Drug Delivery, Volume 28, Issue 1 (2021)

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Drug Delivery, Volume 28, Issue 1 (2021)

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RESEARCH ARTICLE

Article
Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment
Rofida Albash, Carol Yousry, Abdulaziz Mohsen Al-Mahallawi & Ahmed Adel Alaa-Eldin
Pages: 1-9
Published online: 16 Dec 2020
AbstractforUtilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment | Full Text | References | PDF (2 MB) | EPUB
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Article
Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery
Nianan Luo, Jiangbin Li, Yafeng Chen, Yan Xu, Yu Wei, Jianguo Lu & Rui Dong
Pages: 10-18
Published online: 18 Dec 2020
AbstractforHepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery | Full Text | References | PDF (2.3 MB) | EPUB
  • 5832 Views
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Open Access
Article
Progress in the development of stabilization strategies for nanocrystal preparations
Jingru Li, Zengming Wang, Hui Zhang, Jing Gao & Aiping Zheng
Pages: 19-36
Published online: 18 Dec 2020
AbstractforProgress in the development of stabilization strategies for nanocrystal preparations | Full Text | References | PDF (3 MB) | EPUB
  • 7115 Views
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Open Access
Article
The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials
Xi Cheng, Jinrong Wei, Qi Ge, Danlei Xing, Xuefeng Zhou, Yunzhu Qian & Guoqin Jiang
Pages: 37-53
Published online: 18 Dec 2020
AbstractforThe optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials | Full Text | References | PDF (2.8 MB) | EPUB
  • 6230 Views
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Open Access
Article
Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations
Rong-Qin Qi, Wei Liu, Duan-Yu Wang, Fan-Qing Meng, Hong-Ying Wang & Hai-Yan Qi
Pages: 54-62
Published online: 21 Dec 2020
AbstractforDevelopment of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations | Full Text | References | PDF (2.5 MB) | EPUB
  • 2434 Views
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Research Article

Article
Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery
Rikkert Van Durme, Guillaume Crevecoeur, Luc Dupré & Annelies Coene
Pages: 63-76
Published online: 21 Dec 2020
AbstractforModel-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery | Full Text | References | PDF (1.8 MB) | EPUB
  • 2669 Views
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RESEARCH ARTICLE

Article
Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization and in vivo evaluation
Abdurrahman Muhammad Fahmy, Mariam Hassan, Doaa Ahmed El-Setouhy, Saadia Ahmed Tayel & Abdulaziz Mohsen Al-Mahallawi
Pages: 77-86
Published online: 21 Dec 2020
AbstractforStatistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization and in vivo evaluation | Full Text | References | PDF (1.5 MB) | EPUB
  • 3184 Views
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Open Access
Article
Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges: in-vitro and in-vivo evaluation
Muhammed Ossama, Caroline Lamie, Mohamed Tarek, Hebatallah A. Wagdy, Dalia A. Attia & Mohamed M. Elmazar
Pages: 87-99
Published online: 21 Dec 2020
AbstractforManagement of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges: in-vitro and in-vivo evaluation | Full Text | References | PDF (2.5 MB) | EPUB
  • 3046 Views
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Open Access
Article
Development and optimization of sitagliptin and dapagliflozin loaded oral self-nanoemulsifying formulation against type 2 diabetes mellitus
Mohsin Kazi, Abdulmohsen Alqahtani, Ajaz Ahmad, Omar M. Noman, Mohammed S. Aldughaim, Ali S. Alqahtani & Fars K. Alanazi
Pages: 100-114
Published online: 21 Dec 2020
AbstractforDevelopment and optimization of sitagliptin and dapagliflozin loaded oral self-nanoemulsifying formulation against type 2 diabetes mellitus | Full Text | References | PDF (2.6 MB) | EPUB
  • 7917 Views
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Open Access
Article
The relevance of nanotechnology, hepato-protective agents in reducing the toxicity and augmenting the bioavailability of isotretinoin
Khaled M. Hosny, Nabil A. Alhakamy & Khalid S. Al Nahyah
Pages: 115-125
Published online: 23 Dec 2020
AbstractforThe relevance of nanotechnology, hepato-protective agents in reducing the toxicity and augmenting the bioavailability of isotretinoin | Full Text | References | PDF (1.5 MB) | EPUB
  • 2387 Views
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Article
L-EGCG-Mn nanoparticles as a pH-sensitive MRI contrast agent
Jiali Li, Xue Jiang, Lihuan Shang, Zhen Li, Conglian Yang, Yan Luo, Daoyu Hu, Yaqi Shen & Zhiping Zhang
Pages: 126-135
Published online: 26 Dec 2020
AbstractforL-EGCG-Mn nanoparticles as a pH-sensitive MRI contrast agent | Full Text | References | PDF (2.3 MB) | EPUB
  • 3705 Views
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Open Access
Article
Preparation and evaluation of conjugate nanogels of glycyl-prednisolone with natural anionic polysaccharides as anti-arthritic delivery systems
Kohei Mizuno, Yuri Ikeuchi-Takahashi, Yoshiyuki Hattori & Hiraku Onishi
Pages: 136-144
Published online: 29 Dec 2020
AbstractforPreparation and evaluation of conjugate nanogels of glycyl-prednisolone with natural anionic polysaccharides as anti-arthritic delivery systems | Full Text | References | PDF (1.1 MB) | EPUB
  • 2208 Views
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Open Access
Article
Simulating drug penetration during hyperthermic intraperitoneal chemotherapy
Daan R. Löke, Roxan F. C. P. A. Helderman, Nicolaas A. P. Franken, Arlene L. Oei, Pieter J. Tanis, Johannes Crezee & H. Petra Kok
Pages: 145-161
Published online: 11 Jan 2021
AbstractforSimulating drug penetration during hyperthermic intraperitoneal chemotherapy | Full Text | References | PDF (3.2 MB) | EPUB
  • 3320 Views
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Article
Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions
Jun-Yong Wu, Yong-Jiang Li, Xiong-Bin Hu, Si Huang & Da-Xiong Xiang
Pages: 162-170
Published online: 11 Jan 2021
AbstractforPreservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions | Full Text | References | PDF (2.5 MB) | EPUB
  • 5208 Views
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Open Access
Article
Berberine-10-hydroxy camptothecine-loaded lipid microsphere for the synergistic treatment of liver cancer by inhibiting topoisomerase and HIF-1α
Yingjie Qi & Guangxuan Liu
Pages: 171-182
Published online: 11 Jan 2021
AbstractforBerberine-10-hydroxy camptothecine-loaded lipid microsphere for the synergistic treatment of liver cancer by inhibiting topoisomerase and HIF-1α | Full Text | References | PDF (2.1 MB) | EPUB
  • 2643 Views
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Research Article

Article
Anti-tumor effect of local injectable hydrogel-loaded endostatin alone and in combination with radiotherapy for lung cancer
Na Wang, Qin Gao, Juan Tang, YiQing Jiang, LiShi Yang, XiangXiang Shi, Yue Chen, Yan Zhang, ShaoZhi Fu & Sheng Lin
Pages: 183-194
Published online: 11 Jan 2021
AbstractforAnti-tumor effect of local injectable hydrogel-loaded endostatin alone and in combination with radiotherapy for lung cancer | Full Text | References | PDF (3.2 MB) | EPUB
  • 3483 Views
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Article
A novel redox-responsive ursolic acid polymeric prodrug delivery system for osteosarcoma therapy
Daijie Fu, Zhe Ni, Kerong Wu, Peng Cheng, Xiaofeng Ji, Guoyuan Li & Xifu Shang
Pages: 195-205
Published online: 13 Jan 2021
AbstractforA novel redox-responsive ursolic acid polymeric prodrug delivery system for osteosarcoma therapy | Full Text | References | PDF (2.3 MB) | EPUB
  • 2489 Views
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Article
Ocular lamellar crystalline gels for sustained release and enhanced permeation of resveratrol against corneal neovascularization
Minshu Li, Xiang Yu, Lin Zhu, Yiguang Jin & Zhihong Wu
Pages: 206-217
Published online: 21 Jan 2021
AbstractforOcular lamellar crystalline gels for sustained release and enhanced permeation of resveratrol against corneal neovascularization | Full Text | References | PDF (2.6 MB) | EPUB
  • 2643 Views
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RESEARCH ARTICLE

Article
RPE-derived exosomes rescue the photoreceptors during retina degeneration: an intraocular approach to deliver exosomes into the subretinal space
Yange Wang, Qian Zhang, Guoqing Yang, Yuanmeng Wei, Miao Li, Enming Du, Haijun Li, Zongming Song & Ye Tao
Pages: 218-228
Published online: 27 Jan 2021
AbstractforRPE-derived exosomes rescue the photoreceptors during retina degeneration: an intraocular approach to deliver exosomes into the subretinal space | Full Text | References | PDF (2.3 MB) | EPUB
  • 3586 Views
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Open Access
Article
A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis
Soad A. Mohamad, Mohamed A. Safwat, Mahmoud Elrehany, Sherif A. Maher, Ahmed M. Badawi & Heba F. Mansour
Pages: 229-239
Published online: 27 Jan 2021
AbstractforA novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis | Full Text | References | PDF (1.3 MB) | EPUB
  • 2995 Views
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Open Access
Article
A novel irinotecan-lipiodol nanoemulsion for intravascular administration: pharmacokinetics and biodistribution in the normal and tumor bearing rat liver
Marites P. Melancon, Steven Yevich, Rony Avritscher, Adam Swigost, Linfeng Lu, Li Tian, Jossana A. Damasco, Katherine Dixon, Andrea C. Cortes, Nina M. Munoz, Dong Liang, David Liu & Alda L. Tam
Pages: 240-251
Published online: 27 Jan 2021
AbstractforA novel irinotecan-lipiodol nanoemulsion for intravascular administration: pharmacokinetics and biodistribution in the normal and tumor bearing rat liver | Full Text | References | PDF (1.9 MB) | EPUB
  • 3057 Views
  • 3 CrossRef citations
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Article
Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability
Xinhui Du, Na Gao & Xiaoyong Song
Pages: 252-260
Published online: 27 Jan 2021
AbstractforBioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability | Full Text | References | PDF (2.1 MB) | EPUB
  • 2648 Views
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Article
Theoretical model for the diclofenac release from PEGylated chitosan hydrogels
Daniela Ailincai, Maricel Agop, Ioana Cristina Marinas, Andrei Zala, Stefan Andrei Irimiciuc, Lucian Dobreci, Tudor-Cristian Petrescu & Constantin Volovat
Pages: 261-271
Published online: 27 Jan 2021
AbstractforTheoretical model for the diclofenac release from PEGylated chitosan hydrogels | Full Text | References | PDF (1.8 MB) | EPUB
  • 2598 Views
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Research Article

Article
Stimuli-responsive drug delivery systems for head and neck cancer therapy
Jingou Liang, Bina Yang, Xuedong Zhou, Qi Han, Jing Zou & Lei Cheng
Pages: 272-284
Published online: 27 Jan 2021
AbstractforStimuli-responsive drug delivery systems for head and neck cancer therapy | Full Text | References | PDF (1.9 MB) | EPUB
  • 5107 Views
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Retraction

Retraction
RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration
Pages: 285-292
Published online: 27 Jan 2021
AbstractforRETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration | PDF (2.4 MB)
  • 2135 Views
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Research Article

