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Review

Modulation of host adaptive immunity by hRSV proteins

, , , , &
Pages 740-751 | Received 16 Mar 2014, Accepted 31 Jul 2014, Published online: 05 Aug 2014

References

  • Bueno SM, González PA, Pacheco R, Leiva ED, Cautivo KM, Tobar HE, Mora JE, Prado CE, Zúñiga JP, Jiménez J, et al. Host immunity during RSV pathogenesis. Int Immunopharmacol 2008; 8:1320 - 9; http://dx.doi.org/10.1016/j.intimp.2008.03.012; PMID: 18687294
  • Bueno SM, González PA, Riedel CA, Carreño LJ, Vásquez AE, Kalergis AM. Local cytokine response upon respiratory syncytial virus infection. Immunol Lett 2011; 136:122 - 9; http://dx.doi.org/10.1016/j.imlet.2010.12.003; PMID: 21195729
  • Hacking D, Hull J. Respiratory syncytial virus--viral biology and the host response. J Infect 2002; 45:18 - 24; http://dx.doi.org/10.1053/jinf.2002.1015; PMID: 12217726
  • Glezen WP, Taber LH, Frank AL, Kasel JA. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 1986; 140:543 - 6; PMID: 3706232
  • El Saleeby CM, Devincenzo JP. Respiratory syncytial virus load and disease severity in the community. J Med Virol 2011; 83:904 - 5; http://dx.doi.org/10.1002/jmv.22039; PMID: 21412798
  • El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, Devincenzo JP. Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis 2011; 204:996 - 1002; http://dx.doi.org/10.1093/infdis/jir494; PMID: 21881113
  • van Drunen Littel-van den Hurk S, Watkiss ER. Pathogenesis of respiratory syncytial virus. Curr Opin Virol 2012; 2:300 - 5; http://dx.doi.org/10.1016/j.coviro.2012.01.008; PMID: 22709517
  • Thornburg NJ, Hayward SL, Crowe JE Jr.. Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-κB. MBio 2012; 3:e00220-12; http://dx.doi.org/10.1128/mBio.00220-12; PMID: 23249809
  • Nair H, Brooks WA, Katz M, Roca A, Berkley JA, Madhi SA, Simmerman JM, Gordon A, Sato M, Howie S, et al. Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet 2011; 378:1917 - 30; http://dx.doi.org/10.1016/S0140-6736(11)61051-9; PMID: 22078723
  • Gralton J, Tovey ER, McLaws ML, Rawlinson WD. Respiratory virus RNA is detectable in airborne and droplet particles. J Med Virol 2013; 85:2151 - 9; PMID: 23959825
  • Hall CB, Douglas RG Jr., Schnabel KC, Geiman JM. Infectivity of respiratory syncytial virus by various routes of inoculation. Infect Immun 1981; 33:779 - 83; PMID: 7287181
  • Hall CB, Douglas RG Jr.. Modes of transmission of respiratory syncytial virus. J Pediatr 1981; 99:100 - 3; http://dx.doi.org/10.1016/S0022-3476(81)80969-9; PMID: 7252646
  • Domurat F, Roberts NJ Jr., Walsh EE, Dagan R. Respiratory syncytial virus infection of human mononuclear leukocytes in vitro and in vivo. J Infect Dis 1985; 152:895 - 902; http://dx.doi.org/10.1093/infdis/152.5.895; PMID: 2931491
  • Yui I, Hoshi A, Shigeta Y, Takami T, Nakayama T. Detection of human respiratory syncytial virus sequences in peripheral blood mononuclear cells. J Med Virol 2003; 70:481 - 9; http://dx.doi.org/10.1002/jmv.10421; PMID: 12767015
  • Collins PL, Melero JA. Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years. Virus Res 2011; 162:80 - 99; http://dx.doi.org/10.1016/j.virusres.2011.09.020; PMID: 21963675
  • Domachowske JB, Rosenberg HF. Respiratory syncytial virus infection: immune response, immunopathogenesis, and treatment. Clin Microbiol Rev 1999; 12:298 - 309; PMID: 10194461
