Xenobiotica, Volume 42, Issue 8 (2012)

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Xenobiotica, Volume 42, Issue 8 (2012)

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General Xenobiochemistry

Article
Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats
Dan Mei, Jia Li, Haiyan Liu, Li Liu, Xinting Wang, Haifang Guo, Can Liu, Ru Duan & Xiaodong Liu
Pages: 709-718
Published online: 12 Feb 2012
AbstractforInduction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats | Full Text | References | PDF (748.9 KB)
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Article
Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes
Noriaki Yoda, Chie Emoto, Shoichi Date, Satoshi Kondo, Masateru Miyake, Satoru Nakazato, Ken Umehara & Eiji Kashiyama
Pages: 719-730
Published online: 12 Feb 2012
AbstractforCharacterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes | Full Text | References | PDF (726.1 KB)
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Article
Rosuvastatin suppresses the liver microsomal CYP2C11 and CYP2C6 expression in male Wistar rats
Alice Zachařová, Michal Šiller, Alena Špičáková, Eva Anzenbacherová, Nina Škottová, Pavel Anzenbacher & Rostislav Večeřa
Pages: 731-736
Published online: 24 Feb 2012
AbstractforRosuvastatin suppresses the liver microsomal CYP2C11 and CYP2C6 expression in male Wistar rats | Full Text | References | PDF (679.6 KB)
  • 276 Views
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Article
Free radical metabolism of raloxifene in human liver microsomes
Heng-Keang Lim, Min Yang, Wing Lam, Fran Xu, Jie Chen, Yaodong Xu, H. Umesha Shetty, Ke Yang, Jose Silva & David C. Evans
Pages: 737-747
Published online: 29 Feb 2012
AbstractforFree radical metabolism of raloxifene in human liver microsomes | Full Text | References | PDF (1.3 MB)
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Article
Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells
Prateek Bhatia, Michel Bernier, Mitesh Sanghvi, Ruin Moaddel, Roland Schwarting, Anuradha Ramamoorthy & Irving W. Wainer
Pages: 748-755
Published online: 08 Mar 2012
AbstractforBreast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells | Full Text | References | PDF (900.4 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Prediction of drug concentration-time data in humans from animals: a comparison of three methods
Iftekhar Mahmood & Kosalaram Goteti
Pages: 756-765
Published online: 24 Feb 2012
AbstractforPrediction of drug concentration-time data in humans from animals: a comparison of three methods | Full Text | References | PDF (915.4 KB)
  • 452 Views
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics of verapamil and its metabolite norverapamil in rats with hyperlipidaemia induced by poloxamer 407
Young Sun Lee, Ji Na Yoon, In-Soo Yoon, Myung Gull Lee & Hee Eun Kang
Pages: 766-774
Published online: 02 Feb 2012
AbstractforPharmacokinetics of verapamil and its metabolite norverapamil in rats with hyperlipidaemia induced by poloxamer 407 | Full Text | References | PDF (927.3 KB)
  • 460 Views
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Article
Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry
Zhijie Zheng, Tongmeng Yan, Weiying Chen, Ling Ye, Lan Tang & Zhongqiu Liu
Pages: 775-783
Published online: 21 Feb 2012
AbstractforPharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry | Full Text | References | PDF (869.9 KB)
  • 309 Views
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Article
Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices
Cheng-Xian Guo, Qi Pei, Ji-Ye Yin, Xiang-Dong Peng, Bo-Ting Zhou, Ying-Chun Zhao, Lan-Xiang Wu, Xiang-Guang Meng, Guo Wang, Qing Li, Dong-Sheng Ouyang, Zhao-Qian Liu, Wei Zhang & Hong-Hao Zhou
Pages: 784-790
Published online: 01 Mar 2012
AbstractforEffects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices | Full Text | References | PDF (735.7 KB)
  • 457 Views
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Article
The influence of probiotic treatment on sulfasalazine metabolism in rat
Hee Ji Lee, Hu Zhang, David A. Orlovich & J. Paul Fawcett
Pages: 791-797
Published online: 21 Feb 2012
AbstractforThe influence of probiotic treatment on sulfasalazine metabolism in rat | Full Text | References | PDF (905.4 KB)
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Article
Influence of capsaicin on fluctuation of digoxin pharmacokinetics in lipopolysaccharide-treated rats
Ryuji Kato, Akina Higashitani, Takako Irie, Yugo Kusukawa, Yu Yamamoto, Machiko Nakagawa, Yoko Urashima, Makoto Nagata, Tetsuya Hayashi, Yoshio Ijiri & Kazuhiko Tanaka
Pages: 798-807
Published online: 14 Mar 2012
AbstractforInfluence of capsaicin on fluctuation of digoxin pharmacokinetics in lipopolysaccharide-treated rats | Full Text | References | PDF (899.8 KB)
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Topics in Xenobiochemistry

Article
Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes
Dong Dong, Roland Ako, Ming Hu & Baojian Wu
Pages: 808-820
Published online: 02 Mar 2012
AbstractforUnderstanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes | Full Text | References | PDF (1.6 MB)
  • 567 Views
  • 26 CrossRef citations
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Book Review

Book Review
New horizons in predictive toxicology: current status and applications
Nick Plant
Page: 821
Published online: 09 Jul 2012
CitationforNew horizons in predictive toxicology: current status and applications | Full Text | PDF (544.6 KB)
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Obituary

Obituary
David Francis Victor Lewis (1949–2012)
Brian G. Lake, Jean-Lou Dorne & Costas Ioannides
Page: 822
Published online: 09 Jul 2012
CitationforDavid Francis Victor Lewis (1949–2012) | Full Text | PDF (539.2 KB)
  • 492 Views
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