Article
Cubogel as potential platform for glaucoma management
Sinar Sayed, Mostafa Abdel-Moteleb, Maha Mohamed Amin & Omnia Mohamed Khowessah
Pages: 293-305
Published online: 29 Jan 2021
AbstractforCubogel as potential platform for glaucoma management | Full Text | References | PDF (1.9 MB) | EPUB
  • 2402 Views
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Article
Β-Cyclodextrin-graft-poly(amidoamine) dendrons as the nitric oxide deliver system for the chronic rhinosinusitis therapy
Tao Liu, Guowei Li, Xidong Wu, Shaohua Chen, Siyi Zhang, Hong Han, Hongbin Zhang, Xiaoning Luo, Xiang Cai & Dong Ma
Pages: 306-318
Published online: 29 Jan 2021
AbstractforΒ-Cyclodextrin-graft-poly(amidoamine) dendrons as the nitric oxide deliver system for the chronic rhinosinusitis therapy | Full Text | References | PDF (3.9 MB) | EPUB
  • 2276 Views
  • 6 CrossRef citations
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Open Access
Article
Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment
Xingwen Han, Jingjing He, Zhan Wang, Zhongtian Bai, Peng Qu, Zhengdong Song & Wenji Wang
Pages: 319-324
Published online: 01 Feb 2021
AbstractforFabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment | Full Text | References | PDF (1.4 MB) | EPUB
  • 3271 Views
  • 19 CrossRef citations
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Article
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology
Fangzhou Liu, Yuanbai Li, Yang Yang, Meng Li, Yu Du, Yiying Zhang, Jing Wang & Yujing Shi
Pages: 325-342
Published online: 01 Feb 2021
AbstractforStudy on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology | Full Text | References | PDF (5.3 MB) | EPUB
  • 5052 Views
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RESEARCH ARTICLE

Article
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea
Adel F. Alghaith, Sultan Alshehri, Nabil A. Alhakamy & Khaled M. Hosny
Pages: 343-356
Published online: 01 Feb 2021
AbstractforDevelopment, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea | Full Text | References | PDF (2.9 MB) | EPUB
  • 3238 Views
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Research Article

Article
Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke
Hongyin Ma, Zhenmin Jiang, Jiayun Xu, Junqiu Liu & Zhen-Ni Guo
Pages: 357-371
Published online: 01 Feb 2021
AbstractforTargeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke | Full Text | References | PDF (3.2 MB) | EPUB
  • 4782 Views
  • 25 CrossRef citations
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Open Access
Article
Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release
Yucai Wei, Chaoxi Chen, Shuo Zhai, Min Tan, Juebo Zhao, Xiaowen Zhu, Lu Wang, Qun Liu & Tao Dai
Pages: 372-379
Published online: 01 Feb 2021
AbstractforEnrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release | Full Text | References | PDF (1.8 MB) | EPUB
  • 5231 Views
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RESEARCH ARTICLE

Article
Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment
Xianfeng Lu, Yaohui Zhang, Lixiang Wang, Guichen Li, Jianyuan Gao & Ying Wang
Pages: 380-389
Published online: 15 Feb 2021
AbstractforDevelopment of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment | Full Text | References | PDF (2.5 MB) | EPUB
  • 3793 Views
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Retraction

Retraction
RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery
Pages: 390-399
Published online: 17 Feb 2021
AbstractforRETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery | PDF (2.9 MB)
  • 2916 Views
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RESEARCH ARTICLE

Article
Pharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits
Christian J. F. Bertens, Marlies Gijs, Aylvin A. J. Dias, Frank J. H. M. van den Biggelaar, Arkasubhra Ghosh, Swaminathan Sethu & Rudy M. M. A. Nuijts
Pages: 400-407
Published online: 17 Feb 2021
AbstractforPharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits | Full Text | References | PDF (1.5 MB) | EPUB
  • 2093 Views
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Article
Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential
Lin Di & Andrei Maiseyeu
Pages: 408-421
Published online: 17 Feb 2021
AbstractforLow-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential | Full Text | References | PDF (1.3 MB) | EPUB
  • 4519 Views
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Article
Skin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation
Emily H. Steen, Walker D. Short, Hui Li, Umang M. Parikh, Alexander Blum, Natalie Templeman, Nadine Nagy, Paul L. Bollyky, Sundeep G. Keswani & Swathi Balaji
Pages: 422-432
Published online: 19 Feb 2021
AbstractforSkin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation | Full Text | References | PDF (2 MB) | EPUB
  • 2282 Views
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Research Article

Article
Oral delivery of carrier-free dual-drug nanocrystal self-assembled microspheres improved NAD+ bioavailability and attenuated cardiac ischemia/reperfusion injury in mice
Hongfei Nie, Yarong Zhang, Haiyang Yu, Hong Xiao, Tao Li & Qian Yang
Pages: 433-444
Published online: 19 Feb 2021
AbstractforOral delivery of carrier-free dual-drug nanocrystal self-assembled microspheres improved NAD+ bioavailability and attenuated cardiac ischemia/reperfusion injury in mice | Full Text | References | PDF (3.8 MB) | EPUB
  • 3483 Views
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RESEARCH ARTICLE

Article
Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin
Mona Elhabak, Samar Ibrahim & Samar M. Abouelatta
Pages: 445-453
Published online: 23 Feb 2021
AbstractforTopical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin | Full Text | References | PDF (1.8 MB) | EPUB
  • 6431 Views
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Article
Transdermal iontophoresis delivery system for terazosin hydrochloride: an in vitro and in vivo study
Changzhao Jiang, Xiumei Jiang, Xiumin Wang, Jiaxu Shen, Mengjie Zhang, Leilei Jiang, Rui Ma, Tingting Gan, Yingbiao Gong, Jincui Ye & Wenyan Gao
Pages: 454-462
Published online: 23 Feb 2021
AbstractforTransdermal iontophoresis delivery system for terazosin hydrochloride: an in vitro and in vivo study | Full Text | References | PDF (1.7 MB) | EPUB
  • 2828 Views
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Article
Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection
Ming Ming Wen, Ibrahim A. Abdelwahab, Rania G. Aly & Sally A. El-Zahaby
Pages: 463-477
Published online: 23 Feb 2021
AbstractforNanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection | Full Text | References | PDF (2.7 MB) | EPUB
  • 3026 Views
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Research Article

Article
Topical anesthetic and pain relief using penetration enhancer and transcriptional transactivator peptide multi-decorated nanostructured lipid carriers
Tao Jiang, Shuangshuang Ma, Yangyang Shen, Yuwen Li, Ruirui Pan & Huaixin Xing
Pages: 478-486
Published online: 01 Mar 2021
AbstractforTopical anesthetic and pain relief using penetration enhancer and transcriptional transactivator peptide multi-decorated nanostructured lipid carriers | Full Text | References | PDF (2 MB) | EPUB
  • 2176 Views
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Article
Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34)
Dan Wang, Yimeng Du, Wenpeng Zhang, Xiaolu Han, Hui Zhang, Zengming Wang, Nan Liu, Meng Li, Xiang Gao, Xiaomei Zhuang, Jing Gao & Aiping Zheng
Pages: 487-498
Published online: 04 Mar 2021
AbstractforDevelopment and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34) | Full Text | References | PDF (2.5 MB) | EPUB
  • 2285 Views
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Article
Sustained intrathecal delivery of amphotericin B using an injectable and biodegradable thermogel
Wenting Lin, Tao Xu, Zhongzhi Wang & Jianghan Chen
Pages: 499-509
Published online: 04 Mar 2021
AbstractforSustained intrathecal delivery of amphotericin B using an injectable and biodegradable thermogel | Full Text | References | PDF (2.2 MB) | EPUB
  • 2647 Views
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Article
Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells
Qin Wang, Ying-Tzu Yen, Chen Xie, Fangcen Liu, Qin Liu, Jia Wei, Lixia Yu, Lifeng Wang, Fanyan Meng, Rutian Li & Baorui Liu
Pages: 510-519
Published online: 04 Mar 2021
AbstractforCombined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells | Full Text | References | PDF (3.1 MB) | EPUB
  • 2647 Views
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Article
Development of cisplatin-loaded hydrogels for trans-portal vein chemoembolization in an orthotopic liver cancer mouse model
Xinxiang Yang, Wai-Ho Oscar Yeung, Kel Vin Tan, Tak-Pan Kevin Ng, Li Pang, Jie Zhou, Jinyang Li, Changxian Li, Xiangcheng Li, Chung Mau Lo, Weiyuan John Kao & Kwan Man
Pages: 520-529
Published online: 09 Mar 2021
AbstractforDevelopment of cisplatin-loaded hydrogels for trans-portal vein chemoembolization in an orthotopic liver cancer mouse model | Full Text | References | PDF (2.9 MB) | EPUB
  • 3480 Views
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Article
Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo
Inoru Yokoe, Daiki Omata, Johan Unga, Ryo Suzuki, Kazuo Maruyama, Yoshiharu Okamoto & Tomohiro Osaki
Pages: 530-541
Published online: 09 Mar 2021
AbstractforLipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo | Full Text | References | PDF (2.5 MB) | EPUB
  • 1852 Views
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Article
Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice
Yukinobu Kodama, Ayako Tokunaga, Junya Hashizume, Hiroo Nakagawa, Hitomi Harasawa, Tomoaki Kurosaki, Tadahiro Nakamura, Koyo Nishida, Mikiro Nakashima, Mitsuru Hashida, Shigeru Kawakami & Hitoshi Sasaki
Pages: 542-549
Published online: 09 Mar 2021
AbstractforEvaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice | Full Text | References | PDF (1.6 MB) | EPUB
  • 1995 Views
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Review Article

Article
Nanotechnological approach to delivering nutraceuticals as promising drug candidates for the treatment of atherosclerosis
Sindhu C. Pillai, Ankita Borah, Eden Mariam Jacob & D. Sakthi Kumar
Pages: 550-568
Published online: 11 Mar 2021
AbstractforNanotechnological approach to delivering nutraceuticals as promising drug candidates for the treatment of atherosclerosis | Full Text | References | PDF (2.9 MB) | EPUB
  • 3861 Views
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Research Article

