Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 25, Issue 3-4 (2024)

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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 25, Issue 3-4 (2024)

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Review

Review Article
Amyotrophic lateral sclerosis: exploring pathophysiology in the context of treatment
Angela Genge, Steven Wainwright & Christine Vande Velde
Pages: 225-236
Published online: 24 Nov 2023
AbstractforAmyotrophic lateral sclerosis: exploring pathophysiology in the context of treatment | Full Text | References | PDF (1 MB) | EPUB
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Clinical

Article
Analysis of non-motor symptoms in amyotrophic lateral sclerosis
Ali Shojaie, Ahmad Al Khleifat, Payam Sarraf & Ammar Al-Chalabi
Pages: 237-241
Published online: 19 Nov 2023
AbstractforAnalysis of non-motor symptoms in amyotrophic lateral sclerosis | Full Text | References | PDF (600.9 KB) | EPUB
  • 897 Views
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Open Access
Article
Predicting amyotrophic lateral sclerosis (ALS) progression with machine learning
Muzammil Arif Din Abdul Jabbar, Ling Guo, Sonakshi Nag, Yang Guo, Zachary Simmons, Erik P. Pioro, Savitha Ramasamy & Crystal Jing Jing Yeo
Pages: 242-255
Published online: 05 Dec 2023
AbstractforPredicting amyotrophic lateral sclerosis (ALS) progression with machine learning | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 174 Views
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Article
What, how and when do families communicate about ALS? A qualitative exploration of parents’ and children’s perceptions
Marion Sommers-Spijkerman, Anna Stukker, Melinda S. Kavanaugh, Marjolijn Ketelaar, Johanna M. A. Visser-Meily & Anita Beelen
Pages: 256-263
Published online: 09 Dec 2023
AbstractforWhat, how and when do families communicate about ALS? A qualitative exploration of parents’ and children’s perceptions | Full Text | References | PDF (937.9 KB) | EPUB
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Open Access
Article
Diagnostic utility of Gold Coast criteria for amyotrophic lateral sclerosis in Asia
Ryo Otani, Kazumoto Shibuya, Toshio Shimizu, Takamasa Kitaoji, Yu-Ichi Noto, Kota Bokuda, Hideki Kimura, Tomoki Suichi, Keigo Nakamura, Hiroki Kano, Marie Morooka, Yuya Aotsuka, Moeko Ogushi, Sonoko Misawa & Satoshi Kuwabara
Pages: 264-270
Published online: 16 Jan 2024
AbstractforDiagnostic utility of Gold Coast criteria for amyotrophic lateral sclerosis in Asia | Full Text | References | PDF (271.6 KB) | EPUB
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Article
Prognosis of amyotrophic lateral sclerosis patients after tracheostomy invasive ventilation in Korea
Jong-Su Kim, Minae Park, Sojeong Park, Juhee Chae, Yoon-Ho Hong, Kyung Seok Park, Jung-Joon Sung & Seok-Jin Choi
Pages: 271-281
Published online: 10 Feb 2024
AbstractforPrognosis of amyotrophic lateral sclerosis patients after tracheostomy invasive ventilation in Korea | Full Text | References | PDF (761.2 KB) | EPUB | Supplemental
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Clinical Care

Article
Specialized multidisciplinary care improves ALS survival in Belgium: a population-based retrospective study
Frederik Hobin, Joke De Vocht, Nikita Lamaire, Hilde Beyens, Fouke Ombelet & Philip Van Damme
Pages: 282-289
Published online: 19 Jan 2024
AbstractforSpecialized multidisciplinary care improves ALS survival in Belgium: a population-based retrospective study | Full Text | References | PDF (503.2 KB) | EPUB
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Open Access
Article
Supporting people with Motor Neuron Disease (MND) to make decisions about gastrostomy feeding tube placement: a survey of UK healthcare professionals’ practice and beliefs
Sean White, Alicia O’Cathain, Vanessa Halliday, Michael Bradburn & Christopher J. McDermott
Pages: 290-298
Published online: 09 Feb 2024
AbstractforSupporting people with Motor Neuron Disease (MND) to make decisions about gastrostomy feeding tube placement: a survey of UK healthcare professionals’ practice and beliefs | Full Text | References | PDF (538.4 KB) | EPUB | Supplemental
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Open Access
Article
ALS Health care provider wellness
Gregory Hansen, Sarah Burton-MacLeod & Kerri Lynn Schellenberg
Pages: 299-307
Published online: 09 Dec 2023
AbstractforALS Health care provider wellness | Full Text | References | PDF (362.4 KB) | EPUB
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Open Access

