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Volume 11, Issue 9

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 9 (2015)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 9 (2015)

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Editorial

Pharmacokinetic considerations in the use of anticancer drugs during pregnancy: challenges and new developments

David J Bell (Specialist Registrar in Medical Oncology) MRCP(UK) MbChB BSc(Hons) & David J Kerr (Professor of Cancer Medicine) CBE MD DSc FRCP(Glas,Lon,Edin) FRCGP FMedSci

Pages: 1341-1344

Published online: 12 Jun 2015

AbstractforPharmacokinetic considerations in the use of anticancer drugs during pregnancy: challenges and new developments | Full Text | References | PDF (143.4 KB)

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Free Access

Original Research

Article

A double-blinded, placebo-controlled, multicenter clinical trial of N-acetylcysteine for preventing amphotericin B-induced nephrotoxicity

Iman Karimzadeh (Assistant Professor) PharmD PhD, Hossein Khalili (Full Professor) PharmD PhD, Mohammad Mahdi Sagheb (Nephrologist, Associated Professor) MD & Shadi Farsaei (Assistant Professor) PharmD PhD

Pages: 1345-1355

Published online: 07 Jun 2015

AbstractforA double-blinded, placebo-controlled, multicenter clinical trial of N-acetylcysteine for preventing amphotericin B-induced nephrotoxicity | Full Text | References | PDF (487.6 KB)

336 Views
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Review

Translational value of liquid chromatography coupled with tandem mass spectrometry-based quantitative proteomics for in vitro–in vivo extrapolation of drug metabolism and transport and considerations in selecting appropriate techniques

Hajar Al Feteisi (PhD Candidate) BSc MSc, Brahim Achour (Research Associate) MPharm PhD, Amin Rostami-Hodjegan (Professor of Systems Pharmacology) PharmD PhD & Jill Barber (Reader in Pharmacy) MA PhD

Pages: 1357-1369

Published online: 24 Jun 2015

AbstractforTranslational value of liquid chromatography coupled with tandem mass spectrometry-based quantitative proteomics for in vitro–in vivo extrapolation of drug metabolism and transport and considerations in selecting appropriate techniques | Full Text | References | PDF (448.2 KB)

397 Views
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Pharmacodynamic considerations of small molecule targeted therapy for treating B-cell malignancies in the elderly

Anna Korycka-Wołowiec PhD, Dariusz Wołowiec MD PhD & Tadeusz Robak MD PhD

Pages: 1371-1391

Published online: 09 Jul 2015

AbstractforPharmacodynamic considerations of small molecule targeted therapy for treating B-cell malignancies in the elderly | Full Text | References | PDF (963.1 KB)

470 Views
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Considerations when using pharmacokinetic/pharmacodynamic modeling to determine the effectiveness of simple analgesics in children

Brian J Anderson PhD FANZCA FJFICM & Jacqueline A Hannam PhD

Pages: 1393-1408

Published online: 09 Jul 2015

AbstractforConsiderations when using pharmacokinetic/pharmacodynamic modeling to determine the effectiveness of simple analgesics in children | Full Text | References | PDF (919.9 KB) | Supplemental

434 Views
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Review of dose–response curves for acute antimigraine drugs: triptans, 5-HT_1F agonists and CGRP antagonists

Anders Hougaard MD PhD & Peer Tfelt-Hansen MD DMSc

Pages: 1409-1418

Published online: 22 Jun 2015

AbstractforReview of dose–response curves for acute antimigraine drugs: triptans, 5-HT_1F agonists and CGRP antagonists | Full Text | References | PDF (614.1 KB)

840 Views
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Formulation and physiologic factors affecting the pharmacology of carrier-mediated anticancer agents

Andrew T Lucas (Post-doctorate Research Associate) PharmD MS, Andrew J Madden (Post-doctorate Research Associate) PharmD & William C Zamboni PharmD PhD

Pages: 1419-1433

Published online: 14 Jul 2015

AbstractforFormulation and physiologic factors affecting the pharmacology of carrier-mediated anticancer agents | Full Text | References | PDF (634.4 KB)

249 Views
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Drug–drug interactions that interfere with statin metabolism

Takeshi Hirota & Ichiro Ieiri PhD

Pages: 1435-1447

Published online: 10 Jun 2015

AbstractforDrug–drug interactions that interfere with statin metabolism | Full Text | References | PDF (326.2 KB)

1865 Views
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Role of pharmacogenetics of drug-metabolizing enzymes in treating osteosarcoma

Claudia Maria Hattinger PhD & Massimo Serra PhD

Pages: 1449-1463

Published online: 22 Jun 2015

AbstractforRole of pharmacogenetics of drug-metabolizing enzymes in treating osteosarcoma | Full Text | References | PDF (312.5 KB) | Supplemental

168 Views
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Drug Evaluation

Extended release, 6-month formulations of leuprolide acetate for the treatment of advanced prostate cancer: achieving testosterone levels below 20 ng/dl

E David Crawford (Associate Director) MD, Judd W Moul (Professor of Surgery, Professor in Anesthesiology) MD, Oliver Sartor (Medical Director, Professor of Cancer Research) MD & Neal D Shore (Medical Director) MD

Pages: 1465-1474

Published online: 18 Aug 2015

AbstractforExtended release, 6-month formulations of leuprolide acetate for the treatment of advanced prostate cancer: achieving testosterone levels below 20 ng/dl | Full Text | References | PDF (262.3 KB)

789 Views
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Unique pharmacology of tapentadol for treating acute and chronic pain

Nebojsa Nick Knezevic MD PhD, Tatiana Tverdohleb (Research Assistant) MD, Ivana Knezevic (Clinical Research Coordinator) MD & Kenneth D Candido (Chairman) MD

Pages: 1475-1492

Published online: 27 Jul 2015

AbstractforUnique pharmacology of tapentadol for treating acute and chronic pain | Full Text | References | PDF (306 KB)

531 Views
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Albiglutide for treating type 2 diabetes: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy

Andreas Brønden, Signe V Naver, Filip K Knop & Mikkel Christensen (Consultant)

Pages: 1493-1503

Published online: 13 Jul 2015

AbstractforAlbiglutide for treating type 2 diabetes: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy | Full Text | References | PDF (280.3 KB)

385 Views
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Evolocumab in the treatment of dyslipidemia: pre-clinical and clinical pharmacology

Michael M Page & Gerald F Watts (Professor of Cardiometabolic Medicine)

Pages: 1505-1515

Published online: 18 Aug 2015

AbstractforEvolocumab in the treatment of dyslipidemia: pre-clinical and clinical pharmacology | Full Text | References | PDF (542 KB)

925 Views
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