Clinical Pharmacology: Advances and Applications, Volume 8, Issue (2016)

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Clinical Pharmacology: Advances and Applications, Volume 8, Issue (2016)

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Review

Review Article
Pharmacokinetics and safety of posaconazole delayed-release tablets for invasive fungal infections
Nathan P Wiederhold
Pages: 1-8
Published online: 23 Dec 2015
AbstractforPharmacokinetics and safety of posaconazole delayed-release tablets for invasive fungal infections | Full Text | References | PDF (220.4 KB)
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Original Research

Article
Pharmacokinetics of daclizumab high-yield process with repeated administration of the clinical subcutaneous regimen in patients with relapsing-remitting multiple sclerosis
Jonathan Q Tran, Ahmed A Othman, Alvydas Mikulskis, Paul Wolstencroft & Jacob Elkins
Pages: 9-13
Published online: 15 Dec 2022
AbstractforPharmacokinetics of daclizumab high-yield process with repeated administration of the clinical subcutaneous regimen in patients with relapsing-remitting multiple sclerosis | Full Text | References | PDF (326.1 KB)
  • 82 Views
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Open Access
Article
Pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections
Kazuaki Matsumoto, Erika Watanabe, Naoko Kanazawa, Tomohide Fukamizu, Akari Shigemi, Yuta Yokoyama, Kazuro Ikawa, Norifumi Morikawa & Yasuo Takeda
Pages: 15-18
Published online: 30 Mar 2016
AbstractforPharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections | Full Text | References | PDF (243.1 KB)
  • 178 Views
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Open Access

Review

Review Article
Differential pharmacology and clinical utility of empagliflozin in type 2 diabetes
Kashif M Munir & Stephen N Davis
Pages: 19-34
Published online: 20 Apr 2016
AbstractforDifferential pharmacology and clinical utility of empagliflozin in type 2 diabetes | Full Text | References | PDF (373 KB)
  • 200 Views
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Open Access
Review Article
Clinical use and applications of histone deacetylase inhibitors in multiple myeloma
Nidhi Tandon, Vijay Ramakrishnan & Shaji K Kumar
Pages: 35-44
Published online: 06 May 2016
AbstractforClinical use and applications of histone deacetylase inhibitors in multiple myeloma | Full Text | References | PDF (256.3 KB)
  • 97 Views
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Open Access

Original Research

Article
Simultaneous administration of high-dose atorvastatin and clopidogrel does not interfere with platelet inhibition during percutaneous coronary intervention
Rolf P Kreutz, Jeffrey A Breall, Anjan Sinha, Elisabeth von der Lohe, Richard J Kovacs & David A Flockhart
Pages: 45-50
Published online: 03 Jun 2016
AbstractforSimultaneous administration of high-dose atorvastatin and clopidogrel does not interfere with platelet inhibition during percutaneous coronary intervention | Full Text | References | PDF (833 KB)
  • 70 Views
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Open Access
Article
A randomized, double-blind, placebo-, and positive-controlled clinical pilot study to evaluate the efficacy and tolerability of standardized aqueous extracts of Terminalia chebula and Terminalia bellerica in subjects with hyperuricemia
Pingali Usharani, Chandrasekhar Nutalapati, Venkata Kishan Pokuri, Chiranjeevi Uday Kumar & Gangadhar Taduri
Pages: 51-59
Published online: 22 Jun 2016
AbstractforA randomized, double-blind, placebo-, and positive-controlled clinical pilot study to evaluate the efficacy and tolerability of standardized aqueous extracts of Terminalia chebula and Terminalia bellerica in subjects with hyperuricemia | Full Text | References | PDF (694.2 KB)
  • 440 Views
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Review

Review Article
The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies
Melanie Davies, Sudesna Chatterjee & Kamlesh Khunti
Pages: 61-81
Published online: 23 Jun 2016
AbstractforThe treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies | Full Text | References | PDF (807.9 KB)
  • 345 Views
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Original Research