Article
Precise engineering of cetuximab encapsulated gadollium nanoassemblies: in vitro ultrasound diagnosis and in vivo thyroid cancer therapy
Ming Qi, Shufeng Gao, Sihui Nie, Ke Wang & Lingling Guo
Pages: 569-579
Published online: 12 Mar 2021
AbstractforPrecise engineering of cetuximab encapsulated gadollium nanoassemblies: in vitro ultrasound diagnosis and in vivo thyroid cancer therapy | Full Text | References | PDF (2.7 MB) | EPUB
  • 1593 Views
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Article
Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease
Kaixuan Wang, Lingfeng Wang, Ling Chen, Chiwei Peng, Beijiao Luo, Jingxin Mo & Wei Chen
Pages: 580-593
Published online: 17 Mar 2021
AbstractforIntranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease | Full Text | References | PDF (4 MB) | EPUB
  • 3080 Views
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Article
Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy
Mingming Song, Wentao Xia, Zixuan Tao, Bin Zhu, Wenxiang Zhang, Chang Liu & Siyu Chen
Pages: 594-606
Published online: 17 Mar 2021
AbstractforSelf-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy | Full Text | References | PDF (4.7 MB) | EPUB
  • 6675 Views
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Structural and biological investigation of chitosan/hyaluronic acid with silanized-hydroxypropyl methylcellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engineering
Mu Hu, Jielai Yang & Jihai Xu
Pages: 607-619
Published online: 19 Mar 2021
AbstractforStructural and biological investigation of chitosan/hyaluronic acid with silanized-hydroxypropyl methylcellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engineering | Full Text | References | PDF (3.2 MB) | EPUB
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Electrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot for periodontitis treatment
Ting Zhang, Yingqian Qiu, Jinlin Song, Pengfei Zhou, Hang Liao, Yuting Cheng & Xiaohong Wu
Pages: 620-633
Published online: 27 Mar 2021
AbstractforElectrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot for periodontitis treatment | Full Text | References | PDF (3.3 MB) | EPUB
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Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo
Caiqing Wu, Ping Wai Or, Jones Iok Tong Chong, Isuru K. K. Pathirage Don, Ching Hymn Christopher Lee, Kaili Wu, Minbin Yu, David C. C. Lam & Yangfan Yang
Pages: 634-641
Published online: 27 Mar 2021
AbstractforControllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo | Full Text | References | PDF (1.7 MB) | EPUB
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Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment
Eman Abdelhakeem, Mohamed El-Nabarawi & Rehab Shamma
Pages: 642-654
Published online: 31 Mar 2021
AbstractforLipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment | Full Text | References | PDF (2 MB) | EPUB
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Layer-by-Layer assembled nano-drug delivery systems for cancer treatment
Xinyi Zhang, Tianying Liang & Qingming Ma
Pages: 655-669
Published online: 31 Mar 2021
AbstractforLayer-by-Layer assembled nano-drug delivery systems for cancer treatment | Full Text | References | PDF (3.1 MB) | EPUB
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Dasatinib self-assembled nanoparticles decorated with hyaluronic acid for targeted treatment of tumors to overcome multidrug resistance
Yawen Zhang, Xiangle Zeng, Hairong Wang, Ranran Fan, Yike Hu, Xuejie Hu & Jianchun Li
Pages: 670-679
Published online: 01 Apr 2021
AbstractforDasatinib self-assembled nanoparticles decorated with hyaluronic acid for targeted treatment of tumors to overcome multidrug resistance | Full Text | References | PDF (2.5 MB) | EPUB
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pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer
Chao Li, Yifan Wang, Shuo Zhang, Jiaojiao Zhang, Fang Wang, Yunhao Sun, Lirong Huang & Wen Bian
Pages: 680-691
Published online: 05 Apr 2021
AbstractforpH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer | Full Text | References | PDF (2.9 MB) | EPUB
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Microfluidic-based fabrication and characterization of drug-loaded PLGA magnetic microspheres with tunable shell thickness
Chunpeng He, Wenxin Zeng, Yue Su, Ruowei Sun, Yin Xiao, Bolun Zhang, Wenfang Liu, Rongrong Wang, Xun Zhang & Chuanpin Chen
Pages: 692-699
Published online: 05 Apr 2021
AbstractforMicrofluidic-based fabrication and characterization of drug-loaded PLGA magnetic microspheres with tunable shell thickness | Full Text | References | PDF (1.4 MB) | EPUB
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Charge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer
Zimu Li, Qingyun Liu, Yi Zhang, Yao Yang, Xiaomin Zhou, Wei Peng, Zhigang Liang, Xiaowei Zeng, Qiuxu Wang & Nansha Gao
Pages: 700-708
Published online: 05 Apr 2021
AbstractforCharge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer | Full Text | References | PDF (2.5 MB) | EPUB
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In vitro and in vivo antitumor effects of lupeol-loaded galactosylated liposomes
Jun Zhang, Xixi Hu, Guohua Zheng, Hui Yao & Huali Liang
Pages: 709-718
Published online: 07 Apr 2021
AbstractforIn vitro and in vivo antitumor effects of lupeol-loaded galactosylated liposomes | Full Text | References | PDF (2.9 MB) | EPUB
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Preparation of long-acting microspheres loaded with octreotide for the treatment of portal hypertensive
Bing Han, Huan Tang, Qiming Liang, Ming Zhu, Yizhuo Xie, Jinglin Chen, Qianwen Li, Juan Jia, Yan Li, Zhihui Ren, Dengli Cong, Xiaofeng Yu, Dayun Sui & Jin Pei
Pages: 719-732
Published online: 07 Apr 2021
AbstractforPreparation of long-acting microspheres loaded with octreotide for the treatment of portal hypertensive | Full Text | References | PDF (4.4 MB) | EPUB
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A mechanism for improved talc pleurodesis via foam delivery
T. A. Lima, R. A. Coler, G. W. Laub, S. Sexton, L. Curtin, K. M. Laub & N. J. Alvarez
Pages: 733-740
Published online: 08 Apr 2021
AbstractforA mechanism for improved talc pleurodesis via foam delivery | Full Text | References | PDF (1.5 MB) | EPUB
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Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain
Khaled M. Hosny, Amal M. Sindi, Hala M. Alkhalidi, Mallesh Kurakula, Amira H. Hassan, Rana B. Bakhaidar, Walaa A. Abualsunun, Alshaimaa M. Almehmady, Ahmed Khames, Waleed Y. Rizg, Rasha A. Khallaf, Nabil K. Alruwaili & Nabil A. Alhakamy
Pages: 741-751
Published online: 10 Apr 2021
AbstractforDevelopment of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain | Full Text | References | PDF (1.9 MB) | EPUB
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Review Article

Review Article
Role of macrophage in nanomedicine-based disease treatment
Siwei Song, Hui Xia, Mengfei Guo, Sufei Wang, Shujing Zhang, Pei Ma & Yang Jin
Pages: 752-766
Published online: 16 Apr 2021
AbstractforRole of macrophage in nanomedicine-based disease treatment | Full Text | References | PDF (1.9 MB) | EPUB
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Research Article

Article
Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer
Philip J. Kuehl, Christin M. Yingling, Devon Dubose, Michael Burke, David A. Revelli, Wenshu Chen, Wendy W. Dye, Steven A. Belinsky & Mathewos Tessema
Pages: 767-775
Published online: 16 Apr 2021
AbstractforInhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer | Full Text | References | PDF (1.6 MB) | EPUB
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Precise engineering of hybrid molecules-loaded macromolecular nanoparticles shows in vitro and in vivo antitumor efficacy toward the treatment of nasopharyngeal cancer cells
Dongmei Liu, Wenguang Zhang, Xinju Liu & Rongliang Qiu
Pages: 776-786
Published online: 19 Apr 2021
AbstractforPrecise engineering of hybrid molecules-loaded macromolecular nanoparticles shows in vitro and in vivo antitumor efficacy toward the treatment of nasopharyngeal cancer cells | Full Text | References | PDF (3.1 MB) | EPUB
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Tumor-targeted Gd-doped mesoporous Fe3O4 nanoparticles for T1/T2 MR imaging guided synergistic cancer therapy
Shaohui Zheng, Shang Jin, Min Jiao, Wenjun Wang, Xiaoyu Zhou, Jie Xu, Yong Wang, Peipei Dou, Zhen Jin, Changyu Wu, Jingjing Li, Xinting Ge & Kai Xu
Pages: 787-799
Published online: 19 Apr 2021
AbstractforTumor-targeted Gd-doped mesoporous Fe3O4 nanoparticles for T1/T2 MR imaging guided synergistic cancer therapy | Full Text | References | PDF (4.6 MB) | EPUB
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The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death
Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen & Xuan Zhang
Pages: 800-813
Published online: 19 Apr 2021
AbstractforThe synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death | Full Text | References | PDF (4.4 MB) | EPUB
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Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence
Noha M. Badawi, Mona A. Elkafrawy, Rania M. Yehia & Dalia A. Attia
Pages: 814-825
Published online: 26 Apr 2021
AbstractforClinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence | Full Text | References | PDF (1.9 MB) | EPUB
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Enhanced alveo pulmonary deposition of nebulized ciclesonide for attenuating airways inflammations: a strategy to overcome metered dose inhaler drawbacks
Hanan M. El-Laithy, Amal Youssef, Shereen S. El-Husseney, Nesrine S. El Sayed & Ahmed Maher
Pages: 826-843
Published online: 30 Apr 2021
AbstractforEnhanced alveo pulmonary deposition of nebulized ciclesonide for attenuating airways inflammations: a strategy to overcome metered dose inhaler drawbacks | Full Text | References | PDF (2.5 MB) | EPUB
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Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo
Jianrong Yang, Jingtao Zhong, Mi Zhou, Yinghong Zhou, Peng Xiu, Feng Liu, Fuhai Wang, Zelun Li, Yuntian Tang, Yuanyuan Chen, Siyang Yao, Tao Huang, Tianqi Liu & Xiaofeng Dong
Pages: 844-855
Published online: 30 Apr 2021
AbstractforTargeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo | Full Text | References | PDF (3.4 MB) | EPUB
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Drug delivery of amoxicillin molecule as a suggested treatment for covid-19 implementing functionalized mesoporous SBA-15 with aminopropyl groups
Haneen F. Alazzawi, Issam K. Salih & Talib M. Albayati
Pages: 856-864
Published online: 30 Apr 2021
AbstractforDrug delivery of amoxicillin molecule as a suggested treatment for covid-19 implementing functionalized mesoporous SBA-15 with aminopropyl groups | Full Text | References | PDF (1.6 MB) | EPUB
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The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats
Fang Wang, Yu Deng, Jieting Wang, Luying Yu, Fadian Ding, Wei Lian, Qicai Liu & Xinhua Lin
Pages: 865-872
Published online: 07 May 2021
AbstractforThe PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats | Full Text | References | PDF (2.1 MB) | EPUB
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Original Investigation

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Optimization, and in vitro and in vivo evaluation of etomidate intravenous lipid emulsion
Dandan Geng, Yan Li, Chunyan Wang, Bo Ren, Heping Wang, Chensi Wu, Yirong Zhang, Linlin Zhao & Ligang Zhao
Pages: 873-883
Published online: 07 May 2021
AbstractforOptimization, and in vitro and in vivo evaluation of etomidate intravenous lipid emulsion | Full Text | References | PDF (2.6 MB) | EPUB
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Research Article