  • Ahmadian G, Randhawa JS, Easton AJ. Expression of the ORF-2 protein of the human respiratory syncytial virus M2 gene is initiated by a ribosomal termination-dependent reinitiation mechanism. EMBO J 2000; 19:2681 - 9; http://dx.doi.org/10.1093/emboj/19.11.2681; PMID: 10835365
  • Bermingham A, Collins PL. The M2-2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription. Proc Natl Acad Sci U S A 1999; 96:11259 - 64; http://dx.doi.org/10.1073/pnas.96.20.11259; PMID: 10500164
  • Cheng X, Park H, Zhou H, Jin H. Overexpression of the M2-2 protein of respiratory syncytial virus inhibits viral replication. J Virol 2005; 79:13943 - 52; http://dx.doi.org/10.1128/JVI.79.22.13943-13952.2005; PMID: 16254330
  • Johnson CH, Miao C, Blanchard EG, Caidi H, Radu GU, Harcourt JL, Haynes LM. Effect of chemokine receptor CX3CR1 deficiency in a murine model of respiratory syncytial virus infection. Comp Med 2012; 62:14 - 20; PMID: 22330646
  • Marr N, Turvey SE. Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication. Innate Immun 2012; 18:856 - 65; http://dx.doi.org/10.1177/1753425912444479; PMID: 22535679
  • Hallak LK, Spillmann D, Collins PL, Peeples ME. Glycosaminoglycan sulfation requirements for respiratory syncytial virus infection. J Virol 2000; 74:10508 - 13; http://dx.doi.org/10.1128/JVI.74.22.10508-10513.2000; PMID: 11044095
  • Johnson TR, McLellan JS, Graham BS. Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2. J Virol 2012; 86:1339 - 47; http://dx.doi.org/10.1128/JVI.06096-11; PMID: 22090124
  • Tayyari F, Marchant D, Moraes TJ, Duan W, Mastrangelo P, Hegele RG. Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Nat Med 2011; 17:1132 - 5; http://dx.doi.org/10.1038/nm.2444; PMID: 21841784
  • González PA, Carreño LJ, Bueno SM, Riedel CA, Kalergis AM. Understanding respiratory syncytial virus infection to improve treatment and immunity. Curr Mol Med 2013; 13:1122 - 39; http://dx.doi.org/10.2174/1566524011313070007; PMID: 23157678
  • Noton SL, Deflubé LR, Tremaglio CZ, Fearns R. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. PLoS Pathog 2012; 8:e1002980; http://dx.doi.org/10.1371/journal.ppat.1002980; PMID: 23093940
  • Collins PL, Murphy BR. New generation live vaccines against human respiratory syncytial virus designed by reverse genetics. Proc Am Thorac Soc 2005; 2:166 - 73; http://dx.doi.org/10.1513/pats.200501-011AW; PMID: 16113487
  • Liljeroos L, Krzyzaniak MA, Helenius A, Butcher SJ. Architecture of respiratory syncytial virus revealed by electron cryotomography. Proc Natl Acad Sci U S A 2013; 110:11133 - 8; http://dx.doi.org/10.1073/pnas.1309070110; PMID: 23776214
  • Rodriguez R, Ramilo O. Respiratory syncytial virus: how, why and what to do. J Infect 2014; 68:Suppl 1 S115 - 8; http://dx.doi.org/10.1016/j.jinf.2013.09.021; PMID: 24171820
  • Mitra R, Baviskar P, Duncan-Decocq RR, Patel D, Oomens AG. The human respiratory syncytial virus matrix protein is required for maturation of viral filaments. J Virol 2012; 86:4432 - 43; http://dx.doi.org/10.1128/JVI.06744-11; PMID: 22318136
  • Batonick M, Wertz GW. Requirements for Human Respiratory Syncytial Virus Glycoproteins in Assembly and Egress from Infected Cells. Adv Virol 2011; 2011; http://dx.doi.org/10.1155/2011/343408; PMID: 21931576
