Biologics: Targets and Therapy, Volume 6, Issue (2012)

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Biologics: Targets and Therapy, Volume 6, Issue (2012)

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Original Research

Article
Prevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-betalactamase- producing Klebsiella pneumoniae
Pegah Shakib, Sobhan Ghafourian, Mohammad Reza Zolfaghary, Reza Hushmandfar, Reza Ranjbar & Nourkhoda Sadeghifard
Pages: 1-4
Published online: 22 Dec 2011
AbstractforPrevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-betalactamase- producing Klebsiella pneumoniae | Full Text | References | PDF (116 KB)
  • 153 Views
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Open Access
Article
Efficacy of infliximab in refractory Behçet’s disease-associated and idiopathic posterior segment uveitis: a prospective, follow-up study of 50 patients
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Olga Kaloudi, Emanuele Cassarà, Massimo Susini & Ivo Lenzetti
Pages: 5-12
Published online: 29 Dec 2011
AbstractforEfficacy of infliximab in refractory Behçet’s disease-associated and idiopathic posterior segment uveitis: a prospective, follow-up study of 50 patients | Full Text | References | PDF (193.2 KB)
  • 54 Views
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Open Access

Review

Review Article
Monoclonal antibodies and Fc fragments for treating solid tumors
Andrea M Eisenbeis & Stefan J Grau
Pages: 13-20
Published online: 05 Jan 2012
AbstractforMonoclonal antibodies and Fc fragments for treating solid tumors | Full Text | References | PDF (148.6 KB)
  • 48 Views
  • 1 CrossRef citations
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Open Access
Review Article
Eribulin mesylate in the treatment of metastatic breast cancer
Sarika Jain & Tessa Cigler
Pages: 21-29
Published online: 07 Dec 2022
AbstractforEribulin mesylate in the treatment of metastatic breast cancer | Full Text | References | PDF (179.3 KB)
  • 113 Views
  • 4 CrossRef citations
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Open Access

Original Research

Article
Effects of rituximab treatment on the serum concentrations of vitamin D and interleukins 2, 6, 7, and 10 in patients with rheumatoid arthritis
Eman Hasan, Samuel Olusi, Adel Al-Awadhi, Khalid Mokaddem, Prem Sharma & Sunila George
Pages: 31-35
Published online: 01 Feb 2012
AbstractforEffects of rituximab treatment on the serum concentrations of vitamin D and interleukins 2, 6, 7, and 10 in patients with rheumatoid arthritis | Full Text | References | PDF (191.7 KB)
  • 104 Views
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Open Access

Review

Review Article
Local pulmonary administration of factor VIIa (rFVIIa) in diffuse alveolar hemorrhage (DAH) – a review of a new treatment paradigm
Lars Heslet, Jørn Dalsgaard Nielsen & Steen Nepper-Christensen
Pages: 37-46
Published online: 06 Mar 2012
AbstractforLocal pulmonary administration of factor VIIa (rFVIIa) in diffuse alveolar hemorrhage (DAH) – a review of a new treatment paradigm | Full Text | References | PDF (666 KB)
  • 116 Views
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Open Access
Review Article
Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
Josh Neman, Amanda Hambrecht, Cherie Cadry & Rahul Jandial
Pages: 47-57
Published online: 09 Mar 2012
AbstractforStem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering | Full Text | References | PDF (1,000 KB)
  • 84 Views
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Open Access
Review Article
Role of vandetanib in the management of medullary thyroid cancer
Maryse Brassard & Geneviève Rondeau
Pages: 59-66
Published online: 08 Mar 2012
AbstractforRole of vandetanib in the management of medullary thyroid cancer | Full Text | References | PDF (222.4 KB)
  • 71 Views
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Open Access

Original Research

Article
The small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes
Kristy Bolton, David Segal & Ken Walder
Pages: 67-72
Published online: 02 Apr 2012
AbstractforThe small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes | Full Text | References | PDF (204.6 KB)
  • 71 Views
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Open Access

Review

Review Article
Natural killer cells: role in local tumor growth and metastasis
Inge Langers, Virginie M Renoux, Marc Thiry, Philippe Delvenne & Nathalie Jacobs
Pages: 73-82
Published online: 05 Apr 2012
AbstractforNatural killer cells: role in local tumor growth and metastasis | Full Text | References | PDF (1.6 MB)
  • 172 Views
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Open Access

Original Research

Article
NK cell count as predictor of clinical response in patients with rheumatoid arthritis treated with rituximab
Alfredomaria Lurati, Luca Bertani, Mariagrazia Marrazza, Katia Angela Re, Daniela Bompane & Magda Scarpellini
Pages: 83-87
Published online: 11 Apr 2012
AbstractforNK cell count as predictor of clinical response in patients with rheumatoid arthritis treated with rituximab | Full Text | References | PDF (367.8 KB)
  • 73 Views
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Open Access

