Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 1 (2015)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 1 (2015)

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Editorial

Editorial
Human induced pluripotent stem cell-derived hepatocytes for toxicology testing
David A Mann (Product Manager) PhD
Pages: 1-5
Published online: 11 Nov 2014
AbstractforHuman induced pluripotent stem cell-derived hepatocytes for toxicology testing | Full Text | References | PDF (150.3 KB)
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Free Access

Original Research

Article
Evaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers
Shuji Kinoshita & Kazuoki Kondo MD
Pages: 7-14
Published online: 26 Nov 2014
AbstractforEvaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers | Full Text | References | PDF (424.6 KB)
  • 897 Views
  • 19 CrossRef citations
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Review

Review
Mitochondrial toxicity of cardiac drugs and its relevance to mitochondrial disorders
Josef Finsterer MD PhD & Sinda Zarrouk-Mahjoub PhD
Pages: 15-24
Published online: 21 Oct 2014
AbstractforMitochondrial toxicity of cardiac drugs and its relevance to mitochondrial disorders | Full Text | References | PDF (242.6 KB)
  • 695 Views
  • 19 CrossRef citations
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Review
Safety issues and drug–drug interactions with commonly used quinolones
Antonios Douros MD, Katja Grabowski & Ralf Stahlmann
Pages: 25-39
Published online: 26 Nov 2014
AbstractforSafety issues and drug–drug interactions with commonly used quinolones | Full Text | References | PDF (528.6 KB)
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Review
Competition between low-dose aspirin and other NSAIDs for COX-1 binding and its clinical consequences for the drugs’ antiplatelet effects
David Stepensky PhD & Gilad Rimon PhD
Pages: 41-52
Published online: 13 Oct 2014
AbstractforCompetition between low-dose aspirin and other NSAIDs for COX-1 binding and its clinical consequences for the drugs’ antiplatelet effects | Full Text | References | PDF (619 KB)
  • 562 Views
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Review
An extensive pharmacokinetic, metabolic and toxicological review of elderly patients under intensive chemotherapy for acute myeloid leukemia
Imit Kaur PhD, Jonathan E Constance PhD, Ken M Kosak BS, Michael G Spigarelli MD PhD & Catherine MT Sherwin PhD
Pages: 53-65
Published online: 09 Dec 2014
AbstractforAn extensive pharmacokinetic, metabolic and toxicological review of elderly patients under intensive chemotherapy for acute myeloid leukemia | Full Text | References | PDF (301.9 KB)
  • 346 Views
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Review
Pharmacogenetics of coumarin anticoagulants in Brazilians
Guilherme Suarez-Kurtz MD PhD & Mariana R Botton PharmD PhD
Pages: 67-79
Published online: 25 Oct 2014
AbstractforPharmacogenetics of coumarin anticoagulants in Brazilians | Full Text | References | PDF (434.3 KB)
  • 152 Views
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Review
Effects of pesticide chemicals on the activity of metabolic enzymes: focus on thiocarbamates
Cécile Mathieu, Romain Duval (PhD Student) , Ximing Xu (PhD Student) , Fernando Rodrigues-Lima (Professor) & Jean-Marie Dupret (Professor)
Pages: 81-94
Published online: 13 Nov 2014
AbstractforEffects of pesticide chemicals on the activity of metabolic enzymes: focus on thiocarbamates | Full Text | References | PDF (510.4 KB)
  • 242 Views
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Review
Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems
Victor Voicu, Flavian Ştefan Rădulescu & Andrei Medvedovici
Pages: 95-109
Published online: 06 Nov 2014
AbstractforRelationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems | Full Text | References | PDF (666 KB)
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Drug Evaluation

Clinical and pharmacokinetic evaluation of risperidone for the management of autism spectrum disorder
Mariken Dinnissen MSc, Andrea Dietrich MSc PhD, Barbara J van den Hoofdakker MSc PhD & Pieter J Hoekstra MD PhD
Pages: 111-124
Published online: 11 Nov 2014
AbstractforClinical and pharmacokinetic evaluation of risperidone for the management of autism spectrum disorder | Full Text | References | PDF (332.1 KB)
  • 809 Views
  • 10 CrossRef citations
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Pharmacokinetics, pharmacodynamics and clinical efficacy of dapagliflozin for the treatment of type 2 diabetes
Marianna Maranghi MD PhD, Anna Carnovale MD, Cosimo Durante MD PhD, Giovanna Tarquini MD, Giusy Tiseo MD & Sebastiano Filetti MD
Pages: 125-137
Published online: 24 Nov 2014
AbstractforPharmacokinetics, pharmacodynamics and clinical efficacy of dapagliflozin for the treatment of type 2 diabetes | Full Text | References | PDF (391.2 KB)
  • 993 Views
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Pharmacokinetic and pharmacodynamic considerations on the erythropoietin effect and adverse events of darbepoetin
Frieder Keller, Ulla Ludwig & David Czock
Pages: 139-147
Published online: 03 Dec 2014
AbstractforPharmacokinetic and pharmacodynamic considerations on the erythropoietin effect and adverse events of darbepoetin | Full Text | References | PDF (499.7 KB)
  • 322 Views
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Evaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder
Roberto Mandrioli, Michele Protti & Laura Mercolini
Pages: 149-174
Published online: 06 Dec 2014
AbstractforEvaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder | Full Text | References | PDF (467.2 KB)
  • 494 Views
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Further Readings

Related articles
Page: 1
Published online: 12 Dec 2014
CitationforRelated articles | Full Text | PDF (88.2 KB)
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