  • Feldman SA, Audet S, Beeler JA. The fusion glycoprotein of human respiratory syncytial virus facilitates virus attachment and infectivity via an interaction with cellular heparan sulfate. J Virol 2000; 74:6442 - 7; http://dx.doi.org/10.1128/JVI.74.14.6442-6447.2000; PMID: 10864656
  • Gibbs JD, Ornoff DM, Igo HA, Zeng JY, Imani F. Cell cycle arrest by transforming growth factor beta1 enhances replication of respiratory syncytial virus in lung epithelial cells. J Virol 2009; 83:12424 - 31; http://dx.doi.org/10.1128/JVI.00806-09; PMID: 19759128
  • Lindquist ME, Lifland AW, Utley TJ, Santangelo PJ, Crowe JE Jr.. Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication. J Virol 2010; 84:12274 - 84; http://dx.doi.org/10.1128/JVI.00260-10; PMID: 20844027
  • Yoneyama M, Fujita T. Function of RIG-I-like receptors in antiviral innate immunity. J Biol Chem 2007; 282:15315 - 8; http://dx.doi.org/10.1074/jbc.R700007200; PMID: 17395582
  • Onomoto K, Jogi M, Yoo JS, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K, et al. Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS One 2012; 7:e43031; http://dx.doi.org/10.1371/journal.pone.0043031; PMID: 22912779
  • Lindquist ME, Mainou BA, Dermody TS, Crowe JE Jr.. Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication. Virology 2011; 413:103 - 10; http://dx.doi.org/10.1016/j.virol.2011.02.009; PMID: 21377708
  • Langereis MA, Feng Q, van Kuppeveld FJ. MDA5 localizes to stress granules, but this localization is not required for the induction of type I interferon. J Virol 2013; 87:6314 - 25; http://dx.doi.org/10.1128/JVI.03213-12; PMID: 23536668
  • Othumpangat S, Walton C, Piedimonte G. MicroRNA-221 modulates RSV replication in human bronchial epithelium by targeting NGF expression. PLoS One 2012; 7:e30030; http://dx.doi.org/10.1371/journal.pone.0030030; PMID: 22272270
  • Głobińska A, Pawełczyk M, Kowalski ML. MicroRNAs and the immune response to respiratory virus infections. Expert Rev Clin Immunol 2014; 10:963 - 71; http://dx.doi.org/10.1586/1744666X.2014.913482; PMID: 24784476
  • Chen CZ, Schaffert S, Fragoso R, Loh C. Regulation of immune responses and tolerance: the microRNA perspective. Immunol Rev 2013; 253:112 - 28; http://dx.doi.org/10.1111/imr.12060; PMID: 23550642
  • Bakre A, Mitchell P, Coleman JK, Jones LP, Saavedra G, Teng M, Tompkins SM, Tripp RA. Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication. J Gen Virol 2012; 93:2346 - 56; http://dx.doi.org/10.1099/vir.0.044255-0; PMID: 22894925
  • Qin L, Hu CP, Feng JT, Xia Q. Activation of lymphocytes induced by bronchial epithelial cells with prolonged RSV infection. PLoS One 2011; 6:e27113; http://dx.doi.org/10.1371/journal.pone.0027113; PMID: 22216085
  • Tripp RA. Respiratory Syncytial Virus (RSV) Modulation at the Virus-Host Interface Affects Immune Outcome and Disease Pathogenesis. Immune Netw 2013; 13:163 - 7; http://dx.doi.org/10.4110/in.2013.13.5.163; PMID: 24198740
  • Kim TH, Lee HK. Innate immune recognition of respiratory syncytial virus infection. BMB Rep 2014; 47:184 - 91; http://dx.doi.org/10.5483/BMBRep.2014.47.4.050; PMID: 24568879
  • Zeng R, Cui Y, Hai Y, Liu Y. Pattern recognition receptors for respiratory syncytial virus infection and design of vaccines. Virus Res 2012; 167:138 - 45; http://dx.doi.org/10.1016/j.virusres.2012.06.003; PMID: 22698878
