult -onset Still's disease and a patient with herpes zoster and autoimmune abnormalities. Mod Rheumatol 2001; 11:336–9.
  • Sekigawa I, Suzuki J, Nawata M, Ikeda K, Koike M, Iida N, et al. Hemophagocytosis in autoimmune disease. Clin Exp Ftheumatol 2001;19:333–8.
  • Inamo Y, Ryou N, Abe 0, Fuchigami S, Hashimoto K, Fuchigami T, et al. A case report: a pediatric patient with acute lupus hemophagocytic syndrome; differences from reactive hemo-phagocytosis caused by hypercytokinemia. Mod Ftheumatol 2002; 12:72–5.
  • Tsuboi N, Hayashi H, Yukawa N, Arai T, Abe H, Tahara K, et al. Hemophagocytic syndrome (in Japanese). Nippon Naika Gakkai Zasshi 2001;90:1434–40.
  • Kumakura S, Kobayashi S, Ishikura H. Neutrophil phagocytosis in Felty's syndrome. Am J Med 2001;111:579–80.
  • Moriguchi N, Sato W, Miyata H, Yoshioka K. Systemic lupus erythematosus with bilateral salivary gland swelling and clouding of consciousness accompanied by hemophagocytic syndrome - a study of serial determination of serum cytokines (in Japanese). Ftinsho Ketsueki 2002;43:931–6.
  • Katsumata Y, Okamoto H, Harigai M, Ota S, Uesato M, Tochimoto A, et al. Etoposide-ameliorated refractory hemoph-agocytic syndrome in a patient with systemic sclerosis (in Japanese). Ryumachi 2002;42:820–6.
  • Kumakura S, Ishikura H, Kondo M, Murakawa Y, Kobayashi S. Hemophagocytosis associated with MPO-ANCA-positive vas-culitis in systemic sclerosis. Clin Exp Ftheumatol 2002;20:411–4.
  • Reiner AP, Spivak JL. Hematophagic histiocytosis. A report of 23 new patients and a review of the literature. Medicine (Baltimore) 1988;67: 369–88.
  • Tsuda H. Hemophagocytic syndrome (HPS) in children and adults. hit J Hematol 1997;65:215–26.
  • Esumi N, Ikushima S, Todo S, Imashuku S. Hyperferritinemia in malignant histiocytosis and virus-associated hemophagocytic syndrome. N Engl J Med 1987;316:346–7.
  • Esumi N, Ikushima S, Hibi S, Todo S, Imashuku S. High serum ferritin level as a marker of malignant histiocytosis and virus-associated hemophagocytic syndrome. Cancer 1988;61:2071–6.
  • Andreesen R, Osterholz J, Bodemann H, Bross KI, Castabel U, Lohr GW. Expression of transferrin receptors and intracellular ferritin during terminal differentiation of human monocytes. Blood 1984;49:195–202.
  • Warwood M, Hourahane D, Jones BN. Accumulation and release of isoferritins during incubation in vitro of human peripheral mononuclear cells. Br J Haematol 1984;56:31–43.
  • Quismorio FP. Hematologic and lymphoid abnormalities in sys-temic lupus erythematosus. In: Wallace DJ, Hahn BH, editors. Dubois' lupus erythematosus. 5th ed. Baltimore: Williams and Wilkins; 1997. p. 793–816.
  • Larson DL. Systemic lupus erythematosus. Boston: Little, Brown; 1961.
  • Imashuku S, Hibi S. Cytokines in hemophagocytic syndrome. Br J Haematol 1991;77:438–40.
  • Fujiwara F, Hibi S, Imashuku S. Hypercytokinemia in hemoph-agocytic syndrome. Am J Pediatr Hematol Oncol 1993;15:92–8.
  • Tsuda H, Shirono K. Possible role of macrophage-colony-stimulating factor in the development of hemophagocytic syn-drome. Eur J Haematol 1995;54:197.
  • Francois B, Trimoreau F, Vignon P, Fixe P, Praloran V, Gastinne H. Thrombocytopenia in the sepsis syndrome: role of hem-ophagocytosis and macrophage colony-stimulating factor. Am J Med 1997;103:114–20.
  • Imashuku S. Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treat-ment. Int J Hematol 1997;66:135–51.
  • Kawaguchi H, Miyashita T, Herbst H, Niedobitek G, Asada M, Tsuchida M, et al. Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome. J Clin Invest 1993;92:1444–50.
  • Simrell CR, Margolick JB, Crabtree GR, Cossman J, Fauci AS, Jaffe ES. Lymphokine-induced phagocytosis in angiocentric immunoproliferative lesions (AIL) and malignant lymphoma arising in AIL. Blood 1985;65:1469–76.
  • Lay JD, Tsao CJ, Chen JY, Kadin ME, Su U. Upregulation of tumor necrosis factor-alpha gene by Epstein-Barr virus and acti-vation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome. J Chin Invest 1997;100:1969–79.