Article
Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model
Qijun Li, Shiqiang Gong, Weifan Yao, Ziting Yang, Renjun Wang, Zhaojin Yu & Minjie Wei
Pages: 884-893
Published online: 07 May 2021
AbstractforExosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model | Full Text | References | PDF (2.8 MB) | EPUB
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Wei Xin, Yumei Wang, Yan Bian, Jiahui Lin, Wenhao Weng, Xinyi Zhao, Kaijun Gou, Xianmou Guo & Heran Li
Pages: 894-905
Published online: 07 May 2021
AbstractforFacile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug | Full Text | References | PDF (2.8 MB) | EPUB
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Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules
Nabila A. El-Sheridy, Riham M. El-Moslemany, Alyaa A. Ramadan, Maged W. Helmy & Labiba K. El-Khordagui
Pages: 906-919
Published online: 07 May 2021
AbstractforEnhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules | Full Text | References | PDF (3 MB) | EPUB
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Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer
Wenlong Du, Xiaoping Yang, Shenfu He, Jia Wang, Yuanxian Guo, Bangguo Kou, Yongjie Jiang, Pan Bian, Bingtai Li & Lanning Yin
Pages: 920-929
Published online: 11 May 2021
AbstractforNovel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer | Full Text | References | PDF (2.8 MB) | EPUB
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Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer
Feirong Gong, Jian-Chao Ma, Jianguo Jia, Fa-Zhan Li, Jiao-Lan Wu, Shanfeng Wang, Xin Teng & Zhong-Kai Cui
Pages: 930-942
Published online: 11 May 2021
AbstractforSynergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer | Full Text | References | PDF (3.3 MB) | EPUB
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Experimental study on preparation and anti-tumor efficiency of nanoparticles targeting M2 macrophages
Zheng Zeng, Yu Liu, Qinglian Wen, Yixian Li, Jing Yu, Qiang Xu, Wenwu Wan, Yu He, Chen Ma, Yan Huang, Helin Yang, Ou Jiang & Fuyu Li
Pages: 943-956
Published online: 14 May 2021
AbstractforExperimental study on preparation and anti-tumor efficiency of nanoparticles targeting M2 macrophages | Full Text | References | PDF (3 MB) | EPUB
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Identification of a new cell-penetrating peptide derived from the african swine fever virus CD2v protein
Shunli Yang, Xinming Zhang, Yuying Cao, Shuo Li, Junjun Shao, Shiqi Sun, Huichen Guo & Shuanghui Yin
Pages: 957-962
Published online: 19 May 2021
AbstractforIdentification of a new cell-penetrating peptide derived from the african swine fever virus CD2v protein | Full Text | References | PDF (1.9 MB) | EPUB
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Lysosome activable polymeric vorinostat encapsulating PD-L1KD for a combination of HDACi and immunotherapy
Fengkun Lu, Lei Hou, Sizhen Wang, Yingjie Yu, Yunchang Zhang, Linhong Sun, Chen Wang, Zhiqiang Ma & Feng Yang
Pages: 963-972
Published online: 26 May 2021
AbstractforLysosome activable polymeric vorinostat encapsulating PD-L1KD for a combination of HDACi and immunotherapy | Full Text | References | PDF (2.5 MB) | EPUB
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Thymoquinone-entrapped chitosan-modified nanoparticles: formulation optimization to preclinical bioavailability assessments
Iqra Rahat, Syed Sarim Imam, Md. Rizwanullah, Sultan Alshehri, Mohammad Asif, Chandra Kala & Mohamad Taleuzzaman
Pages: 973-984
Published online: 26 May 2021
AbstractforThymoquinone-entrapped chitosan-modified nanoparticles: formulation optimization to preclinical bioavailability assessments | Full Text | References | PDF (2.9 MB) | EPUB
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Green synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer
Wei Zhao, Ji Li, Cheng Zhong, Xuyu Zhang & Yixi Bao
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Published online: 27 May 2021
AbstractforGreen synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer | Full Text | References | PDF (3.1 MB) | EPUB
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cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy
Shuang Yang, Dandan Wang, Xia Zhang, Yaojun Sun & Bin Zheng
Pages: 995-1006
Published online: 27 May 2021
AbstractforcRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy | Full Text | References | PDF (3.6 MB) | EPUB
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Efficacy and safety of novel-targeted drugs in the treatment of pulmonary arterial hypertension: a Bayesian network meta-analysis
Wenhai Fu, Wenjun He, Yuexin Li, Yangxiao Chen, Jingyi Liang, Hui Lei, Lin Fu, Yanghang Chen, Ni Ren, Qian Jiang, Yi Shen, Ran Ma, Tao Wang, Xinni Wang, Nuofu Zhang, Dakai Xiao & Chunli Liu
Pages: 1007-1019
Published online: 01 Jun 2021
AbstractforEfficacy and safety of novel-targeted drugs in the treatment of pulmonary arterial hypertension: a Bayesian network meta-analysis | Full Text | References | PDF (1.9 MB) | EPUB
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Development of a PHBV nanoparticle as a peptide vehicle for NOD1 activation
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Pages: 1020-1030
Published online: 01 Jun 2021
AbstractforDevelopment of a PHBV nanoparticle as a peptide vehicle for NOD1 activation | Full Text | References | PDF (1.6 MB) | EPUB
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A novel dendritic mesoporous silica based sustained hydrogen sulfide donor for the alleviation of adjuvant-induced inflammation in rats
Yue Yu, Zhou Wang, Qinyan Yang, Qian Ding, Ran Wang, Zhaoyi Li, Yudong Fang, Junyi Liao, Wei Qi, Keyuan Chen, Meng Li & Yi Zhun Zhu
Pages: 1031-1042
Published online: 01 Jun 2021
AbstractforA novel dendritic mesoporous silica based sustained hydrogen sulfide donor for the alleviation of adjuvant-induced inflammation in rats | Full Text | References | PDF (3.4 MB) | EPUB
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Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis
Khaled M. Hosny, Amal M. Sindi, Hala M. Alkhalidi, Mallesh Kurakula, Nabil K. Alruwaili, Nabil A. Alhakamy, Walaa A. Abualsunun, Rana B. Bakhaidar, Rahaf H. Bahmdan, Waleed Y. Rizg, Sarah A. Ali, Wesam H. Abdulaal, Majed S. Nassar, Mohammed S. Alsuabeyl, Adel F. Alghaith & Sultan Alshehri
Pages: 1043-1054
Published online: 01 Jun 2021
AbstractforOral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis | Full Text | References | PDF (2.3 MB) | EPUB
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A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids
Jiaolin Wen, Neng Qiu, Zejiang Zhu, Peng Bai, Mengshi Hu, Wenyan Qi, Yan Liu, Ailin Wei & Lijuan Chen
Pages: 1055-1066
Published online: 02 Jun 2021
AbstractforA size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids | Full Text | References | PDF (3.1 MB) | EPUB
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Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models
Hang Chen, Sifan Huang, Heyi Wang, Xinmei Chen, Haiyan Zhang, Youfa Xu, Wei Fan, Yun Pan, Qiuyan Wen, Zhizhe Lin, Xuena Wang, Yongwei Gu, Baoyue Ding, Jianming Chen & Xin Wu
Pages: 1067-1079
Published online: 10 Jun 2021
AbstractforPreparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models | Full Text | References | PDF (2.5 MB) | EPUB
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Facile design of lidocaine-loaded polymeric hydrogel to persuade effects of local anesthesia drug delivery system: complete in vitro and in vivo toxicity analyses
Yan Li, Erxian Zhao, Li Li, Liying Bai & Wei Zhang
Pages: 1080-1092
Published online: 11 Jun 2021
AbstractforFacile design of lidocaine-loaded polymeric hydrogel to persuade effects of local anesthesia drug delivery system: complete in vitro and in vivo toxicity analyses | Full Text | References | PDF (4.1 MB) | EPUB
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β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation
Nadia Shamshad Malik, Mahmood Ahmad, Mohammed S. Alqahtani, Arshad Mahmood, Kashif Barkat, Muhammad Tariq Khan, Ume Ruqia Tulain & Ayesha Rashid
Pages: 1093-1108
Published online: 11 Jun 2021
Abstractforβ-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation | Full Text | References | PDF (3 MB) | EPUB
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Recent advances in cell membrane-camouflaged nanoparticles for inflammation therapy
Rongtao Zhang, Siqiong Wu, Qian Ding, Qingze Fan, Yan Dai, Shiwei Guo, Yun Ye, Chunhong Li & Meiling Zhou
Pages: 1109-1119
Published online: 12 Jun 2021
AbstractforRecent advances in cell membrane-camouflaged nanoparticles for inflammation therapy | Full Text | References | PDF (2.1 MB) | EPUB
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An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice
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Pages: 1120-1131
Published online: 12 Jun 2021
AbstractforAn efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice | Full Text | References | PDF (2.7 MB) | EPUB
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Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone 
Guanxing Sun, Kai Sun & Jie Sun
Pages: 1132-1140
Published online: 12 Jun 2021
AbstractforCombination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone  | Full Text | References | PDF (1.9 MB) | EPUB
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Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging
Kristoffer Hendel, Anders C. N. Hansen, Liora Bik, Charlotte Bagger, Martijn B. A. van Doorn, Christian Janfelt, Uffe H. Olesen, Merete Haedersdal & Catharina M. Lerche
Pages: 1141-1149
Published online: 12 Jun 2021
AbstractforBleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging | Full Text | References | PDF (3.4 MB) | EPUB
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Statistical optimization of bile salt deployed nanovesicles as a potential platform for oral delivery of piperine: accentuated antiviral and anti-inflammatory activity in MERS-CoV challenged mice
Mohamed Y. Zakaria, Eman Fayad, Fayez Althobaiti, Islam Zaki & Ali H. Abu Almaaty
Pages: 1150-1165
Published online: 12 Jun 2021
AbstractforStatistical optimization of bile salt deployed nanovesicles as a potential platform for oral delivery of piperine: accentuated antiviral and anti-inflammatory activity in MERS-CoV challenged mice | Full Text | References | PDF (2.7 MB) | EPUB
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Novel CD123 polyaptamer hydrogel edited by Cas9/sgRNA for AML-targeted therapy
Haibin Wu, Liyu Zhang, Zeen Zhu, Chenxi Ding, Shengquan Chen, Ruiping Liu, Huafeng Fan, Yang Chen & Hui Li
Pages: 1166-1178
Published online: 12 Jun 2021
AbstractforNovel CD123 polyaptamer hydrogel edited by Cas9/sgRNA for AML-targeted therapy | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Development of rotational intraperitoneal pressurized aerosol chemotherapy to enhance drug delivery into the peritoneum
Soo Jin Park, Eun Ji Lee, Hee Su Lee, Junsik Kim, Sunwoo Park, Jiyeon Ham, Jaehee Mun, Haerin Paik, Hyunji Lim, Aeran Seol, Ga Won Yim, Seung-Hyuk Shim, Beong-Cheol Kang, Suk Joon Chang, Whasun Lim, Gwonhwa Song, Jae-Weon Kim, Nara Lee, Ji Won Park, Jung Chan Lee, Hee Seung Kim & On behalf of the KoRIA* trial group
Pages: 1179-1187
Published online: 12 Jun 2021
AbstractforDevelopment of rotational intraperitoneal pressurized aerosol chemotherapy to enhance drug delivery into the peritoneum | Full Text | References | PDF (2 MB) | EPUB
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Repurposing ibuprofen-loaded microemulsion for the management of Alzheimer’s disease: evidence of potential intranasal brain targeting
Ming Ming Wen, Noha Ismail Khamis Ismail, Maha M. A. Nasra & Amal Hassan El-Kamel
Pages: 1188-1203
Published online: 12 Jun 2021
AbstractforRepurposing ibuprofen-loaded microemulsion for the management of Alzheimer’s disease: evidence of potential intranasal brain targeting | Full Text | References | PDF (2.5 MB) | EPUB
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ROS-responsive dimeric prodrug-based nanomedicine targeted therapy for gastric cancer
Jiachi Ma, Yuzhong Chen, Wanqing Liang, Lei Li, Jun Du, Chengwu Pan & Chensong Zhang
Pages: 1204-1213
Published online: 18 Jun 2021
AbstractforROS-responsive dimeric prodrug-based nanomedicine targeted therapy for gastric cancer | Full Text | References | PDF (2.4 MB) | EPUB
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From blood to brain: blood cell-based biomimetic drug delivery systems
Yong-Jiang Li, Jun-Yong Wu, Jihua Liu, Xiaohan Qiu, Wenjie Xu, Tiantian Tang & Da-Xiong Xiang
Pages: 1214-1225
Published online: 18 Jun 2021
AbstractforFrom blood to brain: blood cell-based biomimetic drug delivery systems | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions
Haowen Li, Manzhen Li, Jingxin Fu, Hui Ao, Weihua Wang & Xiangtao Wang
Pages: 1226-1236
Published online: 18 Jun 2021
AbstractforEnhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions | Full Text | References | PDF (2.1 MB) | EPUB
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Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles
Aixue Li, Yunan Zhao, Yixiu Li, Liangdi Jiang, Yongwei Gu & Jiyong Liu
Pages: 1237-1255
Published online: 18 Jun 2021
AbstractforCell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles | Full Text | References | PDF (2.6 MB) | EPUB
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Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery
Ai-Ho Liao, Cheng-Ping Shih, Ming-Wei Li, Yi-Chun Lin, Ho-Chiao Chuang & Chih-Hung Wang
Pages: 1256-1271
Published online: 18 Jun 2021
AbstractforDevelopment of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery | Full Text | References | PDF (4.1 MB) | EPUB
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Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro
Tingting Lang, Nuannuan Li, Jing Zhang, Yi Li, Rong Rong & Yuanlei Fu
Pages: 1272-1280
Published online: 26 Jun 2021
AbstractforProdrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro | Full Text | References | PDF (1.7 MB) | EPUB
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In vivo characterization of carbon dots–bone interactions: toward the development of bone-specific nanocarriers for drug delivery
Rachel DuMez, Esmail H. Miyanji, Lesly Corado-Santiago, Bryle Barrameda, Yiqun Zhou, Sajini D. Hettiarachchi, Roger M. Leblanc & Isaac Skromne
Pages: 1281-1289
Published online: 26 Jun 2021