  • Murawski MR, Bowen GN, Cerny AM, Anderson LJ, Haynes LM, Tripp RA, Kurt-Jones EA, Finberg RW. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. J Virol 2009; 83:1492 - 500; http://dx.doi.org/10.1128/JVI.00671-08; PMID: 19019963
  • Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000; 1:398 - 401; http://dx.doi.org/10.1038/80833; PMID: 11062499
  • Groskreutz DJ, Monick MM, Powers LS, Yarovinsky TO, Look DC, Hunninghake GW. Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol 2006; 176:1733 - 40; http://dx.doi.org/10.4049/jimmunol.176.3.1733; PMID: 16424203
  • Lukacs NW, Smit JJ, Mukherjee S, Morris SB, Nunez G, Lindell DM. Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation. J Immunol 2010; 185:2231 - 9; http://dx.doi.org/10.4049/jimmunol.1000733; PMID: 20624950
  • Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6:981 - 8; http://dx.doi.org/10.1038/ni1243; PMID: 16127453
  • Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441:101 - 5; http://dx.doi.org/10.1038/nature04734; PMID: 16625202
  • Bals R, Hiemstra PS. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 2004; 23:327 - 33; http://dx.doi.org/10.1183/09031936.03.00098803; PMID: 14979512
  • LeVine AM, Whitsett JA, Hartshorn KL, Crouch EC, Korfhagen TR. Surfactant protein D enhances clearance of influenza A virus from the lung in vivo. J Immunol 2001; 167:5868 - 73; http://dx.doi.org/10.4049/jimmunol.167.10.5868; PMID: 11698462
  • Wright JR. Immunomodulatory functions of surfactant. Physiol Rev 1997; 77:931 - 62; PMID: 9354809
  • Crouch E, Wright JR. Surfactant proteins a and d and pulmonary host defense. Annu Rev Physiol 2001; 63:521 - 54; http://dx.doi.org/10.1146/annurev.physiol.63.1.521; PMID: 11181966
  • Barr FE, Pedigo H, Johnson TR, Shepherd VL. Surfactant protein-A enhances uptake of respiratory syncytial virus by monocytes and U937 macrophages. Am J Respir Cell Mol Biol 2000; 23:586 - 92; http://dx.doi.org/10.1165/ajrcmb.23.5.3771; PMID: 11062136
  • Hickling TP, Bright H, Wing K, Gower D, Martin SL, Sim RB, Malhotra R. A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial virus infection in vitro and in vivo. Eur J Immunol 1999; 29:3478 - 84; http://dx.doi.org/10.1002/(SICI)1521-4141(199911)29:11<3478::AID-IMMU3478>3.0.CO;2-W; PMID: 10556802
  • Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M. Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002; 168:5989 - 92; http://dx.doi.org/10.4049/jimmunol.168.12.5989; PMID: 12055204
  • Sano H, Chiba H, Iwaki D, Sohma H, Voelker DR, Kuroki Y. Surfactant proteins A and D bind CD14 by different mechanisms. J Biol Chem 2000; 275:22442 - 51; http://dx.doi.org/10.1074/jbc.M001107200; PMID: 10801802
  • Murakami S, Iwaki D, Mitsuzawa H, Sano H, Takahashi H, Voelker DR, Akino T, Kuroki Y. Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2. J Biol Chem 2002; 277:6830 - 7; http://dx.doi.org/10.1074/jbc.M106671200; PMID: 11724772
  • Miazgowicz MM, Elliott MS, Debley JS, Ziegler SF. Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells. J Inflamm Res 2013; 6:53 - 61; PMID: 23576878
  • Han J, Dakhama A, Jia Y, Wang M, Zeng W, Takeda K, Shiraishi Y, Okamoto M, Ziegler SF, Gelfand EW. Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand. J Allergy Clin Immunol 2012; 130:1175 - 86, e9; http://dx.doi.org/10.1016/j.jaci.2012.08.033; PMID: 23036746
