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Review

Multidimensional Gas Chromatography Methods for Bioanalytical Research

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Pages 2461-2479 | Published online: 11 Nov 2014

References

  • Booth BP . Welcome to bioanalysis. Bioanalysis1 (1), 1–2 (2009).
  • Halket JM , WatermanD, PrzyborowskaAM, PatelRKP, FraserPD, BramleyPM. Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS. J. Exp. Bot. 56 (410), 219–243 (2005).
  • Wells RJ . Recent advances in non-silylation derivatization techniques for gas chromatography. J. Chromatogr. A843 (1–2), 1–18 (1999).
  • McNair HM , MillerJM. Basic Gas Chromatography. John Wiley & Sons, Inc., NJ, USA (2009).
  • Kell DB . Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med. Genomics2, 2 (2009).
  • Mounicou S , SzpunarJ, LobinskiR. Metallomics: the concept and methodology. Chem. Soc. Rev. 38 (4), 1119–1138 (2009).
  • Almstetter M , OefnerP, DettmerK. Comprehensive two-dimensional gas chromatography in metabolomics. Anal. Bioanal. Chem. 402 (6), 1993–2013 (2012).
  • World Anti-Doping Agency . The world anti-doping code. International Standard for Laboratories, Statue Number World Anti-Doping Agency. Montreal, Canada (2004).
  • Schomburg G . Two-dimensional gas chromatography: principles, instrumentation, methods. J. Chromatogr. A703 (1–2), 309–325 (1995).
  • Bertsch W . Two-dimensional gas chromatography. Concepts, instrumentation, and applications – Part 1: fundamentals, conventional two-dimensional gas chromatography, selected applications. J. High Resolut. Chromatogr. 22 (12), 647–665 (1999).
  • Tranchida PQ , SciarroneD, DugoP, MondelloL. Heart-cutting multidimensional gas chromatography: a review of recent evolution, applications, and future prospects. Anal. Chim. Acta716, 66–75 (2012).
  • Simmons MC , SnyderLR. Two-stage gas-liquid chromatography. Anal. Chem. 30 (1), 32–35 (1958).
  • Giddings JC . Two-dimensional separations: concept and promise. Anal. Chem. 56 (12), 1258A–1270A (1984).
  • Liu Z , PhillipsJB. Comprehensive two-dimensional gas chromatography using an on-column thermal modulator interface. J. Chromatogr. Sci. 29 (6), 227–231 (1991).
  • Edwards M , MostafaA, GóreckiT. Modulation in comprehensive two-dimensional gas chromatography: 20 years of innovation. Anal. Bioanal. Chem. 401 (8), 2335–2349 (2011).
  • Marriott PJ , KinghornRM. Longitudinally modulated cryogenic system. A generally applicable approach to solute trapping and mobilization in gas chromatography. Anal. Chem. 69 (13), 2582–2588 (1997).
  • Ledford EB , BillesbachC. Jet-cooled thermal modulator for comprehensive multidimensional gas chromatography. J. High. Resolut. Chromatogr. 23 (3), 202–204 (2000).
  • Seeley JV , SeeleySK. Multidimensional gas chromatography: fundamental advances and new applications. Anal. Chem. 85 (2), 557–578 (2012).
  • Khummueng W , HarynukJ, MarriottPJ. Modulation ratio in comprehensive two-dimensional gas chromatography. Anal. Chem. 78 (13), 4578–4587 (2006).
  • Dallüge J , BeensJ, BrinkmanUAT. Comprehensive two-dimensional gas chromatography: a powerful and versatile analytical tool. J. Chromatogr. A1000 (1–2), 69–108 (2003).
  • Giddings JC . Maximum number of components resolvable by gel filtration and other elution chromatographic methods. Anal. Chem. 39 (8), 1027–1028 (1967).
  • Mostafa A , EdwardsM, GóreckiT. Optimization aspects of comprehensive two-dimensional gas chromatography. J. Chromatogr. A1255, 38–55 (2012).