Review

Review Article
Role of denosumab in the management of skeletal complications in patients with bone metastases from solid tumors
Ursa Brown-Glaberman & Alison T Stopeck
Pages: 89-99
Published online: 12 Apr 2012
AbstractforRole of denosumab in the management of skeletal complications in patients with bone metastases from solid tumors | Full Text | References | PDF (202.7 KB)
  • 161 Views
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Open Access

Original Research

Article
Exacerbation of collagen induced arthritis by Fcγ receptor targeted collagen peptide due to enhanced inflammatory chemokine and cytokine production
Eszter Szarka, Zsuzsa Neer, Péter Balogh, Monika Ádori, Adrienn Angyal, József Prechl, Endre Kiss, Dorottya Kövesdi & Gabriella Sármay
Pages: 101-115
Published online: 12 Apr 2012
AbstractforExacerbation of collagen induced arthritis by Fcγ receptor targeted collagen peptide due to enhanced inflammatory chemokine and cytokine production | Full Text | References | PDF (2.5 MB)
  • 52 Views
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Open Access

Review

Review Article
B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms
Heather L Wilson
Pages: 117-123
Published online: 07 May 2012
AbstractforB cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms | Full Text | References | PDF (146.9 KB)
  • 60 Views
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Open Access
Review Article
Pediatric ulcerative colitis: current treatment approaches including role of infliximab
Gia M Bradley & Maria Oliva-Hemker
Pages: 125-134
Published online: 05 Jun 2012
AbstractforPediatric ulcerative colitis: current treatment approaches including role of infliximab | Full Text | References | PDF (209.9 KB)
  • 103 Views
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Open Access

Letter

Letter
Emerging new clinical applications for palifermin: beyond its use in oral mucositis and graft versus host disease
Shailendra Kapoor
Pages: 135-136
Published online: 06 Jun 2012
CitationforEmerging new clinical applications for palifermin: beyond its use in oral mucositis and graft versus host disease | Full Text | References | PDF (87.6 KB)
  • 58 Views
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Open Access

Review

Review Article
Metastatic gastric cancer – focus on targeted therapies
Judith Meza-Junco & Michael B Sawyer
Pages: 137-146
Published online: 20 Jun 2012
AbstractforMetastatic gastric cancer – focus on targeted therapies | Full Text | References | PDF (342.9 KB)
  • 67 Views
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Open Access

Literature Review

Review Article
Ovarian cancer: emerging molecular-targeted therapies
Carole Sourbier
Pages: 147-154
Published online: 20 Jun 2012
AbstractforOvarian cancer: emerging molecular-targeted therapies | Full Text | References | PDF (848.2 KB)
  • 65 Views
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Open Access

Review

Review Article
Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
Graeme Jones, Erica Darian-Smith, Michael Kwok & Tania Winzenberg
Pages: 155-161
Published online: 02 Jul 2012
AbstractforEffect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate? | Full Text | References | PDF (215.9 KB)
  • 64 Views
  • 9 CrossRef citations
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Open Access
Review Article
The effect of erythropoietin on normal and neoplastic cells
Steve Elliott & Angus M Sinclair
Pages: 163-189
Published online: 07 Dec 2022
AbstractforThe effect of erythropoietin on normal and neoplastic cells | Full Text | References | PDF (2.3 MB)
  • 200 Views
  • 19 CrossRef citations
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Open Access

Original Research

Article
Rituximab is more effective than second anti-TNF therapy in rheumatoid arthritis patients and previous TNFα blocker failure
Joern Kekow, Ulf Mueller-Ladner & Hendrik Schulze-Koops
Pages: 191-199
Published online: 02 Jul 2012
AbstractforRituximab is more effective than second anti-TNF therapy in rheumatoid arthritis patients and previous TNFα blocker failure | Full Text | References | PDF (320.5 KB)
  • 71 Views
  • 11 CrossRef citations
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Open Access
Article
Sustained maintenance of clinical remission after adalimumab dose reduction in patients with early psoriatic arthritis: a long-term follow-up study
Fabrizio Cantini, Laura Niccoli, Emanuele Cassarà, Olga Kaloudi & Carlotta Nannini
Pages: 201-206
Published online: 12 Jul 2012
AbstractforSustained maintenance of clinical remission after adalimumab dose reduction in patients with early psoriatic arthritis: a long-term follow-up study | Full Text | References | PDF (181.2 KB)
  • 73 Views
  • 9 CrossRef citations
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Open Access