Cognition

Article
Verbal expressive language minimally affected in non-demented people living with amyotrophic lateral sclerosis
Elisabeth Kasper, Anna G. M. Temp, Verena Köckritz, Lisa Meier, Judith Machts, Stefan Vielhaber, Andreas Hermann & Johannes Prudlo
Pages: 308-316
Published online: 02 Feb 2024
AbstractforVerbal expressive language minimally affected in non-demented people living with amyotrophic lateral sclerosis | Full Text | References | PDF (457.1 KB) | EPUB | Supplemental
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Biomarkers

Article
Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders
Sanjana Shellikeri, Sunghye Cho, Sharon Ash, Carmen Gonzalez-Recober, Corey T. Mcmillan, Lauren Elman, Colin Quinn, Defne A. Amado, Michael Baer, David J. Irwin, Lauren Massimo, Christopher A. Olm, Mark Y. Liberman, Murray Grossman & Naomi Nevler
Pages: 317-325
Published online: 05 Dec 2023
AbstractforDigital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
A comparison between bioelectrical impedance analysis and air-displacement plethysmography in assessing fat-free mass in patients with motor neurone diseases: a cross-sectional study
Mark R. Janse van Mantgem, Maaike L. Soors D’Ancona, Myrte Meyjes, Leonard H. Van Den Berg, Elles Steenhagen, Annemieke Kok & Ruben P. A. Van Eijk
Pages: 326-335
Published online: 24 Jan 2024
AbstractforA comparison between bioelectrical impedance analysis and air-displacement plethysmography in assessing fat-free mass in patients with motor neurone diseases: a cross-sectional study | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 573 Views
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Open Access

Disease Mechanism

Article
Autophagy dysregulation plays a crucial role in regulatory T-cell loss and neuroinflammation in amyotrophic lateral sclerosis (ALS)
Asef Azad, Ümmü Rana Gökmen, Hilmi Uysal, Sadi Köksoy, Uğur Bilge & Ayşe Esra Manguoğlu
Pages: 336-344
Published online: 01 Nov 2023
AbstractforAutophagy dysregulation plays a crucial role in regulatory T-cell loss and neuroinflammation in amyotrophic lateral sclerosis (ALS) | Full Text | References | PDF (1.3 MB) | EPUB
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Epidemiology/Modelling

Article
Time from amyotrophic lateral sclerosis symptom onset to key disease milestones: analysis of data from a multinational cross-sectional survey
Paulos Gebrehiwet, Johan Brekke, Stacy A. Rudnicki, Jennifer Mellor, Jack Wright, Lucy Earl, Nathan Ball, Halima Iqbal, Owen Thomas & Giorgio Castellano
Pages: 345-357
Published online: 29 Dec 2023
AbstractforTime from amyotrophic lateral sclerosis symptom onset to key disease milestones: analysis of data from a multinational cross-sectional survey | Full Text | References | PDF (837.8 KB) | EPUB | Supplemental
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Open Access
Article
Premorbid lipid levels and long-term risk of ALS—a population-based cohort study
Anders Myhre Vaage, Jūratė Šaltytė Benth, Haakon E. Meyer, Trygve Holmøy & Ola Nakken
Pages: 358-366
Published online: 20 Dec 2023
AbstractforPremorbid lipid levels and long-term risk of ALS—a population-based cohort study | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 588 Views
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Open Access
Article
Medication use and risk of amyotrophic lateral sclerosis: using machine learning for an exposome-wide screen of a large clinical database
Ran S Rotem, Andrea Bellavia, Sabrina Paganoni & Marc G Weisskopf
Pages: 367-375
Published online: 01 Mar 2024
AbstractforMedication use and risk of amyotrophic lateral sclerosis: using machine learning for an exposome-wide screen of a large clinical database | Full Text | References | PDF (222.6 KB) | EPUB | Supplemental
  • 84 Views
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Clinical Trials