  • Poole SK , PooleCF. The orthogonal character of stationary phases for gas chromatography. J. Sep. Sci. 31 (6–7), 1118–1123 (2008).
  • Ong RCY , MarriottPJ. A review of basic concepts in comprehensive two-dimensional gas chromatography. J. Chromatogr. Sci. 40 (5), 276–291 (2002).
  • Phillips JB , BeensJ. Comprehensive two-dimensional gas chromatography: a hyphenated method with strong coupling between the two dimensions. J. Chromatogr. A856 (1–2), 331–347 (1999).
  • Adahchour M , TasşözA, BeensJ, VreulsRJJ, BatenburgAM, BrinkmanUAT. Fast comprehensive two-dimensional gas chromatography (GC × GC) using 50-μm ID second-dimension columns. J. Sep. Sci. 26 (9–10), 753–760 (2003).
  • Marriott PJ . Detector technologies and applications in comprehensive two-dimensional gas chromatography. In : Comprehensive Chromatography in Combination with Mass Spectrometry. Desiderio, DM, Nibbering, NM ( Eds). John Wiley & Sons Inc., NJ, USA, 243–280 (2011).
  • da Silva JM , ZiniCA, CaramãoEB. Evaluation of comprehensive two-dimensional gas chromatography with micro-electron capture detection for the analysis of seven pesticides in sediment samples. J. Chromatogr. A1218 (21), 3166–3172 (2011).
  • Liu X , LiD, LiJ, RoseG, MarriottPJ. Organophosphorus pesticide and ester analysis by using comprehensive two-dimensional gas chromatography with flame photometric detection. J. Hazard. Mater. 263 (2), 761–767 (2013).
  • Lissitsyna K , HuertasS, QuinteroLC, PoloLM. Quantitation method of N, N′-disalicylidene-1,2-propanediamine by comprehensive two-dimensional gas chromatography coupled to a nitrogen chemiluminescence detector. J. Sep. Sci. 36 (11), 1768–1763 (2013).
  • Jones D , ScarlettAG, WestCEet al. Elemental and spectroscopic characterization of fractions of an acidic extract of oil sands process water. Chemosphere93 (9), 1655–1664 (2013).
  • Engel E , RatelJ, BlinetP, ChinS-T, RoseG, MarriottPJ. Benchmarking of candidate detectors for multiresidue analysis of pesticides by comprehensive two-dimensional gas chromatography. J. Chromatogr. A1311, 140–148 (2013).
  • Zrostlikova J , BinkleyJ, WojtowiczP, AdamT. Application of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry in human metabolomic studies. J. Anal. Chem. 66 (13), 1333–1340 (2011).
  • Song SM , MarriottP, WynneP. Comprehensive two-dimensional gas chromatography-quadrupole mass spectrometric analysis of drugs. J. Chromatogr. A1058 (1–2), 223–232 (2004).
  • Purcaro G , TranchidaPQ, RagoneseCet al. Evaluation of a rapid-scanning quadrupole mass spectrometer in an apolar × ionic-liquid comprehensive two-dimensional gas chromatography system. Anal. Chem. 82 (20), 8583–8590 (2010).
  • Schwartz Z , AnY, KonstantynovaKI, JacksonGP. Analysis of household ignitable liquids and their post-combustion weathered residues using compound-specific gas chromatography-combustion-isotope ratio mass spectrometry. Forensic Sci. Int. 233 (1–3), 365–373 (2013).
  • Brailsford AD , GavrilovicI, AnsellRJ, CowanDA, KicmanAT. Two-dimensional gas chromatography with heart-cutting for isotope ratio mass spectrometry analysis of steroids in doping control. Drug Test Anal. 4 (12), 962–969 (2012).
  • Tobias HJ , ZhangY, AuchusRJ, BrennaJT. Detection of synthetic testosterone use by novel comprehensive two-dimensional gas chromatography combustion-isotope ratio mass spectrometry. Anal. Chem. 83 (18), 7158–7165 (2011).