AbstractforIn vivo characterization of carbon dots–bone interactions: toward the development of bone-specific nanocarriers for drug delivery | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage
Xiang Li, Yang Lu, Yuxin Wang, Shengji Zhou, Liangping Li & Fengchao Zhao
Pages: 1290-1300
Published online: 26 Jun 2021
AbstractforThermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage | Full Text | References | PDF (2.9 MB) | EPUB
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Scalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability function approach and in vivo pharmacokinetic study
Marianne J. Naguib & Amal I. A. Makhlouf
Pages: 1301-1311
Published online: 26 Jun 2021
AbstractforScalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability function approach and in vivo pharmacokinetic study | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations
Samuel M. Flaherty, Ian J. Russell & Andrei N. Lukashkin
Pages: 1312-1320
Published online: 26 Jun 2021
AbstractforDrug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations | Full Text | References | PDF (2.1 MB) | EPUB
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Formulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films
Basant A. Habib, Amina S. Abd El-Samiae, Boushra M. El-Houssieny & Randa Tag
Pages: 1321-1333
Published online: 26 Jun 2021
AbstractforFormulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Engineering of injectable hydrogels associate with Adipose-Derived stem cells delivery for anti-cardiac hypertrophy agents
Guangyu Long, Quanhe Wang, Shaolin Li, Junzhong Tao, Boyan Li, Xiangxiang Zhang & Xi Zhao
Pages: 1334-1341
Published online: 28 Jun 2021
AbstractforEngineering of injectable hydrogels associate with Adipose-Derived stem cells delivery for anti-cardiac hypertrophy agents | Full Text | References | PDF (2.2 MB) | EPUB
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Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review
Yabing Hua, Yuhuai Su, Hui Zhang, Nan Liu, Zengming Wang, Xiang Gao, Jing Gao & Aiping Zheng
Pages: 1342-1355
Published online: 28 Jun 2021
AbstractforPoly(lactic-co-glycolic acid) microsphere production based on quality by design: a review | Full Text | References | PDF (1.8 MB) | EPUB
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Assessment of efficacy and safety by CalliSpheres versus HepaSpheres for drug-eluting bead transarterial chemoembolization in unresectable large hepatocellular carcinoma patients
Guangsheng Zhao, Song Liu, Songbai Chen, Zhizhong Ren, Chuang Li, Jie Bian, Jianlin Wu, Jun Zhou & Yuewei Zhang
Pages: 1356-1362
Published online: 28 Jun 2021
AbstractforAssessment of efficacy and safety by CalliSpheres versus HepaSpheres for drug-eluting bead transarterial chemoembolization in unresectable large hepatocellular carcinoma patients | Full Text | References | PDF (993.5 KB) | EPUB
  • 1990 Views
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Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury
Luting Wang, Lin Xu, Junfeng Du, Xiao Zhao, Mei Liu, Jianfang Feng & Kaili Hu
Pages: 1363-1375
Published online: 28 Jun 2021
AbstractforNose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury | Full Text | References | PDF (3.4 MB) | EPUB
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Paclitaxel-loaded polymeric nanoparticles based on α-tocopheryl succinate for the treatment of head and neck squamous cell carcinoma: in vivo murine model
Juan Riestra-Ayora, Carolina Sánchez-Rodríguez, Raquel Palao-Suay, Joaquín Yanes-Díaz, Ana Martín-Hita, María Rosa Aguilar & Ricardo Sanz-Fernández
Pages: 1376-1388
Published online: 28 Jun 2021
AbstractforPaclitaxel-loaded polymeric nanoparticles based on α-tocopheryl succinate for the treatment of head and neck squamous cell carcinoma: in vivo murine model | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Docetaxel loaded mPEG-PLA nanoparticles for sarcoma therapy: preparation, characterization, pharmacokinetics, and anti-tumor efficacy
Jianhua Chen, Eerdunbagena Ning, Zhijun Wang, Ziqi Jing, Guijie Wei, Xue Wang & Pengkai Ma
Pages: 1389-1396
Published online: 28 Jun 2021
AbstractforDocetaxel loaded mPEG-PLA nanoparticles for sarcoma therapy: preparation, characterization, pharmacokinetics, and anti-tumor efficacy | Full Text | References | PDF (1.5 MB) | EPUB
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PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application
Yue Su, Bolun Zhang, Ruowei Sun, Wenfang Liu, Qubo Zhu, Xun Zhang, Rongrong Wang & Chuanpin Chen
Pages: 1397-1418
Published online: 29 Jun 2021
AbstractforPLGA-based biodegradable microspheres in drug delivery: recent advances in research and application | Full Text | References | PDF (3.8 MB) | EPUB
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Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody
Dong Weng, Zhao-Fang Yin, Shan-Shan Chen, Xian He, Nan Li, Tao Chen, Hui Qiu, Meng-Meng Zhao, Qin Wu, Nian-Yu Zhou, Li-Qin Lu, Dan-Li Tang, Jia-Cui Song & Hui-Ping Li
Pages: 1419-1431
Published online: 05 Jul 2021
AbstractforDevelopment and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody | Full Text | References | PDF (3.7 MB) | EPUB
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A bivalent cyclic RGD–siRNA conjugate enhances the antitumor effect of apatinib via co-inhibiting VEGFR2 in non-small cell lung cancer xenografts
Lumin Liao, Bohong Cen, Guoxian Li, Yuanyi Wei, Zhen Wang, Wen Huang, Shuai He, Yawei Yuan & Aimin Ji
Pages: 1432-1442
Published online: 08 Jul 2021
AbstractforA bivalent cyclic RGD–siRNA conjugate enhances the antitumor effect of apatinib via co-inhibiting VEGFR2 in non-small cell lung cancer xenografts | Full Text | References | PDF (3.8 MB) | EPUB
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Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application
Nattihda Parakasikron, Chatchai Chaotham, Pithi Chanvorachote, Chanida Vinayanuwattikun, Visarut Buranasudja, Pornchanok Taweecheep & Kannika Khantasup
Pages: 1443-1454
Published online: 08 Jul 2021
AbstractforDevelopment of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application | Full Text | References | PDF (1.7 MB) | EPUB
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Aging erythrocyte membranes as biomimetic nanometer carriers of liver-targeting chromium poisoning treatment
Qing Yao, Guobao Yang, Hao Wang, Jingzhou Liu, Jinpeng Zheng, Bai Lv, Meiyan Yang, Yang Yang, Chunsheng Gao & Yongxue Guo
Pages: 1455-1465
Published online: 08 Jul 2021
AbstractforAging erythrocyte membranes as biomimetic nanometer carriers of liver-targeting chromium poisoning treatment | Full Text | References | PDF (3.2 MB) | EPUB
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Synergic fabrication of pembrolizumab loaded doxorubicin incorporating microbubbles delivery for ultrasound contrast agents mediated anti-proliferation and apoptosis
Huilin Liu, Xing Li, Zihe Chen, Lianjie Bai, Ying Wang & Weiyang Lv
Pages: 1466-1477
Published online: 14 Jul 2021
AbstractforSynergic fabrication of pembrolizumab loaded doxorubicin incorporating microbubbles delivery for ultrasound contrast agents mediated anti-proliferation and apoptosis | Full Text | References | PDF (3.1 MB) | EPUB
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Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents
Khaled AbouAitah, Imane M. Higazy, Anna Swiderska-Sroda, Reda M. Abdelhameed, Stanislaw Gierlotka, Tarik A. Mohamed, Urszula Szałaj & Witold Lojkowski
Pages: 1478-1495
Published online: 13 Jul 2021
AbstractforAnti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents | Full Text | References | PDF (4.8 MB) | EPUB
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An in vitro visual study of fugitive aerosols released during aerosol therapy to an invasively ventilated simulated patient
Marc Mac Giolla Eain, Mary Joyce & Ronan MacLoughlin
Pages: 1496-1500
Published online: 14 Jul 2021
AbstractforAn in vitro visual study of fugitive aerosols released during aerosol therapy to an invasively ventilated simulated patient | Full Text | References | PDF (1.2 MB) | EPUB
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Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation
Fumin Yuan, Ya-Min Li & Zhuhui Wang
Pages: 1501-1509
Published online: 14 Jul 2021
AbstractforPreserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation | Full Text | References | PDF (940.2 KB) | EPUB
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Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo
Ying Wang, Mimi Guo, Dingmei Lin, Dajun Liang, Ling Zhao, Ruizhi Zhao & Yan Wang
Pages: 1510-1523
Published online: 15 Jul 2021
AbstractforDocetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo | Full Text | References | PDF (4.5 MB) | EPUB
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Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m
Sinar Sayed, Fatma M. Elsharkawy, Maha M. Amin, Hesham A. Shamsel-Din & Ahmed B. Ibrahim
Pages: 1524-1538
Published online: 16 Jul 2021
AbstractforBrain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m | Full Text | References | PDF (3.1 MB) | EPUB
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Engineering of hybrid anticancer drug-loaded polymeric nanoparticles delivery system for the treatment and care of lung cancer therapy
Yang Zhao, Kefeng Liu, Jie Li, Juan Liao & Li Ma
Pages: 1539-1547
Published online: 20 Jul 2021
AbstractforEngineering of hybrid anticancer drug-loaded polymeric nanoparticles delivery system for the treatment and care of lung cancer therapy | Full Text | References | PDF (2.6 MB) | EPUB
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Tumor RNA-loaded nanoliposomes increases the anti-tumor immune response in colorectal cancer
Dandong Dai, You Yin, Yuanbo Hu, Ying Lu, Hongbo Zou, GuangZhao Lu, Qianqian Wang, Jie Lian, Jie Gao & Xian Shen
Pages: 1548-1561
Published online: 21 Jul 2021
AbstractforTumor RNA-loaded nanoliposomes increases the anti-tumor immune response in colorectal cancer | Full Text | References | PDF (5.1 MB) | EPUB
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Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents
Sreekanth Reddy Obireddy & Wing-Fu Lai
Pages: 1562-1568
Published online: 21 Jul 2021
AbstractforPreparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents | Full Text | References | PDF (1.7 MB) | EPUB
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Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity
Aisha Sethi, Mahmood Ahmad, Tayyaba Huma & Waqas Ahmad
Pages: 1569-1584
Published online: 22 Jul 2021
AbstractforPharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity | Full Text | References | PDF (2.7 MB) | EPUB
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Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle
Tomoaki Kurosaki, Yuki Katafuchi, Junya Hashizume, Hitomi Harasawa, Hiroo Nakagawa, Mikiro Nakashima, Tadahiro Nakamura, Chikamasa Yamashita, Hitoshi Sasaki & Yukinobu Kodama
Pages: 1585-1593
Published online: 22 Jul 2021
AbstractforInduction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle | Full Text | References | PDF (1.9 MB) | EPUB
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Preparation and use of nanogels as carriers of drugs
Cuixia Li, Sreekanth Reddy Obireddy & Wing-Fu Lai
Pages: 1594-1602
Published online: 26 Jul 2021
AbstractforPreparation and use of nanogels as carriers of drugs | Full Text | References | PDF (1.5 MB) | EPUB
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Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles
Mei-Qi Xu, Ting Zhong, Xin Yao, Zhuo-Yue Li, Hui Li, Jing-Ru Wang, Zhen-Han Feng & Xuan Zhang
Pages: 1603-1615
Published online: 28 Jul 2021
AbstractforEffect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles | Full Text | References | PDF (2.8 MB) | EPUB
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UTMD promoted local delivery of miR-34a-mimic for ovarian cancer therapy
Yue Li, Meng Du, Jinghui Fang, Jia Zhou & Zhiyi Chen
Pages: 1616-1625
Published online: 28 Jul 2021
AbstractforUTMD promoted local delivery of miR-34a-mimic for ovarian cancer therapy | Full Text | References | PDF (2.7 MB) | EPUB
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Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer
Afrasim Moin, Shahid Ud Din Wani, Riyaz Ali Osmani, Amr S. Abu Lila, El-Sayed Khafagy, Hany H. Arab, Hosahalli V. Gangadharappa & Ahmed N. Allam
Pages: 1626-1636
Published online: 30 Jul 2021
AbstractforFormulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer | Full Text | References | PDF (1.9 MB) | EPUB
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In silico identification and experimental validation of cellular uptake by a new cell penetrating peptide P1 derived from MARCKS
Linlin Chen, Xiangli Guo, Lidan Wang, Jingping Geng, Jiao Wu, Bin Hu, Tao Wang, Jason Li, Changbai Liu & Hu Wang
Pages: 1637-1648
Published online: 02 Aug 2021
AbstractforIn silico identification and experimental validation of cellular uptake by a new cell penetrating peptide P1 derived from MARCKS | Full Text | References | PDF (4.1 MB) | EPUB
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Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction
An’an Sun, Xi Lin, Zhiqiang Xue, Jiyue Huang, Xinxin Bai, Lingling Huang, Xinhua Lin, Shaohuang Weng & Min Chen
Pages: 1649-1663
Published online: 02 Aug 2021
AbstractforFacile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction | Full Text | References | PDF (4.6 MB) | EPUB
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Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism
Xinran Wang, Cai Zhang, Ning Han, Juyuan Luo, Shuofeng Zhang, Chunguo Wang, Zhanhong Jia & Shouying Du
Pages: 1664-1672
Published online: 02 Aug 2021
AbstractforTriglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism | Full Text | References | PDF (2 MB) | EPUB
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Preparation, characterization, and in vitro/vivo evaluation of dexamethasone/poly(ε-caprolactone)-based electrode coatings for cochlear implants
Yanjing Luo, Anning Chen, Muqing Xu, Dongxiu Chen, Jie Tang, Dong Ma & Hongzheng Zhang
Pages: 1673-1684
Published online: 04 Aug 2021
AbstractforPreparation, characterization, and in vitro/vivo evaluation of dexamethasone/poly(ε-caprolactone)-based electrode coatings for cochlear implants | Full Text | References | PDF (4.5 MB) | EPUB