Review Article
Geographical distribution of clinical trials in amyotrophic lateral sclerosis: a scoping review
Beliu García-Parra, Josep M. Guiu, Mónica Povedano, Eduardo L. Mariño & Pilar Modamio
Pages: 376-381
Published online: 23 Feb 2024
AbstractforGeographical distribution of clinical trials in amyotrophic lateral sclerosis: a scoping review | Full Text | References | PDF (661.1 KB) | EPUB | Supplemental
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Meeting Report
The ALSFRS-R Summit: a global call to action on the use of the ALSFRS-R in ALS clinical trials
Angela Genge, Jesse M. Cedarbaum, Jeremy Shefner, Adriano Chio, Ammar Al-Chalabi, Philip Van Damme, Chris McDermott, Jonathan Glass, James Berry, Ruben P.A. van Eijk, Christina Fournier, Julian Grosskreutz, Jinsy Andrews, Vanessa Bertone, Tommy M Bunte, Mathias Couillard, Cathy Cummings, Gale Kittle, John Polzer, Kristiana Salmon, Corey Straub & Leonard H. van den Berg
Pages: 382-387
Published online: 23 Feb 2024
AbstractforThe ALSFRS-R Summit: a global call to action on the use of the ALSFRS-R in ALS clinical trials | Full Text | References | PDF (407.4 KB) | EPUB
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Open Access
Article
ALSFRS-R decline rate prior to baseline is not useful for stratifying subsequent progression of functional decline
Tatsuto Hamatani, Naoki Atsuta, Fumiya Sano, Ryoichi Nakamura, Yukikazu Hayashi & Gen Sobue
Pages: 388-399
Published online: 07 Feb 2024
AbstractforALSFRS-R decline rate prior to baseline is not useful for stratifying subsequent progression of functional decline | Full Text | References | PDF (985.2 KB) | EPUB | Supplemental
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Open Access
Article
Improving the measurement properties of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R): deriving a valid measurement total for the calculation of change
Carolyn A Young, Amina Chaouch, Christopher J Mcdermott, Ammar Al-Chalabi, Suresh K Chhetri, Kevin Talbot, Andrea Malaspina, Roger Mills, Alan Tennant & On behalf of the TONiC study group
Pages: 400-409
Published online: 01 Mar 2024
AbstractforImproving the measurement properties of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R): deriving a valid measurement total for the calculation of change | Full Text | References | PDF (808.6 KB) | EPUB | Supplemental
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Open Access

Genomics

Brief Report
A report of resources used by clinicians in the UK to support motor neuron disease genomic testing
Jade Howard, Hilary L. Bekker, Christopher J. Mcdermott & Alisdair Mcneill
Pages: 410-412
Published online: 02 Jan 2024
AbstractforA report of resources used by clinicians in the UK to support motor neuron disease genomic testing | Full Text | References | PDF (266.6 KB) | EPUB
  • 350 Views
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Open Access
Brief Report
A novel DHTKD1 gene mutation with ALS like presentation: a case report
Deepak Menon, Saraswati Nashi, Manisha Mohanty, Rohin Dubbal, Farsana MK, Seena Vengalil, Aneesha Thomas, Vijay Kumar, Dipti Baskar, Gautham Arunachal & Atchayaram Nalini
Pages: 413-415
Published online: 25 Oct 2023
AbstractforA novel DHTKD1 gene mutation with ALS like presentation: a case report | Full Text | References | PDF (261.9 KB) | EPUB
  • 108 Views
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ALS Untangled

Case Report
ALSUntangled #72: Insulin
Andrew Brown, Carmel Armon, Paul Barkhaus, Morgan Beauchamp, Tulio Bertorini, Mark Bromberg, Javier Mascias Cadavid, Gregory T. Carter, Jesse Crayle, Eva L. Feldman, Terry Heiman-Patterson, Sartaj Jhooty, Alexandra Linares, Xiaoyan Li, Elise Mallon, Christopher Mcdermott, Tasnim Mushannen, George Nathaniel, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Lenka Slactova, Paul Wicks & Richard Bedlack
Pages: 416-419
Published online: 28 Nov 2023
AbstractforALSUntangled #72: Insulin | Full Text | References | PDF (467.8 KB) | EPUB
  • 615 Views
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Free Access
Case Report
ALSUntangled #73: Lion’s Mane
Maya Muhanna, Issac Lund, Mark Bromberg, Paul Wicks, Michael Benatar, Benjamin Barnes, Kaitlyn Pierce, Dylan Ratner, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Greg Carter, Javier Mascias Cadavid, Christopher McDermott, Jonathan D Glass, Gary Pattee, Carmel Armon, Richard Bedlack & Xiaoyan Li
Pages: 420-423
Published online: 23 Dec 2023
AbstractforALSUntangled #73: Lion’s Mane | Full Text | References | PDF (455.4 KB) | EPUB
  • 1299 Views
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Free Access

Correction

Correction
Correction
Page: (I)
Published online: 21 Feb 2024
CitationforCorrection | Full Text | PDF (93.2 KB) | EPUB
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Free Access
Correction
Correction
Page: (II)
Published online: 17 Apr 2024
CitationforCorrection | Full Text | PDF (94.5 KB) | EPUB
  • 38 Views
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Free Access

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