  • Lawrence JS, Craddock CG Jr, Campbell TN. Antineutrophil serum; its use in studies of white cell dynamics. J Lab Clin Med 1967;69:88–101.
  • Simpson DM, Ross R. Effects of heterologus anti-neutrophil serum in guinea pigs. Hematologic and ultrastructural observa-tions. Am J Pathol 1971;65:79–102.
  • Indik ZK, Park JG, Hunter S, Schreiber AD. The molecular dissection of Fc gamma receptor-mediated phagocytosis. Blood 1995;86:4389–99.
  • Duvall E, Wyllie AH, Morris RG. Macrophage recognition of cells undergoing programmed cell death (apoptosis). Immunol-ogy 1985;56:351–8.
  • Wyllie AH. Apoptosis: Cell death in tissue regulation. J Pathol 1987;153:313–6.
  • Arends MJ, Wyllie AH. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 1991;32:223–54.
  • Platt N, da Silva RP, Gordon S. Recognizing death: the phagocytosis of apoptotic cells. Trends Cell Biol 1998;8:365–72.
  • Ren Y, Savill J. Apoptosis: the importance of being eaten. Cell Death Differ 1998;5:563–8.
  • Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992;148:2207–16.
  • Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, Campbell PA, et al. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol 1992;149: 4029–35.
  • Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 2000;405:85–90.
  • Savill J, Dransfield I, Hogg N, Haslett C. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 1990;343:170–3.
  • Savill J, Hogg N, Ren Y, Haslett C. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recogni-tion of neutrophils undergoing apoptosis. J Chin Invest 1992;90: 1513–22.
  • Touhami M, Bourge JF, Legrand C. Increased adhesion of the promyelocytic leukaemia cell line, NB4, to fibronectin and thrombospondin upon all-trans-retinoic acid treatment. Br J Haematol 1999;104: 706–14.
  • Ren Y, Savill J. Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergo-ing apoptosis. J Immunol 1995;154:2366–74.
  • Devitt A, Moffatt OD, Raykundalia C, Capra JD, Simmons DL, Gregory CD. Human CD14 mediates recognition and phagocyto-sis of apoptotic cells. Nature 1998;392:505–9.
  • Manfredi AA, Rovere P, Heltai S, Galati G, Nebbia G, Tincani A, et al. Apoptotic cell clearance in systemic lupus erythematosus. II. Role of beta2-glycoprotein I. Arthritis Rheum 1998;41:215–23.
  • Manfredi AA, Rovere P, Galati G, Heltai S, Bozzolo E, Soldini L, et al. Apoptotic cell clearance in systemic lupus erythematosus. I. Opsonization by antiphospholipid antibodies. Arthritis Rheum 1998;41:205–14.
  • Pittoni V, Ravirajan CT, Donohoe S, MacHin SJ, Lydyard PM, Isenberg DA. Human monoclonal anti-phospholipid anti-bodies selectively bind to membrane phospholipid and beta2-glycoprotein I (beta2-GPI) on apoptotic cells. Chin Exp Immunol 2000;119:533–43.
  • Platt N, Suzuki H, Kurihara Y, Kodama T, Gordon S. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc Natl Acad Sci USA 1996;93: 12456–60.
  • Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002;417:182–7.
  • Selleri C, Sato T, Anderson S, Young NS, Maciejewski JP. Inter-feron-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol 1995;165:538–46.
  • Maciejewski J, Selleri C, Anderson S, Young NS. Fas antigen expression on CD34+ human marrow cells is induced by inter-feron gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 1995;85:3183–90.
  • Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. N Engl J Med 1997;336:1365–72.
  • Hasegawa D, Kojima S, Tatsumi E, Hayakawa A, Kosaka Y, Nakamura H, et al. Elevation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamond—Blackfan anemia. Blood 1998;9:2793–9.
  • Kumakura S, Ishikura H, Kobayashi S. Hemophagocytic syn-drome, a possible association with aplastic anemia? Internal Med 2003;42;1262–4.
  • Kumakura S, Kondo M, Tsumura H, Murakawa Y, Ishikura H, Kobayashi S. Hemophagocytic syndrome (in Japanese). Jpn J Clin Immun 2000;23:670–3.
  • Henter JI, Elinder G, Ost A. Diagnostic guidelines for hemoph-agocytic lymphohistiocytosis. The FHL Study Group of the His-tiocyte Society. Semin Oncol 1991;18:29–33.
  • Marton PF. Erythrophagocytosis in the human bone marrow as disclosed by iliacal bone biopsies. Scand J Haematol 1975;14:153–9.
  • Kumakura S, Ishikura H, Tsumura H, Kobayashi S. Phagocytosis of terminally differentiated acute promyelocytic leukemia cells by marrow histiocytes during treatment with all-trans retinoic acid. Leuk Lymphoma 2003;44:2147–50.
  • Favara BE. Hemophagocytic lymphohistiocytosis: a hemophago-cytic syndrome. Semin Diagn Pathol 1992;9:63–74.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.