  • Koek MM , MuilwijkB, van der WerfMJ, HankemeierT. Microbial metabolomics with gas chromatography/mass spectrometry. Anal. Chem. 78 (4), 1272–1281 (2006).
  • Theodoridis GA , GikaHG, WantEJ, WilsonID. Liquid chromatography–mass spectrometry based global metabolite profiling: a review. Anal. Chim. Acta711, 7–16 (2012).
  • Pasikanti KK , HoPC, ChanECY. Gas chromatography/mass spectrometry in metabolic profiling of biological fluids. J. Chromatogr. B871 (2), 202–211 (2008).
  • Nicholson JK , LindonJC, HolmesE. ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica29 (11), 1181–1189 (1999).
  • Jeremy R . Bioinformatics: An Introduction. SpringerLondon, UK (2009).
  • Mitrevski BS , KouremenosKA, MarriottPJ. Accelerating analysis for metabolomics, drugs and their metabolites in biological samples using multidimensional gas chromatography. Bioanalysis1 (2), 367–391 (2009).
  • Fernie AR , TretheweyRN, KrotzkyAJ, WillmitzerL. Metabolite profiling: from diagnostics to systems biology. Nat. Rev. Mol. Cell Biol. 5 (9), 763–769 (2004).
  • Roessner-Tunali U , HegemannB, LytovchenkoAet al. Metabolic profiling of transgenic tomato plants overexpressing hexokinase reveals that the influence of hexose phosphorylation diminishes during fruit development. Plant Physiol. 133 (1), 84–99 (2003).
  • Horning EC , HorningMG. Metabolic profiles: gas-phase methods for analysis of metabolites. Clin. Chem. 17 (8), 802–809 (1971).
  • Mercuro G , BassareoPP, DeiddaM, CadedduC, BarberiniL, AtzoriL. Metabolomics: a new era in cardiology?J. Cardiovasc. Med. 12 (11), 800–805 (2011).
  • Pearson H . Meet the human metabolome. Nature446 (7131), 8 (2007).
  • Wishart DS , TzurD, KnoxCet al. HMDB: The Human Metabolome Database. Nucleic Acids Res. 35 (Suppl. 1), D521–D526 (2007).
  • Wishart DS , JewisonT, GuoACet al. HMDB 3.0 – The Human Metabolome Database in 2013. Nucleic Acids Res. 41 (D1), D801–D807 (2013).
  • Hartonen M , MattilaI, RuskeepääA-L, OrešicM, HyötyläinenT. Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. J. Chromatogr. A1293, 142–149 (2013).
  • Rocha SM , CaldeiraM, CarrolaJ, SantosM, CruzN, DuarteIF. Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry. J. Chromatogr. A1252, 155–163 (2012).
  • Asiago VM , AlvaradoLZ, ShanaiahNet al. Early detection of recurrent breast cancer using metabolite profiling. Cancer Res. 70 (21), 8309–8318 (2010).
  • Reichenbach SE , TianX, TaoQ, LedfordEBJr, WuZ, FiehnO. Informatics for cross-sample analysis with comprehensive two-dimensional gas chromatography and high-resolution mass spectrometry (GC × GC-HRMS). Talanta83 (4), 1279–1288 (2011).
  • Mal M , KohPK, CheahPY, ChanECY. Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry. Anal. Bioanal. Chem. 403 (2), 483–493 (2012).
  • Pasikanti KK , EsuvaranathanK, HongYJet al. Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry. J. Proteome Res. 12 (9), 3865–3873 (2013).
  • Kouremenos KA , PittJ, MarriottPJ. Metabolic profiling of infant urine using comprehensive two-dimensional gas chromatography: application to the diagnosis of organic acidurias and biomarker discovery. J. Chromatogr. A1217 (1), 104–111 (2010).