Review

Review Article
Hepatocellular carcinoma: natural history, current management, and emerging tools
Christopher L Tinkle & Daphne Haas-Kogan
Pages: 207-219
Published online: 17 Jul 2012
AbstractforHepatocellular carcinoma: natural history, current management, and emerging tools | Full Text | References | PDF (227 KB)
  • 100 Views
  • 14 CrossRef citations
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Open Access
Review Article
Cetuximab and biomarkers in non-small-cell lung carcinoma
Nitin Patil, Mohammed Abba & Heike Allgayer
Pages: 221-231
Published online: 13 Jul 2012
AbstractforCetuximab and biomarkers in non-small-cell lung carcinoma | Full Text | References | PDF (1.1 MB)
  • 57 Views
  • 2 CrossRef citations
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Open Access
Review Article
Clinical utility of targeted treatments in the management of epithelial ovarian cancer
Cheryl Twu & Ernest S Han
Pages: 233-244
Published online: 26 Jul 2012
AbstractforClinical utility of targeted treatments in the management of epithelial ovarian cancer | Full Text | References | PDF (253.5 KB)
  • 46 Views
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Open Access

Short Report

Article
Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010
Ritsuko Kubota-Koketsu, Mikihiro Yunoki, Yoshinobu Okuno & Kazuyoshi Ikuta
Pages: 245-247
Published online: 27 Jul 2012
AbstractforSignificant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010 | Full Text | References | PDF (133.4 KB)
  • 54 Views
  • 2 CrossRef citations
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Open Access

Review

Review Article
New developments in the management of hepatitis C virus infection: focus on boceprevir
Marina Berenguer & F Xavier López-Labrador
Pages: 249-256
Published online: 03 Aug 2012
AbstractforNew developments in the management of hepatitis C virus infection: focus on boceprevir | Full Text | References | PDF (500.1 KB)
  • 49 Views
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Open Access
Review Article
Emerging role of multikinase inhibitors for refractory thyroid cancer
Cesar A Perez, Belisario A Arango, Michel Velez, Luis E Raez & Edgardo S Santos
Pages: 257-265
Published online: 07 Dec 2022
AbstractforEmerging role of multikinase inhibitors for refractory thyroid cancer | Full Text | References | PDF (249 KB)
  • 65 Views
  • 3 CrossRef citations
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Open Access
Review Article
Castration-resistant prostate cancer: potential targets and therapies
Aijaz Parray, Hifzur R Siddique, Sanjeev Nanda, Badrinath R Konety & Mohammad Saleem
Pages: 267-276
Published online: 17 Aug 2012
AbstractforCastration-resistant prostate cancer: potential targets and therapies | Full Text | References | PDF (200.3 KB)
  • 76 Views
  • 1 CrossRef citations
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Open Access
Review Article
Subcutaneous immunoglobulin therapy: a new option for patients with primary immunodeficiency diseases
Lisa Kobrynski
Pages: 277-287
Published online: 24 Aug 2012
AbstractforSubcutaneous immunoglobulin therapy: a new option for patients with primary immunodeficiency diseases | Full Text | References | PDF (281.4 KB)
  • 186 Views
  • 14 CrossRef citations
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Open Access
Review Article
The molecular profile of luminal B breast cancer
Chad J Creighton
Pages: 289-297
Published online: 24 Aug 2012
AbstractforThe molecular profile of luminal B breast cancer | Full Text | References | PDF (2.3 MB)
  • 1046 Views
  • 50 CrossRef citations
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Open Access
Review Article
OnabotulinumtoxinA in the treatment of neurogenic bladder
Aziz Gulamhusein & Altaf Mangera
Pages: 299-306
Published online: 28 Aug 2012
AbstractforOnabotulinumtoxinA in the treatment of neurogenic bladder | Full Text | References | PDF (183.5 KB)
  • 58 Views
  • 0 CrossRef citations
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Open Access
Review Article
The role of epigenetic mechanisms and processes in autoimmune disorders
Judith M Greer & Pamela A McCombe
Pages: 307-327
Published online: 06 Sep 2012
AbstractforThe role of epigenetic mechanisms and processes in autoimmune disorders | Full Text | References | PDF (1.6 MB)
  • 211 Views
  • 24 CrossRef citations
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Open Access
Review Article
Lebrikizumab in the personalized management of asthma
Neil C Thomson, Manish Patel & Andrew D Smith
Pages: 329-335
Published online: 14 Sep 2012
AbstractforLebrikizumab in the personalized management of asthma | Full Text | References | PDF (653.9 KB)
  • 99 Views
  • 17 CrossRef citations
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Open Access
Review Article
First-line treatment of EGFR-mutant non-small-cell lung cancer: the role of erlotinib and other tyrosine kinase inhibitors
Kim-Son H Nguyen & Joel W Neal
Pages: 337-345
Published online: 25 Sep 2012
AbstractforFirst-line treatment of EGFR-mutant non-small-cell lung cancer: the role of erlotinib and other tyrosine kinase inhibitors | Full Text | References | PDF (228.4 KB)
  • 78 Views
  • 11 CrossRef citations
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Open Access
Review Article
B-cell targeted therapy in systemic lupus erythematosus: potential of rituximab
E Wiesik-Szewczyk & M Olesinska
Pages: 347-354
Published online: 07 Dec 2022
AbstractforB-cell targeted therapy in systemic lupus erythematosus: potential of rituximab | Full Text | References | PDF (200.8 KB)
  • 68 Views
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Open Access
Review Article
Introduction to the use of belatacept: a fusion protein for the prevention of posttransplant kidney rejection
Giovanbattista Ippoliti, Andrea Maria D’Armini, Marco Lucioni, Mazen Marjieh & Mario Viganò
Pages: 355-362
Published online: 04 Oct 2012
AbstractforIntroduction to the use of belatacept: a fusion protein for the prevention of posttransplant kidney rejection | Full Text | References | PDF (2.9 MB)
  • 79 Views
  • 3 CrossRef citations
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Open Access
Review Article
Treatment of experienced and naïve patients with hepatitis C: focus on telaprevir
Roberta D’Ambrosio, Alessio Aghemo & Massimo Colombo
Pages: 363-370
Published online: 18 Oct 2012
AbstractforTreatment of experienced and naïve patients with hepatitis C: focus on telaprevir | Full Text | References | PDF (186.9 KB)
  • 45 Views
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Open Access
Review Article
Clinical use of biologics in vasculitis syndromes
Marino Paroli
Pages: 371-378
Published online: 25 Oct 2012
AbstractforClinical use of biologics in vasculitis syndromes | Full Text | References | PDF (164.7 KB)
  • 66 Views
  • 0 CrossRef citations
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Open Access
Review Article
Role of CD44 as a marker of cancer stem cells in head and neck cancer
Serena Trapasso & Eugenia Allegra
Pages: 379-383
Published online: 01 Nov 2012
AbstractforRole of CD44 as a marker of cancer stem cells in head and neck cancer | Full Text | References | PDF (351.5 KB)
  • 143 Views
  • 12 CrossRef citations
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Open Access
Review Article
Belatacept for prevention of acute rejection in adult patients who have had a kidney transplant: an update
David Wojciechowski & Flavio Vincenti
Pages: 385-393
Published online: 02 Nov 2012
AbstractforBelatacept for prevention of acute rejection in adult patients who have had a kidney transplant: an update | Full Text | References | PDF (439.8 KB)
  • 62 Views
  • 1 CrossRef citations
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Open Access
Review Article
Potential role of 124I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer
Marc C Smaldone, David YT Chen, Jian Q Yu & Elizabeth R Plimack
Pages: 395-407
Published online: 19 Nov 2012
AbstractforPotential role of 124I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer | Full Text | References | PDF (1.7 MB)
  • 94 Views
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Open Access

