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CASE REPORT

Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient

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Pages 436-440 | Received 07 Nov 2006, Accepted 01 Jun 2007, Published online: 02 Jan 2014

References

  • McCurry J. Japan deaths spark concerns over arthritis drug. Lancet 2004;363:461.
  • Kamata Y, Nara H, Kamimura T, Haneda K, Iwamoto M, Masuyama J, et al. Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. Intern Med 2004;43:1201–4.
  • Takeishi M, Akiyama Y, Akiba H, Adachi D, Hirano M, Mimura T. Leflunomide induced acute interstitial pneumonia. J Ftheumatol 2005;32:1160–3.
  • Suissa S, Hudson M, Ernst P. Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritis. Arthritis Rheum 2006;54:1435–9.
  • Sakai F, Noma S, Kurihara Y, Yamada H, Azuma A, Kudoh S, et al. Leflunomide-related lung injury in patients with rheumatoid arthritis: imaging features. Mod Ftheumatol 2005;15:173–9.
  • Ochi S, Harigai M, Mizoguchi F, Iwai H, Hagiyama H, Oka T, et al. Leflunomide-related acute interstitial pneumonia in two patients with rheumatoid arthritis: autopsy findings with a mosaic pattern of acute and organizing diffuse alveolar damage. Mod Ftheumatol 2006;16:316–20.
  • Hirabayashi Y, Shimizu H, Kobayashi N, Kudo K. Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis. Intern Med 2006;45:689–91.
  • Savage DG, Ogundipe A, Allen RH, Stabler SP, Lindenbaum J. Etiology and diagnostic evaluation of macrocytosis. Am J Med Sci 2000;319:343–52.
  • Scott JM, Weir DG. Drug-induced megaloblastic change. Clin Haematol 1980;9:587–606.
  • Inokuma S, Kono H, Nakayama H, Yamazaki J. Immunoglobulin and lymphocyte decrease concurrent with adverse reactions induced by methotrexate for RA. Ann Rheum Dis 2000;59: 495–6.
  • Inokuma S, Sakata M, Yoshida A, Shiratori K, Kiyosawa H. Bucil-lamine induced pulmonary injury occurs with immunoglobulin decrease. J Ftheumatol 1996;23:1282–5.
  • Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA, Campbell GD, et al. Guideline for the management of adults with community-acquired pneumonia. Am J Respir Crit Care Med 2001;163:1730–54.
  • Chan J, Sanders DC, Du L, Pillans P I. Leflunomide-associated pancytopenia with or without methotrexate. Ann Pharmacother 2004;38:1206–11.
  • Auer J, Hinterreiter M, Allinger S, Kirchgatterer A, Knoflach P. Severe pancytopenia after leflunomide in rheumatoid arthritis. Acta Med Austriaca 2000;27:131–2.

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