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Volume 7, Issue 8

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 7, Issue 8 (2011)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 7, Issue 8 (2011)

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Editorial

Article

Have physiologically-based pharmacokinetic models delivered?

Andrea N Edginton PhD & Ghanashyam Joshi MSc

Pages: 929-934

Published online: 18 Jul 2011

AbstractforHave physiologically-based pharmacokinetic models delivered? | Full Text | References | PDF (176.9 KB)

430 Views
10 CrossRef citations
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Reviews

Article

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children

Saskia N de Wildt (Pediatric Intensivist, Clinical Pharmacologist) MD PhD

Pages: 935-948

Published online: 08 May 2011

AbstractforProfound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children | Full Text | References | PDF (297 KB)

920 Views
65 CrossRef citations
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Article

The mechanistic basis for the induction of hepatic steatosis by xenobiotics

David E Amacher PhD, DABT, FACB

Pages: 949-965

Published online: 21 Apr 2011

AbstractforThe mechanistic basis for the induction of hepatic steatosis by xenobiotics | Full Text | References | PDF (250 KB)

433 Views
20 CrossRef citations
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Article

Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs

Kimie Sai PhD & Yoshiro Saito PhD

Pages: 967-988

Published online: 17 May 2011

AbstractforEthnic differences in the metabolism, toxicology and efficacy of three anticancer drugs | Full Text | References | PDF (477.4 KB)

624 Views
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Article

Bioactivation of herbal constituents: simple alerts in the complex system

Zhong-Ze Fang, Yan-Yan Zhang, Xiu-Li Wang, Yun-Feng Cao, Hong Huo & Ling Yang

Pages: 989-1007

Published online: 24 May 2011

AbstractforBioactivation of herbal constituents: simple alerts in the complex system | Full Text | References | PDF (1.2 MB)

322 Views
30 CrossRef citations
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Article

Plasma protein binding and blood-free concentrations: which studies are needed to develop a drug?

Mario Pellegatti (DMPK Director (now retired)) , Sabrina Pagliarusco (DMPK principal scientist) , Lara Solazzo (DMPK scientist) & Dimitri Colato (DMPK scientist)

Pages: 1009-1020

Published online: 02 Jun 2011

AbstractforPlasma protein binding and blood-free concentrations: which studies are needed to develop a drug? | Full Text | References | PDF (436.2 KB)

1745 Views
23 CrossRef citations
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Article

Toxicological considerations for intravitreal drugs

Fernando M Penha MD PhD, Eduardo B Rodrigues MD, Bruno A Furlani MD, Eduardo Dib MD, Gustavo B Melo MD & Michel E Farah MD

Pages: 1021-1034

Published online: 01 Jun 2011

AbstractforToxicological considerations for intravitreal drugs | Full Text | References | PDF (592.5 KB)

589 Views
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Drug Evaluation

Article

Pharmacokinetic evaluation of levocetirizine

Marta Ferrer MD PhD

Pages: 1035-1047

Published online: 04 Jun 2011

AbstractforPharmacokinetic evaluation of levocetirizine | Full Text | References | PDF (440.2 KB)

836 Views
6 CrossRef citations
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