Advanced search
Publication Cover
Bioanalysis Volume 1, 2009 - Issue 1
Submit an article Journal homepage
163
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Development of a LC–MS/MS Method to Analyze 5-Methoxy-N,N-Dimethyltryptamine and Bufotenine: Application to Pharmacokinetic Study

Hong-Wu ShenDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY14260-1200, USA. Tel.: +1 716 645 2842 Fax: +1 716 645 [email protected]View further author information
,
Xi-Ling JiangDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY14260-1200, USA. Tel.: +1 716 645 2842 Fax: +1 716 645 [email protected]View further author information
&
Ai-Ming YuDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY14260-1200, USA. Tel.: +1 716 645 2842 Fax: +1 716 645 [email protected]View further author information
Pages 87-95 | Published online: 27 Mar 2009

Bibliography

  • Yu AM . Indolealkylamines: biotransformations and potential drug–drug interactions. AAPS J10(2) , 242–253 (2008).
  • Brush DE , BirdSB, BoyerEW. Monoamine oxidase inhibitor poisoning resulting from Internet misinformation on illicit substances. J. Toxicol. Clin. Toxicol.42(2) , 191–195 (2004).
  • Long H , NelsonLS, HoffmanRS. α-methyltryptamine revisited via easy Internet access. Vet. Hum. Toxicol.45(3) , 149 (2003).
  • Muller AA . New drugs of abuse update: foxy methoxy. J. Emerg. Nurs.30(5) , 507–508 (2004).
  • Alatrash G , MajhailNS, PileJC. Rhabdomyolysis after ingestion of “foxy,” a hallucinogenic tryptamine derivative. Mayo Clin. Proc.81(4) , 550–551 (2006).
  • Sklerov J , LevineB, MooreKA, KingT, FowlerD. A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation. J. Anal. Toxicol.29(8) , 838–841 (2005).
  • Ott J . Pharmanopo-psychonautics: human intranasal, sublingual, intrarectal, pulmonary and oral pharmacology of bufotenine. J. Psychoactive Drugs33(3) , 273–281 (2001).
  • Ott J . Pharmepena-psychonautics: human intranasal, sublingual and oral pharmacology of 5-methoxy-N,N-dimethyl-tryptamine. J. Psychoactive Drugs33(4) , 403–407 (2001).
  • McKenna DJ . Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges. Pharmacol. Ther.102(2) , 111–129 (2004).
  • Callaway JC , GrobCS, McKennaDJet al. A demand for clarity regarding a case report on the ingestion of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in an ayahuasca preparation. J. Anal. Toxicol. 30(6) , 406–407; author reply 407 (2006).
  • Agurell S , HolmstedtB, LindgrenJE. Metabolism of 5-methoxy-N,-N dimethyltryptamine- 14C in the rat. Biochem. Pharmacol.18(10) , 2771–2781 (1969).
  • Yu AM , IdleJR, HerraizT, KupferA, GonzalezFJ. Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics13(6) , 307–319 (2003).
  • Yu AM , IdleJR, GonzalezFJ. Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab. Rev.36(2) , 243–277 (2004).
  • Roth BL , ChoudharyMS, KhanN, UluerAZ. High-affinity agonist binding is not sufficient for agonist efficacy at 5-hydroxytryptamine2A receptors: evidence in favor of a modified ternary complex model. J. Pharmacol. Exp. Ther.280(2) , 576–583 (1997).
  • McBride MC . Bufotenine: toward an understanding of possible psychoactive mechanisms. J. Psychoactive Drugs32(3) , 321–331 (2000).
  • Fuller RW , SnoddyHD, PerryKW. Tissue distribution, metabolism and effects of bufotenine administered to rats. Neuropharmacology34(7) , 799–804 (1995).
  • Karkkainen J , ForsstromT, TornaeusJet al. Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues. Scand. J. Clin. Lab. Invest. 65(3) , 189–199 (2005).
  • Forsstrom T , TuominenJ, KarkkainenJ. Determination of potentially hallucinogenic N-dimethylated indoleamines in human urine by HPLC/ESI-MS-MS. Scand. J. Clin. Lab. Invest.61(7) , 547–556 (2001).
  • Barker SA , Littlefield-ChabaudMA, DavidC. Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method. J. Chromatogr. B Biomed. Sci. Appl.751(1) , 37–47 (2001).
  • Chen BH , LiuJT, ChenWX, ChenHM, LinCH. A general approach to the screening and confirmation of tryptamines and phenethylamines by mass spectral fragmentation. Talanta74(4) , 512–517 (2008).
  • Karkkainen J , RaisanenM, HuttunenMOet al. Urinary excretion of bufotenin (N,N-dimethyl-5-hydroxytryptamine) is increased in suspicious violent offenders: a confirmatory study. Psychiatry Res. 58(2) , 145–152 (1995).
  • Winter JC , FilipinkRA, TimineriD, HelsleySE, RabinRA. The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors. Pharmacol. Biochem. Behav.65(1) , 75–82 (2000).
  • Krebs-Thomson K , RuizEM, MastenV, BuellM, GeyerMA. The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats. Psychopharmacology (Berl.)189(3) , 319–329 (2006).
  • Yu AM , HainingRL. Expression, purification, and characterization of mouse CYP2d22. Drug Metab. Dispos.34(7) , 1167–1174 (2006).
  • Corchero J , GranvilCP, AkiyamaTEet al. The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4α on the disposition of debrisoquine in the mouse. Mol. Pharmacol. 60(6) , 1260–1267 (2001).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.