Article
Population pharmacokinetic modeling of glibenclamide in poorly controlled South African type 2 diabetic subjects
Virendra Rambiritch, Poobalan Naidoo, Breminand Maharaj & Goonaseelan Pillai
Pages: 83-92
Published online: 15 Dec 2022
AbstractforPopulation pharmacokinetic modeling of glibenclamide in poorly controlled South African type 2 diabetic subjects | Full Text | References | PDF (801.3 KB)
  • 446 Views
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Open Access
Article
Systematic review and network meta-analysis of stroke prevention treatments in patients with atrial fibrillation
Amy Tawfik, Joanna M Bielecki, Murray Krahn, Paul Dorian, Jeffrey S Hoch, Heather Boon, Don Husereau & Petros Pechlivanoglou
Pages: 93-107
Published online: 15 Dec 2022
AbstractforSystematic review and network meta-analysis of stroke prevention treatments in patients with atrial fibrillation | Full Text | References | PDF (840 KB)
  • 138 Views
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Open Access
Article
The effect of weight, body mass index, age, sex, and race on plasma concentrations of subcutaneous sumatriptan: a pooled analysis
Sagar Munjal, Anirudh Gautam, Alan M Rapoport & Dennis M Fisher
Pages: 109-116
Published online: 01 Sep 2016
AbstractforThe effect of weight, body mass index, age, sex, and race on plasma concentrations of subcutaneous sumatriptan: a pooled analysis | Full Text | References | PDF (1.4 MB)
  • 86 Views
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Open Access
Article
Exposure-response analysis to assess the concentration–QTc relationship of CC-122
Yan Li, Leonidas N Carayannopoulos, Michael Thomas, Maria Palmisano & Simon Zhou
Pages: 117-125
Published online: 09 Sep 2016
AbstractforExposure-response analysis to assess the concentration–QTc relationship of CC-122 | Full Text | References | PDF (1.3 MB)
  • 112 Views
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Review

Review Article
Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives
Béla Z Schmidt, Jérémy B Haaf, Teresinha Leal & Sabrina Noel
Pages: 127-140
Published online: 21 Sep 2016
AbstractforCystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives | Full Text | References | PDF (1.3 MB)
  • 249 Views
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Open Access

Original Research

Article
Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects
Virendra Rambiritch, Poobalan Naidoo & Goonaseelan Pillai
Pages: 141-153
Published online: 26 Sep 2016
AbstractforGlibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects | Full Text | References | PDF (754.5 KB)
  • 76 Views
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Open Access
Article
Bioavailability study of dronabinol oral solution versus dronabinol capsules in healthy volunteers
Neha Parikh, William G Kramer, Varun Khurana, Christina Cognata Smith & Santosh Vetticaden
Pages: 155-162
Published online: 15 Dec 2022
AbstractforBioavailability study of dronabinol oral solution versus dronabinol capsules in healthy volunteers | Full Text | References | PDF (704.9 KB)
  • 122 Views
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Review

Review Article
Skin models for the testing of transdermal drugs
Eman Abd, Shereen A Yousef, Michael N Pastore, Krishna Telaprolu, Yousuf H Mohammed, Sarika Namjoshi, Jeffrey E Grice & Michael S Roberts
Pages: 163-176
Published online: 19 Oct 2016
AbstractforSkin models for the testing of transdermal drugs | Full Text | References | PDF (1 MB)
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Review Article
LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
Farzaneh Atashrazm & Nicolas Dzamko
Pages: 177-189
Published online: 15 Dec 2022
AbstractforLRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives | Full Text | References | PDF (754.4 KB)
  • 326 Views
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Open Access

Original Research

Article
A prospective, observational study comparing the PK/PD relationships of generic Meropenem (Mercide®) to the innovator brand in critically ill patients
Mervyn Mer, Jacques Rene Snyman, Constance Elizabeth Jansen van Rensburg, Jacob John van Tonder & Ilze Laurens
Pages: 191-198
Published online: 17 Nov 2016
AbstractforA prospective, observational study comparing the PK/PD relationships of generic Meropenem (Mercide®) to the innovator brand in critically ill patients | Full Text | References | PDF (660.2 KB)
  • 88 Views
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Open Access

Case Report

Case Report
A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis
Binny Thomas, Mahmoud Mohamed, Moza Al Hail, Fatma Alzahra Y Awwad, Ramy M Wahba, Sabir B Hassan, Khalid Omar, Wessam El Kassem & Palivalappila Abdul Rouf
Pages: 199-202
Published online: 13 Dec 2016
AbstractforA case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis | Full Text | References | PDF (149.3 KB)
  • 104 Views
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Original Research

Article
A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin
Ronald Goldwater, William G Kramer, Douglas A Hamilton, Eric Lang, Jianyuan Wang, Donna E Madden, Peter G Lacouture, Atulkumar Ramaiya & Daniel B Carr
Pages: 203-212
Published online: 15 Dec 2016
AbstractforA Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin | Full Text | References | PDF (561.8 KB)
  • 66 Views
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