  • Qiao J, Li A, Jin X. TSLP from RSV-stimulated rat airway epithelial cells activates myeloid dendritic cells. Immunol Cell Biol 2011; 89:231 - 8; http://dx.doi.org/10.1038/icb.2010.85; PMID: 20603637
  • Lay MK, González PA, León MA, Céspedes PF, Bueno SM, Riedel CA, Kalergis AM. Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response. Microbes Infect 2013; 15:230 - 42; http://dx.doi.org/10.1016/j.micinf.2012.11.012; PMID: 23246463
  • Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med 1974; 139:380 - 97; http://dx.doi.org/10.1084/jem.139.2.380; PMID: 4589990
  • Zammit DJ, Cauley LS, Pham QM, Lefrançois L. Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 2005; 22:561 - 70; http://dx.doi.org/10.1016/j.immuni.2005.03.005; PMID: 15894274
  • Monick MM, Powers LS, Hassan I, Groskreutz D, Yarovinsky TO, Barrett CW, Castilow EM, Tifrea D, Varga SM, Hunninghake GW. Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17. J Immunol 2007; 179:1648 - 58; http://dx.doi.org/10.4049/jimmunol.179.3.1648; PMID: 17641031
  • Iannello A, Debbeche O, Martin E, Attalah LH, Samarani S, Ahmad A. Viral strategies for evading antiviral cellular immune responses of the host. J Leukoc Biol 2006; 79:16 - 35; http://dx.doi.org/10.1189/jlb.0705397; PMID: 16204622
  • Pretel E, Camporeale G, de Prat-Gay G. The non-structural NS1 protein unique to respiratory syncytial virus: a two-state folding monomer in quasi-equilibrium with a stable spherical oligomer. PLoS One 2013; 8:e74338; http://dx.doi.org/10.1371/journal.pone.0074338; PMID: 24058549
  • Ling Z, Tran KC, Teng MN. Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I. J Virol 2009; 83:3734 - 42; http://dx.doi.org/10.1128/JVI.02434-08; PMID: 19193793
  • Spann KM, Tran KC, Collins PL. Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines. J Virol 2005; 79:5353 - 62; http://dx.doi.org/10.1128/JVI.79.9.5353-5362.2005; PMID: 15827150
  • Munir S, Le Nouen C, Luongo C, Buchholz UJ, Collins PL, Bukreyev A. Nonstructural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells. J Virol 2008; 82:8780 - 96; http://dx.doi.org/10.1128/JVI.00630-08; PMID: 18562519
  • Munir S, Hillyer P, Le Nouën C, Buchholz UJ, Rabin RL, Collins PL, Bukreyev A. Respiratory syncytial virus interferon antagonist NS1 protein suppresses and skews the human T lymphocyte response. PLoS Pathog 2011; 7:e1001336; http://dx.doi.org/10.1371/journal.ppat.1001336; PMID: 21533073
  • Bitko V, Shulyayeva O, Mazumder B, Musiyenko A, Ramaswamy M, Look DC, Barik S. Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kappaB-dependent, interferon-independent mechanism and facilitate virus growth. J Virol 2007; 81:1786 - 95; http://dx.doi.org/10.1128/JVI.01420-06; PMID: 17151097
  • Elliott J, Lynch OT, Suessmuth Y, Qian P, Boyd CR, Burrows JF, Buick R, Stevenson NJ, Touzelet O, Gadina M, et al. Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. J Virol 2007; 81:3428 - 36; http://dx.doi.org/10.1128/JVI.02303-06; PMID: 17251292
  • Wright PF, Karron RA, Madhi SA, Treanor JJ, King JC, O’Shea A, Ikizler MR, Zhu Y, Collins PL, Cutland C, et al. The interferon antagonist NS2 protein of respiratory syncytial virus is an important virulence determinant for humans. J Infect Dis 2006; 193:573 - 81; http://dx.doi.org/10.1086/499600; PMID: 16425137