Original Research

Article
Limited cross-reactivity of mouse monoclonal antibodies against Dengue virus capsid protein among four serotypes
Megumi Noda, Promsin Masrinoul, Chaweewan Punkum, Chonlatip Pipattanaboon, Pongrama Ramasoota, Chayanee Setthapramote, Tadahiro Sasaki, Mikiko Sasayama, Akifumi Yamashita, Takeshi Kurosu, Kazuyoshi Ikuta & Tamaki Okabayashi
Pages: 409-416
Published online: 26 Nov 2012
AbstractforLimited cross-reactivity of mouse monoclonal antibodies against Dengue virus capsid protein among four serotypes | Full Text | References | PDF (1.2 MB)
  • 83 Views
  • 0 CrossRef citations
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Open Access
Article
Anti-tumor necrosis factor (TNF) drugs for the treatment of psoriatic arthritis: an indirect comparison meta-analysis
Kristian Thorlund, Eric Druyts, J Antonio Aviña-Zubieta & Edward J Mills
Pages: 417-427
Published online: 03 Dec 2012
AbstractforAnti-tumor necrosis factor (TNF) drugs for the treatment of psoriatic arthritis: an indirect comparison meta-analysis | Full Text | References | PDF (270.2 KB)
  • 70 Views
  • 9 CrossRef citations
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Open Access
Article
Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70
Michelle E Orme, Katherine S MacGilchrist, Stephen Mitchell, Dean Spurden & Alex Bird
Pages: 429-464
Published online: 17 Dec 2012
AbstractforSystematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70 | Full Text | References | PDF (1,018.4 KB)
  • 106 Views
  • 8 CrossRef citations
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Open Access
Article
Clofilium inhibits Slick and Slack potassium channels
Maria de los Angeles Tejada, Kathleen Stolpe, Anne-Kristine Meinild & Dan A Klaerke
Pages: 465-470
Published online: 13 Dec 2012
AbstractforClofilium inhibits Slick and Slack potassium channels | Full Text | References | PDF (822.4 KB)
  • 97 Views
  • 7 CrossRef citations
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Open Access

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