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Square root law model for the delivery and intestinal absorption of drugs: a case of hydrophilic captopril
Valentina Anuta, Constantin Mircioiu, Victor Voicu, Ion Mircioiu & Roxana Sandulovici
Pages: 1685-1694
Published online: 06 Aug 2021
AbstractforSquare root law model for the delivery and intestinal absorption of drugs: a case of hydrophilic captopril | Full Text | References | PDF (1.7 MB) | EPUB
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Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment
Yu Wang, Qianmei Wang, Wei Feng, Qian Yuan, Xiaowei Qi, Sheng Chen, Pu Yao, Qing Dai, Peiyuan Xia, Dinglin Zhang & Fengjun Sun
Pages: 1695-1708
Published online: 17 Aug 2021
AbstractforFolic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment | Full Text | References | PDF (4 MB) | EPUB
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Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer
Fangyuan Guo, Nan Yu, Yunlong Jiao, Weiyong Hong, Kang Zhou, Xugang Ji, Huixing Yuan, Haiying Wang, Aiqin Li, Guoping Wang & Gensheng Yang
Pages: 1709-1721
Published online: 31 Aug 2021
AbstractforStar polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer | Full Text | References | PDF (3 MB) | EPUB
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In silico identification and experimental validation of cellular uptake and intracellular labeling by a new cell penetrating peptide derived from CDN1
Xiangli Guo, Linlin Chen, Lidan Wang, Jingping Geng, Tao Wang, Jixiong Hu, Jason Li, Changbai Liu & Hu Wang
Pages: 1722-1736
Published online: 31 Aug 2021
AbstractforIn silico identification and experimental validation of cellular uptake and intracellular labeling by a new cell penetrating peptide derived from CDN1 | Full Text | References | PDF (4.6 MB) | EPUB
  • 1906 Views
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Study on mechanism of low bioavailability of black tea theaflavins by using Caco-2 cell monolayer
Fengfeng Qu, Zeyi Ai, Shuyuan Liu, Haojie Zhang, Yuqiong Chen, Yaomin Wang & Dejiang Ni
Pages: 1737-1747
Published online: 31 Aug 2021
AbstractforStudy on mechanism of low bioavailability of black tea theaflavins by using Caco-2 cell monolayer | Full Text | References | PDF (2.2 MB) | EPUB
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Black phosphorus conjugation of chemotherapeutic ginsenoside Rg3: enhancing targeted multimodal nanotheranostics against lung cancer metastasis
Jie Xiong, Hongmei Yuan, Hongge Wu, Jing Cheng, Shengli Yang & Ting Hu
Pages: 1748-1758
Published online: 31 Aug 2021
AbstractforBlack phosphorus conjugation of chemotherapeutic ginsenoside Rg3: enhancing targeted multimodal nanotheranostics against lung cancer metastasis | Full Text | References | PDF (3 MB) | EPUB
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Immunosuppressive effect of PLGA-FK506-NPs in treatment of acute cardiac rejection via topical subcutaneous injection
Cheng Deng, Qiaofeng Jin, Ya Wu, Huiling Li, Luyang Yi, Yihan Chen, Tang Gao, Wenyuan Wang, Jing Wang, Qing Lv, Yali Yang, Jia Xu, Wenpei Fu, Li Zhang & Mingxing Xie
Pages: 1759-1768
Published online: 31 Aug 2021
AbstractforImmunosuppressive effect of PLGA-FK506-NPs in treatment of acute cardiac rejection via topical subcutaneous injection | Full Text | References | PDF (2.5 MB) | EPUB
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New-generation photosensitizer-anchored gold nanorods for a single near-infrared light-triggered targeted photodynamic–photothermal therapy
Zongjunlin Liu, Fang Xie, Jun Xie, Jianhao Chen, Yang Li, Qin Lin, Fanghong Luo & Jianghua Yan
Pages: 1769-1784
Published online: 02 Sep 2021
AbstractforNew-generation photosensitizer-anchored gold nanorods for a single near-infrared light-triggered targeted photodynamic–photothermal therapy | Full Text | References | PDF (4.9 MB) | EPUB
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Synergic fabrication of succimer coated titanium dioxide nanomaterials delivery for in vitro proliferation and in vivo examination on human aortic endothelial cells
Ming Qi, Chunfang Li, Ze Song & Lei Wang
Pages: 1785-1794
Published online: 02 Sep 2021
AbstractforSynergic fabrication of succimer coated titanium dioxide nanomaterials delivery for in vitro proliferation and in vivo examination on human aortic endothelial cells | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Glutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity
Walaa Ebrahim Abd El Hady, Osama Abd El-Aazeem Soliman, Hassan Mohamed El Sabbagh & Elham Abdelmonem Mohamed
Pages: 1795-1809
Published online: 02 Sep 2021
AbstractforGlutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity | Full Text | References | PDF (3.9 MB) | EPUB
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Experimental anti-tumor effect of emodin in suspension – in situ hydrogels formed with self-assembling peptide
Weipeng Wei, Jianhua Tang, Lei Hu, Yujie Feng, Hongfang Li, Chengchen Yin & Fushan Tang
Pages: 1810-1821
Published online: 02 Sep 2021
AbstractforExperimental anti-tumor effect of emodin in suspension – in situ hydrogels formed with self-assembling peptide | Full Text | References | PDF (5.3 MB) | EPUB
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Brain-targeting delivery of MMB4 DMS using carrier-free nanomedicine CRT-MMB4@MDZ
Yimeng Du, Jing Gao, Hui Zhang, Xiaohui Meng, Dong Qiu, Xiang Gao & Aiping Zheng
Pages: 1822-1835
Published online: 13 Sep 2021
AbstractforBrain-targeting delivery of MMB4 DMS using carrier-free nanomedicine CRT-MMB4@MDZ | Full Text | References | PDF (2.6 MB) | EPUB
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Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment
Khaled M. Hosny, Waleed Y. Rizg, Hala M. Alkhalidi, Walaa A. Abualsunun, Rana B. Bakhaidar, Alshaimaa M. Almehmady, Adel F. Alghaith, Sultan Alshehri & Amani M. El Sisi
Pages: 1836-1848
Published online: 13 Sep 2021
AbstractforNanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment | Full Text | References | PDF (1.7 MB) | EPUB
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Combination immunotherapy of chlorogenic acid liposomes modified with sialic acid and PD-1 blockers effectively enhances the anti-tumor immune response and therapeutic effects
Xixi Li, Shunyao Zhu, Ping Yin, Shuangshuang Zhang, Juewen Xu, Qin Zhang, Senlin Shi & Ting Zhang
Pages: 1849-1860
Published online: 13 Sep 2021
AbstractforCombination immunotherapy of chlorogenic acid liposomes modified with sialic acid and PD-1 blockers effectively enhances the anti-tumor immune response and therapeutic effects | Full Text | References | PDF (3 MB) | EPUB
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Article
Targeted treatment for osteoarthritis: drugs and delivery system
Liwei Mao, Wei Wu, Miao Wang, Jianmin Guo, Hui Li, Shihua Zhang, Jiake Xu & Jun Zou
Pages: 1861-1876
Published online: 13 Sep 2021
AbstractforTargeted treatment for osteoarthritis: drugs and delivery system | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Tailoring thixotropic mixed-lipid nanoconstructs of voriconazole for the management of Vulvovaginal candidiasis: Formulation, statistical optimization, in vitro characterization and in vivo assessment
Wessam H. Abd-Elsalam, Yosra Ibrahim Nagy & Samar M. Abouelatta
Pages: 1877-1889
Published online: 14 Sep 2021
AbstractforTailoring thixotropic mixed-lipid nanoconstructs of voriconazole for the management of Vulvovaginal candidiasis: Formulation, statistical optimization, in vitro characterization and in vivo assessment | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Rational formulation engineering of fraxinellone utilizing 6-O-α-D-maltosyl-β-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy
Jianbo Li, Tiange Feng, Weijing Yang, Yaru Xu, Shuaishuai Wang, Huijie Cai, Zhilei Liu, Hong Qiang & Jinjie Zhang
Pages: 1890-1902
Published online: 14 Sep 2021
AbstractforRational formulation engineering of fraxinellone utilizing 6-O-α-D-maltosyl-β-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng & Changmei Zhang
Pages: 1903-1914
Published online: 14 Sep 2021
AbstractforDesign and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug | Full Text | References | PDF (3.2 MB) | EPUB
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Advances in subcutaneous injections: PRECISE II: a study of safety and subject preference for an innovative needle-free injection system
E. Lynne Kelley, Richard H. Smith, Gillian Corcoran, Sandra Nygren, Mary V. Jacoski & Andrea Fernandes
Pages: 1915-1922
Published online: 20 Sep 2021
AbstractforAdvances in subcutaneous injections: PRECISE II: a study of safety and subject preference for an innovative needle-free injection system | Full Text | References | PDF (1.3 MB) | EPUB
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Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy
Gang Chen, Aftab Ullah, Gang Xu, Zhou Xu, Fei Wang, Tianqing Liu, Yi Su, Tangjie Zhang & Kaikai Wang
Pages: 1923-1931
Published online: 22 Sep 2021
AbstractforTopically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Novel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development
Paul-Octavian Stanescu, Ionut-Cristian Radu, Rebeca Leu Alexa, Ariana Hudita, Eugenia Tanasa, Jana Ghitman, Oana Stoian, Aristidis Tsatsakis, Octav Ginghina, Catalin Zaharia, Mikhail Shtilman, Yaroslav Mezhuev & Bianca Galateanu
Pages: 1932-1950
Published online: 22 Sep 2021
AbstractforNovel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development | Full Text | References | PDF (4.3 MB) | EPUB
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Article
Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing
Lianghui Zhao, Xia Qi, Tao Cai, Zheng Fan, Hongwei Wang & Xianli Du
Pages: 1951-1961
Published online: 25 Sep 2021
AbstractforGelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system
Xueju Qi, Cong Gao, Chuanjin Yin, Junting Fan, Xiaochen Wu & Chuanlong Guo
Pages: 1962-1971
Published online: 25 Sep 2021
AbstractforImproved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system | Full Text | References | PDF (3 MB) | EPUB
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Article
Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro, in vivo evaluation, and dermatokinetic studies
Lihua Chen, Majed Alrobaian, Obaid Afzal, Imran Kazmi, Sunil K. Panda, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Waleed H. Almalki, Hanadi A. Katouah, Tanuja Singh, Kriti Soni, Abdul Hafeez, Sarwar Beg, Vikas Kumar & Mahfoozur Rahman
Pages: 1972-1981
Published online: 25 Sep 2021
AbstractforCrotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro, in vivo evaluation, and dermatokinetic studies | Full Text | References | PDF (1.7 MB) | EPUB
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Article
A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer
Zhiyuan Zhang, Tianhao Su, Yanjing Han, Zeran Yang, Jian Wei, Long Jin & Haining Fan
Pages: 1982-1994
Published online: 27 Sep 2021
AbstractforA convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer | Full Text | References | PDF (3.7 MB) | EPUB
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Surface-engineered smart nanocarrier-based inhalation formulations for targeted lung cancer chemotherapy: a review of current practices
Xian-Yan Yu, Xue Jin & Zhang-Xuan Shou
Pages: 1995-2010
Published online: 27 Sep 2021
AbstractforSurface-engineered smart nanocarrier-based inhalation formulations for targeted lung cancer chemotherapy: a review of current practices | Full Text | References | PDF (2 MB) | EPUB
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Article
Wettability and contact angle affect precorneal retention and pharmacodynamic behavior of microspheres
Hanyu Liu, Xinyue Han, Huamei Li, Qi Tao, Jie Hu, Shuo Liu, Huaixin Liu, Jun Zhou, Wei Li, Fan Yang, Qineng Ping, Shijie Wei, Hongmei Liu, Huaqing Lin & Dongzhi Hou
Pages: 2011-2023
Published online: 27 Sep 2021
AbstractforWettability and contact angle affect precorneal retention and pharmacodynamic behavior of microspheres | Full Text | References | PDF (3.1 MB) | EPUB
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Article
RGD-targeted redox responsive nano micelle: co-loading docetaxel and indocyanine green to treat the tumor
Lili Ren, Junfang Nie, Jie Wei, Yaning Li, Jun Yin, Xiaolong Yang & Guoguang Chen
Pages: 2024-2032
Published online: 27 Sep 2021
AbstractforRGD-targeted redox responsive nano micelle: co-loading docetaxel and indocyanine green to treat the tumor | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy
Yanwen Zheng, Fanhua Kong, Songyang Liu, Xi Liu, Dongni Pei & Xiongying Miao
Pages: 2033-2043
Published online: 27 Sep 2021
AbstractforMembrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Determining the effect of ocular chemical injuries on topical drug delivery
Ghazala Begum, Thomas Leigh, David Stanley, Ann Logan & Richard James Blanch
Pages: 2044-2050
Published online: 01 Oct 2021
AbstractforDetermining the effect of ocular chemical injuries on topical drug delivery | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy
Zequn Zhang, Xi Liu, Zhaolong Shen, Jun Quan, Changwei Lin, Xiaorong Li & Gui Hu
Pages: 2051-2061
Published online: 01 Oct 2021
AbstractforEndostatin in fibrosis and as a potential candidate of anti-fibrotic therapy | Full Text | References | PDF (2 MB) | EPUB
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Article
O/W microemulsion droplets diffuse through hydrogel network to achieve enhanced transdermal drug delivery
Lina Shen, Xiaolin Hou, Zhi Wang, Teng Guo, Zehui He, Shuyao Ruan, Zhenda Liu, Hang Ruan, Yongtai Zhang & Nianping Feng
Pages: 2062-2070
Published online: 01 Oct 2021
AbstractforO/W microemulsion droplets diffuse through hydrogel network to achieve enhanced transdermal drug delivery | Full Text | References | PDF (2.4 MB) | EPUB
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Article
In vitro and in vivo evaluation of self-assembled chitosan nanoparticles selectively overcoming hepatocellular carcinoma via asialoglycoprotein receptor
Rensong Sun, Linlin Fang, Xia Lv, Jiani Fang, Yuting Wang, Dapeng Chen, Liang Wang, Jun Chen, Yan Qi, Zeyao Tang, Jianbin Zhang & Yan Tian
Pages: 2071-2084
Published online: 01 Oct 2021
AbstractforIn vitro and in vivo evaluation of self-assembled chitosan nanoparticles selectively overcoming hepatocellular carcinoma via asialoglycoprotein receptor | Full Text | References | PDF (3.9 MB) | EPUB
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Critical Review