  • Wu W, Tran KC, Teng MN, Heesom KJ, Matthews DA, Barr JN, Hiscox JA. The interactome of the human respiratory syncytial virus NS1 protein highlights multiple effects on host cell biology. J Virol 2012; 86:7777 - 89; http://dx.doi.org/10.1128/JVI.00460-12; PMID: 22593156
  • Jeffree CE, Brown G, Aitken J, Su-Yin DY, Tan BH, Sugrue RJ. Ultrastructural analysis of the interaction between F-actin and respiratory syncytial virus during virus assembly. Virology 2007; 369:309 - 23; http://dx.doi.org/10.1016/j.virol.2007.08.007; PMID: 17825340
  • Groskreutz DJ, Monick MM, Yarovinsky TO, Powers LS, Quelle DE, Varga SM, Look DC, Hunninghake GW. Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells. J Immunol 2007; 179:2741 - 7; http://dx.doi.org/10.4049/jimmunol.179.5.2741; PMID: 17709487
  • Lindemans CA, Coffer PJ, Schellens IM, de Graaff PM, Kimpen JL, Koenderman L. Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism. J Immunol 2006; 176:5529 - 37; http://dx.doi.org/10.4049/jimmunol.176.9.5529; PMID: 16622022
  • Collins PL, Graham BS. Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol 2008; 82:2040 - 55; http://dx.doi.org/10.1128/JVI.01625-07; PMID: 17928346
  • Becker Y. Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy--a review. Virus Genes 2006; 33:235 - 52; PMID: 16972040
  • Rixon HW, Brown G, Aitken J, McDonald T, Graham S, Sugrue RJ. The small hydrophobic (SH) protein accumulates within lipid-raft structures of the Golgi complex during respiratory syncytial virus infection. J Gen Virol 2004; 85:1153 - 65; http://dx.doi.org/10.1099/vir.0.19769-0; PMID: 15105532
  • Fuentes S, Tran KC, Luthra P, Teng MN, He B. Function of the respiratory syncytial virus small hydrophobic protein. J Virol 2007; 81:8361 - 6; http://dx.doi.org/10.1128/JVI.02717-06; PMID: 17494063
  • Gan SW, Ng L, Lin X, Gong X, Torres J. Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain. Protein Sci 2008; 17:813 - 20; http://dx.doi.org/10.1110/ps.073366208; PMID: 18369195
  • Triantafilou K, Kar S, Vakakis E, Kotecha S, Triantafilou M. Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation. Thorax 2013; 68:66 - 75; http://dx.doi.org/10.1136/thoraxjnl-2012-202182; PMID: 23229815
  • Gan SW, Tan E, Lin X, Yu D, Wang J, Tan GM, Vararattanavech A, Yeo CY, Soon CH, Soong TW, et al. The small hydrophobic protein of the human respiratory syncytial virus forms pentameric ion channels. J Biol Chem 2012; 287:24671 - 89; http://dx.doi.org/10.1074/jbc.M111.332791; PMID: 22621926
  • Langedijk JP, de Groot BL, Berendsen HJ, van Oirschot JT. Structural homology of the central conserved region of the attachment protein G of respiratory syncytial virus with the fourth subdomain of 55-kDa tumor necrosis factor receptor. Virology 1998; 243:293 - 302; http://dx.doi.org/10.1006/viro.1998.9066; PMID: 9568029
  • Segovia J, Sabbah A, Mgbemena V, Tsai SY, Chang TH, Berton MT, Morris IR, Allen IC, Ting JP, Bose S. TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One 2012; 7:e29695; http://dx.doi.org/10.1371/journal.pone.0029695; PMID: 22295065
  • Melero JA, García-Barreno B, Martínez I, Pringle CR, Cane PA. Antigenic structure, evolution and immunobiology of human respiratory syncytial virus attachment (G) protein. J Gen Virol 1997; 78:2411 - 8; PMID: 9349459
