White Matter Disease Severity of the Brain and Its Association With Geriatric Syndromes

References

• . Cigolle CT, Langa KM, Kabeto MU, Tian Z, Blaum CS. Geriatric conditions and disability: The Health and Retirement Study. Ann Intern Med. 2007;147(3):156–164
   PubMed Web of Science ®Google Scholar
• . Flacker JM. What is a geriatric syndrome anyway? J Am Geriatr Soc. 2003;51(4):574–576
   PubMed Web of Science ®Google Scholar
• . Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc. 2007;55(5):780–791
   PubMed Web of Science ®Google Scholar
• . Strandberg TE, Pitkala KH, Tilvis RS, O'Neill D, Erkinjuntti TJ. Geriatric syndromes—vascular disorders? Ann Med. 2013;45(3):265–273
   PubMed Web of Science ®Google Scholar
• . Kovaic JC, Castellano JM, Fuster V. The links between complex coronary disease, cerebrovascular disease, and degenerative brain disease. Ann N Y Acad Sci. 2012;254:99–105
   Google Scholar
• . Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci. 2010;65(10):1028–1041
   PubMed Web of Science ®Google Scholar
• . Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke. 1995;26(7):1293–1301
   PubMed Web of Science ®Google Scholar
• . Taylor WD, Macfall JR, Provenzale JM, . Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlations with vascular risk factors. Am J Roentgenol. 2003;181(2):571–576
   PubMedGoogle Scholar
• . Oishi M, Mochizuki Y. Regional cerebral blood flow and cerebrospinal fluid glutamate in leukoaraiosis. J Neurol. 1998;245(12):777–780
   PubMedGoogle Scholar
• . van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Glin J. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriosclerosis and dilated perivascular spaces. Brain. 1991;114(Pt 2):761–774
   PubMed Web of Science ®Google Scholar
• . Kuo HK, Lipsitz LA. Cerebral white matter changes and geriatric syndromes: is there a link? J Gerontol A Biol Sci Med Sci. 2004;59(8):818–826
   PubMed Web of Science ®Google Scholar
• . Tinetti ME, Inouye SK, Gill TM, Doucette JT. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA. 1995;273(17):1348–1353
   PubMed Web of Science ®Google Scholar
• . Saliba P, Elliott M, Rubenstein LZ, . The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community. J Am Geriatr Soc. 2001;49(12):1691–1699
   PubMed Web of Science ®Google Scholar
• . Brickman AM, Siedlecki KL, Muraskin J, . White matter hyperintensities and cognition: testing the reserve hypothesis. Neurobiol Aging. 2011;32(9);1588–1598
   PubMed Web of Science ®Google Scholar
• . Burton EJ, Mckeith IG, Burn DJ, Firbank MJ, O'Brien JT. Progression of white matter hyperintensities in Alzheimer's disease, dementia with Lewy bodies, and Parkinson disease dementia: a comparison with normal aging. Am J Geriatr Psychiatry. 2006;14(10):842–849
   PubMed Web of Science ®Google Scholar
• . Firbank MJ, O'Brien JT, Pakrasi S, . White matter hyperintensities and depression—preliminary results from the LADIS study. Int J Geriatr Psychiatry. 2005;20(7):674–679
   PubMedGoogle Scholar
• . Whitman GT, Tang T, Lin A, Baloh RW. A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Neurology. 2001;57(6);990–994
   PubMedGoogle Scholar
• . Srikanth V, Beare R, Blizzard L, . Cerebral white matter lesions, gait, and the risk of incident falls: a prospective population-based study. Stroke. 2009;40(1):175–180
   PubMedGoogle Scholar
• . Kuchel GA, Moscufo N, Guttmann CR, . Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol A Biol Med Sci. 2009;64(8):902–909
   PubMedGoogle Scholar
• . Wahlund LO, Barkhof F, Fazekas F, ; European Task Force on Age-Related White Matter Changes. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. 2001;32(6):1318–1322
   PubMed Web of Science ®Google Scholar
• . Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc. 2007;55(5):780–791
   PubMed Web of Science ®Google Scholar
• . Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256(3):183–194
   PubMed Web of Science ®Google Scholar
• . American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, (DSM-IV) 4th ed. Washington DC; American Psychiatric Association, 1994
   Google Scholar
• . Katz S, Down TD, Cash HR, Grotz RC. Progress in the development of the index of ADL. Gerontologist. 1970;10(1):20–30
   PubMed Web of Science ®Google Scholar
• . Lawton MO, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179–186
   PubMed Web of Science ®Google Scholar
• . Cigolle CT, Langa KM, Kabeto MU, Tian Z, Blaum CS. Geriatric syndromes and disability: the Health and Retirement Study. Ann Intern Med. 2007;147(3):156–164
   PubMed Web of Science ®Google Scholar
• . Liao D, Cooper L, Cai J, . The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study. Neuroepidemiology. 1997;16(3):149–162
   PubMed Web of Science ®Google Scholar
• . Breteler MM, van Swieten JC, Bots ML, . Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: The Rotterdam Study. Neurology. 1994;44(7):1246–1252
   PubMed Web of Science ®Google Scholar
• . Lindgren A Roijer A, Rudling O, . Cerebral lesions on magnetic resonance imaging, heart disease, and vascular risk factors in subjects without stroke. A population-based study. Stroke. 1994;25(5):929–934
   PubMed Web of Science ®Google Scholar
• . Manolio TA, Kronmal RA, Burke GL, . Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study. Stroke. 1994;25(2):318–327
   PubMed Web of Science ®Google Scholar
• . Murray AD, Staff RT, Shenkin SD, Deary IJ, Starr JM, Whalley LJ. Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people. Radiology. 2005;237(1):251–257
   PubMed Web of Science ®Google Scholar
• . van der Flier WM, van Straaten EC, Barkhof F, ; LADIS study group. Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: The LADIS study. J Neurol Neurosur Psychiatry. 2005;76(11):1497–1500
   PubMedGoogle Scholar
• . Tadic SC, Griffiths D, Murrin A, Schaefer W, Aizenstein HJ, Resnick NM. Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence. Neuroimage. 2010;51(4):1294–1302
   PubMed Web of Science ®Google Scholar
• . El Assar M, Angulo J, Vallejo S, Peiro C, Sanchez-Ferrer CF, Rodriguez-Manas L. Mechanisms involved in the aging-induced vascular dysfunction. Front Physiol. 2012;3:132. doi: 10.3389/fphys.2012.00132
   PubMed Web of Science ®Google Scholar
• . Topokian R, Barrick TR, Howe FA, Markus HS. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry. 2010;81(2):192–197
   PubMedGoogle Scholar
• . North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012;110(8):1097–1108
   PubMed Web of Science ®Google Scholar
• . Dai DF, Rabinovitch PS, Ungvari Z. Mitochondria and cardiovascular aging. Circ Res. 2012;110(8):1109–1124
   PubMed Web of Science ®Google Scholar
• . Araki A, Ito H. Diabetes mellitus and geriatric syndromes. Geriatr Gerontol Int. 2009;9(2):1105–1114
   Google Scholar
• . Scuteri A, Nilsson PM, Tzourio C, Redon J, Laurent S. Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications. J Hypertens. 2011;29(8):1469–1477
   PubMedGoogle Scholar
• . Hachinski VC, Potter P, Merskey H. Leuko-araiosis. Arch Neurol. 1987;44(1):21–23
   PubMedGoogle Scholar
• . Grueter BE, Schulz UG. Age-related cerebral white matter disease (leukoaraiosis): a review. Postgrad Med J. 2012;88(1036):79–87
   PubMed Web of Science ®Google Scholar