Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

Samar El-Kalyoubia Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, EgyptView further author information

Mohamed M. Khalifab Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information

Mahmoud T. Abo-Elfadlc Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt;d Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, EgyptView further author information

Ahmed A. El-Sayede Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Giza, EgyptView further author information

Ahmed Elkamhawyf College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University—Seoul, Goyang, Republic of Korea;g Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptCorrespondence[email protected]
View further author information

Kyeong Leef College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University—Seoul, Goyang, Republic of KoreaView further author information

Ahmed A. Al-Karmalawyh Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt

https://orcid.org/0000-0002-8173-6073 View further author information

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Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

ienz_a_2242714_sm0473.pdf

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Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

ienz_a_2242714_sm0473.pdf

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