  • Chirkova T, Boyoglu-Barnum S, Gaston KA, Malik FM, Trau SP, Oomens AG, Anderson LJ. Respiratory syncytial virus G protein CX3C motif impairs human airway epithelial and immune cell responses. J Virol 2013; 87:13466 - 79; http://dx.doi.org/10.1128/JVI.01741-13; PMID: 24089561
  • Harcourt JL, Karron RA, Tripp RA. Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxis. J Infect Dis 2004; 190:1936 - 40; http://dx.doi.org/10.1086/425516; PMID: 15529257
  • Harcourt J, Alvarez R, Jones LP, Henderson C, Anderson LJ, Tripp RA. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. J Immunol 2006; 176:1600 - 8; http://dx.doi.org/10.4049/jimmunol.176.3.1600; PMID: 16424189
  • Johnson TR, Teng MN, Collins PL, Graham BS. Respiratory syncytial virus (RSV) G glycoprotein is not necessary for vaccine-enhanced disease induced by immunization with formalin-inactivated RSV. J Virol 2004; 78:6024 - 32; http://dx.doi.org/10.1128/JVI.78.11.6024-6032.2004; PMID: 15141000
  • Tripp RA, Dakhama A, Jones LP, Barskey A, Gelfand EW, Anderson LJ. The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P. J Virol 2003; 77:6580 - 4; http://dx.doi.org/10.1128/JVI.77.11.6580-6584.2003; PMID: 12743318
  • Miao C, Radu GU, Caidi H, Tripp RA, Anderson LJ, Haynes LM. Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab’)2 components mediates reduced pulmonary inflammation in mice. J Gen Virol 2009; 90:1119 - 23; http://dx.doi.org/10.1099/vir.0.009308-0; PMID: 19264600
  • Tripp RA, Jones LP, Haynes LM, Zheng H, Murphy PM, Anderson LJ. CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein. Nat Immunol 2001; 2:732 - 8; http://dx.doi.org/10.1038/90675; PMID: 11477410
  • Tripp RA, Moore D, Jones L, Sullender W, Winter J, Anderson LJ. Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice. J Virol 1999; 73:7099 - 107; PMID: 10438795
  • Johnson TR, Johnson JE, Roberts SR, Wertz GW, Parker RA, Graham BS. Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challenge. J Virol 1998; 72:2871 - 80; PMID: 9525607
  • Stevens WW, Sun J, Castillo JP, Braciale TJ. Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease. Viral Immunol 2009; 22:243 - 51; http://dx.doi.org/10.1089/vim.2009.0016; PMID: 19594395
  • Chang J, Choi SY, Jin HT, Sung YC, Braciale TJ. Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection. J Immunol 2004; 172:503 - 8; http://dx.doi.org/10.4049/jimmunol.172.1.503; PMID: 14688360
  • Mastrangelo P, Hegele RG. RSV fusion: time for a new model. Viruses 2013; 5:873 - 85; http://dx.doi.org/10.3390/v5030873; PMID: 23518574
  • McLellan JS, Chen M, Leung S, Graepel KW, Du X, Yang Y, Zhou T, Baxa U, Yasuda E, Beaumont T, et al. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science 2013; 340:1113 - 7; http://dx.doi.org/10.1126/science.1234914; PMID: 23618766
  • Ternette N, Tippler B, Uberla K, Grunwald T. Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F-protein of respiratory syncytial virus. Vaccine 2007; 25:7271 - 9; http://dx.doi.org/10.1016/j.vaccine.2007.07.025; PMID: 17825960
  • Openshaw PJ, Tregoning JS. Immune responses and disease enhancement during respiratory syncytial virus infection. Clin Microbiol Rev 2005; 18:541 - 55; http://dx.doi.org/10.1128/CMR.18.3.541-555.2005; PMID: 16020689