Review
Biomimetic phototherapy in cancer treatment: from synthesis to application
Yifan Zhao, Cuixia Shi & Jie Cao
Pages: 2085-2099
Published online: 01 Oct 2021
AbstractforBiomimetic phototherapy in cancer treatment: from synthesis to application | Full Text | References | PDF (3.9 MB) | EPUB
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Research Article

Article
Targeting delivery and minimizing epidermal diffusion of tranexamic acid by hyaluronic acid-coated liposome nanogels for topical hyperpigmentation treatment
Ying Liu, Yue Han, Tingting Zhu, Xianglei Wu, Wenxin Yu, Jiafang Zhu, Ying Shang, Xiaoxi Lin & Tianlan Zhao
Pages: 2100-2107
Published online: 01 Oct 2021
AbstractforTargeting delivery and minimizing epidermal diffusion of tranexamic acid by hyaluronic acid-coated liposome nanogels for topical hyperpigmentation treatment | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Co-delivery of sorafenib and crizotinib encapsulated with polymeric nanoparticles for the treatment of in vivo lung cancer animal model
Tian Zhong, Xingren Liu, Hongmin Li & Jing Zhang
Pages: 2108-2118
Published online: 05 Oct 2021
AbstractforCo-delivery of sorafenib and crizotinib encapsulated with polymeric nanoparticles for the treatment of in vivo lung cancer animal model | Full Text | References | PDF (4.1 MB) | EPUB
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Article
A comprehensive study of the basic formulation of supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) of albendazolum
Hani Alothaid, Mohammed S. Aldughaim, Azeez Oriyomi Yusuf, Umama Yezdani, Alaa Alhazmi, Mahmoud M. Habibullah & Mohammad Gayoor Khan
Pages: 2119-2126
Published online: 06 Oct 2021
AbstractforA comprehensive study of the basic formulation of supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) of albendazolum | Full Text | References | PDF (938 KB) | EPUB
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Article
Transdermal delivery of triptolide–phospholipid complex to treat rheumatoid arthritis
Xin-Yi Liu, Wen-Jun Pei, Ye-Zhen Wu, Fang-Li Ren, Si-Yu Yang & Xiu Wang
Pages: 2127-2136
Published online: 07 Oct 2021
AbstractforTransdermal delivery of triptolide–phospholipid complex to treat rheumatoid arthritis | Full Text | References | PDF (2 MB) | EPUB
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Article
Alginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery
Dong Xu, Tao Qiao, Yue Wang, Qiang-Song Wang & Yuan-Lu Cui
Pages: 2137-2149
Published online: 07 Oct 2021
AbstractforAlginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Dendrimer-based posaconazole nanoplatform for antifungal therapy
Shengzhuang Tang, Jesse Chen, Jayme Cannon, Zhengyi Cao, James R. Baker Jr & Su He Wang
Pages: 2150-2159
Published online: 07 Oct 2021
AbstractforDendrimer-based posaconazole nanoplatform for antifungal therapy | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Hybrid chitosan-lipid nanoparticles of green tea extract as natural anti-cellulite agent with superior in vivo potency: full synthesis and analysis
Sara A. Abosabaa, Mona G. Arafa & Aliaa Nabil ElMeshad
Pages: 2160-2176
Published online: 08 Oct 2021
AbstractforHybrid chitosan-lipid nanoparticles of green tea extract as natural anti-cellulite agent with superior in vivo potency: full synthesis and analysis | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Novel cubosome based system for ocular delivery of acetazolamide
Hoda E. Teba, Islam A. Khalil & Heba M. El Sorogy
Pages: 2177-2186
Published online: 18 Oct 2021
AbstractforNovel cubosome based system for ocular delivery of acetazolamide | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
Yingqiu Xie, Chengling Mu, Bexultan Kazybay, Qinglei Sun, Aidana Kutzhanova, Guldan Nazarbek, Na Xu, Lazzat Nurtay, Qian Wang, Amr Amin & Xugang Li
Pages: 2187-2197
Published online: 18 Oct 2021
AbstractforNetwork pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Acute myocardial infarction therapy: in vitro and in vivo evaluation of atrial natriuretic peptide and triphenylphosphonium dual ligands modified, baicalin-loaded nanoparticulate system
Jie Wang, Shouwen Zhang & Lizhe Di
Pages: 2198-2204
Published online: 18 Oct 2021
AbstractforAcute myocardial infarction therapy: in vitro and in vivo evaluation of atrial natriuretic peptide and triphenylphosphonium dual ligands modified, baicalin-loaded nanoparticulate system | Full Text | References | PDF (1.1 MB) | EPUB
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Article
CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas
Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin & Chien-Ming Hsieh
Pages: 2205-2217
Published online: 18 Oct 2021
AbstractforCPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Targeted delivery and stimulus-responsive release of anticancer drugs for efficient chemotherapy
Lei Qiao, Xue Yuan, Hui Peng, Guisong Shan, Min Gao, Xiaoqing Yi & Xiaoyan He
Pages: 2218-2228
Published online: 20 Oct 2021
AbstractforTargeted delivery and stimulus-responsive release of anticancer drugs for efficient chemotherapy | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles
Ahmed K. Kammoun, Alaa Khedr, Maha A. Hegazy, Ahmad J. Almalki, Khaled M. Hosny, Walaa A. Abualsunun, Samar S. A. Murshid & Rana B. Bakhaidar
Pages: 2229-2240
Published online: 20 Oct 2021
AbstractforFormulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy
Mengyu Chen, Yuexin Cui, Wenyan Hao, Yueyue Fan, Jingqiu Zhang, Qianqian Liu, Mingrui Jiang, Yang Yang, Yingzi Wang & Chunsheng Gao
Pages: 2241-2255
Published online: 20 Oct 2021
AbstractforLigand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy | Full Text | References | PDF (4.4 MB) | EPUB
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Article
GLUT1 targeting and hypoxia-activating polymer-drug conjugate-based micelle for tumor chemo-thermal therapy
Pengkai Ma, Guijie Wei, Jianhua Chen, Ziqi Jing, Xue Wang & Zhijun Wang
Pages: 2256-2267
Published online: 20 Oct 2021
AbstractforGLUT1 targeting and hypoxia-activating polymer-drug conjugate-based micelle for tumor chemo-thermal therapy | Full Text | References | PDF (3.8 MB) | EPUB
  • 2011 Views
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Article
Local drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment
Dong-Hyun Kim, Thu Nhan Nguyen, Young-Min Han, Phuong Tran, Jinhyung Rho, Jae-Young Lee, Hwa-Young Son & Jeong-Sook Park
Pages: 2268-2277
Published online: 20 Oct 2021
AbstractforLocal drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium
Emilia Szymańska, Małgorzata Krzyżowska, Krzysztof Cal, Barbara Mikolaszek, Jakub Tomaszewski, Sławomir Wołczyński & Katarzyna Winnicka
Pages: 2278-2288
Published online: 20 Oct 2021
AbstractforPotential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies
Rofida Albash, Abdurrahman M. Fahmy, Mohammed I.A. Hamed, Khaled M. Darwish & Rania Moataz El-Dahmy
Pages: 2289-2300
Published online: 02 Nov 2021
AbstractforSpironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer
Zhehong Zhu, Manran Wu, Juan Sun, Zhengyuan Huangfu, Lingling Yin, Weipeng Yong, Jing Sun, Guanglin Wang, Fenghua Meng & Zhiyuan Zhong
Pages: 2301-2309
Published online: 03 Nov 2021
AbstractforRedox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer | Full Text | References | PDF (2.2 MB) | EPUB
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Letter to the Editor