  • Wojtowicz P , ZrostlíkováJ, KovalczukT, SchurekJAdamT. Evaluation of comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry for the diagnosis of inherited metabolic disorders using an automated data processing strategy. J. Chromatogr. A1217 (51), 8054–8061 (2010).
  • Li X , XuZ, LuXet al. Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: biomarker discovery for diabetes mellitus. Anal. Chim. Acta633 (2), 257–262 (2009).
  • Oresic M , SimellS, Sysi-AhoMet al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to Type 1 diabetes. J. Exp. Med. 205 (13), 2975–2984 (2008).
  • Oresic M , TangJ, Seppanen-LaaksoTet al. Metabolome in schizophrenia and other psychotic disorders: a general population-based study. Genome Med. 3 (3), 19 (2011).
  • Lankinen M , SchwabU, Seppanen-LaaksoTet al. Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women. J. Nutr. 141 (1), 31–36 (2011).
  • Sanchez JM , SacksRD. Development of a multibed sorption trap, comprehensive two-dimensional gas chromatography, and time-of-flight mass spectrometry system for the analysis of volatile organic compounds in human breath. Anal. Chem. 78 (9), 3046–3054 (2006).
  • Libardoni M , StevensPT, WaiteJH, SacksR. Analysis of human breath samples with a multi-bed sorption trap and comprehensive two-dimensional gas chromatography (GC × GC). J. Chromatogr. B842 (1), 13–21 (2006).
  • Das MK , BishwalSC, DasAet al. Investigation of gender-specific exhaled breath volatome in humans by GC × GC–TOF-MS. Anal. Chem. 86 (2), 1229–1237 (2013).
  • Phillips M , CataneoRN, ChaturvediAet al. Detection of an extended human volatome with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. PLoS ONE8 (9), e75274 (2013).
  • Phillips M , ByrnesR, CataneoRNet al. Detection of volatile biomarkers of therapeutic radiation in breath. J. Breath Res. 7 (3), 1–8 (2013).
  • Dekeirsschieter J , StefanutoP-H, BrasseurC, HaubrugeE, FocantJ-F. Enhanced characterization of the smell of death by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC × GC–TOF MS). PLoS ONE7 (6), e39005 (2012).
  • Stadler S , StefanutoPH, BroklM, ForbesSL, FocantJF. Characterization of volatile organic compounds from human analogue decomposition using thermal desorption coupled to comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. Anal. Chem. 85 (2), 998–1005 (2013).
  • Kueh AJ , MarriottPJ, WynnePM, VineJH. Application of comprehensive two-dimensional gas chromatography to drugs analysis in doping control. J. Chromatogr. A1000 (1–2), 109–124 (2003).
  • Song SM , MarriottP, KotsosA, DrummerOH, WynneP. Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC × GC–TOF MS) for drug screening and confirmation. Forensic Sci. Int. 143 (2–3), 87–101 (2004).
  • Mitrevski BS , BrennaJT, ZhangY, MarriottPJ. Application of comprehensive two-dimensional gas chromatography to sterols analysis. J. Chromatogr. A1214 (1–2), 134–142 (2008).
  • Mitrevski BS , WilairatP, MarriottPJ. Evaluation of World Anti-Doping Agency criteria for anabolic agent analysis by using comprehensive two-dimensional gas chromatography-mass spectrometry. Anal. Bioanal. Chem. 396 (7), 2503–2511 (2010).
  • Silva AI Jr , PereiraHM, CasilliA, ConceicaoFC, Aquino NetoFR. Analytical challenges in doping control: comprehensive two-dimensional gas chromatography with time of flight mass spectrometry, a promising option. J. Chromatogr. A1216 (14), 2913–2922 (2009).
  • Barbosa SS , LealFD, PadilhaMCet al. Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry. Quim. Nova35 (5), 982–987 (2012).
  • Zhang Y , TobiasHJ, AuchusRJ, BrennaJT. Comprehensive two-dimensional gas chromatography fast quadrupole mass spectrometry (GC × GC-qMS) for urinary steroid profiling: mass spectral characteristics with chemical ionization. Drug Test Anal. 3 (11–12), 857–867 (2011).