  • Takeuchi R, Tsutsumi H, Osaki M, Sone S, Imai S, Chiba S. Respiratory syncytial virus infection of neonatal monocytes stimulates synthesis of interferon regulatory factor 1 and interleukin-1beta (IL-1beta)-converting enzyme and secretion of IL-1beta. J Virol 1998; 72:837 - 40; PMID: 9420296
  • Haynes LM, Moore DD, Kurt-Jones EA, Finberg RW, Anderson LJ, Tripp RA. Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol 2001; 75:10730 - 7; http://dx.doi.org/10.1128/JVI.75.22.10730-10737.2001; PMID: 11602714
  • McDermott DS, Knudson CJ, Varga SM. Determining the breadth of the respiratory syncytial virus-specific T cell response. J Virol 2014; 88:3135 - 43; http://dx.doi.org/10.1128/JVI.02139-13; PMID: 24371055
  • Rock MT, Crowe JE Jr.. Identification of a novel human leucocyte antigen-A*01-restricted cytotoxic T-lymphocyte epitope in the respiratory syncytial virus fusion protein. Immunology 2003; 108:474 - 80; http://dx.doi.org/10.1046/j.1365-2567.2003.01619.x; PMID: 12667209
  • Fu Y, He J, Zheng X, Wu Q, Zhang M, Wang X, Wang Y, Xie C, Tang Q, Wei W, et al. Intranasal immunization with a replication-deficient adenoviral vector expressing the fusion glycoprotein of respiratory syncytial virus elicits protective immunity in BALB/c mice. Biochem Biophys Res Commun 2009; 381:528 - 32; http://dx.doi.org/10.1016/j.bbrc.2009.02.075; PMID: 19233131
  • De Baets S, Schepens B, Sedeyn K, Schotsaert M, Roose K, Bogaert P, Fiers W, Saelens X. Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice. J Virol 2013; 87:3314 - 23; http://dx.doi.org/10.1128/JVI.03019-12; PMID: 23302879
  • Behera AK, Matsuse H, Kumar M, Kong X, Lockey RF, Mohapatra SS. Blocking intercellular adhesion molecule-1 on human epithelial cells decreases respiratory syncytial virus infection. Biochem Biophys Res Commun 2001; 280:188 - 95; http://dx.doi.org/10.1006/bbrc.2000.4093; PMID: 11162498
  • Ruigrok RW, Crépin T. Nucleoproteins of negative strand RNA viruses; RNA binding, oligomerisation and binding to polymerase co-factor. Viruses 2010; 2:27 - 32; http://dx.doi.org/10.3390/v2010027; PMID: 21994598
  • Tawar RG, Duquerroy S, Vonrhein C, Varela PF, Damier-Piolle L, Castagné N, MacLellan K, Bedouelle H, Bricogne G, Bhella D, et al. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science 2009; 326:1279 - 83; http://dx.doi.org/10.1126/science.1177634; PMID: 19965480
  • Oliveira AP, Simabuco FM, Tamura RE, Guerrero MC, Ribeiro PG, Libermann TA, Zerbini LF, Ventura AM. Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells. Virus Res 2013; 177:108 - 12; http://dx.doi.org/10.1016/j.virusres.2013.07.010; PMID: 23892143
  • Money VA, McPhee HK, Mosely JA, Sanderson JM, Yeo RP. Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction. Proc Natl Acad Sci U S A 2009; 106:4441 - 6; http://dx.doi.org/10.1073/pnas.0805740106; PMID: 19251668
  • Galloux M, Tarus B, Blazevic I, Fix J, Duquerroy S, Eléouët JF. Characterization of a viral phosphoprotein binding site on the surface of the respiratory syncytial nucleoprotein. J Virol 2012; 86:8375 - 87; http://dx.doi.org/10.1128/JVI.00058-12; PMID: 22623798
  • González PA, Prado CE, Leiva ED, Carreño LJ, Bueno SM, Riedel CA, Kalergis AM. Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells. Proc Natl Acad Sci U S A 2008; 105:14999 - 5004; http://dx.doi.org/10.1073/pnas.0802555105; PMID: 18818306