Letter
New perpective for an old problem: extracellular vesicle based management of respiratory distress syndrome
Defne Engur & Abdullah Kumral
Pages: 2310-2312
Published online: 03 Nov 2021
First Page PreviewforNew perpective for an old problem: extracellular vesicle based management of respiratory distress syndrome | Full Text | References | PDF (301.5 KB) | EPUB
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Research Article

Article
Metronomic delivery of orally available pemetrexed-incorporated colloidal dispersions for boosting tumor-specific immunity
Ruby Maharjan, Laxman Subedi, Rudra Pangeni, Saurav Kumar Jha, Seo Hee Kang, Kwan-Young Chang, Youngro Byun, Jeong Uk Choi & Jin Woo Park
Pages: 2313-2328
Published online: 03 Nov 2021
AbstractforMetronomic delivery of orally available pemetrexed-incorporated colloidal dispersions for boosting tumor-specific immunity | Full Text | References | PDF (3.4 MB) | EPUB
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Review Article

Review
Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors
Xianhu Zeng, Zhipeng Li, Chunrong Zhu, Lisa Xu, Yong Sun & Shangcong Han
Pages: 2329-2347
Published online: 03 Nov 2021
AbstractforResearch progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors | Full Text | References | PDF (4 MB) | EPUB
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Research Article

Article
Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
Sultan Alshehri & Syed Sarim Imam
Pages: 2348-2360
Published online: 08 Nov 2021
AbstractforFormulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel | Full Text | References | PDF (2.4 MB) | EPUB
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Article
ROS-Activated homodimeric podophyllotoxin nanomedicine with self-accelerating drug release for efficient cancer eradication
Bingfeng Liang & Dangxia Zhou
Pages: 2361-2372
Published online: 08 Nov 2021
AbstractforROS-Activated homodimeric podophyllotoxin nanomedicine with self-accelerating drug release for efficient cancer eradication | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Triolein emulsion enhances temozolomide brain delivery: an experimental study in rats
Won-Bae Seung, Seung Heon Cha, Hak Jin Kim, Seon Hee Choi, Juho Lee, Dongmin Kwak, Hyunwoo Kim, Jin-Wook Yoo, Yong-Woo Kim, Sang Kyoon Kim & Da-Sol Lee
Pages: 2373-2382
Published online: 08 Nov 2021
AbstractforTriolein emulsion enhances temozolomide brain delivery: an experimental study in rats | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Ion-dependent slow protein release from in vivo disintegrating micro-granules
Patricia Álamo, Eloi Parladé, Hèctor López-Laguna, Eric Voltà-Durán, Ugutz Unzueta, Esther Vazquez, Ramon Mangues & Antonio Villaverde
Pages: 2383-2391
Published online: 08 Nov 2021
AbstractforIon-dependent slow protein release from in vivo disintegrating micro-granules | Full Text | References | PDF (2 MB) | EPUB
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Article
Recent advances in the local antibiotics delivery systems for management of osteomyelitis
Reem Khaled Wassif, Maha Elkayal, Rehab Nabil Shamma & Seham A. Elkheshen
Pages: 2392-2414
Published online: 10 Nov 2021
AbstractforRecent advances in the local antibiotics delivery systems for management of osteomyelitis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Enhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization
Qing Hu, Xiaoling Fu, Yanping Su, Yanfang Wang, Sihuan Gao, Xiaoqin Wang, Ying Xu & Changxi Yu
Pages: 2415-2426
Published online: 12 Nov 2021
AbstractforEnhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres
MJ Rodrigo, D Garcia-Herranz, A Aragón-Navas, M Subias, T Martinez-Rincón, S Mendez-Martínez, MJ Cardiel, J García-Feijoo, J Ruberte, R Herrero-Vanrell, L Pablo, E Garcia-Martin & I Bravo-Osuna
Pages: 2427-2446
Published online: 12 Nov 2021
AbstractforLong-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Targeted therapy of rheumatoid arthritis via macrophage repolarization
Xu Zhou, Dandan Huang, Runkong Wang, Mingquan Wu, Liyang Zhu, Wei Peng, He Tu, Xuangeng Deng, He Zhu, Zhong Zhang, Xinming Wang & Xi Cao
Pages: 2447-2459
Published online: 12 Nov 2021
AbstractforTargeted therapy of rheumatoid arthritis via macrophage repolarization | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection
Ji Luo, Xiaobo Li, Siyuan Dong, Peiyao Zhu, Wenke Liu, Shuguang Zhang & Jiang Du
Pages: 2460-2468
Published online: 12 Nov 2021
AbstractforLayer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy
Ailing Zhang, Jianbo Li, Shuaishuai Wang, Yaru Xu, Qinglian Li, Zhe Wu, Chenxu Wang, Haiyang Meng & Jinjie Zhang
Pages: 2469-2479
Published online: 12 Nov 2021
AbstractforRapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Silmitasertib-induced macropinocytosis promoting DDP intracellular uptake to enhance cell apoptosis in oral squamous cell carcinoma
Shaojuan Song, Xin Xia, Jiajia Qi, Xiaopei Hu, Qian Chen, Jiang Liu, Ning Ji & Hang Zhao
Pages: 2480-2494
Published online: 12 Nov 2021
AbstractforSilmitasertib-induced macropinocytosis promoting DDP intracellular uptake to enhance cell apoptosis in oral squamous cell carcinoma | Full Text | References | PDF (4 MB) | EPUB
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Article
Targeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity
Qiyi Feng, Junhuai Xu, Xinyi Liu, Haibo Wang, Junjie Xiong & Kai Xiao
Pages: 2495-2509
Published online: 29 Nov 2021
AbstractforTargeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability
Muhammad Ayub Khan, Muhammad Mohsin Ansari, Sadia Tabassam Arif, Abida Raza, Ho-Ik Choi, Chang-Wan Lim, Ha-Yeon Noh, Jin-Su Noh, Salman Akram, Hafiz Awais Nawaz, Muhammad Ammad, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Jin-Ki Kim & Alam Zeb
Pages: 2510-2524
Published online: 29 Nov 2021
AbstractforEplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability | Full Text | References | PDF (2.6 MB) | EPUB
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RESEARCH ARTICLE

Article
N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
Xiangrui Yang & Shichao Wu
Pages: 2525-2533
Published online: 29 Nov 2021
AbstractforN-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke | Full Text | References | PDF (2 MB) | EPUB
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Research Article

Article
Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis
Ya-Wen Zhang, Ling-Lan Tu, Yi Zhang, Jie-Chao Pan, Gao-Li Zheng & Li-Na Yin
Pages: 2534-2547
Published online: 02 Dec 2021
AbstractforLiver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis | Full Text | References | PDF (3.2 MB) | EPUB
  • 1964 Views
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Article
Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats
Man Zhang, Yang Bai, Chang Xu, Jinti Lin, JiaKang Jin, Ankai Xu, Jia Nan Lou, Chao Qian, Wei Yu, Yulian Wu, Yiying Qi & Huimin Tao
Pages: 2548-2561
Published online: 02 Dec 2021
AbstractforNovel optimized drug delivery systems for enhancing spinal cord injury repair in rats | Full Text | References | PDF (4.5 MB) | EPUB
  • 2453 Views
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Article
Development and evaluation of luteolin loaded pegylated bilosome: optimization, in vitro characterization, and cytotoxicity study
Ameeduzzafar Zafar, Nabil K. Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Mohd Yasir, Mohammed M. Ghoneim, Sultan Alshehri, Md. Khalid Anwer, Alanood S. Almurshedi & Abdullah S. Alanazi
Pages: 2562-2573
Published online: 06 Dec 2021
AbstractforDevelopment and evaluation of luteolin loaded pegylated bilosome: optimization, in vitro characterization, and cytotoxicity study | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Construction, characterization, and bioavailability evaluation of honokiol-loaded porous starch by melting method without any solvent
Weiwei Wu & Haiyang Xu
Pages: 2574-2581
Published online: 06 Dec 2021
AbstractforConstruction, characterization, and bioavailability evaluation of honokiol-loaded porous starch by melting method without any solvent | Full Text | References | PDF (1.3 MB) | EPUB
  • 908 Views
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Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy
Caihong Lu, Jinpeng Zheng, Yaning Ding, Yuanyuan Meng, Fangyun Tan, Wei Gong, Xiaoyang Chu, Xiaolong Kong & Chunsheng Gao
Pages: 2582-2593
Published online: 06 Dec 2021
AbstractforCepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy | Full Text | References | PDF (3.8 MB) | EPUB
  • 2802 Views
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Article
Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses
Congcong Li, Chaoxi Chen, Yucai Wei, Min Tan, Shuo Zhai, Juebo Zhao, Lu Wang & Tao Dai
Pages: 2594-2602
Published online: 06 Dec 2021
AbstractforCyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses | Full Text | References | PDF (2.2 MB) | EPUB
  • 2477 Views
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Article
Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates
Lianqi Liu, Fei Xie, Dian Xiao, Xin Xu, Zheng Su, Yanming Wang, Shiyong Fan, Xinbo Zhou & Song Li
Pages: 2603-2617
Published online: 13 Dec 2021
AbstractforSynthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Fabrication and characterization of Agarwood extract-loaded nanocapsules and evaluation of their toxicity and anti-inflammatory activity on RAW 264.7 cells and in zebrafish embryos
Manar A. Eissa, Yumi Z. H.-Y. Hashim, Mohd Hamzah Mohd Nasir, Yusilawati Ahmad Nor, Hamzah Mohd. Salleh, Muhammad Lokman Md. Isa, Saripah S. S. Abd-Azziz, Nor Malia Abd Warif, Eman Ramadan & Noha M. Badawi
Pages: 2618-2633
Published online: 13 Dec 2021
AbstractforFabrication and characterization of Agarwood extract-loaded nanocapsules and evaluation of their toxicity and anti-inflammatory activity on RAW 264.7 cells and in zebrafish embryos | Full Text | References | PDF (2.4 MB) | EPUB
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