  • Zhang Y , TobiasHJ, BrennaJT. Highly sensitive and selective analysis of urinary steroids by comprehensive two-dimensional gas chromatography combined with positive chemical ionization quadrupole mass spectrometry. Analyst137 (13), 3102–3110 (2012).
  • Moore C , RanaS, CoulterC, FeyerhermF, PrestH. Application of two-dimensional gas chromatography with electron capture chemical ionization mass spectrometry to the detection of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in hair. J. Anal. Toxicol. 30 (3), 171–177 (2006).
  • Marin SJ , ColesR, UrryFM, McMillinGA. Confirmation of cannabinoids in meconium using two-dimensional gas chromatography with mass spectrometry detection. J. Chromatogr. B858 (1–2), 59–64 (2007).
  • Milman G , BarnesAJ, LoweRH, HuestisMA. Simultaneous quantification of cannabinoids and metabolites in oral fluid by two-dimensional gas chromatography mass spectrometry. J. Chromatogr. A1217 (9), 1513–1521 (2010).
  • Guthery B , BassindaleA, PillingerCT, MorganGH. The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 23 (3), 340–348 (2009).
  • Guthery B , BassindaleT, BassindaleA, PillingerCT, MorganGH. Qualitative drug analysis of hair extracts by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. J. Chromatogr. A1217 (26), 4402–4410 (2010).
  • Barnes BB , SnowNH. Analysis of salvinorin A in plants, water, and urine using solid-phase microextraction-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry. J. Chromatogr. A1226, 110–115 (2012).
  • Tobias HJ , SacksGL, ZhangY, BrennaJT. Comprehensive two-dimensional gas chromatography combustion isotope ratio mass spectrometry. Anal. Chem. 80 (22), 8613–8621 (2008).
  • Menéndez-Carreño M , SteenbergenH, JanssenH-G. Development and validation of a comprehensive two-dimensional gas chromatography–mass spectrometry method for the analysis of phytosterol oxidation products in human plasma. Anal. Bioanal. Chem. 402 (6), 2023–2032 (2012).
  • van der Meer JA , TrapHC, NoortD, van der SchansMJ. Comprehensive gas chromatography with time of flight MS and large volume introduction for the detection of fluoride-induced regenerated nerve agent in biological samples. J. Chromatogr. B878 (17–18), 1320–1325 (2010).
  • Hashimoto S , ZushiY, FushimiA, TakazawaY, TanabeK, ShibataY. Selective extraction of halogenated compounds from data measured by comprehensive multidimensional gas chromatography/high resolution time-of-flight mass spectrometry for non-target analysis of environmental and biological samples. J. Chromatogr. A1282, 183–189 (2013).
  • Kouremenos KA , JohanssonM, MarriottPJ. Advances in gas chromatographic methods for the identification of biomarkers in cancer. J. Cancer3, 404–420 (2012).
  • Lumachi F , BassoSM, BassoU. Breast cancer recurrence: role of serum tumor markers CEA and CA 15–13. In : Methods of Cancer Diagnosis, Therapy and Prognosis. Hayat, MA ( Ed.). Springer, London, UK, 109–115 (2008).
  • Lumachi F , ErmaniM, BrandesAA, BassoS, BassoU, BoccagniP. Predictive value of different prognostic factors in breast cancer recurrences: multivariate analysis using a logistic regression model. Anticancer Res. 21 (6a), 4105–4108 (2001).
  • Adahchour M , BeensJ, BrinkmanUAT. Recent developments in the application of comprehensive two-dimensional gas chromatography. J. Chromatogr. A1186 (1–2), 67–108 (2008).
  • Chan EC , KohPK, MalMet al. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J. Proteome Res. 8 (1), 352–361 (2009).
  • Issachar D , HollandJF, SweeleyCC. Metabolic profiles of organic acids from human plasma. Anal. Chem. 54 (1), 29–32 (1982).

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